Showing 15 results for Jafari
Iraj Nabipoor, Farhad Vafaju, Mohammad-Saïd Mohajeri, Houman Salimepour, Shahram Abutalebi, Peyman Andalib, Mojtaba Jafari,
Volume 2, Issue 1 (17 2003)
Abstract
Background: Diabetes mellitus, the most common metabolic disorder of childhood, has important physical and emotional complications this urges the role of patient education and self-monitoring. Diabetes is costly since patients have to do several lab tests and spend a lot on treatment.
Methods: 150 patients with IDDM entered this cross-sectional study. The metabolic control and degree to which these patients were utilizing available facilities were determined and compared with same surveys from Germany, France, USA, Australia, and Saudi Arabia.
Results: 91.3% of patients had no glucometer thus were unable to do self-monitoring. HbA1C had been regularly determined in only 8.66%. Insulin therapy was improper or inadequate in 59.1%. The quality of metabolic control was significantly poorer than the other mentioned nations (P< 0.001).
Conclusion: The study advocates educational programs for diabetics. Complete insurance coverage and free weekly lab tests are also suggested.
Ali Jafarian, Fatemeh Shidfa, Alireza Parsapour, Hasan Emami Razavi,
Volume 5, Issue 0 (Vol5,Medical Ethics and History of Medicine 2005)
Abstract
Background: Kidney transplantation is one of the major progresses of medical science with many ethical debates. The shortage of organs and the increases in waiting list for cadaver transplantation has leaded to transplantation from living donors. In this article, we discuss the ethics of transplantation from living kidney donors.
Methods: For compiling this article, we searched in Pubmed and Ovid by the keywords of kidney transplantation, living donor, ethics.
Results: At the first, the history and statistics of kidney transplantation in Iran and other countries are reviewed. We discussed the living kidney transplantation regarding to principles of nonmaleficence, autonomy and justice. The ethical issues of different groups of living donors and the proponents and opponents opinions are expressed. Because of the importance of unrelated living donors, this group is discussed more briefly.
Conclusion: It is realistic to consider the living kidney transplantation as the last option. Arranging a legal and social organization to control the monetary relationship of the recipients and donors and to determine the preferences of kidney receipt in waiting list is reasonable. It is essential to increase the cadaver transplantation resources to decrease the need of kidney transplantation from living donors.
Ali Jafarian, Saeedeh Sadeghi, Alireza Parsapour, Hasan Emami Razavi,
Volume 5, Issue 0 (Vol5,Medical Ethics and History of Medicine 2005)
Abstract
Background: Nowadays, many progresses have been occurred in medical science and transplantation process. Transplantation is now a life- saving standard treatment for some end stage diseases. Although the organs from brain death donors, are the best resource for cadaverous transplantation, there are many controversies among physicians about it's definition. The other important issue in transplantation is disparity between the supply and demand of organs. Because of the increasing demand for cadaverous organs it is necessary to use some new methods to fascilitate the availability of these resources. What is noteworthy is that each of these methods has some essential ethical issues that should be observed. Surely regarding these issues would prevent the future harms to human being and society.
Methods: For compiling the article, we searched in pubmed and ovid databases for keywords of cadaverous transplantation, brain death, medical ethics, informed consent.
Results: In this article, after a review of transplantation statistics in Iran and other countries we presented a definition for brain death and some methods to expand donor pools. Then ethical views in brain death and informed consent process for cadaverous organs transplantation was discussed.
Conclusion: In using cadaverous organs for transplantation, informed consent and respect to autonomy are very important. All people in the society are authorized to accept or refuse organ donation after their death and , physicians can only encourage and support them.
Asal Ataie-Jafari, Saeed Hosseini, Ramin Heshmat, Mohammad Parviz, Sormeh Raees-Zadeh, Mehdi Yousefi, Mohammad Pajouhi,
Volume 5, Issue 4 (17 2006)
Abstract
Background: The risk of cardiovascular diseases increase in diabetic patients. So, it is important for patients to achieve the optimal lipid levels. Nutrition including consumption of anthocyanins plays a primary role in reducing the risk of heart disease and hypertension. In this study, we assessed the effect of concentrated sour cherry juice (SCJ) consumption as a rich source of anthocyanins on lipid profile and blood pressure of type II diabetic patients.
Methods: In this quasi-experimental study 16 type II diabetic women with fasting blood sugar ≥110 mg/dl and LDL-C ≥100 mg/dl were recruited and consumed 40 g/day of SCJ for 6 weeks. Measurements of weight, lipid profile and blood pressure were done in baseline and after completion of the study. A 2-day food records was completed by patients so. The Wilcoxon test was used for statistical analysis.
Results: Mean (± SD) age, weight, total cholesterol, LDL-C, systolic and diastolic blood pressure were 53.6±8.8 years, 72.8±14.9 kg, 213.9±27/0 mg/dl, 118.4±14.7 mg/dl, 129.1±15.7 mmHg and 81.7±8.1 mmHg respectively in the beginning of the study. After consumption of SCJ, a significant decrease (P<0.05) in weight, total cholesterol, LDL-C, systolic and diastolic blood pressure was seen. Changes in serum triglyceride and HDL-C concentrations were not significant statistically.
Conclusion: It is concluded that SCJ consumption may modify cardiovascular disease risk factors in diabetic type 2 patients.
Sedigheh Asgari, Alireza Ghandi, Shahriar Adibi, Gholamreza Dashti, Gholam Ali Naderi, Alireza Helalat, Narges Jafari Dinani,
Volume 6, Issue 3 (17 2007)
Abstract
Background: Atherosclerosis is the leading cause of death necessitates more research to find better solutions to this general concern. Due to the side effects of chemical compounds, more attention has been paid to herbal remedies. This study was designed to investigate the effects of Nigella sativa, on atherosclerosis and its risk factors in hypercholesterolemic rabbits.
Methods: Fifteen rabbits were randomly distributed into three groups of five each.( Normal diet group, hypercholesterolemic diet group (1% cholesterol) and group that received hypercholesterolemic diet supplemented with 5% nigella sativa). Animal groups received their own diets and water for a period of 8 weeks. At the beginning of the treatment period, blood samples were taken from all animals to measure biochemical factors. Same procedure was performed at the end of the period then the left and right coronary arteries and the aorta of each animal were dissected to study fatty streak formation (FSF).
Results: Dietary use of Nigella sativa significantly decreased cardiovascular FSF as well as blood cholesterol and LDL in hypercholesterolemic animals. Though not significant but blood HDL was increased and reduction in C-reactive protein (CRP), triglyceride (TG) and oxidized LDL was observed in the same animals.
Conclusion: The results indicate that Nigella sativa inhibits the development of atherosclerosis. This may be related to the effect of Nigella sativa on plasma lipoproteins in addition to its antioxidant and anti-inflammatory properties.
Asal Ataie-Jafari, Saeed Hosseini, Hamid Alavi-Majd, Farideh Tahbaz,
Volume 7, Issue 2 (17 2007)
Abstract
Background: Milk and fermented milk products have been known as foods with possible hypocholesterolemic effects. In this study we compared the effects of milk replacement with regular and probiotic yogurt in normocholesterolemic (N) and hypercholesterolemic (H) subjects.
Methods: Twenty eight subjects with total serum cholesterol 160-280 mg/dl were included. They did not consume yogurt for 2 weeks after that 300 g/day of milk was added to their diet. Then, blood lipids were measured and they were randomly allocated to 2 groups to receive either 300g/day of ordinary yogurt or probiotic yogurt for 6 weeks as a substitution for milk. Blood lipid tests were repeated at the end of the study. Subjects in both groups were divided into these two subgroups according to their baseline blood cholesterol level: subgroup N (cholesterol<220mg/dl) and H (cholesterol≥220mg/dl). Blood lipid changes were compared between these subgroups in each experimental group.
Results: Total cholesterol and LDL-C levels reduced in the H as compared to N subgroup after regular yogurt consumption instead of milk and the reduction of LDL-C was significant (P=0.033). The effect of milk replacement with probiotic yogurt on total cholesterol and LDL-C reduction in H compared to N subgroup was higher than regular yogurt consumption (P=0.028 and P=0.014 for total cholesterol and LDL-C respectively).
Conclusion: The higher the baseline blood cholesterol level, the more beneficial effects of milk replacement with yogurt, especially probiotic yogurt. So, it is suggested for hypercholesterolemic individuals to consume more yogurt as the source of dairy products in their diet.
Behzad Foruotan, Sahar Molzemi, Hoosin Harati Por, Shahram Molzemi, Nahide Bolbol Haghighi, Fatemeh Sadat Alam Al-Hoda, Amir Hossein Ashenaii, Seyed Reza Mousavi, Mohammad Reza Jafari, Mohsen Choopani Moghaddam,
Volume 13, Issue 5 (7-2014)
Abstract
Background: Finding effective drugs is considered for healing diabetic wounds by researchers. The purpose of this study is to evaluate the wound healing effects of palmatine in the healing of skin wounds in normal and diabetic rats.
Methods: In this study 16 male Wistar rats were dهvided into four groups (Negative control, Positive control, The first experimental,The second experimental) . A 4 cm2 wound was created in the left side of the spinal cord in each of these groups and the process of wound healing was macroscopically evaluated.
Results: The wounds of the diabetic groups (the diabetes was coused by streptozocin) showed longer healing process in comparison with the normal groups and the wound healing in the experimental groups which were treated by palmitine was faster in comparison with the control group.
Conclusions: the results showed that palmatine speeds the wound healing up in normal and diabetic samples.
Nima Baziar, Kurosh Djafarian, Zhaleh Shadman, Mostafa Qorbani, Mohsen Khoshniat Nikoo, Farideh Razi,
Volume 13, Issue 5 (7-2014)
Abstract
Background: Vitamin D deficiency is associated with impaired insulin secretion, glucose intolerance and type 2 diabetes. This study was conducted to investigate the effects of supplementation with 50,000 IU vitamin D on improving serum vitamin D levels and insulin resistance in vitamin D insufficient or deficient type 2 diabetic patients.
Methods: In this double blind randomized clinical trial, 81 type 2 diabetic patients with vitamin D levels between 10-30 ng/ml were randomly assigned to intervention (50,000 IU vitamin D3 once a week) and control (placebo once a week) groups according to gender. The study duration was 8 weeks. At the beginning and the end of study, blood samples were collected after 12 hours overnight fasting and fasting serum glucose, insulin and 25-hydroxyvitamin D were measured. Insulin resistance was obtained by HOMA-IR calculation.
Results: After 8 weeks supplementation with vitamin D, 25-hydroxyvitamin D level was significantly increased and reached to normal levels in the intervention group. Fasting serum glucose and insulin concentrations and HOMA-IR were significantly decreased in the vitamin D group, but there were no significant changes in the placebo group.
Conclusion: Supplementation with 50,000 IU vitamin D for 8 weeks compared to placebo can improve inadequate levels of vitamin D and glycemic indicators in vitamin D insufficient or deficient type 2 diabetic patients.
Maryam Djamnezhad , Kurosh Djafarian, Mostafa Qorbani, Asal Ataie-Jafari, Saeed Hosseini,
Volume 14, Issue 1 (1-2015)
Abstract
Background: There is increasing interest about the relationship between metabolism, obesity and function of thyroid hormones in recent decades. This study aimed to determine the validity of a “thyroid and metabolism questionnaire” and its relationship with metabolism status and function of thyroid hormones.
Methods: It was a descriptive cross-sectional study on 164 people aged 20-64 years who were selected randomly from nutrition clinic. “Thyroid and Metabolism questionnaire” including 25 questions were completed for everyone. Biochemical parameters including serum level of T3, T4 and TSH were measured. Resting energy expenditure [REE] was measured by indirect calorimeter.
Results: The mean measured REE and calculated with Harris-Benedict formula were 1826.7 ± 475.34 and 2277.6 ± 454.54 kcal in men and 1410.8 ± 205.5 and 1670.73 ± 136.10 kcal in women respectively. The final score of this questionnaire had no significant association with measured REE. REE showed indirect relationship with serum level of T3, T4, T3/T4 and inverse relationship with TSH. Metabolism status of every participant was obtained via measuring and calculating REE with set and formula. The metabolism status of participants showed no agreements with metabolism status that predicted from “Thyroid and Metabolism” questionnaire. There was no significant association between metabolism status that was measured by indirect calorimeter and calculated from “Thyroid and Metabolism” questionnaire. From 25 questions of this questionnaire, only questions number 1, 4, 16 and 23 showed significant association with measured REE [P< 0.05].
Conclusion: Results of this study showed that “Thyroid and Metabolism” questionnaire had internal consistency, but not validity.
Maryam Bahadori , Leila Kohan, Nosaybeh Jafari ,
Volume 14, Issue 2 (1-2015)
Abstract
Background: obesity is the major health problems affecting communities worldwide and the prevalence is rapidly rising. Obesity as a lifestyle-related factor increases the risk of many diseases. Omentin is a new adipocytokine that is abundantly expressed in visceral fat tissue and its expression levels reversely correlated with obesity. The purpose of this study was to investigate the association between Val109Asp genetic polymorphism of Omentin gene and obesity risk in women. Methods: This case - control study was done on 260 women, including 186 women with BMI<30 as a control group and 74 women with BMI&ge30 with obesity. Omentin genotypes were determined by the use of polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP). The data were analyzed using the computer software SPSS for windows version17. Results: Genotype frequencies of the Asp/Asp, Asp/Val and Val/Val in the control group were 65.6%, 31.7%, 2.7% and obese patients were 51.4%, 39.2%, 9.5%, respectively. Comparison of genotype frequencies in the two groups showed that women with Val/Val genotype in compare to Asp/Asp had greater risk for complications of obesity (OR: 4.5, 95%CI: 1.3-14.9, P: 0.01). Conclusion: There is significant association between Val109Asp polymorphism in omentin gene and obesity in Iranian women.
Zahra Jafari, Neda Mehrdad, Farshad Sharifi, Hamid Haghani, Soghra Nikpour,
Volume 15, Issue 4 (5-2016)
Abstract
Background: Prevalence of diabetes increases along with aging. Due to various reasons, rate of falling in the aged suffering from diabetes is higher. Therefore, this study aims at determining factors relating falling of the aged suffering from type 2 diabetes.
Methods: A total of 60 years old or older with type 2 diabetes that referred to selected hospitals of Tehran University of Medical Sciences using continues method. Cases that had experienced falling during last year and controls that had no such experience were assigned to two separate groups. Questionnaire used in this study included demographic data and factors relating falling. Data obtained were analyzed using descriptive statistics, independent t- test, Chi square and logistic regression.
Results: Results showed that postural blood pressure (p=0.02) dizziness (p=0.05), fecal incontinency (p<0.01), auditory disorder (p<0.01), visual disorder (p<0.01), pain in the lower extremity (p= 0.027), taking anti-coagulation medicine (p=0.017) had a significant correlation with falling.
Conclusion: Multivariate logistic regression illustrated that fecal incontinency and auditory disorder happened along with falling in the aged suffering from type 2 diabetes. Therefore, preventing falling must be considered in care plan for such groups of people.
Gholamreza Jafari Nadoushan, Hossein Hadinedoushan, Nasim Namiranian, Saeed Rezaei,
Volume 18, Issue 5 (7-2019)
Abstract
Background: Diabetes mellitus, which is associated with elevated blood glucose, lipids and liver enzymes, may results in alterations in the production of inflammatory cytokines, including chitinase-3-like protein 1 (YKL-40) and high-sensitivity C-reactive protein (hs-CRP), which induce and promote complications of diabetes such as atherosclerosis.The aim of this study was to evaluate the serum level of chitinase-3 like 1 protein (YKL-40) and high-sensitive C-reactive protein (hs-CRP) in type 2 diabetes with coronary artery disease compared to diabetic and healthy control.
Methods: This cross-sectional study was performed on 87 subjects in four groups, including: 23 samples as healthy control (Group 1), 22 patients with type 2 diabetes (Group 2), 20 patients with coronary artery disease (Group 3) and 22 patients with type 2 diabetes and coronary artery disease (Group 4). Serum Fasting blood sugar (FBS), Cholesterol, Triglyceride, Low density lipoprotein (LDL-C), High density lipoprotein (HDL-C), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), YKL-40 and hs-CRP were determined.
Results: The mean serum levels of FBS (Group 1 with 2 and 4, Group 2 and 3, P = 0.001), Cholesterol (Group 1 and 3, P = 0.03), Triglyceride (Group 2 and 3,p=0.027), HDL-C (Group 1 with 3 and 4, P = 0.02, P = 0.01 respectively), ALT (Group 1 and 4, P = 0.03, Group 2 and 4, P = 0.02) and AST (Group 2 and 4, P = 0.009) were significantly different..The mean serum levels of YKL-40 were significantly difference in the group 1(4.81±1.27 ng/ml) and group 2 (15.52±4.61 ng/ml) (P=0.01), group 3 (19.2±2.75 ng/ml, P=0.017) and group 4 (16.1±4.17 ng/ml, P=0.04). Also, The mean serum levels of hs-CRP in the group 3 (4.49± 1.53 μg/ml) and group 4 (1.28 ± 0.43 μg/ml) was significantly difference (P= 0.028).
Conclusion: Serum levels of YKL-40 are increased in people with type 2 diabetes and coronary artery disease. It is recommended to determine the serum level of this marker in these patients.
Afshar Jafari, Ali Zarghami Khameneh, Saeid Nikookheslat, Pooran Karimi,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Autophagy is a new therapeutic strategy aimed at reducing the diabetic abnormalities. While excessive or insufficient autophagic activity during diabetes leads to altered cellular homeostasis. So, aim of the present study was conducted to determine the effect of eight-week high-intensity interval training (HIIT) along with caffeine injection on the levels of some myocardial autophagy-related proteins in diabetic rats.
Methods: In experimental design, fifty male white wistar rats with an age range of 3-2 months (average weight 250±25 g) were randomly divided into 5 groups of homogeneous 10 rats in each group: Healthy control (C: intraperitoneal injection of saline), Diabetic control (D: high-fat diet combined with a single intraperitoneal injection of streptozotocin, Diabetic with training (D+T: running with intensity at the 85-90% of maximum speed in 5 to 12 bout of 2 min-1; 5 days/week for 8 weeks), Diabetic with caffeine supplementation(D+CA: intraperitoneal injection of pure caffeine at 70 mg.kg-1 5 days/week for 8 weeks), Diabetic with training and with caffeine supplementation (D+T+CA). For evaluate changes in the expression profile of some of the genes associated with autophagy signaling pathway (LC3-II, ULK-1, Beclin1) in the myocardium (left ventricular), based on Western blot analysis will be used. Also, the one-way analysis of variance (ANOVA) and Tukey post hoc test were be used to analyze the data.
Results: The expression of all autophagic proteins in diabetic with trained and non-trained groups was higher than in healthy
group (P≤0.05). On the one hand, the expression of autophagy-related proteins in the trained group with caffeine supplementation was significantly higher than that of the training group without caffeine intake (P=0.001).
Conclusion: The findings of this study suggest that caffeine injection exacerbated the expression of autophagic proteins induced by diabetes; On the other hand, high-intensity interval training can as a preventive strategy, modulate diabetes-induced myocardial autophagy.
Hadis Jafari Sohi, Eidy Alijani, Amir Sarshin, Fariba Aghaei,
Volume 21, Issue 3 (9-2021)
Abstract
Background: Exercise and the simultaneous use of progenitor cells is a new strategy aimed for reducing diabetic disorders. One of the known mechanisms is angiogenic disorders caused by diabetes. Therefore, the present study was performed to determine the simultaneous effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in the skeletal muscle of diabetic rats.
Methods: In this study, 30 rats were randomly divided into 5 groups: healthy, diabetic control (D) trained diabetic (DR), diabetic with endothelial progenitor cell injection (DI), diabetic trained with endothelial progenitor cell injection (DRI) were divided. VEGF protein expression was measured by Western blotting and insulin resistance index was measured by ELISA. The data were analyzed using two-factor analysis of variance test with SPSS software version 19 at a significance level of 5%.
Results: In this study, 6 weeks of resistance training or progenitor cell injection caused a significant increase in VEGF and a significant decrease in insulin resistance index in diabetic rats. In the group that used simultaneous exercise and injection compared to the group with exercise and injection and these changes were significant in the group of simultaneous use of exercise and injection compared to the group of exercise with injection.
Conclusion: Based on the results of this study, it can be stated that resistance training or injection of endothelial progenitor cells can stimulate angiogenesis in skeletal muscle, also the simultaneous use of these two factors is a better way to increase angiogenesis in rats
Hadis Jafari Sohi, Eidy Alijani, Amir Sarshin, Fariba Aghaei,
Volume 21, Issue 6 (3-2022)
Abstract
Background: Angiogenesis disorders are known mechanisms of diabetes. With the aim of reducing angiogenesis disorders, resistance training and its combination with endothelial progenitor cell injection are new strategies. Therefore, the present study was performed to determine the effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in the skeletal muscle of diabetic rats.
Methods: In this study, 30 rats were randomly divided into 5 groups: healthy, control (D) diabetic, trained diabetic (DR), endothelial progenitor cell (DI) diabetic, trained endothelial progenitor cell (DRI) diabetic) Were divided. Ang1 and Tie2 protein expression changes were measured by Western blotting. Data were analyzed using two-factor analysis of variance with SPSS software version 19 at a significance level of 5% α≤.
Results: In this study, 6 weeks of resistance training led to a significant increase in Ang1 and Tie2 proteins. But injection of endothelial progenitor cells was significant only on the amount of Tie2 protein. The interactive effect of resistance training and endothelial progenitor cell injection was significant only on the amount of Tie 2 protein. In other words, the combination of resistance training and endothelial progenitor cell injection was superior to Tie2 protein expression than training or injection alone.
Conclusion: It can be said that resistance training improves angiogenesis in diabetics. Combining resistance training with endothelial progenitor cell injections could possibly stimulate angiogenesis in skeletal muscle and be a new strategy in the treatment of diabetic disorders.
