Fariba Soltanzadeh, Masoumeh Nezhadali, Leila Pishkar,
Volume 23, Issue 3 (9-2023)
Abstract
Background: Type 2 diabetes is a metabolic disease and the most common endocrine disorder. Visfatin is a cytokine with insulin-mimetic effects which is associated with diabetes. The rs61330082 polymorphism is located in the promoter region of visfatin gene and regulates visfatin gene expression. The aim of this study is to investigate the association of rs61330082 polymorphism of the visfatin gene with biochemical and anthropometric variables, visfatin level, diabetes and insulin resistance.
Methods: This case‑control study was performed on 80 patients with type 2 diabetes and 80 controls (persons without diabetes). Biochemical and anthropometric parameters were determined using standard methods. Insulin and visfatin levels were measured by ELISA method. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism method. The data was analyzed with SPSS software.
Results: LDL-C level in healthy people and fasting blood sugar level in patients showed a significant difference in carriers of rs61330082 polymorphism genotypes. No associations was found between visfatin level and single nucleotide polymorphism rs61330082 in the current study. Regression analysis showed that genotypes of rs61330082 polymorphism are not significantly associated with type 2 diabetes and insulin resistance.
Conclusion: The rs61330082 polymorphism is associated with LDL-C in healthy subjects and FBS in patients with T2D. Visfatin rs61330082 polymorphism is not associated with visfatin level and type 2 diabetes and insulin resistance.
Masoumeh Nezhadali,
Volume 25, Issue 3 (7-2025)
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and inadequate insulin secretion by pancreatic beta cells. Insulin resistance is the most important characteristic of T2DM, in which the peripheral tissues, including the liver, skeletal muscles, and adipose tissue, shows a lower response to the presence of insulin and insulin function is impaired. Adipose tissue, in addition to storing fat, synthesizes and secretes several bioactive peptides called adipokine and cytokine, which play an important role in regulating metabolism, inflammation, obesity and diabetes.
Methods: In the present study, searches were conducted in the Persian and Latin databases PubMed, Science Direct, Google Scholar, SID, and Magiran using keywords such as Diabetes, Insulin Resistance, Adipokine, Adiponectin, Leptin, Resistin, TNF-α, IL-6, RBP-4, Chemerin, Vaspin, Visfatin, Omentin, and Aplin to retrieve articles published from 2011 to 2024.
Results: The results indicated that adiponectin levels are reduced in patients with T2DM and insulin resistance. Elevated levels of leptin and retinol-binding protein-4 play a crucial role in the development of insulin resistance and T2DM. According to the evidence, adiponectin, resistin, TNF-α, interleukin-6, vaspin, and visfatin are associated with insulin resistance and T2DM. Contradictory results were found regarding the associations of omentin, apelin, and chemerin with insulin resistance and T2DM.
Conclusion: Adipocytokines may serve as biomarkers for predicting and early diagnosis of insulin resistance and T2DM.
