Showing 5 results for Ghazalian
Saeideh Tabibirad, Hosein Abednatanzi, Hojatallah Nikbakht, Farshad Ghazalian, Mandana Gholami,
Volume 18, Issue 5 (7-2019)
Abstract
Background: Obesity increases the risk of developing type 2 diabetes with regard to the hormones involved. The purpose of this quasi-experimental study was to investigate the effect of aerobic exercise on Dpp-4 and GLP-1 in obese women with type 2 diabetes.
Methods: From among obese women with type-2 diabetes mellitus 35-50 years old referred to the Diabetes Association of Saveh, 20 people were voluntarily selected and randomly assigned to two groups of control (10) and Experiment group (10) were divided. Twenty four hours before the beginning of the training, the individual characteristics of the subjects included age, height, weight, body mass index and research variables (insulin resistance, Dpp-4 and GLP-1) in the pre-test and the training group Aerobic exercise lasted for 8 weeks, 3 sessions per week, and 45-60 minutes each session, and the control group did not practice. After 8 weeks and 24 hours after the last training session, the individual characteristics and variables of the research were again measured. Data were analyzed by independent t-test and dependent t-test at p≤0.05.
Results: There was a significant increase in the level of GLP-1 (P= 0.001) and a significant decrease in DPP-4 level (P= 0.001) in the aerobic exercise group compared to the control group.
Conclusion: Results showed that Dpp-4 and GLP-1 values were significantly different in aerobic training group after 8 weeks compared to control group. It was also found that aerobic training significantly increased the level of GLP-1 and decreased the level of DPP-4.
Fatemeh Janbozorgi, Farshad Ghazalian, Khosrow Ebrahim, Hosein Abed Natanzi , Mandana Gholami,
Volume 22, Issue 4 (11-2022)
Abstract
Introduction: The purpose of this research was to explain the protective effect of quercetin on cardiac fatigue caused by exercise in skyrunning runners.
Methods: 26 professional sky running athletes voluntarily and purposefully participated in this race. Random people were placed in 2 groups: quercetin (13 people) and placebo (13 people). The race was held in the central Alborz mountains, the total distance traveled was 21 km and 200 meters, the altitude of the starting point was 1650 meters above sea level, the maximum altitude was 3150 meters above sea level. Before and immediately and 1 hour after the end of the race, blood was taken from the subjects. In order to check the changes of the studied variables, the independent T-test was used at the significance level of alpha 0.05.
Results: The amount of cardiac troponin T decreased significantly immediately and 1 hour after the end of the race in the quercetin group compared to the placebo group (P < 0.05). No significant difference was observed between the two groups of quercetin and placebo in the pre-test, immediately after the test and 1 hour after the test (P>0.05).
Conclusion: It seems that the increase of free fatty acids after the competition and long-term sports play an important role in reducing cardiac inotropic during the same period. Skyrunning competitions cause an increase in heart damage indices in professional athletes, despite this, quercetin supplementation reduces the increase in cardiac troponin T and can have a protective effect on the athlete's heart
Masuad Jahantash, Hossein Abednatanzi, Mandana Gholami, Farshad Ghazalian,
Volume 22, Issue 6 (3-2023)
Abstract
Background: Type 2 diabetes is the most common endocrine disease that can cause tissue damage and apoptosis. The purpose of the present study was to study the changes in the expression of related liver apoptosis genes after High Intensity Training (HIT) and royal jelly in type 2 diabetic rats.
Methods: The statistical sample of the study was 36 male rats that became diabetic after 20 weeks of high-fat diet and injection of 25 ml/kg of STZ. Fasting glucose between 150 and 400 mg/dl was considered as the criteria for type 2 diabetes. Diabetic rats were placed in 4 groups: control, HIIT, Jelly, and HIIT-Jelly. The HIITprotocol was performed 8 weeks, 5 sessions / week with intense 2-minute intervals with 2-8 intervals and 80-90% vo2max and one-minute rest intervals with 50-56% vo2max and Royal Jelly gavage at 100 mg/kg for 5 days / week. Data analysis was done using one-way and two-factor analysis of variance and post hoc test.
Results: The results showed that compared to the control group, HIIT led to a significant decrease in glucose and insulin resistance index. Also, HIIT and royal jelly consumption led to a decrease in Bax gene expression and an increase in Bcl2 gen expression and a decrease in the Bax/Bcl2 ratio in liver cells compared to the control group (P<0.05).
Conclusion: HIIT with royal jelly in diabetic rats led to the reduction and improvement of glycemic index and insulin resistance and appropriate changes in the expression of liver apoptotic genes.
Alireza Zandinezhad, Hossein Abednatanzi, Farshad Ghazalian, Alireza Barari,
Volume 23, Issue 3 (9-2023)
Abstract
Background: The aim of the present study was to study the changes in the expression of Cox-1 and Cox-2 genes in liver tissue and tumor volume after aerobic exercise and consumption of pineapple extract in mice with skin cancer.
Methods: This fundamental-laboratory study was conducted on 32 male C57BL/6 mice in four groups including control, aerobic exercise, pineapple extract and aerobic-pineapple exercise. After tumor induction, the animals underwent aerobic training program for six weeks and pineapple extract was gavage at 300mg/kg. The weight and tumor volume of mice were measured. After obtaining blood and tissue samples, expression of Cox-1 and Cox-2 genes in liver tissue was done by RT-PCR method. Then the data were analyzed using one-way analysis of variance, two-factor analysis of variance and post hoc test, and the significance level of p≤0.05 was considered.
Results: Compared to the control group, aerobic exercise and pineapple-exercise showed a significant decrease in tumor volume and a decrease in the expression of Cox-1 (0.59±0.97) and Cox-2 (0.5±0.4) gene expression in the aerobic-Pineapple compared to the control group (1±0) (p≤0.05). Cox1 gene expression increased significantly in the Aerobic exercise group, but a significant decrease was observed in the pineapple-Aerobic group. Also, Cox2 gene expression in the liver tissue in the exercise group Aerobic and interactive Aerobic-pineapple group had a significant decrease compared to the control, but in the pineapple group compared to the control, the difference in the expression of this gene was not significant.
Conclusion: The results of the present study showed that the expression of Cox 1 gene was significantly increased in the aerobic training group and significantly decreased in the pineapple-training group. Cox-2 gene expression in the liver tissue in the aerobic training group and the pineapple-training interactive group had a significant decrease compared to the control, because the Cox-2 enzyme is related to inflammation and pain, angiogenesis, cancer and Alzheimer's disease. Therefore, it can be concluded that its inhibition or reduction can be considered as a promising and effective strategy for the treatment and prevention of cancer.
Shadi Jalalian, Hossein Abednatanzi, Mandana Gholami, Farshad Ghazalian,
Volume 23, Issue 4 (11-2023)
Abstract
Background: Oxidative stress and insulin resistance in type 2 diabetes are one of the factors in the development of cognitive disorders and Alzheimer's. So measuring the changes in beta amyloid gene expression and insulin resistance as one of the prominent disorders in type 2 diabetes, following HIIT and thyme’s honey consumption is the aim of the research.
Methods: The present study was conducted with 36 young male Wistar rats, which were divided into 4 groups: control (C), interval training (T), thyme’s honey (H) and interval training-thyme’s honey (TH) was performed. The rats in the T and TH groups were trained for two months with intervals and intensity gradually increasing, and in the H and TH groups, they received 3 g/kg of thyme’s honey. Weight, fasting glucose and insulin were measured through the kit and insulin resistance index was done through the formula and gene expression were evaluated by RT-PCR. The findings were subjected to one-way and two-way ANOVA and Bonferroni's test.
Results: Non-significant (NS) increase in weight, significant increase in insulin and significant decrease in gene expression in all intervention groups compared to C, significant decrease in fasting glucose in T and TH groups compared to C, significant decrease in insulin resistance in T group compared to other groups, NS increase was observed in group H and TH compared to C.
Conclusion: HIIT and thyme’s honey had synergistic effect to reduce glucose and beta-amyloid gene expression as a preventive strategy for the occurrence of pathological features related to Alzheimer's and memory impairment in diabetics.
