Majid Karandish, Fateme Mofidi, Mohamad Taha Jalali, Anahita Mansouri,
Volume 13, Issue 3 (3-2014)
Abstract
Background: Alternate Day Fasting (ADF) is one of dietary regimens in which food is available only
every other day. Available limited evidence shows that this regimen may result in beneficial effects
similar to classic caloric restriction, including weight loss and other associated useful effects of weight
loss.
Methods: Twelve week-old Wistar rats were obtained from animal house of Jundi Shapur University
and fed a standard diet. Food was provided ad-libittum (AL) until 13 week of age. At that time rats
were assigned to one of two groups: AL fed ad libitum or ADF, provided access to food every other
day. Body weight was measured each week on the same day and time. Food intake was measured
daily. Fasting blood glucose levels were measured before and after the intervention. Statistical tests
performed as two-tailed and P value of less than 0.05 was considered as statistically significance level.
Results: At the end of the intervention period body weight and food intakes of the (ADF) group were
significantly lower than AL group (p<0.05) but there were not significant changes in fasting blood
glucose levels.
Conclusion: According to findings of this experimental study, ADF regimen could be used as an
individualized eating strategy for weight loss but it could not have beneficial effects on fasting blood
glucose levels.
