Showing 6 results for Khosravi
Mohammad Hossein Niknam, Ali Rafinejad, Ali Akbar Amirzargar, Farideh Khosravi, Bagher Larijani,
Volume 3, Issue 2 (16 2004)
Abstract
Background: Type 1A Diabetes Mellitus (T1DM) is a chronic and progressive auto- immune disorder resulting from immune mediated destruction of Langerhans islet beta cells. The etiology of T1DM like the other autoimmune diseases is unknown and many factors are involved, Both humoral and cell-mediated immunity have a critical role in T1DM pathogenesis. The cytokines, the immunomodulatory peptides, are responsible for the immune cell recruitment and producing auto-antibodies by the immune effector cells. To evaluate the role of cytokines in sensitivity or resistance to T1DM, we have employed IFN gamma to determine their gene polymorphisms and their association with T1DM.
Methods: 30 patient suffering from T1DM and 40 normal control were studied simultaneously .PCR technique was used to characterize the polymorphisms of cytokine. Salting out method was performed for DNA isolation .The polymorphosime of IFN gamma gene was determined on position UTR+5664`5.The PCR products were evaluated by Gel Electerophoresis Technique.
Results: There was a significant difference between patient and control group in TT allele IFN gamma gene: p<0.05, RR: 0.39(0.22
Sedigheh Asgari, Mojgan Gharipour, Gholamali Naderi, Babak S Abet, Alireza Khosravi, Mohammad Hashemi,
Volume 4, Issue 2 (17 2004)
Abstract
Background: Atherosclrosis is a process that initiated with hypercholestrolemia and fatty streak formation. Previous studies showed oxidative modification of LDL render immunogenic and autoantibodies to epitopes of oxidized LDL. Oxidized LDL (OX-LDL), has antigenic properties. Antibodies against oxidized LDL have been proposed to be independent predictors of atherosclerosis development. The main aims of the current study were to compare antibody titers to different types of oxidized LDL (Cu+2-LDL, Malondialdehyde-LDL) and Native-LDL between angiographically documented coronary patients, non-documented patients and healthy subjects. Correlation between autoantibodies against oxidized LDL and increased risks of cardiovascular diseases has been shown.
Methods: As a case-control study, we evaluated angiographically documented coronary patients, non-documented patients and healthy subjects to measure anti-OX-LDL autoantibody levels.
Enzyme-linked immunosorbent assay was used to measure anti-OX-LDL autoantibodies. ANOVA test used for statistical analysis.
Results: Titers of anti-Malondialdehydo-LDL autoantibodies were 3.55±0.415, 0.361±0.20, 0.093±0.078 respectively in each group (P<0.005). There was not statistically meaningful difference, between native-LDL and Cu+2-LDL antibodies.
Conclusion: It seems the titre of autoantibodies against OX-LDL considered as a predictor of progression of atherosclerosis. Our data provide further support for a role of oxidatively modified LDL in atherogenesis.
Masoumeh Habibian, Mearaj Khosravi,
Volume 15, Issue 2 (1-2016)
Abstract
Background: Regular exercise training is an effective nonpharmacological strategy in the prevention of mortality and morbidity due to cardiovascular disease in patients with diabetes. Therefore, the aim of this study was to assess the effect of 8 weeks regular swimming exercise intervention on the cardiac levels of Matrix mettaloproteinase-2(MMP-2) and transforming growth factor-β1 (TGF- β1) in diabetic rats.
Methods: Twenty eight male Wistar rats with were randomly divided into 4 groups (7 rats per group) of control, diabetes, exercise, diabetes-exercise. Diabetes induced whit alloxan (90 mg/k g, intraperitoneally, ip) in rats. The animals exercised by swimming training at 5 min to 30 min per day, five days a week over 8 weeks. The rats were killed 72 h after the last treatments and cardiac MMP-2 activity and TGF- β1 levels were evaluated by Zymography and ELIZA method. A one-way analysis of variance was used to data analysis (P<0.05).
Results: The results showed that the inducing of diabetes resulted in a significant increase in the levels of cardiac TGF-β1 (P<0.001) and a decrease in the MMP-2 activity (P<0.001) compared with control group. Furthermore 8 weeks swimming training significantly attenuated the levels TGF-β1 (P=0.001) and normalized MMP-2 activity (P=0.005) in trained diabetic rats.
Conclusion: It seems that regular swimming exercise may have great therapeutic potential in the treatment of diabetes-induced cardiac injury by suppressing elevation the levels of TGF-β1 and upregulation of MMP-2 activity.
Rahman Soori, Nikoo Khosravi, Shaghayegh Jafarpour, Azam Ramezankhani,
Volume 16, Issue 2 (1-2017)
Abstract
Background: Inflammation plays an essential role in the insulin resistance process, and chemokines, such as chemerin, seem to play a pivotal role in the pathogenesis of insulin resistance. The aim of this study was to compare the effects of aerobic exercise and caloric restriction on chemerin levels and insulin resistance index in women with type 2 diabetes.
Methods: In a quasi-experimental study, 30 type 2 diabetes women were recruited (Mean age: 49.3±5.4 yr; weight: 78.8±7.3kg). Subjects randomly were divided into three groups: caloric restriction (experimental group 1 or CR), aerobic exercise with caloric restriction (experimental group 2 or EX+CR) and control group. In CR group, subjects follow a diet with 25% caloric restriction for 12 weeks. Subjects in CR+EX group used a training program including aerobic exercise and running on treadmill and diet with 50% caloric restriction of CR group (12.5% caloric restriction+12.5% increase in energy expenditure). Before and after 12 weeks, blood sampling for measurement of chemerin, IL-6, glucose and insulin was carried out. Data were analyzed by paired sample t-test and one way ANOVA at significant level of p<0.05.
Results: Results showed that body mass index (BMI), waist to hip ratio (WHR), insulin resistance index (HOMA-IR) and interleukin6 decreased significantly in experimental groups. chemerin levels were increased significantly in CR (P=0.001) and EX+CR groups (P=0.001). Significant correlation were seen between changes of chemerin with changes of BMI, WHR, HOMA-IR and interleukin6 (P<0.05).
Conclusion: According to the relationship between chemerin and insulin resistance and also, its effectiveness of aerobic exercise and caloric restriction, decreased levels of chemerin may play a special role in reduction of insulin resistance.
Roohangiz Alirezaei Shahraki, Ahmad Aliakbari Kamrani, Robab Sahaf, Yahola Abolfathi Momtaz, Narjes Khosravi Samani,
Volume 17, Issue 5 (7-2018)
Abstract
Background: Diabetes is a chronic disease that is increasing in the world that has a different outbreak in different societies. 90% to 95% of all types of diabetes include type 2 diabetes. This disease is spreading due to the Industrial life and urbanization .The Nationwide Program for Prevention and Control of Diabetes is already under way for controlling the disease and its side-effects. This study is intended to probe into the effects of the program in the country.
Methods: This study used a cross-sectional pre- and post-test design involving 100 elderly patients newly introduced to be suffering from diabetes who were selected by convenience sampling in Isfahan. The data collection methods were a questionnaire on demography and health, and another one on patients’ levels of fasting blood sugar (FBS) and hemoglobin glycosides (HbA1c(The data was gathered before and three months after the patients’ entrance into the program.
Results: The mean and standard deviation of the fasting blood sugar before the program were 172.73 and 71.68 and after the program 143.02 and 51.19, respectively (P<.001; t=5.30). And finally, glycated hemoglobin mean and standard deviation before the program were 8.24 and 1.9 and after the program 7.44 and 1.66, respectively (P<.001; t=4.79).
Conclusion: The results indicate the importance of the program for the prevention and control of the elderly patients’ diabetes by controlling their fasting blood sugar and glycated hemoglobin.It is recommended that this program be implemented in all health centers of the country.
Sepideh Salehi, Niku Khosravi, Maryam Delfan,
Volume 19, Issue 5 (6-2020)
Abstract
Background: The prevalence of type 2 diabetes is rapidly increasing in the world. As a result of this disease, long-term insulin resistance develops, as a result of which pancreatic beta cells are destroyed and disappear, as a result insulin is not released. Recently, a protein called lipasin, which is responsible for signaling the liver to beta cells, has been discovered, and previous reports have shown that lipasin/betatrophin increases pancreatic β cell proliferation. Therefore, the aim of this study was to investigate the effect of eight weeks of high intensity interval training (HIIT) and endurance training on lipasin gene expression in rats with type 2 diabetes.
Methods: The study was performed on 25 Wistar rats with a mean weight of 160±10 g and age of 8 weeks. After induction of diabetes, the rats were randomly divided into three groups of 6: control and endurance and HIIT. And exercise was performed for eight weeks (5 sessions per week). QRT-PCR technique was used to evaluate changes in hepatic lipasin gene expression.
Results: The present study showed that after eight weeks of endurance training and HIIT, the expression of lipasin gene in the liver of rats in the training group increased significantly compared to the control group (P = 0.037); Also, a significant negative correlation was observed between lipasin gene expression and insulin resistance index in the exercise group compared to the control group (r = -0.605, P = 0.037).
Conclusion: It seems that performing eight weeks of endurance training and HIIT, by increasing the expression of lipasin gene can increase beta cells in diabetic patients and may be an effective non-pharmacological intervention to reduce the symptoms of this disease.
