Showing 4 results for Haghpanah
Sayed Mahmoud Sajjadi-Jazi, Farshad Sharifi, Mehdi Varmaghani, Hamidreza Aghaei Meybodi, Farshad Farzadfar, Vahid Haghpanah, Bagher Larijani,
Volume 19, Issue 3 (2-2020)
Abstract
Background: The aim of this study was to estimate the prevalence of clinical hyperthyroidism at the national and sub-national levels using the claims data.
Methods: National anti-thyroid medications (methimazole and propylthiouracil) sales data in 2014 were extracted from pharmaceutical sales data that were reported by Iran's Food and Drug Administration (FDA). By using prescriptions data of Social Security Insurance Organization (SSIO) and Medical Services Insurance Organization (MSIO) in 2014, age-sex-province proportions of drug consumptions and Defined Daily Dose (DDD) of anti-thyroid medications were calculated. Moreover, by systematic review and meta-analysis of published literatures in hyperthyroidism in Iran, the prescription rate of anti-thyroid medications was calculated. Finally by using the whole data, the prevalence of clinical hyperthyroidism was estimated in each age and sex groups in national and provincial levels.
Results: : The prevalence (95% confidence interval) of clinical hyperthyroidism in Iran in 2014 is 0.32% (0.21-0.51%); 0.44% (0.29-0.68%) in females and 0.2% (0.12-0.33%) in males. Among provinces the least prevalence rate of clinical hyperthyroidism is 0.24% (0.16-0.38%) which belongs to Sistan and Baluchistan, and the highest prevalence rate is 0.38% (0.24-0.6%) which belongs to Gilan.
Conclusion: The prevalence rate that reported by this study is compatible with other surveys which performed in the world and Iran. As a result using claims data is a good source to predict prevalence of chronic diseases that have specific drugs.
Zohreh Gholizadeh Siahmazgi, Shiva Irani, Ali Ghiaseddin, Parviz Fallah, Vahid Haghpanah,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Xanthohumol is one of the main bioactive compounds extracted from the female flowers of the hops plant (
Humulus lupulus L), that has been shown in several studies to have anti-cancer effects.The MAPK/ERK pathway is one of the key pathways in the regulation of gene expression, cell growth and survival. The abnormal activation of this pathway leads to the uncontrolled cell proliferation in thyroid cancer. This study aims to perform a bioinformatic screening of the proteins in the MAPK/ERK pathway and introduce them as target protein to Xanthohumol. In addition, due to the significant role of EGFR, Grb2, SOS proteins in the MAPK/ERK pathway
, they have also been studied.
Method: Using SwissADME software, first the physicochemical, pharmacokinetic and pharmacodynamic characteristics of Xanthohumol are predicted. Then three-dimensional structure of Xanthohumol and target proteins (EGFR, Grb2, SOS, RAS, BRAF, MEK1, MEK2, ERK1, ERK2) were collected from PubChem database and Protein Data Bank, finally, using Auto Dock 4.1.the molecular docking were studied.
Results: Our study shows lack of cytotoxicity in Xanthohumol. In addition, Xanthohumol with proper physicochemical properties does not induce drug resistance through pump P-glycoprotein mechanism. Analysis of molecular docking indicate that Xanthohumol has inhibitory potential to the all proteins studied. Note that its strongest interaction is with MEK2 protein with binding energy-7.04kcal.mol
-1.
Conclusion: According to our results, Xanthohumol has inhibitory potential to the all proteins present in the MAPK/ERK pathway. It lacks cytotoxicity. Thus, it can be considered as an alternative inhibitor for the MAPK/ERK pathway in thyroid cancer cells.
Ali Ghandali, Seyed Mohammad Tavangar, Amir Pejman Hashemi Taheri, Farshad Sharifi, Vahid Haghpanah, Neda Hatami, Mohammad Reza Mohajeri Tehrani, Sayed Mahmoud Sajjadi-Jazi,
Volume 21, Issue 1 (3-2021)
Abstract
Background: In this study, we investigated the diagnostic power of ultrasound in the diagnosis of malignancy in thyroid nodules in Iranian patients. For this purpose, we examined the relationship between ultrasound findings and pathology findings.
Methods: The present study is a retrospective study. The patients with a diagnosis of thyroid nodules who underwent ultrasound and FNA, were included in this study. To assess the relationship between the results of FNA and the ultrasound characteristics of nodules, we classified the results of FNA into malignant and benign groups and then compared ultrasound characteristics between the two groups. In cases which the FNA results were indeterminate (AUS/FLUS or FN/SFN), the postoperative pathology result was considered (if thyroid surgery was done and the result was available).
Results: In total, 201 nodules were included in this study. The results showed that hypoechogenicity, irregular/ill-defined margin, microcalcification, malignant flow pattern in Doppler sonography and concurrent cervical lymphadenopathy with suspicious features were significantly associated with malignant thyroid nodules. However, other ultrasound findings, such as the size and location of the nodule, presence of a cystic components within the nodule, the presence of a Halo sign, and the presence of a taller-than-wide shape, could not distinguish between benign and malignant nodules. Finally, the results of the present study showed that the accuracy of ultrasound in the diagnosis of malignancy in thyroid nodules is high.
Conclusion: This study suggests that the use of ultrasound can be very effective in diagnosing malignancy in thyroid nodules.
Parisa Karimzadeh, Mahdis Khazaeli Najafabadi, Sina A Sharghi, Farzaneh Karimi Birgani, Effat Asadollahpour, Somayeh Parichehreh-Dizaji, Mahnaz Pejman Sani, Sayed Mahmoud Sajjadi-Jazi, Mahmood Naderi, Hilda Samimi, Shirzad Nasiri, Seyed Mohammad Tavangar, Bagher Larijani, Vahid Haghpanah,
Volume 25, Issue 6 (1-2026)
Abstract
Background: Biobanks are biological repositories that collect, process, store, and distribute human biological samples. Among them, tumor banks play a central role in biomedical research. The overall goal of a tumor bank is to collect cancerous and normal samples under standardized conditions for basic, clinical, or applied research.
Methods: Tumor samples from patients with endocrine neoplasms were collected from excess tissue samples not required for diagnostic purposes after surgery in the surgical department of Dr. Shariati Hospital, Tehran, Iran. In addition, relevant biological samples such as serum, plasma and DNA were collected in parallel. Prior to sampling, informed consent was obtained from the patients and a questionnaire was completed. After rapid freezing with isopentane, tissue samples were stored in a liquid nitrogen tank, while other biological materials, such as serum, were stored in a -80°C freezer.
Results: Tissue, plasma, serum, and DNA samples collected from patients with endocrine neoplasms were stored in separate barcoded storage boxes in the biobank and were made available to researchers.
Conclusion: The use of bioproducts in domestic research and international networks has strengthened research collaborations through supporting the collection and distribution of tissues, especially cancer tissues. This trend plays an important role in facilitating basic and applied research in various fields of cancer, including molecular biology, immunology, genetics and pharmacology, and will pave the way for scientific advances and therapeutic innovations.
