Showing 3 results for Nasiri
Shahram Safa, Alireza Esteghamati, Mohsen Nasiri Tousi, Hosein Foroutan, Hadi Ghofrani, Akram Sarbyaei, Mehrshad Abbasi,
Volume 5, Issue 2 (18 2005)
Abstract
Background: The liver plays a main role in the production and metabolism of lipoproteins, and then impaired lipid metabolism is often seen in patients with liver cirrhosis and chronic hepatitis (CH). As a result, plasma lipid levels could be as useful indicators of liver function and patient's prognosis especially in liver cirrhosis.
Methods: We measured the lipoprotein levels in 77 consecutive patients with liver cirrhosis and CH. 47 men (61%) and 30 women (39%) with mean age 43years (SD=16.4) and mean BMI 26(SD=4.2) have been recruited as patients group. Child score and MELD scale was determined in patients group. The control group was age and sex matched with patients group.
Results: In case group, the levels of HDL LDL, TG, and total cholesterol were significantly lower than control group (p <0.0001). In patients with cirrhosis, the levels of LDL, HDL and total cholesterol were progressively lower when comparing patients in Child class A with patients in class C (p<0.0001).This difference was more significant in LDL and total cholesterol and between upper Child scores ,similarly decreasing in LDL, HDL ,and total cholesterol level was observed when MELD score increased (P<0.0001).
Conclusion: There is a correlation between plasma lipid levels and liver function, so it may be mentioned as an accessible and reliable indicator of liver function in cirrhotic and CH patients.
Maryam Ghorbani, Rozita Fathi, Khadijeh Nasiri, Farhad Ahmadi,
Volume 19, Issue 1 (1-2020)
Abstract
Background: Skeletal muscle as an endocrine tissue is involved in the regulation of metabolic activity, production and secretion of hormones including myokines. The aim of the present study was to investigate the effect of eight weeks of aerobic training combined with ethanol consumption on plasma lipid profile and glucose levels, triglyceride content and mayonectin, irisin and leptin gene expression in the gastrocnemius muscle in male rats.
Methods: A number of 32 rats with a weighing average of 200 ± 10 g were divided into four groups control, aerobic training, ethanol with dose of 4 g/kgbw, and ethanol +aerobic training. At the end of the period, values of lipid profile and plasma glucose, the amount of triglyceride of the gastrocnemius muscle and the relative levels of mayonectin, irisin and leptin gene expression were evaluated. Data were analyzed using two-way ANOVA.
Results: The plasma triglyceride levels in the aerobic training and ethanol+aerobic training groups were significantly decreased compared to the control group (P≤0.05). The gastrocnemius muscle triglyceride values were significantly increased in the ethanol +aerobic training (P≤0.0001) and aerobic training groups (P≤0.01) compared to the control group. The results showed that aerobic training significantly increased myonectin gene expression in aerobic training group (P≤0.05), but the expression of irisin and leptin genes did not change significantly in different groups.
Conclusion: Aerobic training during the eight-week was able to improve lipid content, especially plasma triglyceride and skeletal muscle triglyceride, and possibly regulate body metabolism by altering the levels of myokines, especially myonectin.
Parisa Karimzadeh, Mahdis Khazaeli Najafabadi, Sina A Sharghi, Farzaneh Karimi Birgani, Effat Asadollahpour, Somayeh Parichehreh-Dizaji, Mahnaz Pejman Sani, Sayed Mahmoud Sajjadi-Jazi, Mahmood Naderi, Hilda Samimi, Shirzad Nasiri, Seyed Mohammad Tavangar, Bagher Larijani, Vahid Haghpanah,
Volume 25, Issue 6 (1-2026)
Abstract
Background: Biobanks are biological repositories that collect, process, store, and distribute human biological samples. Among them, tumor banks play a central role in biomedical research. The overall goal of a tumor bank is to collect cancerous and normal samples under standardized conditions for basic, clinical, or applied research.
Methods: Tumor samples from patients with endocrine neoplasms were collected from excess tissue samples not required for diagnostic purposes after surgery in the surgical department of Dr. Shariati Hospital, Tehran, Iran. In addition, relevant biological samples such as serum, plasma and DNA were collected in parallel. Prior to sampling, informed consent was obtained from the patients and a questionnaire was completed. After rapid freezing with isopentane, tissue samples were stored in a liquid nitrogen tank, while other biological materials, such as serum, were stored in a -80°C freezer.
Results: Tissue, plasma, serum, and DNA samples collected from patients with endocrine neoplasms were stored in separate barcoded storage boxes in the biobank and were made available to researchers.
Conclusion: The use of bioproducts in domestic research and international networks has strengthened research collaborations through supporting the collection and distribution of tissues, especially cancer tissues. This trend plays an important role in facilitating basic and applied research in various fields of cancer, including molecular biology, immunology, genetics and pharmacology, and will pave the way for scientific advances and therapeutic innovations.
