Showing 2 results for Ghanbarian
Seyed Mehrdad Sulati, Arash Ghanbarian, Maziayar Rahmani, Narghes Sarbazi, Sima Alah Verdian, Fereidoun Azizi,
Volume 2, Issue 2 (17 2003)
Abstract
Background: Risk factors of cardiovascular disorders have been the subject of several studies. Recently, simultaneous high waist circumference (WC) and high serum triglyceride (Tg) has been proposed as a simple screening measure to predict non-traditional risk factors. This study has looked at the risk factors of cardiovascular disorders present in subjects with this phenotype.
Methods: Non diabetic females of age 18-65 years who had been enrolled in the Tehran Lipid and Glucose Study (TLGS) were recruited.
Based on fasting Tg and WC, subjects fell into four categories: TgHWH ( Tg>160 mg/dl, WC>80 cm), TgHWL (Tg>160 mg/dl,WC<80 cm), TgLWH(Tg<160 mg/dl,WC>80 cm) and TgLWL (Tg<160 mg/dl,WC<80 cm).
Cardiovascular risk factors including lipid profiles and anthropometric variables were compared between the categories. The prevalence of hypertension, LDL-C>130 mg/dl, total cholesterol>220 mg/dl and HDL- C<45 mg/dl were also determined in each category.
Results: 5630 subjects were studied. TgLWL and TgHWH constituted to 27.5 % and 31.9 % of subjects, respectively. Mean age of subjects dropping in TgLWL, TgLWH, TgHWL and TgHWH groups was 28±10, 39±12, 36+12 and 46±11, respectively and TgHWH subjects were significantly older than other groups (p<.001).
Systolic and diastolic blood pressures, body mass index and WC were significantly higher in TgHWH. Significantly higher levels of total cholesterol, triglycerides and LDL-C and significantly lower level of HDL-C were found in the TgHWH group. The prevalence of subjects with four or more risk factors was 61.4% in TgHWH versus 1% in TgLWL group.
Conclusion: Parallel high waist circumference and high serum triglycerides (TgHWH) can find use as a simple screening measure to predict other risk factors of cardiovascular disorders.
Farzad Hadaegh, Hadi Harati, Arash Ghanbarian, Fereidoun Azizi,
Volume 4, Issue 4 (17 2005)
Abstract
Background: To evaluate the role of lipid markers including total cholesterol (TC), LDL-C and HDL-C vs. lipid indices (TC/HDL-C, LDL-C/HDL-C and non-HDL-C) as short term predictors of cardiovascular outcomes in adults over 30 years.
Methods: As a nested case and control study, there were 207 CVD events among participants of Tehran Lipid and Glucose Study (TLGS) documented during 3 years of follow-up. Those cases that were free of CVD at baseline (132 subjects) were matched to 264 controls for age and sex. In all subjects, demographic and clinical data including blood pressure and anthropometric measurements as well as serum lipids, fasting and 2-hour glucose were available from the database of the TLGS. We estimated the relative risk (RR) for each lipid parameter in a multiple stepwise regression model after adjustment for family history of premature CHD, smoking, systolic and diastolic blood pressure, fasting and 2-hour plasma glucose and waist-to-hip ratio.
Results: The RRs associated with an increase of ≈1 SD of independent lipid predictors in the multivariate model were as follow: total cholesterol (RR=1.6 [1.2-2.0], SD= 1.3 mmol/L), LDL-C (RR=1.5 [1.1-2.0], SD= 1 mmol/L), non-HDL-C (RR=1.6 [1.2-2.1], SD= 1.2 mmol/L) and cholesterol/HDL-C (RR= 1.5 [1.1-2.0], SD= 1.8). The comparing of these four independent variables with ROC curve analysis showed that there was no significant difference in their predictive power for cardiovascular outcome. There was no association between HDL-C, triglyceride and LDL-C/HDL-C and CVD outcome in multivariate analysis.
Conclusion: This study showed that TC, LDL-C, non-HDL-C and TC/HDL-C have similar predictive values for short term prediction of CVD outcome. It seems TC may be a reasonable choice for short term prediction of CVD outcome, because of lower cost.
