Showing 7 results for Hedayati
Mitra Neiafar, Fatemeh Esfahanian, Alireza Esteghamati, Ramin Heshmat, Mehdi Hedayati, Masoumeh Karami, Mehrshad Abbasi, Manochehr Nakhjavani,
Volume 4, Issue 4 (17 2005)
Abstract
Background: Oxidized low-density lipoprotein (Ox-LDL), a key factor in the development of atherosclerosis, can cause endothelial dysfunction and augment lipid accumulation within the arterial wall. Increased oxidative stress in diabetes contributes to this process. Ox-LDL is a highly immunogenic molecule and it is not clear whether anti oxidized LDL antibodies (OLAB) are pathogenic or protective in atherosclerosis? The aim of this study was to evaluate Ox-LDL and its antibody in type 2 diabetes and healthy subjects.
Methods: As a case-control study we evaluated 81 type 2 diabetic patients and 69 non-diabetic healthy persons aged 40 to 65 years. Controls were sex and BMI matched with diabetic patients. Patients with history of cigarette smoking, antioxidant or antihyperlipidemic drugs consumption, coronary heart disease, hypertension , and renal impairment were excluded. We measured serum level of Ox-LDL(two monoclonal antibody of Mercodia co.) and OLAB by ELISA. Lipid profile, serum electrolytes, and HbA1c (HPLC) were also determined. Ox-LDL and its antibody were compared between diabetic patients and controls and the correlation with lipid profile, HbA1c and BMI were assessed.
Results: Serum Ox-LDL concentration and Ox-LDL to LDL ratio were distinctively higher in controls (15.7+-6.9 vs. 11.8+-5.6, P < 0.005). Ox-LDL concentrations were correlated with LDL-C (rs=0.36, P<0.0005) and total cholesterol (rs=0.31, P<0.0005) in both groups but not with age and HbA1c. In diabetic patients, Ox-LDL and its antibody were positively correlated (rs=0.26, P<0.05). Obese diabetic patients (BMI > 30) had higher Ox-LDL concentrations in comparison with diabetic patients with BMI less than 30.
Conclusion: In diabetic patients Ox-LDL level is lower than non-diabetics and is correlated with its antibodies. Based on previous findings, we suppose that the pattern of LDL oxidation enhances Ox-LDL recognition by macrophage via specific legends. This results in low serum Ox-LDL concentrations in diabetes.
Bita Faam, Maryam Zarkesh, Maryam Sadat Daneshpour, Fereidoun Azizi, Mehdi Hedayati,
Volume 13, Issue 2 (1-2014)
Abstract
Background: It is now evident that adipose tissue functions as an endocrine organ by releasing
adipokines, and the levels of a number of inflammatory markers elevated in overweight and obese
individuals. The objective of this study was to examine the association between inflammatory markers
(IMs) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Homocystein (Hcy) and obesity
variables in Tehran Lipid and Glucose Study (TLGS) adults.
Methods: In this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years,
were randomly recruited from among TLGS population. Individuals were categorized based on the
waist circumference. The serum levels of IMs were determined using the Enzyme Linked
Immunosorbent Assay (ELISA) method.
Results: The mean age of participants was 46.1±16.1years and Abdominal obesity were present in
199(56.5%) individuals. The levels of hs-CRP and IL-6 were higher in abdominally obese group
(1507±3.3 vs. 577.8±4.3 ng/mL p<0.001) (3.6±3.3 vs. 1.9±3.8 pg/mL p< 0.001), and in the same
group, the best predictors (based on the adjusted R2) for hs-CRP, IL-6 and Hcy were waist (WC),
waist to height ratio (WHtR) and wrist, respectively. Hip and WHtR were the best predictors for Hcy
and hs-CRP in normal group there was no variable significantly correlated with IL-6, therefore it was
not possible to consider an independent predictor for IL-6.
Conclusion: According to this study, obesity is associated with IM levels, and in abdominally obese
group, the best predictor for Hcy, hs-CRP and IL-6 were Wrist, waist and WHtR respectively.
Toktam Mahmudzadeh, Marziyeh Saghebjoo, Ali Seghatol Eslami, Mehdi Hedayati,
Volume 13, Issue 3 (3-2014)
Abstract
Background: Diabetes is considered as one of the health problems in all societies. Exercise training
and drug interventions, especially herbal medicines, consider as approaches to improving diabetes.
The objective of this study was to investigate the effect of 6 weeks of aerobic training and Pistacia
atlantica extract consumption on pancreatic β-cells function in streptozotocin-induced diabetic rats.
Methods: Thirty six male Wistar rats divided into five groups: normal control, diabetic control,
diabetes+aerobic training, diabetes+extract, diabetes+aerobic training+extract. Diabetes was induced
by intra-peritoneal injection of streptozotocin (40mg/kg). Exercise program was include 6 weeks of
aerobic training on a treadmill (5 sessions per week, 40 minutes per session, with a speed of 20m/min
and 5% incline). Extract groups were received Pistacia atlantica extract based on body weight, at the
end of each training session. After 6 weeks of aerobic training and Pistacia atlantica extract
consumption, plasma glucose and insulin levels were measured for determination of β-cells function
(HOMA-B). Data were analyzed via ANOVA, with a significant level P<0.05.
Results: HOMA-B index in diabetic control group was significantly higher than normal control group
(P=0.0001). Also mean of HOMA-B index in diabetes+extract and diabetes+exercise training+extract
groups was significantly lower than diabetic control group (P values 0.003, 0.001 respectively) and
between mean of HOMA-B index in diabetic control group with diabetes+aerobic training group were
observed no significant differences (P=0.052).
Conclusion: The results of this study showed that Pistacia atlantica extract consumption, alone and
along with aerobic training leads to significant improvement in pancreatic β-cells function in diabetic
rats. Also extract consumption along with aerobic training in comparison to training alone has had
greater impact on the improvement of pancreatic β-cells function. It seems that aerobic training along
with the use of specific herbal plants can be considered as a complementary therapy in improvement
of diabetics.
Zahra Jamshidi Khezerlou, Sajad Ahmadizad, Mehdi Hedayati, Hiwa Rahmani, Azade Movahedi,
Volume 13, Issue 4 (5-2014)
Abstract
Background: The aim of this study was to compare responses of Visfatin and insulin resistance index to various resistance exercise protocols.
Methods: Ten healthy male subjects performed three resistance exercise protocols including maximal strength (three sets of 5 repetition at 85% of 1-RM with 3-min rest between sets), hyperthrophy (three sets of 10 repetition at 70% of 1-RM with 2-min rest between sets) and strength-endurance (three sets of 15 repetition at 55% of 1-RM with 1-min rest between sets) in three separate sessions. Two blood samples were taken before and after resistance exercise protocol. Responses to different resistance exercise protocols were compared by using repeated measures of ANOVA (3×2).
Results: Irrespective of resistance exercise protocol, results showed that plasma visfatin reduced significantly (P<0.05) in response to resistance exercise. Between group comparisons revealed that reductions in visfatin concentration in response to strength-endurance and hypertrophy protocols were significantly higher than maximal strength protocol (P<0.05). Analysis showed that not only glucose, insulin and insulin resistance index did not change in response to resistance exercise significantly, but also there was no significant difference among the responses to different resistance exercise protocols (P>0.05). In addition, there was no significant relationship between changes in visfatin and other parameters (P>0.05).
Conclusion: It could be concluded that performing strength-endurance and hypertrophy protocols that cause reductions in visfatin, possibly due to changes in growth hormone during these protocols, could be beneficial in reducing the hyperinsulinemia.
Maryam Sadat Daneshpour, Bahareh Sedaghatikhayat, Mehdi Hedayati, Fereidoun Azizi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries. Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density cholesterol (HDL) levels. The present review aims to discover the genetic variant reported in association with MetS. Methods: The database for genotypes and phenotypes (dbGaP) and the database for genetic associations and human genome (HuGE navigator) were utilized in order to search for genes and their corresponding polymorphisms related to MetS. Additionally, an electronic literature search for other Iranian studies and the genetic aspect of TLGS was completed using PubMed. Results: For phenotype selection in PheGenI, 30 traits were chosen and after the analysis, 21 of them were in common results with MetS. After finding the common variation between traits and MetS, omitting the repeated SNPs, 173 variations were remained. Finally, results distinguished six of the most important genetic regions found to have strong association with MetS. Conclusion: Identifying major genes that are responsible for the metabolic syndrome may improve the medical care for treating individuals with metabolic syndrome, and eventually may lead to personalized medicine in which treatment is tailored genetically to the patient’s needs. The present candidate regions is a respectable start to replicate genetic studies in large affected Iranian individual which we hope leads us to improve our medical care in this field.
Bita Faam, Asieh Zahedi, Mehdi Hedayati, Fereidoun Azizi, Mohammad Ali Mansournia, Maryam Daneshpour,
Volume 15, Issue 1 (1-2016)
Abstract
Background: The scavenger receptor class B type I (SR-BI), as the high density lipoprotein cholesterol (HDL-C) receptor, is a key component in the reverse cholesterol transportation. The objective of this study was to assess the association between exon1 (G→A) polymorphism of SR-BI gene and lipid profiles among the Tehran Lipid and Glucose Study (TLGS) population.
Methods: This cross-sectional study included 774 adults (322 males and 452 females) aged 20–70 years, who were randomly selected from among TLGS population. Anthropometrical and biochemical variables for participants were measured. Selected SR-BI gene polymorphism was determined with restriction fragment length polymorphism (RFLP) using the Alu restriction enzyme.
Results: according to the results of current study, in the Tehran population, the allele frequency of SR-BI (G→A) polymorphism was 0.159 for an allele (minor allele) and 0.841 for G allele. Allele frequencies were in conformity with Hardy–Weinberg equilibrium. The result of this study showed that Subjects with the less common allele (allele A), after adjusting for age, have lower HDL-CandHDL3concentrations (p=0.046, p=0.041 respectively).
Conclusion: lipid disorders are caused by the interaction of environmental and genetic factors; therefore, exon1 (G→A) polymorphism of SR-BI gene could not be the only cause for the abnormality in the HDL-C levels. In future, this polymorphism may be use as a molecular marker for diagnosis.
Laleh Ranjbar, Farzaneh Taghian, Mehdi Hedayati,
Volume 17, Issue 4 (5-2018)
Abstract
Background: Apelin is an Adipokine which is recently discovered and widely secreted from white adipose tissue and in fat and overweight person, apelin values and gene expression increase .In this study, the effect of one period aerobic exercise and vitamin D consumption on weight, plasma apelin values and insulin resistance in overweight women was researched.
Method: In order to doing this reasearch 40 women whom have over weight with , average old , weight , height, BMI and WHR respectively : (30.37 ± 6.91) years old , (74.89 ± 12.97) kg , (157 ± 7.02) m , (30.08 ± 3.95) kg/m2 , (0.81 ± 0.07). After passing the medical sepration dived to 4 experimental group: 1st experiment group (aerobic exercise) n=10, 2nd experimental group (aerobic exercise and vitamin D) n=10, 3rd experimental group (vitamin D) n=10 and control group n=10. At first body composition was measured th included: BMI, WHR, weight, waist and hip size. After that the blood sample was taken from triables. (Fasting) and amount of the apelin, glucose, insulin, vitamin D, triglycerides, cholesterol, LDL and HDL were measured. Then experimental group 1 and 2 were encounterd and emotionalized by an aerobic exercise (treadmill) after 10 weeks all of the measure mented conversionxls were measure again befor the test. For comparisoning of the groupa that befor and after the test was used from –t test and if was used from the variance test for comparisoning two group.
Results: results showed that after 10 week of aerobic exercise an vitamin D using : BMI, WHR, apelin, cholesterol, LDL, glucose, insulin and insulin resistance were reduced, a triglyceride also decrease and HDL had a significant increasing.
Conclusion: Result confirmed the positive effect of the aerobic exercise on body compositions apelin and plasmas Lipoprotein and also showed that using vitamin D using in obese people and people who have overweight can be beneficials.
