Showing 6 results for Madani
Seyed Pejman Madani, Bagher Larijani, Mohammad Hashem Erfani, Ramin Heshmat,
Volume 3, Issue 2 (16 2004)
Abstract
Background: Diabetic Neuropathy is the most common and troublesome complication of Diabetes Mellitus, leading to the greatest morbidity and mortality and resulting in a huge economic burden for diabetes care. Early diagnosis of distal symmetric sensorimotor polyneuropathy, a common complication of diabetes, may decrease morbidity by allowing potential therapeutic interventions.
Methods: In 68 diabetic patients after neuropathy screening by U.K and Michigan scores, Bilateral sural nerve conduction parameters as nerve conduction velocity, latency and amplitude were determined and analysed.
Results: 54.4% of patients had Rt sural abnormal response, 50% had abnormality in left side and 39.7% had bilateral abnormality. There was significant statistical correlation between Michigan physical score and electrophysiologic finding (P-value < 0.003) but no correlation with U.K score (P-value > 0.3). The most prevalent abnormal electrophysiologic finding was amplitude decrement of sural response.
Conclusion: Sural nerve response is one of the simplest and most sensitive peripheral sensory nerves for electrophysiologic study of diabetic neuropathy and its evaluation is recommended in all diabetic patients in spite of normal physical examination and history for detection of subclinical neuropathic cases. For increment of sensitivity, amplitude measurement of sensory response is highly recommended.
Hossein Madani, Sadegh Valian Boroujeni, Noushin Naghsh,
Volume 4, Issue 2 (17 2004)
Abstract
Background: Alloxan is on of the xenobiotic agents which is classified as diabetogenic materials. Magnesium is an important cofactor regulating the activity of carbohydrate enzymes and lipid synthesis. In this study the contrasting effects of Alloxan and magnesium on plasma free fatty acids (FFA) in rats was investigated.
Methods: Male mature rats were used as test models for the diabetes induction. 28 rats received Alloxan (120mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction.
Results: The results were compared to the control groups, and confirmed the presence of diabetes in rats. Analysis of plasma FFA showed a significant increase (751.25 mM), compared to the control group (286.68 mM). In contrast, Measurement of red blood cell (RBC) Magnesium showed a significant decrease from 7.18 mg/dL in control group to 4.89 mg/dL in diabetic rats.
Conclusion: The results of this study showed that in diabetic condition, there was an inverse relationship between plasma FFA and RBC Magnesium. Therefore, these data suggest that analysis of the effects of Magnesium upon induction of diabetic condition could provide important information for management of diabetes.
Hossein Madani, Nargol Ahmady Mahmoodabady, Akbar Vahdati,
Volume 5, Issue 2 (18 2005)
Abstract
Background: Type 1 diabetes or insulin dependent diabetes mellitus is an autoimmune disease probably caused by various factors such genetics, environmental stresses, viral infections and diet. The disease is associated with damage to pancreatic insulin-producing β cells. Many researches have been performed to study the therapeutic effects of herbal medications on diabetes mellitus. The protective effects of some plants such as Cuminum cyminum, Trigonella foenum-graecum, Saliva sclarea, Allium ampeloprasum etc in diabetes induced rats were reported. Dill with the scientific name of Anethum graveolens, is a plant from umbellifera. This family which contains flavonoid compounds.
Methods: In this research, effects of hydroalchoholic extract of this plant on blood glucose level, lipids and lipoproteins in Alloxan-induced diabetic rats was investigated. Fifteen adult male rats, weighing 200-250 gr, were used in three five member groups. Rats in the control group, received physiological serum. as intraperitoneal (IP). In diabetic control group (DCG), diabetes was induced using Alloxan monohydrate at a dose of 120 mg/kgbw. In addition to diabetes induction just like DCG, the treated diabetic control group (TDCG) rats were dosed with 300 mg/kgbw hydroalcoholic Anethum graveolens extract. All rats received all materials via intraperitoneal injection (IP). 48 hours after the last IP, blood sample was taken from each animal via cardiac puncture to measure blood factors.
Results: The results indicated significant reduction in glucose, total cholesterol, triglyceride, LDL and VLDL levels in TDCG rats compared to DCG rats. Due to the use of dill extract, HDL level was significantly increased.
Conclusion: Effect of Anethum graveolens is related to antioxidant compounds. This compounds affect glucose absorbtion and beta cells regeneration. The results of this research indicate that using hydroalcoholic extract of Anethum graveolens could effectively decrease blood sugar levels.
Nargol Ahmadi Mahmoodabadi, Hossein Madani, Parvin Mahzooni, Akbar Vahdati,
Volume 6, Issue 1 (19 2006)
Abstract
Background: Artichoke with the scientific name of Cynara scolymuse is a plant from compositae family. In this research, the effect of hydro alcoholic artichoke extract on serum glucose, lipids and lipoproteins and prevention of type 1 diabetes mellitus was investigated.
Methods: Twenty mature male Rats with mean weight of 200-250 gr in four groups were arranged. Rats in the control group, received physiological serum. The Second group (diabetic) received 120 mg/kgbw Alloxan monohydrate. The Third group (diabetic + Glibenclamide) received 0.5 mg/kgbw Glibenclamide in addition of the similar treatment with second group. The Fourth group (Alloxan monohydrate + Cynara scolymus), received 120 mg/kgbw Alloxan monohydrate with 300 mg/kgbw of Cynara scolymus simultaneously. Prescribing materials in all groups was done as interaperitoneal injection(IP). Fourty eight hours after last IP, blood sample was taken from each animal via cardiac puncture to measure blood factors.
Results: The results indicated significant reduction in glucose, cholesterol, triglyceride, VLDL and LDL levels in the treated group with extract and Alloxan monohydrate simultaneously as to compared diabetic group. Also, the result indicated significant increase in HDL level. Hydroalcoholic Artichoke extract could not reduce blood glucose level as compared with Glibenclamide, but had similar effects on other factors in comparison with Glibenclomide.
Conclusion: Artichoke contains antioxidants compounds, that plays a protective role on beta cells against Alloxan. The results of this research indicate that hydro alcoholic extract of Cynara scolymus could effectively prevent type 1 diabetes mellitus.
Somayeh Madanipour, Abbas Sadeghi, Hasan Purrazi,
Volume 24, Issue 4 (10-2024)
Abstract
Background: Adipogenesis is a dynamic process that leads to the phenotype of mature fat cells and plays a significant role in obesity and diabetes. The present study investigates the effect of Eight –Weeks of High-Intensity Interval Training (HIIT) and L -carnitine Consumption on the expression of BMP7 protein in visceral adipose tissue in diabetic rats.
Methods: In an experimental clinical-intervention study, 50 male Wistar rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). The training program consisted of eight weeks, 5 sessions per week (6 to 12 2-minute sessions with an intensity of 85-90% of the maximum speed). The subjects received 30 mg/kg body weight L-carnitine through drinking water. Visceral fat was extracted and the expression level of BMP7 protein was assessed using Western Blotting. Data analysis was performed by one-way ANOVA and Tukey post hoc test at a significant level of (P< 0.05).
Results: The results showed that the expression of BMP7, the adipogenesis stimulating protein, in (D + T) and (D + LC + T) groups increased significantly (P< 0.001).
Conclusion: According to the results, it seems that HIIT exercise alone and with L-carnitine Consumption is more effective in the expression of protein associated with adipogenesis expression in visceral fat. However, a clear statement requires further research in this area.
Mrs Atefeh Khalaji, Dr Abbas Sadeghi, Miss Somayeh Madanipour,
Volume 24, Issue 5 (12-2023)
Abstract
Introduction: Understanding adipogenesis, the process of adipocyte development, may provide new insights to treat type II diabetes and related metabolic diseases. The present study investigates the effect of eight weeks of moderate-intensity continuous training and L-carnitine supplementation on Wnt10b protein expression related to visceral adipose tissue adipogenesis in streptozotocin (STZ)-induced diabetes in male rats.
Methods: In an experimental clinical-intervention study, 50 streptozotocin-induced 3 months diabetic rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). ). The training program consisted of three times a week for 30 minutes on a treadmill at a speed of 15 meters per minute. Five days a week, 30 mg/kg of L-Carnitine was given through drinking water. Expression of Wnt10b protein at visceral fat was measured by western blot method. Data analysis was performed with one-way analysis of variance and Tukey’s post hoc tests at a significant level (P<0.05).
Results: the results showed that the expression of Wnt10b protein, the Lipolysis inhibitory protein, in both (D+LC+T) groups and (D+T) decreased significantly (P<0.001).
Conclusion: According to the results, it seems that MICT exercise with L-carnitine supplement and alone is more effective in decreasing the expression of protein associated with adipogenesis in visceral fat. However, a clear statement requires further research in this area.
