Showing 16 results for Kazemi
Azam Karami Paskohani, Masoud Rahmati , Abdolreza Kazemi ,
Volume 14, Issue 3 (3-2015)
Abstract
Background: Diabetic neuropathy leads to skeletal muscle atrophy however atrophy signaling mechanisms are not well documented. The aim of the present study was to investigate Sunday Driver (Syd) gene expression in soleus muscle of Wistar male rats with diabetic neuropathy. Methods: Twelve male Wistar rats were randomly assigned in 3 groups: diabetic trained, diabetic untrained and healthy control. Two weeks after STZ injection (45 mg/Kg), diabetic neuropathy was demonstrated with mechanical allodynia and thermal hyperalgesia tests and after which moderate endurance training protocol was performed for 6 weeks. 48 hours after final training session, the rats were dissected and soleus muscle tissues were removed. Also Sydgene expression was measured with Real time- PCR methods. Results: Soleus muscle weight was decreased in diabetic groups (P=0.001), but compared with diabetic untrained group, was higher in diabetic trained group (P=0.001). Sydgene expression in diabetic untrained group was higher than healthy control group (P=0.001). Also, compared with diabetic untrained group, training significantly decreased Sydgene expression and blood glucose levels in diabetic trained group. (P=0.001 and P=0.0001, respectively). Conclusion: In soleus muscle of diabetic rats, Sydm RNAup-regulation is involved in development of muscle atrophy and training as a non-pharmacotherapy strategy can modulate and get it close to normal levels. So, it is suggested that Syd should be noted as a novel treatment in diabetes disease.
Masoud Rahmati, Abdolreza Kazemi, Naimeh Nekoie , Hadi Kerendi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: The possibility that childhood obesity is a chronic disease in adulthood becomes enormous. The incidence and spread of obesity has increased substantially over the past two decades. The importance of personal health and quality of life has prompted researchers to study in this field. The aim of this study was to investigate the changes of serum levels of leptin, insulin, lipid profile, and body mass index after a period of sprint interval training in obese children. Methods: In this study, 30 obese children aged 9 to 11 years were randomly targeted placed in two groups (Training and control group). Sprint interval training was conducted for 8 weeks. Before and after training, measurements of leptin, insulin, lipid profile, and body mass index were measured. Data were analyzed using independent t-test (p<0.05). Results: Data analysis showed that after training, leptin, insulin and cholesterol levels were significantly reduced (p=0.001). Also, a significant decrease in BMI was seen (p=0.01). Conclusion: Sprint interval training on leptin, insulin and cholesterol in obese children has a significant impact and this exercise improve body mass index in these individuals.
Masoud Rahmati, Abdolreza Kazemi, Mohammad Hosein Archangi, S.jalal Taherabadi,
Volume 14, Issue 6 (9-2015)
Abstract
Background: Neuropathic pain is associated with a profound impact on quality of life and daily activity in patients and caused high medical costs. Because of the nerves destructive nature in this disease, the neurotrophins are high regarded for their possible effects on survival, growth and development and neuronal functions as a possible therapeutic strategy. So the aim of this study is investigation of the chronic effects of decreased activity in neuropathic pain form on the NFG gene expression in the sciatic nerve of Spinal nerve ligated rats.
Methods: Ten adult male Wistar rats in the weight range of 250±30 gr randomly were divided into two groups including healthy control (C), ligation sciatic nerve ligation. Over the six weeks neuropathic pain behavior tests were conducted continually in groups. In the end change of NGF gene expression in sciatic nerve was measured with Real time PCR technique and calculated using the 2-&Delta&DeltaCT method.
Results: After 6 weeks, neuropathic pain behavior tests showed that pain threshold of thermal hyperalgesia and mechanical allodynia in the SNL group was significantly lower than the control group (P&le0.05). In addition, NGF gene expression in sciatic nerve ligation group compared to controls increased significantly (P&le0.05).
Conclusion: The findings of this study suggest that the development of neuropathic pain and decreased physical activity is associated with increased endogenous NGF. Although it is not clear that increase in NGF expression is due to the nature of neuropathic pain or nerve damage, it is clear that excessive expression of NGF is associated with neuropathic pain.
Fahimeh Kazemi, Saleh Zahedi Asl,
Volume 16, Issue 2 (1-2017)
Abstract
Background: Recently the role of apelin in inflammation has been known. However, the effect of exercise training-induced cytokine apelin in diabetes status hasn’t been investigated. The purpose of this study was to determine the atni-inflammation effect of 8-week aerobic training on apelin plasma concentration in diabetic male rats.
Methods: Twenty eight diabetic male Wistar rats were randomly divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide (95 mg/kg body weight) and streptozotocin (60 mg/kg body weight). The training group ran 8-week on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the training, plasma concentrations of glucose, insulin, TNF-α and apelin were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation was used for analyzing data. P<0.05 was considered to be statistically significant.
Results: Results showed a significant decrease in plasma concentrations of glucose, insulin and TNF-α and HOMA-IR in trained diabetic vs control diabetic group, a significant increase in plasma concentration of apelin in trained diabetic group vs non-diabetic and control diabetic group and a significant negative correlation between plasma concentrations of apelin and TNF-α in trained diabetic group.
Conclusion: It appears that 8-week aerobic training by improvement of insulin sensitivity and decrease of inflammation can increase plasma concentration of apelin in diabetic male rats.
Seyed Ali Hosseini, Fatemeh Rezvanipour, Nasibeh Kazemi, Omidreza Salehi, Maryam Kasraeian,
Volume 17, Issue 1 (3-2018)
Abstract
Background: Gestational diabetes in on of common complications of pregnancy which has different complications for fetus and mother. Aim of present study was to review the effect of six weeks aqua training in second trimester of pregnancy on visfatin and glucose tolerance of gestational diabetic women.
Methods: In this semi experimental research 24 gestational diabetic mothers who recourse to hafez clinic of shiraz city which were in 23- 24 week of pregnancy select as sample and divided in two groups of 12 persons of aqua training and control. Aqua training group trained aqua trainings 6 weeks, 3 sessions per week and 45 minutes per session. In this period of the time control group has just their daily activities. For measure the research variables fasting blood sample gathered from antecubital vein in pretest and post test.
Results: Six weeks aqua training in second trimester of pregnancy has significant effect on increase of visfatin and decrease of glucose tolerance of gestational diabetic women (p=0.001).
Conclusion: It seems that for improvement of visfatin levels and glucose tolerance of gestational diabetic women can use six weeks aqua training in second trimester of pregnancy.
Sina Azadnajafabad, Sahar Saeedi Moghaddam, Esmaeil Mohammadi, Negar Rezaei, Nazila Rezaei, Shohreh Naderimagham, Rosa Haghshenas, Erfan Ghasemi, Yosef Farzi, Elham Abdolhamidi, Sahar Mohammadi Fateh, Hossein Zokaei, Ameneh Kazemi, Ozra Tabatabaei-Malazy, Farshad Farzadfar, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Non-Communicable Diseases (NCDs) are the major cause of premature death and disability due to diseased globally, imposing a heavy burden on the health systems. Four main categories of NCDs are cardiovascular diseases, neoplasms, diabetes, and chronic respiratory diseases. Iran, the second greatest country in the Middle East Region, has been through an important transition period of communicable diseases toward NCDs in the last decades. One of the effective approaches to control NCDs is implementation of population-based studies and interventions, trying to reduce risk factors and incidence of NCDs through investigations in the populations. Endocrinology and Metabolism Research Institute (EMRI) and Non-Communicable Diseases Research Center (NCDRC) are the pioneers trying to study and control various NCDs during the last decades in Iran. In this review, we are going to inspect some of the major completed and ongoing projects of this research institute to highlight valuable efforts to reduce burden of NCDs in Iran, and make a successful example for national and regional public health policy makers and authorities.
Abolfazl Kazemi, Hamid Bahador,
Volume 21, Issue 3 (9-2021)
Abstract
Background: Today, in most hospitals in Iran, there is an extensive database of patient characteristics that includes a large amount of information related to medical, family and medical records. Finding a knowledge model of this information can help to predict the performance of the medical system and improve educational processes.
Methods: Data mining techniques are analytical tools that are used to extract meaningful knowledge from a large data set. In this study, the information of 500 people referred to Shahid Bolandian Health Center in Qazvin has been used. In this research, a predicted model has been performed using decision tree data mining methods and neural network and Bayesian network.
Results: The decision tree model has the highest accuracy and the Bayesian network has the lowest accuracy in diagnosing diabetic patients, and consequently the decision tree has the least error and the Bayesian network has the highest error. The decision tree model with 95.68% had the highest accuracy in prediction.
Conclusion: Fat has the greatest effect in predicting diabetes and gender has the least effect in predicting diabetes. Based on the decision tree analysis, the rules obtained among the stated characteristics of age and sugar variables have the greatest effect in predicting the occurrence of diabetes (according to software analysis) and by creating a proper diet can prevent this disease Prevented.
Soroor Kazemi, Sheida Sodagar, Sadegh Taghiloo, Maryam Bahrami Hidji, Nooshin Shirzad,
Volume 22, Issue 5 (12-2022)
Abstract
Background: The present study was conducted with the aim of comparing lifestyle education based on the Bezenf model and the World Health Organization model on FBS, 2HPPBS, HbA1c in patients with type II diabetes.
Methods: The research method was a semi-experimental and multi-group expanded type with pre-test-post-test designs and a control group with a follow-up period. The statistical population of this research included all patients with type II diabetes referred to the endocrinology department of Imam-Khomeini Hospital in 1400. In this research, from a list of 100 people with diabetes, 60 diabetic patients who met the entry criteria were identified. Then 45 people were randomly selected and replaced by random replacement in two experimental groups and one control group. Each experimental group received group psychological interventions separately, and at the end, both groups were subjected to a post-test. The obtained data were analyzed using mixed analysis with repeated measurements.
Results: The results indicate the effect of lifestyle education based on the Bezenf model and the World Health Organization model on FBS (P=0/001), 2HPPBS (P=0/001) and HbA1c (P=0/006) and the stability of this effect was in the follow-up phase. Also, compared to lifestyle education based on the World Health Organization model, lifestyle education based on the Bezenf model was a more effective method to reduce HbA1c in type 2 diabetes patients but the difference in the effect of the two groups on FBS and 2HPPBS was not significant.
Conclusion: The results indicated the effectiveness of both educational models and the superiority of the BAZENF educational model. Therefore, Lifestyle education based on the Bezenf model and the World Health Organization model can be used by therapists as adjunctive treatments in interventions for people with type 2 diabetes.
Fatemeh Kazeminasab, Mohadeseh Shojaei, Mousa Khalafi,
Volume 22, Issue 6 (3-2023)
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a pathological syndrome associated with increased serum levels of liver enzymes. The purpose of this study was to investigate the impact of exercise training on liver enzymes (ALT, AST, and GGT) and liver fat content in adults with NAFLD.
Methods: The PubMed, Web of Science, SID, Magiran, and Google scholar databases were searched until February 2022 for English and Persian articles. Meta-analyses were performed to compare the impact of exercise training on liver function in patients with fatty liver. SMD and 95% confidence interval (95% CI) were calculated using effect models. Also, the I2 test was used to determine heterogeneity, and the Funnel plot and Egger tests at a significant level of 0.1 were used to determine publication bias.
Results: The results of meta-analysis of 36 studies with 1602 patient with NAFLD, showed that exercise training caused a significant decrease in ALT enzyme [SMD=-0.73, (95% CI: -0.51 to -0.95), p=0.001], AST enzyme [SMD=-0.61, (95% CI: -0.39 to -0.83), p=0.001], GTT enzyme [SMD=-0.66, (95% CI: -0.18 to -1.14), p =0.007], and intrahepatic fat [SMD=-0.58, (95% CI: -0.78 to -0.38), p=0.001].
Conclusion: The findings of the present meta-analysis show the important role of exercise training (aerobic, resistance, and combined training) in improving liver function. So, all three types of aerobic, resistance, and combined exercise are suggested as a non-drug approach to reduce liver enzymes and intrahepatic fat for adults with NAFLD.
Saeid Shamlou Kazemi, Ali Heidarianpour,
Volume 23, Issue 3 (9-2023)
Abstract
Background: During menopause, women are more exposed to the risk factors of many diseases, including metabolic syndrome, and sirtuin-1 may be involved in this disorder. The aim of this study was to investigate the effect of circular resistance training and moderate intensity continuous training on metabolic indices and Sirtuin1 serum level in women with metabolic syndrome.
Methods: This study was conducted as a clinical trial in women with metabolic syndrome in two intervention groups (15 people in resistance training group and 15 people in continuous training group) and a control group (15 people). The intervention group underwent an exercise program for eight weeks and three sessions per week, and the control group had their own routine program. After the last training session, serum levels of Sirtein1 and lipid factors were measured. To analyze the data, t-test and covariance were used at a significant level (P≤0.05).
Results: The results of the t-test showed that there was a significant difference in the intra-group changes of the studied variables (SIRT1, HDL, LDL, TG, FBS, Total Cholesterol) in both exercise groups (P≥0.05), but in No significant difference was observed in the control group (P<0.05). The results of the covariance test showed that there is a significant difference between the three groups in the indices (SIRT1, HDL, LDL, TG, FBS, Total Cholesterol) after the test (P<0.05).
Conclusion: Eight weeks of circular resistance training program and continuous training with moderate intensity has a positive effect on metabolic indices and serum level of Sirtuin1 in people with metabolic syndrome.
Fatemeh Sabaghian, Fatemeh Kazeminasab, Amir Ghanbarpour,
Volume 23, Issue 4 (11-2023)
Abstract
Background: The purpose of this study was to investigate the impact of aerobic exercise on the function of local renin-angiotensin system and insulin resistance in the Gastrocnemius muscle of type 2 diabetic mice.
Methods: The number of 18 male C57BL/6 mice were divided into two groups: 1. Mice fed with a standard diet for 12 weeks (control group), 2. Mice fed with a high-fat diet for 12 weeks with streptozotocin injection (diabetes group). Diabetic mice were randomly divided into two groups: 1. Diabetes-Sedentary group, 2. Diabetes-exercise group. The mice of the training group exercised on the treadmill for eight weeks and five days/week with an average speed of 19 m/min and for 45 minutes. 24 hours after the last training session, the mice were sacrificed. The Gastrocnemius muscle tissue was extracted and stored in -80°C freezer to measure the expression level of angiotensin 2, Mass receptor, At1 receptor and glucose transporter 4 (Glut 4).
Results: The results showed that the expression of Mass and Glut4 receptor in diabetes-exercise mice was significantly higher than diabetes-sedentary group. Also, the expression of angiotensin 2, HOMA-IR, and fasting glucose in the muscle of diabetes-exercise mice were significantly lower vs. diabetes-sedentary mice. Also, the expression of At1 receptor in the diabetes-exercise group was insignificantly lower than in the diabetes-sedentary group.
Conclusion: The findings of the present study show the important role of exercise in improving the local renin-angiotensin system in skeletal muscle. Eight weeks of aerobic training can reduce muscular insulin resistance and improve type 2 diabetes by decreasing the expression of angiotensin 2, At1 receptor and increasing the Mass receptor.
Fatemeh Kazeminasab, Nafiseh Hasanpour,
Volume 24, Issue 1 (3-2024)
Abstract
Background: Leptin and adiponectin are adipokines produced by fat cells and play an important role in obesity. The purpose of this study was to compare the effect of low-calorie diet (LCD) and exercise (Exe) on leptin and adiponectin in middle-aged and elderly adults with overweight and obesity.
Methods: A systematic search was conducted in PubMed, Web of Science, SID, Magiran, and Google scholar databases for English and Persian articles published until August 2023. The effect size and 95% confidence interval (CI) were calculated using the random effect model.
Results: The results of 25 studies with 2063 middle-aged and elderly people with overweight and obesity showed that the combination of exercise and diet compared to exercise alone causes a significant decrease in serum leptin [SMD=-0.4, P=0.001], and a significant increase in serum adiponectin [SMD=0.17, P=0.02] in middle-aged and elderly adults with overweight and obesity. Also, findings showed that the diet compared to exercise alone causes a decrease in serum leptin [SMD=-0.16, P=0.1], and a significant increase in serum adiponectin [SMD=0.05, P=0.7] in middle-aged and elderly adults with overweight and obesity. Also, diet compared to exercise alone does not cause a significant change in serum leptin [SMD=-0.11, P=0.2], and serum adiponectin [SMD=0.02, P=0.8] in middle-aged and elderly adults with overweight and obesity. Conclusion: It is suggested that middle-aged and elderly people to achieve hypoleptinemia and hyperadiponectinemia, use a combination Include exercise training and low-calorie diet in your lifestyle.
Batool Yamani Ardakani, Maliehe Mobarakian, Vali Bahrevar, Moradali Zareipour, Sadegh Kazemi, Mojtaba Fattahi Ardakani,
Volume 24, Issue 2 (6-2024)
Abstract
Background: Despite the increased use of complementary medicine by diabetic patients, there is no clear estimation of complementary and herbal medicine use by these patients in Iran. This study was conducted to investigate the uses of herbal medicine among patients with type II diabetes in Yazd, Iran, in 2022.
Methods: A cross-sectional study was carried out on 633 patients with type II diabetes referred to the Diabetes Research Center in Yazd City from June to September 2022. A questionnaire-based theory of planned behavior developed and validated by the researcher was used for data collection. In addition to demographics and disease-related information, the instrument included questions about using herbal medicine used. Descriptive statistics, Chi-square, Fisher's exact, and linear regression tests were used to analyze the data.
Results: The most common herb used was cinnamon (34.7%). The majority of patients used herbs daily (56.9%). Using herbal medicine was significantly associated with Attitude (r= 0.48, p< 0.001) Subjective norm (r= 0.39, p< 0.001), perceived behavior control (r= 0.38, p< 0.001) and intention (r= 0.4, p< 0.001). Constructs of the theory of planned behavior 73% predicted intention to use herbal medicine. Subjective norm structure had the highest predictive power of intention to consume herbal medicine (ß= 0.49, p< 0.001).
Conclusion: Subjective norm is the most predictor of intention to use Herbal medicines in patients with diabetes. Therefore, it is very important to pay attention to the beliefs, customs, and culture of the surrounding community in the correct self-management of disease control and the use of effective drug control.
Omid Zafarmand, Fatemeh Kazeminasab,
Volume 25, Issue 1 (4-2025)
Abstract
Background: Physical activity and green tea are one of the recommended ways to control obesity and its complications such as cardiovascular diseases, diabetes and liver inflammation. The aim of this study was to evaluate the combined effect of exercise training and green tea on lipid profile in adults with overweight and obesity.
Methods: A systematic search of English and Persian articles published in PubMed, Web of Science, Scopus, SID, Civilica, and Magiran databases was conducted until June 2024.
Results: A total of 14 studies with 390 adults with overweight and obesity, of which 198 subjects were in the combined exercise and green tea group with an average age of 34 years old and BMI with an average of 30 kg.m2, of which 192 subjects in the control group with an average age of 34 years old and BMI with an average of 31 kg.m2 entered the present meta-analysis. The results showed that the combination of exercise training and green tea caused a significant decrease in TC [WMD=-22.923 mg/dL, P=0.001], TG [WMD=-9.946 mg/dL, P=0.001], LDL [WMD=-11.675 mg/dL, P=0.001] and significant increase in HDL [WMD=8.888 mg/dL, P=0.017] in adults with overweight and obesity, compared to the control group.
Conclusion: The results of this meta-analysis showed that the combination of exercise training and green tea in overweight and obese adults decreases TC, TG, LDL and increases HDL. Therefore, exercise and green tea can be suggested to to adults with overweight and obesity as a non-medicinal and practical solution to improve lipid profile.
Zoliekha Rahimi, Saeid Shamlou Kazemi, Ali Hemati Afif,
Volume 25, Issue 4 (9-2025)
Abstract
Background: Moderate and intense aerobic exercise increases the production of free radicals, and on the other hand, the use of antioxidant supplements such as grape seed extract (GSE) has been suggested as one of the ways to deal with oxidative stress. Based on this, the aim of this study was to determine the interventions effect of combined exercise and consumption of GSE on some factors of oxidative and antioxidant stress in postmenopausal women with type 2 diabetes.
Methods: The current study was conducted as a clinical trial on the 80 women with type 2 diabetes, who were randomly divided into four groups (20 people): control, exercise, GSE supplement, exercise + GSE supplement. The combined exercise protocol consisted of aerobic (20 minutes of treadmill running at an intensity of 60–70% of reserve heart rate) and strength training (at an intensity of 70% of one repetition maximum), which was performed for eight weeks (five days/week). GSE supplement was taken in the form of 200 mg capsules daily (morning and noon). Samples (five cc) were taken before and after eight weeks of interventions. In order to determine the acceptance or rejection of the null hypothesis of intragroup and intergroup changes, was used the two-way AVOVA, and then Tukey's post hoc test to determine different groups by SPSS version 25 (P≤ 0.05).
Results: The values of total antioxidant capacity (TAC) and serum glutathione reduction (GSH) in the GSE and exercise + GSE groups increased significantly compared to the control and exercise groups (P= 0.001). Serum malondialdehyde (MDA) levels in the GSE group showed a significant decrease compared to the control and exercise groups (P= 0.001).
Conclusion: It seems that the intervention of grape seed extract is more effective in reducing oxidative stress than combined exercise. The consumption of this extract alone, as well as with combined exercise, has a significant effect on increasing the total antioxidant capacity and reducing GSH (glutathione).
Mansoureh Karimi, Fatemeh Sharafifard, Fatemeh Kazeminasab,
Volume 25, Issue 6 (1-2026)
Abstract
Background: Metabolic syndrome in obese children and adolescents raises the risk of cardiovascular disease and type 2 diabetes. Research suggests that exercise training may improve cardiometabolic health in this population. This meta-analysis aims to evaluate the impact of exercise on these risk factors in children and adolescents with metabolic syndrome., and behavioral outcomes in children and promoting awareness, self-care skills, and quality of life in families.
Methods: A systematic search of English and Persian articles was conducted from PubMed, Web of Science, and Scopus databases without time limits until May 2024. In data analysis, a random-effects model was used to calculate the weighted mean difference (WMD), standardized mean difference (SMD) and 95% confidence interval (CI). Also, heterogeneity of studies was assessed with the I² test.
Results: The results of 6 studies involving 1,761 participants demonstrated that exercise training led to significant reductions in body weight [WMD = −6.32 kg, P=0.001], waist circumference [WMD = −9.11 cm, P=0.001], LDL [WMD = −0.52 mmol/L, P=0.001], TC [WMD = −0.65 mmol/L, P=0.001], serum TG [WMD = -0.56 mmol/L, P=0.001)], fasting glucose [WMD = −0.19 mmol/L, P=0.03], fasting insulin [SMD = −1.01, P=0.001], and HOMA-IR [WMD = −1.60, P=0.001] compared to the control group in obese children and adolescents with metabolic syndrome.
Conclusion: Exercise interventions significantly reduce body weight, waist circumference, and blood pressure, while improving lipid profiles, including serum LDL, TC, and TG levels, in obese children and adolescents with metabolic syndrome. However, these interventions exhibited no significant impact on serum HDL concentrations. Consequently, to reduce cardiovascular risk factors and improve metabolic conditions, it is essential to implement long-term exercise interventions.
