Showing 3 results for Faramarzi
Mahdi Ghafari, Mohamad Faramarzi, Ebrahim Banitalebi,
Volume 17, Issue 4 (5-2018)
Abstract
Background: Lipid metabolism disorder in muscle plays an important role in creating insulin resistance in skeletal muscle. Perilipin 3 (PLIN3) is one of PLIN proteins in regulation of muscle lipolysis. The purpose of this study was compared two different endurance training intensities on perilipin 3 protein expression in skeletal muscle, serum insulin levels and glucose in streptozotocin-induced diabetic rats.
Method: 24 male Wistar rats were randomly divided into three groups. Low and high and high-intensity and control group. Endurance training was applied three times a week for eight weeks. The low-intensity exercise group was trained to the treadmill by running at a speed of 60 percent of vo2max and high-intensity training 85%Vo2max. The expression of the plin2 protein was analyzed by Western blot technique. To determine the significance of differences between the groups, the results were analyzed using one-way ANOVA and Tukey post-hoc test (α= 0.05).
Results: Direct comparison between the groups by ANOVA showed significant differences in perilipin 3 (p=0.0006). Tukey's post hoc test showed that there was a statistical difference between the mean values of the diabetic control group and high-intensity endurance group (P = 0.01). Perilipin 3 not significantly increased in low-intensity exercise compared to the control group (P=0. 67). Also, the comparison between groups showed, there was significant difference between the three groups. The serum levels of glucose and insulin (respectively p=0.001 and p=.001).
Conclusion: The results of the present study showed that the Effects of with high-intensity endurance training increase the expression perilipin 3 in diabetes rats.
Mousa Khalafi, Marzieh Faramarzi, Kayvan Sharifmoradi,
Volume 23, Issue 2 (5-2023)
Abstract
Background: CTRP3 is known to be an adipose tissue-derived anti-inflammatory hormone that leads to improved insulin resistance. However, the effects of exercise training on this adipokine are poorly understood. Therefore, the aim of the present meta-analysis was to investigate the effect of exercise training on circulating CTRP3 levels in adults with metabolic disorders.
Methods: A comprehensive search was conducted in PubMed and Web of Science databases through October 2022 using the keywords "exercise training" and "CTRP3". The inclusion criteria for the current research included human studies with metabolic disorders, exercise training intervention, and circulating CTRP3 values. Standardized mean difference (SMD) and 95% confidence interval were calculated using random method.
Results: A total of 9 studies including 12 intervention arms and 365 participants with metabolic disorders were included in the meta-analysis. The results of data analysis showed that exercise training led to a significant increase in CTRP3 [0.57, (CI: 1.10 to 0.03) P=0.03]. Also, the results of the I2 test showed that there is a high and significant heterogeneity (I2 =84.59, P=0.001) and the results of the Egger test showed a significant publication bias (P=0.001).
Conclusion: Exercise training with a moderate effect size leads to a significant increase in circulating CTRP3 levels in individual with metabolic and cardiovascular diseases, which may be a mediator of the beneficial effects of exercise training.
Laleh Bagheri, Mohammad Faramarzi, Zahra Hemati Farsani, Masoumeh Hossein Zadeh,
Volume 23, Issue 6 (1-2024)
Abstract
Background: Fetoin-A and -B are hepatokines that are related to type 2 diabetes. The aim of the present study was to investigate the effect of a period of resistance and endurance training with Ursolic acid consumption on the levels of Fetoin-A and -B in the liver tissue of elderly diabetics.
Methods: Fifty six 21-month-old male diabetic rats were randomly divided into seven equal groups of control (C), Ursolic acid supplement (UA), supplement+resistance exercise (UA+R), supplement+endurance exercise (UA+E), Resistance training (R), endurance training (E) and sham group (D). Resistance training protocol with intensity of 60% MVCC, 14-20 times of ladder climbing with one minute rest between each effort and endurance training including running on Treadmill at high intensity 60-75% and low intensity 30-40% of maximum speed for five days per week for eight weeks. Supplemented groups received 500 mg/kg UA in combination with a high-fat meal.
Results: Fetoin-A level was significantly decreased in UA, E, UA+E groups (p≤0.05) and only in R and UA+R groups, there was no significant decrease. Also, The amount of Fetoin-B in diabetic rats in the UA, E, R, UA+E groups decreased significantly (p≤0.05) and only in the UA+R training group there were no significant changes. The amount of Fetoin-A and Fetoin-B was significantly different between E and R and UA+R and UA+E groups (p≤0.05), which the largest decrease was in the UA+E group.
Conclusion: Considering the beneficial effects of exercise training as well as UA supplementation on hepatokines, it seems that the simultaneous application of two interventions of exercise training and UA supplementation has a more therapeutic effect on the hepatic hepatokines of diabetics.
