Showing 3 results for Mokhtari
Fatemeh Mokhtari, Fahime Esfarjani, Mehdi Kargar Fard,
Volume 13, Issue 4 (5-2014)
Abstract
Background: Physical activity with diet and medication–considered fundamental in the treatment of diabetes. The aim of this study was to determine the effect of combined 12-week aerobic exercise and barley β glucan (BBG) on blood glucose and lipid profile in patients with type 2 diabetes.
Methods: Twenty- four female volunteers (49±5 years) were selected, and after completion of questionnaires, were randomly divided into three groups a) aerobic training with diet group (n=8), b) diet group (n=8) and c) control group (n=8). The diet group used one barley bread per day with 4 gram beta glucan during 12 week. The combined group participated in progressive walking training program with intensity of 60-70% of maximal heart rate 2 to 3 times a week, 20 to 60 minutes in each session in addition to diet program. The variables measured included blood sugar, triglyceride, cholesterol, LDL, HDL. For data analysis ANOVA used to compare mean differences between groups.
Results: Results indicated significant difference in blood sugar between control and experimental groups while non significant changes was observed in lipid profile.
Conclusion: Aerobic exercise and BBG can decrease blood glucose in patients with diabetes Therefore, it should be considered seriously as part of the treatment of these patients.
Elham Mokhtari, Amir Sarshin, Foad Feizolahi, Eidi Alijani,
Volume 22, Issue 2 (7-2022)
Abstract
Background: Type 1 diabetes is associated with decreased skeletal muscle capillary and improper regulation of angiogenesis pathways in skeletal muscle. This research intended to study the effect of resistance training and endothelial stem cell injection on βeta-actin, phosphorylated and total AKT of skeletal muscle in type 1 diabetic rats.
Methods: In this experimental study, 36 male Wistar rats (age 6 weeks) were divided into six groups of control (healthy), basal diabetic control, diabetic control, diabetes + stem cell injection, diabetes + resistance training and diabetes + stem cell injection + resistance training. In this study, rats became diabetic intraperitoneally using streptozotocin as a single dose of 40 mg/kg. Resistance exercises including climbing a one-meter ladder with weights hanging from the tail were performed for 17 sessions. 500,000 bone-derived stem cells were injected by a cell counter. The levels of βeta-actin, phosphorylated and total AKT in skeletal muscle tissue of rat were measured by using the Western blotting method.
Results: The results showed that resistance training led to significant increase in Pho-AKT, β-actin and Pho-AKT/AKT ratio and significant decrease in AKT of muscle tissue in type 1 diabetic rats (P<0.001). Injection of stem cells leads to significant increase in Pho-AKT and Pho-AKT/AKT ratio and resistance training with simultaneous injection of stem cells leads to significant increase in Pho-AKT, β-actin and significant decrease in Akt of muscle tissue in type 1 diabetic rats (P<0.001).
Conclusion: According to the results, it is possible that the intervention of resistance training with injection of stem cells can help regulate the pathways of skeletal muscle angiogenesis in type 1 diabetes.
Masoumeh Shojaei Barjouei, Somayeh Norouzi, Parsa Bernoos, Kimia Mokhtari, Azizeh Asadzadeh,
Volume 22, Issue 3 (9-2022)
Abstract
Background: Diabetes mellitus is a group of metabolic disorders that are associated with elevated blood glucose levels due to impaired insulin secretion, insulin function, or both. alpha-glucosidase is a key enzyme in hydrolyzing carbohydrates and raising blood sugar levels. This study aimed to investigate the bioinformatics of inhibition of the alpha-glucosidase enzyme by the main constituents of Salvia officinalis.
Methods: This research was done by descriptive-analytical method. To study how the compounds interact and the amount of binding energy in the active site of the enzyme, the three-dimensional structure of the compounds and proteins were obtained from PubChem and PDB database, respectively. After energy optimization by Hyperchem software, docking studies were performed by AutoDock 4.2 software and the Swiss ADME server was used to obtain Lipinski parameters and physical and chemical properties of the compounds.
Results: The studied compounds were similar to the two positive control compounds, Voglibose and miglitol, in terms of binding energy and how they interact. The best docking results are related to the camphor . In fact, this compound with the most negative binding energy level (-3.95 Kcal / mol) has a greater tendency to bind to key amino acids in the active site of the alpha glucosidase enzyme.
Conclusion: Due to the appropriate interactions of Salvia officinalis.compounds with enzymes, after confirming the results in vitro and in vivo, this plant can be used as a suitable drug candidate in the treatment of diabetes.
