Hossein Hossein Zadeh, Farid Ilami,
Volume 1, Issue 1 (18 2001)
Abstract
Objective: To evaluate the effect of hyperglycemia on the antinociceptive activity of baclofen, a GABAB agonist, in mice.
Methods: We examined the antinociceptive effect of baclofen (2.5–7.5mg/kg injected intraperitoneally) in alloxan-induced mice using the hot-plate and tail-flick tests, both thermal tests.
Results: Baclofen produced a dose-dependent inhibition of hot-plate response in both normoglycemic and diabetic mice. The antinociceptive activity of baclofen was slightly reduced in diabetic mice. In comparison, the antinociceptive activity of morphine (10mg/kg), used as control, was significantly reduced in diabetic mice.
Conclusion: Our results show that hyperglycemia reduces the antinociceptive action of baclofen less than it does that of morphine.
Laleh Bagheri, Mohammad Faramarzi, Zahra Hemati Farsani, Masoumeh Hossein Zadeh,
Volume 23, Issue 6 (1-2024)
Abstract
Background: Fetoin-A and -B are hepatokines that are related to type 2 diabetes. The aim of the present study was to investigate the effect of a period of resistance and endurance training with Ursolic acid consumption on the levels of Fetoin-A and -B in the liver tissue of elderly diabetics.
Methods: Fifty six 21-month-old male diabetic rats were randomly divided into seven equal groups of control (C), Ursolic acid supplement (UA), supplement+resistance exercise (UA+R), supplement+endurance exercise (UA+E), Resistance training (R), endurance training (E) and sham group (D). Resistance training protocol with intensity of 60% MVCC, 14-20 times of ladder climbing with one minute rest between each effort and endurance training including running on Treadmill at high intensity 60-75% and low intensity 30-40% of maximum speed for five days per week for eight weeks. Supplemented groups received 500 mg/kg UA in combination with a high-fat meal.
Results: Fetoin-A level was significantly decreased in UA, E, UA+E groups (p≤0.05) and only in R and UA+R groups, there was no significant decrease. Also, The amount of Fetoin-B in diabetic rats in the UA, E, R, UA+E groups decreased significantly (p≤0.05) and only in the UA+R training group there were no significant changes. The amount of Fetoin-A and Fetoin-B was significantly different between E and R and UA+R and UA+E groups (p≤0.05), which the largest decrease was in the UA+E group.
Conclusion: Considering the beneficial effects of exercise training as well as UA supplementation on hepatokines, it seems that the simultaneous application of two interventions of exercise training and UA supplementation has a more therapeutic effect on the hepatic hepatokines of diabetics.
