Showing 16 results for Mehrdad
Massoud Amini, Mehrdad Hosseinpour, Gashtasb Sattari, Sasan Haghighi,
Volume 1, Issue 1 (18 2001)
Abstract
Background: Oral glucose tolerance testing (OGTT) is the gold standard for the diagnosis of diabetes mellitus and impaired glucose tolerance (IGT), but is time-consuming and difficult to perform. We investigated the value of glycosylated hemoglobin (HbA1C) in screening for diabetes mellitus and IGT.
Methods: In a cross-sectional study, we measured the HBA1C levels of 497 people referred for OGTT. We calculated the sensitivity and specificity of HbA1C at 1, 2, 3 and 4 SD above the normal mean. We plotted receiver operating characteristic (ROC) curves after assigning our subjects to the diabetic, IGT, ‘diabetic+IGT’, or normal group, based on WHO criteria for OGTT.
Results: HbA1C levels (mean ± SD) in the four groups were 9.2±1.5, 8.4±1.3, 7.9±0.8 and 6.8±0.7 percent in the diabetic, diabetic+IGT, IGT and normal groups, respectively. All differences were statistically significant (p<0.0001). ROC curve analysis showed that HbA1C levels above 7.5% (mean + 1SD) gave the best combination of sensitivity and specificity for the detection of diabetes (97.53% and 73.8%), IGT (66.37 and 69.44%), and diabetes+IGT (80.22% and 86.66%).
Conclusions: An HbA1C level of >7.5% is an optimal cutoff point for diabetes screening programs.
Masoud Amini, Maryam Mohammadi, Mehrdad Hosseinpour,
Volume 1, Issue 2 (18 2002)
Abstract
Introduction: In this study, we compared the level of glycosylated haemoglobin in patients with essential hypertension and healthy controls.
Method: 70 non-diabetic patients with essential hypertension were recruited into the study along with 140 controls without any significant medical history. Persons with a history of metabolic disease, anaemia, renal disease, splenectomy, pregnancy, or on medication were excluded from the study. A blood sample was taken from each participant and immediately sent to the EEMRC laboratory, where fasting blood sugar and glycosylated haemoglobin levels were measured by the glucose oxidase and thiobarbituric acid (colorimetry) method, respectively. The unpaired t-test was used to compare means. A p-value of less than 0.05 was considered significant.
Results: Mean fasting blood glucose was 103.1±16.1mg/dl in the hypertensive group and 92±7mg/dl in controls (p<0.05). Mean glycosylated haemoglobin levels were 7.38±0.78% in the hypertensive group and 6.5±0.85% in controls (p<0.05). Conclusion: People with essential hypertension have a higher level of glycosylated haemoglobin than healthy controls.
Seyed Mehrdad Sulati, Arash Ghanbarian, Maziayar Rahmani, Narghes Sarbazi, Sima Alah Verdian, Fereidoun Azizi,
Volume 2, Issue 2 (17 2003)
Abstract
Background: Risk factors of cardiovascular disorders have been the subject of several studies. Recently, simultaneous high waist circumference (WC) and high serum triglyceride (Tg) has been proposed as a simple screening measure to predict non-traditional risk factors. This study has looked at the risk factors of cardiovascular disorders present in subjects with this phenotype.
Methods: Non diabetic females of age 18-65 years who had been enrolled in the Tehran Lipid and Glucose Study (TLGS) were recruited.
Based on fasting Tg and WC, subjects fell into four categories: TgHWH ( Tg>160 mg/dl, WC>80 cm), TgHWL (Tg>160 mg/dl,WC<80 cm), TgLWH(Tg<160 mg/dl,WC>80 cm) and TgLWL (Tg<160 mg/dl,WC<80 cm).
Cardiovascular risk factors including lipid profiles and anthropometric variables were compared between the categories. The prevalence of hypertension, LDL-C>130 mg/dl, total cholesterol>220 mg/dl and HDL- C<45 mg/dl were also determined in each category.
Results: 5630 subjects were studied. TgLWL and TgHWH constituted to 27.5 % and 31.9 % of subjects, respectively. Mean age of subjects dropping in TgLWL, TgLWH, TgHWL and TgHWH groups was 28±10, 39±12, 36+12 and 46±11, respectively and TgHWH subjects were significantly older than other groups (p<.001).
Systolic and diastolic blood pressures, body mass index and WC were significantly higher in TgHWH. Significantly higher levels of total cholesterol, triglycerides and LDL-C and significantly lower level of HDL-C were found in the TgHWH group. The prevalence of subjects with four or more risk factors was 61.4% in TgHWH versus 1% in TgLWL group.
Conclusion: Parallel high waist circumference and high serum triglycerides (TgHWH) can find use as a simple screening measure to predict other risk factors of cardiovascular disorders.
Mehrdad Roghani, Tourandokht Baluchnejadmojarad, Samaneh Taheri,
Volume 7, Issue 2 (17 2007)
Abstract
Background: Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids to normal levels is very important. The effect of oral administration of Vaccinium myrtillus (VM) on serum glucose and lipids in diabetic rats was investigated.
Methods: Female Wistar rats were divided into 4 groups: control, VM-treated control, diabetic, and VM-treated diabetic groups. The treatment groups received oral administration of plant-mixed food (6.25%) for 4 weeks. Serum glucose, triglyceride, total cholesterol, LDL- and HDL- cholesterol levels were determined before the study, and at 2nd and 4th weeks after the study.
Results: Serum glucose level in diabetic group increased 2 and 4 weeks after the experiment as compared to data one week before the study (P<0.001) and VM treatment of diabetic rats did have a significant hypoglycemic effect (P<0.01). In addition, triglyceride level in diabetic group increased 4 weeks after the experiment in comparison with related data one week before the study (P<0.05) and there was a significant lower level of triglyceride in VM-treated diabetic rats (P<0.05). Furthermore, there was no significant changes regarding serum total cholesterol, HDL- and LDL- cholesterol levels in treated diabetic group as compared to untreated diabetic group.
Conclusion: Oral administration of VM has a significant hypoglycemic effects and leads to an appropriate changes only in triglyceride level.
Neda Nazari, Hossein Fakhrzadeh, Farshad Sharifi, Seyed Masoud Arzaghi, Mahtab Alizadeh, Neda Mehrdad, Shervan Shoaei, Baharak Najafi, Mostafa Qorbani,
Volume 13, Issue 1 (1-2014)
Abstract
Introduction: The height measurements in the elderly are associated with several problems. In this study
we used a model to predict of the Iranian people aged height from age, shin length and forearm length.
Methods: A total 165 aged people ≥60 years were randomly selected based on medical record number of
about 800 eligible older people who lived in Kahrizak Charity Foundation. Standing height, shin length
and forearm length were measured. Data from 99 participants were used to creat a predicting multivariate
linear regression model for estimation of standing height of older men and women. The data of the rest
66 participants were used for models testing.
Result: The following equations were created:
Men height = 78.928+ (1.430× shin length) + (0.817×forearm length)-(0.176×age)
The height of women = 71.694+ (1.414×shin length) + (1.084× forearm length)-(0.277× age)
R2
were calculated as 0.63 for men and 0.52 for women. Error of estimation was +0.44 cm and it was -
0.16cm and +1.09cm for men and women respectively. Estimated heights were not significantly different
from standing statures.
Conclusion: height was predictable from shin length and for forearm lengths and also age with a
relatively small error in the estimation among Iranian older people. The error of model is more in women
than men.
Baharak Najafi, Seyed Masoud Arzaghi, Hossein Fakhrzadeh, Farshad Sharifi, Shervan Shoaei, Mahtab Alizadeh, Mohsen Asadi Lari, Reza Fadayevatan, Neda Mehrdad,
Volume 13, Issue 1 (1-2014)
Abstract
Introduction: Mental disorders are common in the elderly.The purpose of this study was to assess the
general health status and its related factors among people ≥ 65 years in different districts of Tehran.
Methods: This study has used data of the participants ≥ 65 years old in urban health equity and response
tool (Urban-HEART) study. Finally the data of 1313 elderly were considered for this study. Variables
included demographic characteristics (gender, age, education level, family size, marital status and
employment status) and mental health using the Persian GHQ -28 questionnaire (domains: somatic,
depression, insomnia and anxiety) and quality of life using the SF12.
Results: The mean age of participants was 73.68 (5.91) (women=627 and men=686). GHQ-28 median of
scores the participants were 24.00 (22.00)[20.00 (27.00) in women and 19.00 (19.00) in men
(P<0.01)].Based on GHQ-28 cut-point 23, 50.2%of the participants had mental health problems, [61.2%
women and 40.1% men (P<0.01)].The residents of third municipality districts had the best mental health
(26.3% of men and 38.5% of women had mental health problems) and the aged of 20th municipality
district had the worst health status (65.7% of males and 84.2% of women had mental health problems).In
multivariable logistic regression model, for each year of increment age, 2.9% chance of mental health
problems increased (P<0.01). With increasing level of education, mental health status was improved (P
trend < 0.01). The relationship between family size and mental health was not significant (P =0.06).
Conclusion: Mental health status of the elderly in Tehran was worse than the many other countries. The
elderly lived in 20th
municipal district, had the worst and the dwellers in the 3th
district had the best mental
health status.
Sima Ghassemi, Baharak Najafi , Alireza Memari , Neda Nazari, Fariborz Bakhtiari, Mahtab Alizadeh Khoei, Seyed Masood Arzaghi, Shervan Shoaee, Neda Mehrdad, Farshad Sharifi,
Volume 13, Issue 6 (9-2014)
Abstract
Background: Falling is one of the health problems among aged population. Elderly living in institutions are at greater risk of falling than those dwellings in the community, due to their health status and environmental conditions. This study was designed and conducted aimed to address the factors affecting falls in Kahrizak Charity Foundation (KCF).
Methods: This is a prospective longitudinal study, which 194 of residents of KCF were participating in it with inclusion criteria were selected by Random Cluster sampling. They were enrolled after signing an informed consent. At baseline the data of demographic, lifestyle, past medical history and visual ability were collected by interviewing. The anthropometric measurements were performed as well. Cognitive status data were collected using abbreviated mental test (AMT) questionnaire and mini mental state examination (MMSE), balance status was assessed using the Tinetti mobility test (TMT) and its balance and gait sub- scores, depression was detected using the geriatric depression scale-15 (GDS-15). The participants were monitored for the falls occurrence its complications by daily call with caregivers and filling out the special forms for the recording of the falls occurrence by the head nurse. Data were analyzed using univariate and multivariable Cox-regression models.
Results: The mean age of the participants was76.02 (8.82) years and the mean follow-up days was 754.40±189.26 days. 44 cases of falls were recorded during follow-up (over two years). The fall rate was 22.7 subjects per 100 participants per year. History of stroke, Parkinson's disease, visual loss, taking antidepressants, TMT score and TMT balance sub-score after adjustment (for age, sex, body mass index and survival time) were associated with falls.
Conclusion: The falls among nursing home elderly residents were associated with a history of chronic diseases such as stroke and Parkinson's diseases, visual acuity, use of antidepressants and the TMT and its balance sub score.
Zahra Jafari, Neda Mehrdad, Farshad Sharifi, Hamid Haghani, Soghra Nikpour,
Volume 15, Issue 4 (5-2016)
Abstract
Background: Prevalence of diabetes increases along with aging. Due to various reasons, rate of falling in the aged suffering from diabetes is higher. Therefore, this study aims at determining factors relating falling of the aged suffering from type 2 diabetes.
Methods: A total of 60 years old or older with type 2 diabetes that referred to selected hospitals of Tehran University of Medical Sciences using continues method. Cases that had experienced falling during last year and controls that had no such experience were assigned to two separate groups. Questionnaire used in this study included demographic data and factors relating falling. Data obtained were analyzed using descriptive statistics, independent t- test, Chi square and logistic regression.
Results: Results showed that postural blood pressure (p=0.02) dizziness (p=0.05), fecal incontinency (p<0.01), auditory disorder (p<0.01), visual disorder (p<0.01), pain in the lower extremity (p= 0.027), taking anti-coagulation medicine (p=0.017) had a significant correlation with falling.
Conclusion: Multivariate logistic regression illustrated that fecal incontinency and auditory disorder happened along with falling in the aged suffering from type 2 diabetes. Therefore, preventing falling must be considered in care plan for such groups of people.
Maryam Mortezaee, Abbasali Raz, Shole Mansouri, Zohreh Annabestani, Zahra Mirzaeezadeh, Bagher Larijani, Mehrdad Hashemi, Kobra Omidfar,
Volume 15, Issue 5 (7-2016)
Abstract
Background: Insulin resistance and progressive β-cells failure are the key factors in type 2 diabetes mellitus (T2DM) pathogenesis. Many studies support a primary role of RBP4 in insulin resistance and suggest that genetic variations which alter the expression level of RBP4 might influence the risk of T2DM and its complications. Diabetic foot is one of the main complications of diabetes leading to disability and hospitalization. In addition, it reduces quality of life and imposes great cost to patients. The purpose of this study was to evaluate the correlation between two single nucleotide polymorphisms (rs10882273 and rs10882283) of RBP4 genes with diabetic foot ulcer in order to identify a biomarker for prediction of diabetic foot ulcer.
Methods: This is a case-control study. Two single nucleotide polymorphisms of RBP4 genes were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 133 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.
Results: The Chi-square test revealed no significant difference in frequency of TT, CC and TC alleles of rsl0882273 between case and control groups (P=0.414). Also, Comparison of AA, CC and AC alleles of rsl0882283 in both groups did not show significant difference (P=0.85).
Conclusion: According to this study, there is no relationship between two single nucleotide polymorphisms of RBP4 genes (rs10882273 and rs10882283) with diabetic foot ulcer in type2 diabetes patients.
Sharare Hassanzade, Abbasali Raz, Masoumeh Mansouri, Zahra Mirzaeezadeh, Bagher Larijani, Mehrdad Hashemi, Kobra Omidfar,
Volume 16, Issue 1 (1-2017)
Abstract
Background: Type 2 diabetes is a metabolic disorder characterized by high blood sugar levels that can damage nerves. Many organs are affected ،especially the foot that leading to loss of sensation. These factors make favorable conditions for the development of diabetic foot ulcers. Polymorphisms (Thr399Ile) of Toll Like Receptor4 (TLR4) gene due to malfunction of TLR4 protein which plays an important role in immunity. The purpose of this study was to determine the parameters which are affecting the imbalance resulting in chronic inflammation and wound healing. By showing the relationship between single nucleotide polymorphism (Thr399Ile) of TLR4 gene with diabetic foot ulcer we can identify a biomarker for prediction of diabetic foot ulcer.
Methods: This is a case-control study. Single nucleotide polymorphisms of TLR4 gene were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 120 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.
Results: The Chi-square test revealed significant difference in frequency of TT, CC and TC alleles of (Thr399Ile) between case and control groups (P=0.021).
Conclusion: According to this study, there is a relationship between single nucleotide polymorphisms (Thr399Ile) of TLR4 gene with diabetic foot ulcer in type 2 diabetes patients
Sahar Shafiee, Abbasali Raz, Neda Adibi, Masoomeh Mansouri, Zohreh Annabestani, Zahra Mirzaeezadeh, Mehrdad Hashemi, Kobra Omidfar,
Volume 17, Issue 1 (3-2018)
Abstract
Background: Type 2 diabetes is the most common type of diabetes, and a complex endocrine metabolic disorder that one of its main complications is diabetic foot ulcers. Matrix metalloproteinases (MMPs) are one of the key enzymes in the reconstruction of extracellular matrix which have proteolytic activity. The aim of this research is based on evaluating relationship between -1562 C>T allele at MMP-9 gene promoter with diabetic foot ulcer in type II diabetic patients. If such correlation proves, it can be used as a prognostic biomarker in patients with high-risk.
Methods: This is a case-control study. The single nucleotide polymorphism of -1562C>T allele of MMP9 gene promoter was genotyped by hit Tetra ARMS PCR technique in 100 diabetic patients with foot ulcer grade 1 or 2 as the case group according Wagner classification and in 100 diabetic patients without foot ulcer as the control group. Results: The Chi-square test revealed significant difference in genotype frequency of CC, CT and TT alleles of -1562C>T allele of MMP9 gene promoter between case and control groups (P=0.000).
Conclusion: According to this study, there is a relationship between -1562C>T allele of MMP9 gene promoter with diabetic foot ulcer in type2 diabetes patients. Thus we can introduce this biomarker for evaluation of risk and prognosis of diabetic foot ulcers.
Mahnaz Sanjari, Maryam Aalaa, Mohammadreza Amini, Neda Mehrdad, Mohammadreza Mohajeri,
Volume 19, Issue 3 (2-2020)
Abstract
Background: Diabetic foot is one of the main complications of diabetes, which is caused by a significant proportion of patients with diabetes and which imposes costs on the family and the health system around the world. This review aims to summarize the latest findings in the field of diabetic foot based on clinical guidelines.
Methods: In this review study, in order to achieve the best clinical guide in the field of diabetic foot by determining the search strategy and inclusion criteria, all related clinical guides were searched in the databases and websites of clinical guidelines. Clinical guidelines related to diabetic foot care were searched and retrieved from January 2000 to early 2019 and screened separately by two researchers to select the selected clinical guideline.
Results: Based on the study criteria, the clinical guide of the International Diabetic Foot Working Group was selected as the most complete guide in the field of diabetic foot. This summary is based on the International Working Group on the Diabetic Foot (IWGDF) Guidance 2015, consist of five documents including prevention of foot ulcers in at‐risk patients, footwear and offloading principles, diagnosis, prognosis and management of peripheral artery disease, foot infections in patients with diabetes and enhance healing of chronic ulcers of the foot in diabetes.
Conclusion: This Summary Guidance for Daily Practice is intended to overview of the main aspects of the prevention and treatment of foot problems in patients with diabetes. This summary guidance is adviced at healthcare providers and specialists in foot care throughout the world.
Fatemeh Bandarian, Nazli Namazi, Mohammad Pajouhi, Mohammadreza Amini, Neda Mehrdad, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Endocrinology and Metabolism Research Institute (EMRI) was established in 1993. EMRI has progressed step by step from the beginning and has reached maturity in the last 25 years. EMRI has expanded, advanced in human resources and infrastructures (laboratories and new technologies) and gained first rank in endocrine research in various fields. It has also worked with regional and international organizations such as the World Health Organization (WHO), the International Osteoporosis Foundation (IOF), and the American Clinical Endocrine Society (AACE). This article provides an overview of EMRI activities over a quarter of a century.
Abdolmansour Tahmasbi, Mehrdad Movahednasab, Melika Hamedi, Vahid Vosooghi-Postin Doz, Reza Lotfi,
Volume 22, Issue 4 (11-2022)
Abstract
Backgrund: Saffron petals contain flavonoid compounds, glycosides, and anthocyanins. Considering the trend of increasing the use of medicinal plants in modern medicine in order to treat some diseases, the upcoming experiment was designed to investigate the effectiveness of the hydroalcoholic extract of saffron petals and alkaline water in comparison with the commercial drug metformin on the blood glucose level of diabetic rats.
Methods: In this experiment, 28 male Wistar rats were divided into 4 groups. 1) Diabetic animals (negative control), 2) Diabetic animals that received 200 mg of dry saffron petal extract daily, 3) Diabetic animals that had free access to alkaline water, 4) Diabetic animals that received 100 mg/kg BW metformin daily. They did the duration of the experiment was considered to be 28 days. During this period, feed and water consumption will be measured and recorded on a daily basis and weight on a weekly basis. At the end of the experiment, blood biochemical indices were measured.
Results: Weight and blood triglycerides were not affected by experimental treatments. While the feed consumed, water consumed, insulin, glucose, cholesterol, HDL, LDL and liver enzymes were significantly affected by the experimental treatments.
Conclusion: According to the results, the use of alkaline water and saffron petal extract positively reduced the blood glucose of mice and also had significant effects on feed and water consumption, cholesterol, HDL and LDL of animals. However, the definitive confirmation of the results of this experiment requires more studies and investigations in this field.
Atefeh Ketabdar, Seyed Reza Attarzadeh Hosseini, Mehrdad Fathei, Mohamad Mosaferi,
Volume 23, Issue 5 (12-2023)
Abstract
Background: Fatty liver disease and its relationship with cardiovascular diseases is one of the concerns of today's society, therefore the present study was conducted to investigate the effect of eight weeks of endurance training and growth hormone injections on Cardiac mitochondrial PGC1α content and some oxidative stress indices in mice with hepatic damage.
Methods: In this experimental study, 21 male mice were, randomly, divided into three groups (n=7): control (C), Exercise (E), Exercise + Growth Hormone (EGH) group. The Medium intensity endurance training program was performed for eight weeks and 5 sessions with an intensity of 50% VO2max of per week. The somatropin injection protocols were 1 mg/ kilogram/body weight, respectively. Statistical analysis of the data was performed using the software SPSS, using One-Way ANOVA and post hoc Tukey tests.
Results: PGC1a levels increased in both groups compared to the control group. SOD and MDA levels increased and decreased in both groups compared to the control group, respectively. The reduction of HOMA levels was significant only in E group compared to the control group. Also, the difference between E and E-GH group was significant. ALT/AST ratio decreased in both groups compared to the control group. The reduction of LDL/HDL ratio was significant only in group E compared to the control group.
Conclusion: Endurance training has produced a more effective response in improving NAFLD markers than GH peptides. Growth hormone injection can have negative consequences on some indicators of this abnormality.
Mehrdad Yousefinejad, Mahnaz Omidi, Abdolhossin Taheri Kalani,
Volume 24, Issue 3 (7-2024)
Abstract
Background: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and insulin resistance index in diabetic rats.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P= 0.001 and P= 0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
