Showing 3 results for Nikbakht
Hamed Rezaei Nasab, Abdolhamid Habibi, Masoud Nikbakht, Mohamad Rashno, Saeid Shakerian,
Volume 18, Issue 4 (4-2019)
Abstract
Background: Oxidative stress plays a key role in the onset and development of diabetes Complications, Including diabetic cardiomyopathy. The purpose of this study was to investigate the role of dichloroacetate (DCA) on SOD and GPX expression following six weeks’ endurance training in cardiac muscle of diabetic male rats.
Methods: In this experimental study, 64 male Wistar rats were selected and randomly divided into eight groups after streptozotocin (STZ) solution diabetic treatment. The endurance training protocol was performed on a treadmill for 6 weeks. In the present study, for Inhibition of PDK4 in the cardiac muscle, intraperitoneal injection of DCA of 50 mg/ kg body weight was used. Gene expressions were measured by Real-Time PCR method. One-way ANOVA and Tukey's test were used to analyze the data.
Results: The results of the study showed that after endurance training, PDK4 gene expression increased and SOD and GPX genes expression in training endurance + diabetic group and endurance training group decreased compared to control group (P <0.05). By Inhibition of PDK4, the of SOD and GPX genes expression increased in DCA + training endurance + diabetic group and DCA + endurance training group compared to control group (P <0.05).
Conclusion: According to the results of this study, DCA injections may reduce the recurrence of free radicals induced by endurance training in diabetic patients by mitochondrial adaptation. Which can reduce the oxidative stress in the heart tissue of diabetic patients and increase cardiac efficiency.
Saeideh Tabibirad, Hosein Abednatanzi, Hojatallah Nikbakht, Farshad Ghazalian, Mandana Gholami,
Volume 18, Issue 5 (7-2019)
Abstract
Background: Obesity increases the risk of developing type 2 diabetes with regard to the hormones involved. The purpose of this quasi-experimental study was to investigate the effect of aerobic exercise on Dpp-4 and GLP-1 in obese women with type 2 diabetes.
Methods: From among obese women with type-2 diabetes mellitus 35-50 years old referred to the Diabetes Association of Saveh, 20 people were voluntarily selected and randomly assigned to two groups of control (10) and Experiment group (10) were divided. Twenty four hours before the beginning of the training, the individual characteristics of the subjects included age, height, weight, body mass index and research variables (insulin resistance, Dpp-4 and GLP-1) in the pre-test and the training group Aerobic exercise lasted for 8 weeks, 3 sessions per week, and 45-60 minutes each session, and the control group did not practice. After 8 weeks and 24 hours after the last training session, the individual characteristics and variables of the research were again measured. Data were analyzed by independent t-test and dependent t-test at p≤0.05.
Results: There was a significant increase in the level of GLP-1 (P= 0.001) and a significant decrease in DPP-4 level (P= 0.001) in the aerobic exercise group compared to the control group.
Conclusion: Results showed that Dpp-4 and GLP-1 values were significantly different in aerobic training group after 8 weeks compared to control group. It was also found that aerobic training significantly increased the level of GLP-1 and decreased the level of DPP-4.
Mahboobeh Rangraz Tabatabaei, Masoud Nikbakht, Rohollah Ranjbar, Farhad Daryanoosh, Mohsen Ghanbarzadeh,
Volume 23, Issue 1 (5-2023)
Abstract
Background: The release of adipokines from adipose tissue depots plays a key role in regulating metabolic homeostasis and several other physiological processes, including diabetes, obesity, and vascular diseases. This study investigated the effect of eight weeks of high intensity interval training (HIIT) on asprosin, lipid profile and insulin resistance in type 2 diabetic male rats.
Methods: 24 male Sprague Dawley rats were randomly divided into four equal groups: control (C), control traning (C+T), diabet (D) and diabet traning (D+T). Diabetes was induced by the combined method of high fat diet and low dose strepotozocin injection. The traning group performed the HIIT program on the treadmill for eight weeks. Data were analyzed using one-way ANOVA and bonferroni post hoc test at a significance level of P<0.05.
Results: The results showed increased plasma asprosin in D group compared to C (P=0.0001) and decreased in C+T group compared to C (P=0.03) and D+T group compared to D (P=0.04). There was no significant difference in HOMA-IR between the C and C+T group (P=0.9) but decreased in D+T compared to D (P=0.0001). HDL increased in D+T group compared to the D (P=0.0001) and decreased TG and LDL (P=0.001). There was no significant difference between TG and LDL in the C group compared to the C+T, but HDL increased in C+T (P=0.01).
Conclusion: Plasma asprosin increases in rats with type 2 diabetes and HIIT can reduce the complications of diabetes by improved lipid profile and reduce asprosin and insulin resistance.
