Showing 2 results for Gharipour
Seddigheh Asgari, Gholamali Naderi, Mojgan Gharipour, Gholamreza Dashti , Ali Sajadian,
Volume 3, Issue 1 (16 2004)
Abstract
New studies have introduced atherosclerosis as an inflammatory disorder. Usage of anti-inflammatory drugs thus can be useful in preventing atherosclerosis and anti-inflammatory herbal medicines without side effects seem desirable in this view.
Amirkahiria Odorutissima (AO) (umbelliferae) is an Iranian flora being traditionally used a:> an antiinflammatory drug. This study assessed the effects of this plant on the development and progression of fatty streaks.
Methods: Twenty male rabbits were obtained from Iran Pasture institute and were kept under standard condition for two weeks, then randomly divided into four groups with different diets. Groups 1 were fed on rabbit chow (normal cholesterol), group 2 were fed on a high cholesterol diet. group 3 were fed on normal cholesterol diet supplemented with AO, group 4 were fed on high cholesterol diet supplemented with AO. After 12 weeks, the animals were killed and biopsied for their aortas and right and left branches of coronary arteries. Biochemical factors were measured at baseline and after 12 weeks. Levels of cholesterol, LDL, HDL. triglyceride and fasting blood sugar (FBS) were determined by enzymatic methods, and quantitative CRP were determined with turbidometrie methods, malondialdehyde (MDA) and antioxidant capacity were determined with spectrophotometry.
Results: The results indicated that there was a significant difference between AO supplemented group compared with other groups (p<0.05) in terms of mean grade o"' fatty streak o"' right and left coronary arteries and aorta. At the end of the 12 weeks period, cholesterol. LDL and CRP were significantly reduced in the groups 3 and 4 (p<0.05).
Conclusion: This study suggests a protective role for Amirkahiria odoratissima Mozaffahan against the development of fatty streak the mechanism of which should be investigated in future studies.
Sedigheh Asgari, Mojgan Gharipour, Gholamali Naderi, Babak S Abet, Alireza Khosravi, Mohammad Hashemi,
Volume 4, Issue 2 (17 2004)
Abstract
Background: Atherosclrosis is a process that initiated with hypercholestrolemia and fatty streak formation. Previous studies showed oxidative modification of LDL render immunogenic and autoantibodies to epitopes of oxidized LDL. Oxidized LDL (OX-LDL), has antigenic properties. Antibodies against oxidized LDL have been proposed to be independent predictors of atherosclerosis development. The main aims of the current study were to compare antibody titers to different types of oxidized LDL (Cu+2-LDL, Malondialdehyde-LDL) and Native-LDL between angiographically documented coronary patients, non-documented patients and healthy subjects. Correlation between autoantibodies against oxidized LDL and increased risks of cardiovascular diseases has been shown.
Methods: As a case-control study, we evaluated angiographically documented coronary patients, non-documented patients and healthy subjects to measure anti-OX-LDL autoantibody levels.
Enzyme-linked immunosorbent assay was used to measure anti-OX-LDL autoantibodies. ANOVA test used for statistical analysis.
Results: Titers of anti-Malondialdehydo-LDL autoantibodies were 3.55±0.415, 0.361±0.20, 0.093±0.078 respectively in each group (P<0.005). There was not statistically meaningful difference, between native-LDL and Cu+2-LDL antibodies.
Conclusion: It seems the titre of autoantibodies against OX-LDL considered as a predictor of progression of atherosclerosis. Our data provide further support for a role of oxidatively modified LDL in atherogenesis.
