Showing 4 results for Hojati
Farideh Alah Gahi, Abdolhosin Shiravi, Vida Hojati,
Volume 15, Issue 3 (2-2016)
Abstract
Background: Finding effective drugs have been considered for healing diabetic wounds by researchers. The purpose of this study was to evaluate the effects on wound healing ointment Alcoholic extract of grape seed skin is normal and diabetic rats.
Methods: In this study 48 male Wistar rats into four groups (negative control, positive control, the first experimental, the second experimental) were divided. Groups tested in the injured area of 3 cm2 were created on the left spine. The wound healing was evaluated macroscopically. The results are reported as Mean ± SD. Statistical inference border (P ≥0.05) and (P ≥0.01) and (P ≥0.001).
Results: Compared with normal wound healing in diabetic groups were later and Wound healing in experimental groups treated with Vitis Vinifera more quickly than the control group, respectively.
Conclusions: In this study the skin ointment Vitis Vinifera accelerates the wound healing is normal and diabetic samples.
Soleiman Ghamaridaz, Vida Hojati, Sahar Molzemi, Bostan Roudi,
Volume 23, Issue 4 (11-2023)
Abstract
Background: Diabetes is associated with hormonal and biochemical changes, and with the production of free radicals and oxidative stress, it plays an important role in the occurrence of many metabolic injuries. Garlic plant and kombucha mushroom play a major role in the prevention and treatment of complications caused by oxidative stress due to their antioxidant and anti-apoptotic properties.
Methods: 40 male Wistar rats, divided into five groups of eight, including: control (diabetic and receiving citrate buffer), Negative control group (diabetic, with 55 mg/kg of streptozotocin intraperitoneally), experimental group 1 (diabetic and receiving 50 mg/kg garlic extract), experimental group 2 (diabetic and receiving 50 mg/kg kombucha mushroom) and experimental group 3 (diabetic and receiving 50 mg/kg kombucha mushroom and 50 mg/kg of garlic extract) were divided. After two months passed after the mice became diabetic, the extracts were injected subcutaneously for two weeks. After that, the rats were anesthetized with ketamine and xylisine, and blood was taken directly from the heart.
Results: The Negative control group had higher glucose, triglyceride, cholesterol and LDL and lower insulin and HDL than the control group. The treatment groups of garlic, kombucha and garlic + kombucha caused a significant decrease in glucose, cholesterol, triglyceride and LDL levels and a significant increase in HDL and insulin compared to the Negative control group (p < 0.05). The highest therapeutic effect was shown by the garlic + kombuja group.
Conclusion: The combined extract of kombucha and garlic has favorable effects on sugar control and reducing cholesterol and Triglyceride.
Ghazale Yavari, Sahar Molzemi, Vida Hojati, Zahra Kordi,
Volume 24, Issue 5 (12-2024)
Abstract
Background: Dysfunction of pancreatic beta cells causes a decrease in insulin and an increase in serum glucose, resulting in diabetes. Diabetes has caused dysfunction by damaging various organs, including tissues that are at risk of diabetes. So we've looked at the effect of Vicia sativa on skin wounds caused by high blood sugar.
Methods: In this study, 48 male mouse heads of the wistar breed with a weight range of 220 to 250 grams were divided into 4 control groups, Shem, experimental one (diabetic group+ oserin), experimental two(diabetic+ V. sativa). At the same time as the mice became diabetic with a dose of 50 mg/kg streptosotocin, the rest of the groups received the citrate buffer intra-peritoneal. After the rats were unconscious with the anesthetic and their back hair was shaved in the 3 cm long test groups on the left side of the spine, and the treated groups were treated with 14 days of MG/kg200 dose of mascara extract on the wounds. The wound healing process was examined macroscopically and microscopically on days 7 and 14.
Results: The wound of diabetic groups treated with streptozocin showed a later repair compared to the control group, and the wound healing was faster in experimental groups treated with alcoholic extract of the mascara than in the control group.
Conclusion: The results indicated that the alcoholic extract of the mascara accelerated the healing of skin wounds of healthy and diabetic samples.
Elham Imanian, Vida Hojati, Farid Ebnerasuly,
Volume 25, Issue 5 (12-2025)
Abstract
Background: Blood fat is a global problem and one of the major threats to society's health. Hyperlipidemia is considered a multigenic disease, most of the genes related to it remain unknown. rs1205 is one of the polymorphisms of the C-Reactive Protein (CRP) gene that causes the change of the nucleotide C to T and is one of the risk factors for increasing low-density lipoprotein (LDL) level. This study aimed to investigate the prevalence of rs1205 polymorphism in CRP gene and its relationship with LDL level in Iranian population.
Methods: The total number of samples was 137, including 79 controls and 58 patients (LDL above 130 mg/dL). Then the samples were analyzed using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method for the presence or absence of rs1205 polymorphism in the CRP gene. The PCR product was transferred on agarose gel. After observing the bands and checking their correctness, different alleles were examined.
Results: 56.2% of the samples had a body mass index (BMI) lower than 25 and 43.8% had a BMI higher than 25. The frequency percentage of genotypes showed that CT genotype is equal to 47.4%, CC genotype is equal to 36.5% and TT genotype is equal to 16.1%. 57.7% of the samples had LDL below 130 and 42.3% had LDL above 130.
Conclusion: A significant relationship wasn't observed between the rs1205 polymorphism and the serum LDL level of the studied population. Also, the difference in age and gender of the samples had no effect on this relationship. It is possible that the lack of difference in ethnicity is one of the possible reasons for the non-significance of the results of this study.
