Showing 3 results for Hajizadeh
Akbar Hajizadeh Moghaddam, Marzieh Ahmadalizadeh, Reza Seyrafi, Mahbobeh Aghagolzadeh, Sedigheh Khanjani,
Volume 17, Issue 6 (10-2018)
Abstract
Background: Diabetes mellitus is a worldwide prevalence of metabolic diseases and its important complications are gastrointestinal disturbances. A wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like diabetes and cancer. However, the poor oral bioavailability and instability of curcumin had greatly limited its further applications. The purpose of this study was to evaluate the effects of Nanocurcumin on the oxidative stress and tissue changes of small intestine in diabetic mice.
Methods: In this experimental study, animals were divided to five groups: Control, sham, diabetic (Intraperitoneal injection of 120 mg/kg of Streptozotocin) and diabetic groups treated with Nanocurcumin (7.5 and 15 mg/kg body weight) for 21days. At the end of experiment, catalase (CAT) activity and Malondialdehyde (MDA) level were measured in intestinal tissue. For histological assessment, villi length and crypt depth in small intestine were investigated.
Results: The oral administration of Nanocurcumin significantly increased intestinal CAT activity (P<0.05) and decreased MDA level (P<0.001). Also, the Villi length in diabetic groups treated with Nanocurcumin showed a significant increase compared to diabetic group (P<0.05).
Conclusion: The findings of this study showed that Nanocurcumin has a protective effect on diabetes-induced digestive disorders due to its antioxidant properties.
Mohammad Azimi Alamouti , Niloufar Shayan, Maryam Momeni, Masoumeh Nouri, Azam Koohkan, Ensiyeh Hajizadeh-Saffar, Fatemeh Soltanolizadeh, Maliheh Mahmoudi, Mahin Jamshidi Makiani, Marzieh Ebrahimi,
Volume 18, Issue 3 (3-2019)
Abstract
Background: For nearly 100 years, amniotic membranes have been used to treat various types of skin wounds. Amniotic extract is one of the derivatives of amniotic membrane that contains all the properties of amniotic membrane. The aim of this study was to evaluate the safety of the amniotic membrane extract in the treatment of diabetic ulcers.
Methods: This study was an Open labeled clinical trial without control group. A total of 10 patients with Wagner Grade 2 diabetic foot ulcers were selected in both sexes. The extract was used every 48 hours in the first week and every 72 hours from the second week until the end of the wound treatment. Patients were followed up weekly until wound healing.
Results: In this study 80% of patients were men and 20% were women with mean age (56.7 ± 8.7) years. The ulcer duration was 8.9 ± 2.12 weeks. The mean area of ulcers at the time of entry into the wound group ≥ 500 mm2, 977.5 ± 201.9 and in the wound group ≤500 mm2 was 145.6 ± 36.4. At 4 weeks post treatment, the wound healing rate in the wound group was ≤500mm2 ,98.9 ± 2.40 % and in the wound group ≥mm2 500 was 92.1 ± 7.23%. in sixth week of treatment, ulcers were complete closure in both groups.
Conclusion: The results of this study suggest that the use of amniotic extract can be effective in the healing of diabetes foot ulcer without any side effects.
Seyed Morteza Tayebi, Elham Hajizadeh, Rasoul Eslami, Meraj Mirzaei,
Volume 25, Issue 4 (9-2025)
Abstract
Background: Type 2 diabetes is a prevalent metabolic disorder characterized by insulin resistance and impaired glucose absorption. The COVID-19 pandemic and associated quarantines led to significant lifestyle changes, including reduced physical activity among diabetic individuals. This study investigates the patterns of physical activity and perceptions among diabetic individuals in post-COVID Iran.
Methods: An online questionnaire was created using the "Pors Online" platform and shared via social media. Among 435 participants from 35 Iranian cities, 400 responses (200 diabetics and 200 healthy individuals) were deemed complete and valid for analysis. The data were analyzed using an independent t-test, with a significance level set at P< 0.05.
Results: The results showed that the physical activity level of diabetic individuals was significantly lower than that of non-diabetic individuals P< 0.05. Additionally, their preferred types of physical activities differed; both groups showed the most interest in walking and the least interest in traditional games. The primary motivation for exercise among diabetic individuals was disease prevention, but financial barriers had the greatest impact on reducing their physical activity P< 0.05. Their main sources of information about physical activity were magazines and books.
Conclusion: Improving access to sports facilities and tailored equipment for diabetics, coupled with awareness campaigns on the benefits of exercise, is essential. Developing customized sports programs suited to the health conditions of diabetics can enhance their participation and overall well-being.
