Search published articles


Showing 19 results for Nouri

Hossein Fakhrzadeh, Peyman Faridnia, Mehrzad Bahtouei, Mostafa Mohaghegh, Rasool Pourebrahim, Reza Baradar-Jalili, Ali-Reza Vassigh, Masoomeh Nouri,
Volume 1, Issue 2 (18 2002)
Abstract

Introduction: In order to determine the relationship between serum lipid profile and diabetes mellitus as well as other cardiovascular risk factors, we carried out a cross-sectional study of 1255 oil industry workers at the Kharg Island oil terminal.
Methods: Increased levels of total cholesterol (TC≥200mg/dl), triglyceride (TG≥200mg/dl), and low-density lipoprotein (LDL≥130mg/dl) were seen in 32.7%, 39.5% and 18.5% of the workers, respectively. Decreased levels of high-density lipoprotein (HDL<40mg/dl) were seen in 13.1% of workers. 61.3% of the workers had a body mass index (BMI) ≥25kg/m2. Visceral obesity (waist circumference >100cm) was seen 32.4% of workers.
Results: There was a direct and significant relationship between TC levels and BMI (p<0.001), and between TG levels and BMI (p<0.0001). The same correlation existed between waist circumference and both TC (p<0.02) and TG (p<0.06). There was also a direct correlation between LDL levels and waist circumference (p<0.04). 10.6% of workers had some disorder of glucose metabolism. There was a direct correlation between diabetes and both TC and HDL levels (p<0.04 and p<0.05, respectively). 42.4% of workers smoked and 57.4% had a sedentary lifestyle. There was a trend toward lower blood glucose and cholesterol levels as the level of physical activity increased (p=0.1 and p=0.08, respectively). There was a significant difference between blue- and white-collar workers in the prevalence of excess weight, visceral obesity, diastolic hypertension, diabetes and cigarette smoking, but not serum lipid profile and level of physical activity.
Conclusion: The significant prevalence of dyslipidaemia and other cardiovascular risk factors in the oil workers of Kharg Island requires systematic preventive interventions to reduce cardiovascular mortality and morbidity in this population.
R Heshmat, H Fakhrzadeh, R Pour-Ebrahim, M Nouri, F Alaeddini,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Cardiovascular disorders are responsible of nearly fifty percent of deaths in industrial and developing countries. However numerous studies have revealed considerable differences in distribution of cardiovascular risk factors at the national, regional and ethnic levels. There is a necessity to elucidate the status of all recognized risk factors in any population to attribute these differences in the incidence of cardiovascular events to the changes in some risk factors or natural history of the disease in that society. The study of cardiovascular risk factors in the 17th zone of Tehran is performed according to the model of MONICA project of WHO. In this project the trend of cardiovascular events and their association with changes in risk factors is monitored in more than twenty countries and 35 centers. In this article we describe some aspects of the statistical design and sampling procedure of our aformentioned study such as sampling framework, sampling methods and its rationale, best size of clusters, sample size and sample selection in each cluster.
H Fakhrazadeh, R Pour-Ebrahim, M Nouri , R Heshmat, E Javadi, I Rahimi, B Larijani,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Introduction: Urbanization, establishment of sedentary life style and unhealthy diet in association with environmental stress has led the cardiovascular risk factors to prevail in the metropolitan city of Tehran. Survey of lifestyle related cardiovascular risk factors is one of the priorities of Tehran university population laboratory in the 17th zone of Tehran.
Methods:1573 inhabitants of 17th zone of Tehran were recruited by one stage cluster random sampling according to the model of WHO MONICA project.
Results: 58.6% of men and 64% of women had BMI ≥ 25 kg/m2. 41.7% of men and 37.6% of women had hypertension. 8.9% of men and 12.2% of women had diabetes. 34.4% of men and 44.6% of women had total cholesterol ≥ 200 mg/dl. 34.1% of men and 32.6% of women had triglyceride ≥ 200 mg/dl. 34.7% of men and 4.2% of women were regular smokers. 21% of participants had positive family history of cardiovascular disorders.
Conclusion: The prevalence of hypertension in this region is high, that of dyslipidemia relatively lower than the other studies performed in Iran. The prevalence of Diabetes and overweight /obesity is high and comparable to other Iranian studies. It seems that the population of this zone is at high risk for stroke and then coronary heart disease. This fact must be considered in the future interventional programs to control cardiovascular risk factors in the region.
H Fakhrzadeh, M Nouri, R Pour-Ebrahim, S Ghotbi, R Heshmat, Mh Bastanhagh,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Introduction: Hypertension is the most important modifiable cardiovascular risk factor. Hypertension is the leading global risk factor for mortality and as the third leading risk factor for cardiovascular disease burden. This survey has been conducted to determine the prevalence of hypertension among the inhabitants of 25-64 aged in 17th zone of Tehran, selected as Population Lab Region.
Methods: In a population-based cross-sectional survey conducted based on MONICA/WHO project, blood pressure measured with standard sphygmomanometer in sitting position after 10 minutes of resting in 1573 people. Blood samples collected in Venoject tubes for laboratory evaluation. Analysis was performed using the more conservative threshold of SBP ≥ 160 mm Hg and/or DBP≥ 95 mm Hg according to the criteria of the World Health Organization (WHO).
Results: A total of 1573 persons (615 men and 958 women) were evaluated. Hypertension prevalence (SBP≥160 or DBP≥95 or using antihypertensive drugs) was 29% in men and 34.8 in women. There was a significant correlation between systolic and diastolic blood pressure and BMI (p<0/0001). 58% of men and 55.8% of women with hypertension were obese (35>BMI>27).The mean of systolic and diastolic blood pressure had meaningful correlation with cholesterol, LDL, HDL, TG and homocysteine.
Conclusion: These results revealed that the prevalence of hypertension among this population was greater than supposed. The hypertension trend from 1992 is rising. Obesity is one of the most important associated risk factors of hypertension. High prevalence of other cardiovascular risk factors is a matter of concern to this population.
M Mobasseri, H Fakhrzadeh, R Pourebrahim, M Nouri, P Shoushtarizadeh, M Pajouhi,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Introduction: Hyperlipidemia is a major cardiovascular risk factor. This survey has been performed to determine the prevalence of hyperlipidemia in the 17th zone of Tehran.
Methods: 1573 individuals 25-64 aged were recruited from the inhabitants of the 17th zone of Tehran through one stage cluster sampling. Standard questionnaires were filled out for all of the participants. Lipid profile was categorized according to the NCEP:ATP III criteria.
Results: 59% had ideal cholesterol levels, 27.1% borderline and 13.9% had high cholesterol levels. Hypercholesterolemia was more prevalent in women than men. 55% had ideal LDL-cholesterol level. Prevalence of hyper-LDL (>160mg/dl) was 2.3%. Hyper LDL was more prevalent in women than men (p<0.001). Prevalence of hypo-HDL was 13.8% and it was more common in men than women (p<0.001). 33.4% had high triglyceride levels.
Conclusion: Prevalence of dyslipidemia in this area of Tehran is not as high as that obtained from other urban studies. This fact should be considered in the future interventional programs which focus on noncommunicable disease management.
R Heshmat, H Fakhrzadeh, R Pour-Ebrahim, M Nouri , M Pajouhi,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Background: Obesity and overweight, as the most common metabolic disorders, are great health problem during recent decades. Obesity takes a role as independent or concordant risk factor for many diseases. So, it has a considerable share in burden of morbidities and mortalities. Urbanization and its consequences in increasing of incomes and per capita energy uptake, besides the notable reduction in physical activities are the main causes of increased rates of obesity in developing countries. This survey has been conducted to evaluate the obesity and overweight status and their pattern among the inhabitants of 25-64 aged in 17th zone of Tehran, selected as Population Lab region.
Methods: This study is a part of the Cardiovascular Risk Factors Survey in the Population Lab region. This survey has been designed and conducted based on MONICA/WHO project. A total of 1573 people have been recruited and assessed on age, weight, height, waist and hip circumferences. Body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were determined for comparing between groups.
Results: There was a significant difference in mean BMI between two sexes (26.13 kg/m2 in men vs. 28.86 kg/m2 in women). As well, WC and WHR were diverse between men and women (WC: 91.70 cm vs. 89.15 cm WHR: 0.91 vs. 0.85, respectively). Obesity prevalence was 18.6% among men and 38.3% among women. Prevalence of high WC and abnormal WHR were higher among women than men.
Conclusion: These results revealed that prevalence of obesity among adults was very high. The prevalence in women was more than two times than in men. This finding may be in part because of little physical activity and high proportions of carbohydrates intake instead of protein in daily energy uptake and also because of physiological differences among women. Proper and effective planning to achieve applied strategies for improving the social knowledge and awareness and also improving the life style and nutrition status of the people is highly necessiated.
H Fakhrzadeh, P Ebrahim Pour, M Nouri, R Pourebrahim, R Heshmat, P Shoushtarizadeh, B Larijani,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Introduction: Metabolic syndrome includes obesity, hypertriglyceridemia, glucose intolerance, hypertension and lipid profile abnormalities. The risk of cardiovascular diseases with this syndrome is higher than every components alone. In view of its burden and high mortality rate, this syndrome should be noted.
Methods: The 25-64 aged individuals in 17th zone of Tehran were studied. It was designed according to the WHO MONICA (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) project using the ATP III criteria. The parameters have been used for the risk analysis were Waist Circumference (WC), fasting serum triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), blood pressure (BP) and fasting plasma glucose (FPG).
Results: The crude prevalence rate of the metabolic syndrome was 29.9% and the age-adjusted prevalence was 27.5%. The prevalence increased with age. The highest prevalence among different age-groups was seen in women aged 55-64 years. In the whole population, the most metabolic abnormalities were hypertriglyceridemia and hypertension that were present in more than half of the population. The people with metabolic syndrome had higher BMI than rest.
Conclusion:
Results demonstrate high metabolic syndrome rate among target population specially in women. In view. of correlation between metabolic syndrome and cardiovascular disease, it must be the priority of interventional preventive measures. Improving the diet, changing the lifestyle and increasing physical activity can be helpful.
Sh Jazayeri, M Nouri, R Pourebrahim, H Fakhrzadeh, B Larijani,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Introduction: Nutrition plays an important role in the protection and promotion of health. To plan and implement programs aiming at improving community nutritional status, a knowledge of the existing situation is essential. The aim of this cross-sectional study was to determine food and nutrient intakes of the inhabitants in Tehran University of Medical Sciences population laboratory.
Methods: In a sample of 310 women and 185 men, selected by clustered random sampling, food intake was determined using the 24-hour dietary recall (on two non-consecutive days). Weights and heights were also measured on the first visit. For analysis of data, Dorosti Food Processor, Diet Analysis plus and SPSS software were used.
Results: The average (mean ± SD) intakes of energy, protein, carbohydrate, total fat, saturated fat, cholesterol, vitamin A, B2 ,B6 ,B12, folic acid, zinc, iron, and calcium were 2902±336cal, 88±15gr, 461±69gr, 80±19gr, 27±7gr, 272±112mg, 943±319µgr RE, 1.2±.35mgr, 1.2± .37mg, 2.9±2.67µgr, 294±73.7µgr, 10.48± 2.25mg, 28.90±5.81mg, and 537±123mg in men, and 2226±234cal , 66±11gr, 344±41gr, 70±14gr, 22±6gr , 205±85mgr ,882±291µgr RE, .88±.22mg, 1.14± .24mg, 2.2±2.07µgr, 270±60.7µgr, 8.65±1.62mg, 22.66±4.27mg, and 433±113mg in women, respectively. The average (mean +SD) daily numbers of servings of the food guide pyramid main groups, namely, grains, fruits, vegetables, dairy, and meat were 12.74±3.80 ,1.52±1.44, 4.30±2.74, .97±.72 , and .9±.98 in men, and 9.8±3.3, 2.87±2.06, 2.88±2.40, .82±.60, and .86±.84 in women, respectively. Most of these intakes are under current recommendations. Thirty eight percent of the men and 23% of the women had a daily cholesterol intake of at least 300 mg. In addition, the proportions of the men and women with a daily total fat intake of at least 75 gram was 43% and 35%, respectively.
Conclusion: The findings show that while the intake of most micronutrients is lower than respective RDAs, the intake of fat and cholesterol are higher than the current recommendations. This indicates that the community is undergoing nutrition transition. It is recommended that further studies be conducted to identify more comprehensively nutritional problems of the community in question, so that appropriate programs can be prepared and implemented.
M Nouri, F Adili , R Pouebrahim, R Heshmat, H Fakhrzadeh,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Introduction: Cigarette smoking is a major modifiable risk factor for cardiovascular disease and it has been identified as the single most important cause of cardiovascular accident related deaths in most countries.
Methods: 1573 people who lives in 17th zone of Tehran (Population Research Center of Tehran University of Medical Sciences) were investigated by a cross- sectional study. A group of trained persons collected data by the standard questionnaire that contained demographic and smoking status characteristics. Furthermore the fasting blood samples were taken for more evaluation. Data were analyzed with SPSS software.
Results: According to this study 37/4% of men and 4/2% of women were smoker. There were relationship between cigarette smoking and serum level of homocysteine, Folic Acid, cholesterol, LDL, HDL, Uric Acid, hypertension and BMI (P<0/05). But it was no significant with vitamin B12 and TG statistically.
Conclusion: There were relationship between cigarette smoking and male gender, age, unmarried status and the level of education. So public education should be accomplished in society specially among families for prevention of cardiovascular risk factors.
H Fakhrzadeh, S Ghotbi, R Pour-Ebrahim, M Nouri, R Heshmat, A Shafaee, B Larijani,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Introduction: Elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin B12 and folate insufficiency. Folate and vitamin B12 have a protective effect on cardiovascular disease. This effect may be partly explained by mechanisms independent of homocysteine. This survey is the first population based study to evaluate the plasma total homocysteine, folic acid and vitamin B12 in 1214 healthy Iranian persons.
Methods: This study which was a part of the Cardiovascular Risk Factors Survey in the Population Lab region, has been designed and conducted based on MONICA/WHO project. A total of 1214 people have been recruited and assessed on serum homocysteine, folic acid and vitamin B12 with interview, questionnaires, examination and blood sampling. Blood samples were gathered in Venoject tubes and analyzed according to standard methods.
Results: The variables were assessed in 1214 participants include 428 men (35.3%) and 786 women (64.7%). Prevalence of hyperhomocysteinemia was 96.4% in men and 83.3% in women (p<0.0001). Geometric mean of serum homocysteine was 19.02 ± 1.46 µmol/l in men and 14.05± 1.45 µmol/l in women (p<0.004) and increased with age. Folic acid deficiency was seen in 527 (98.9% )men and 833 women (98.0%). 161 (30.1%)men and 232(27.2%) women had vitamin B12 deficiency.
Conclusion:
These results revealed that the prevalence of hyperhomocysteinemia, folic acid and vitamin B12 deficiency was higher than other communities considerably. Preventive interventions as food fortification with folic acid is necessary.
B Larijani, S Mortaz Hejri, R Pour-Ebrahim, M Nouri, R Heshmat, P Shooshtarizadeh , Mh Bastanhagh,
Volume 3, Issue 0 (Vol 5,Sup. 1, MONICA project 2004)
Abstract

Background: Diabetes is one of the most common chronic diseases worldwide. The number of diabetic patients in Iran is estimated 1.5 million. This survey has been conducted to evaluate diabetes and impaired fasting glucose status among 25-64 aged inhabitants of 17th zone of Tehran, selected as Population Lab region.
Methods: This study is a part of the Cardiovascular Risk Factors Survey in the Population Lab region. This survey has been designed and conducted based on MONICA/WHO project. A total of 1573 people have been recruited and assessed on age, weight, height, waist and hip circumferences. Body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were determined for comparing between groups. The known diabetic cases were found as history of taking antihyperglycemic agents or report of their family physician and new cases were diagnosed as FPG≥126mg/dl according to the ADA 2004criteria.IFG was determined by 100≤FPG≤126.Adjusted prevalences are calculated according to the 1375 census data.
Results: type 2 diabetes prevalence was 10.9% and the prevalence of IFG was 5% in this population. The age adjusted prevalences were 9.3% and 4.5% respectively. prevalences were higher in women than men in all age groups. people with diabetes had higher body mass index, waist, waist to hip ratio, mean systolic and diastolic blood pressure(p<0.05).9/8% of diabetic patients were unaware of their disease.
Conclusion: These results revealed that the prevalence of diabetes among women was higher than men. This finding may be in part because of little physical activity .Proper and effective planning to achieve the applied strategies for improving the social knowledge and awareness and also improving the life style of the people is highly necessiated.
Hosein Fakhrzadeh, Sara Ghotbi, Ramin Heshmat, Rasoul Pour-Ebrahim, Masoumeh Nouri, Alireza Shafaee, Bagher Larijani,
Volume 5, Issue 2 (18 2005)
Abstract

Background: Elevated total plasma Homocysteine, is an independent risk factor for cardiovascular disease. Folate and vitamin B12 have not only a protective effect on cardiovascular disease but also an essential effect on total Homocysteine concentrations (tHcy). This survey has been conducted to evaluate the determinants of tHcy in 1191 healthy Iranian adults.
Methods: This study which was a part of the Cardiovascular Risk Factors Survey in the Population Lab Region, has been designed and conducted based on MONICA/WHO project. A total of 1191 people have been recruited and assessed on serum Homocysteine, Folic acid and vitamin B12, triglycerides, cholesterol, HDL-C, LDL-C, FBS, BMI, BP and smoking, with interview, questionnaires, examination and blood sampling. Blood samples were analyzed according to standard methods.
Results: The variables were assessed in 1191 participants include 416 men (34.9%) and 775 women (65.1%). Prevalence of hyperhomocysteinemia was correlated significantly with male sex and aging. Hcy levels were inversely related to serum Folate and vitamin B12 concentrations. After further adjustments, we detected a positive correlation between tHcy and age, male sex, smoking and BMI, and a negative one with LDL-C and diabetes. Although there was a correlation between tHcy and blood pressure, after age, sex, BMI and smoking adjustment, it just remained significant in women and with systolic blood pressure.
Conclusion: We found that dietary and lifestyle parameters such as Folate intake and smoking habit are the main determinants of distribution of plasma Homocysteine in an apparently healthy population. We assumed that lifestyle changes could have considerable subsequences in public health. Our findings confirm the potential advantages of dietary improvements and increased intake of nutrients along with smoking cessation in order to prevent cardiovascular diseases in high-risk patients.
Fatemeh Adili, Hossein Fakhrzadeh, Masoumeh Nouri, Jalil Makarem, Bagher Larijani,
Volume 5, Issue 2 (18 2005)
Abstract

Background: Cardiovascular diseases are described as the most important health problems in developing countries which are developed in parallel with industrialization of communities. Based on the high morbidity and mortality of cardiovascular disease, this study was performed for examining the population lab inhabitants’ knowledge and practice.
Methods: In this cross – sectional study, 1576 inhabitants of the Population Lab Region were studied by cluster random sampling in 2002. 181 persons were selected from this population. The frequency of each cardio- vascular diseases risk factor such as hyperlipidemia, smoking, obesity, hypertension, Diabetes, family history of heart attack, being man, stress and excitement, sedentary life style, salty food, vegetables fruits, fatty food and red meat consumption, were assessed. In addition, the population study's practice regarding controlling the risk factors of cardiovascular diseases was determined, as well. Moreover, specific questionnaire and direct interview were used for collecting data and then the gathering data was analyzed by SPSS and EPI – Info soft wares.
Results: In this study, 71.8% of people were women while 28.2% of them were men. Besides, there was a significant relationship between the people’s knowledge about cardiovascular disease and the level of their education (P < 0.001). According to the results, 65.2% of population believed that heart attack was the most prevalent cause of death in comparison with 44% of them considered car accident and 13.3% agreed with cancers. On the other hand, 74% of people used liquid oil in their food and 77.9% of them knew the side effects of unhealthy foods such as salty food as one of the cardiovascular risk factors.
Conclusion: The inhabitants' knowledge regarding to the risk factors of cardiovascular diseases was approximately acceptable. However, there was a significant different between their knowledge and practice. Therefore, providing suitable educational programs for improving people’s nutrition, physical activity and the other relevant factors for preventing cardiovascular risk factors would be mentioned.
Parvin Mirmiran, Nazanin Nouri, Maryam Beheshti Zavareh, Fereidoun Azizi,
Volume 6, Issue 4 (17 2007)
Abstract

Background: Only limited data are available on the benefits of fruits and vegetable consumption on CVD risk factors. The aim of this study was to examine whether and to what extent intake of fruits and vegetables are inversely associated with cardiovascular (CVD) risk factors in adults.                                                           

Methods: In this population-based cross-sectional study a representative sample of 840 Tehranian adults (361 men and 479 women) aged 18-74 years were randomly selected in 1998. Usual dietary intake was assessed with the use of food frequency questionnaire. Portion sizes of consumed foods were converted from household measures to grams and analyzed by using Nutritionist III software designed for Iranian foods. Subjects were categorized based on category cut-points. : 0-1.9, 2-2.9, 3.0-3.9, and>=4 servings/d.

Results: In multivariate logistic regression after adjusting for confounders, dietary fruits and vegetable were found to be significantly and inversely associated with CVD risk factors. Adjusted odds ratio for high LDL concentrations were 1.00, 0.88, 0.81, 0.75(P for trend < 0.01) in first model which was adjusted for age, body mass index (BMI), energy intake, smoking status, dietary cholesterol, and prevalence of diabetes mellitus and coronary artery disease, a trend which was not appreciably altered by additional adjustment for education, physical activity, and saturated, polyunsaturated, total fat, Potassium and vitamin C intakes. This association was observed across categories of smoking status, physical activity, and tertiles of the Keys score.

Conclusion: Consumption of fruits and vegetables more than 4 servings a day is associated with lower concentrations of total cholesterol and LDL-C and with decrease in the risk of cardiovascular diseases.


Mohammad Reza Sharif, Saeed Nouri,
Volume 13, Issue 5 (7-2014)
Abstract

Background: Diabetes Mellitus (DM) is one the most common chronic disease, with many complications including renal failure, blindness and non traumatic amputation. Prevention of complications is possible through monitoring and control of blood glucose levels. Considering how easy home blood glucose monitoring is, we decided to evaluate the performance of two available glucometers for detection of blood glucose compared with standard laboratory methods. Methods: In this study, 369 patients with diabetes who admitted to the Shahid Beheshti hospital laboratory in 2013 selected by simple way. After fasting blood glucose testing at the laboratory by lancet devices for ONCALL and GLUCOCARD Glucometers, capillary blood was taken, and glucose measurements were performed by a special strips. Finally, we compared of capillary blood glucose levels of 369 patients as determined by test strips (Glucometers) with venous blood glucose levels measurements by the enzymatic method (the standard laboratory kit), and the results was evaluated by statistical tests such as the mean ± standard deviation, and Pearson correlation. Results: The mean blood glucose measurements reported using the Glucocard glucometer, the ONCALL glucometer and the standard laboratory method were 127.0±51.6mg/dl, 117.9±42.1 mg/dL and 118.09±51.9 mg/dL. Results obtained using the ONCALL Glucometer had no differences with the standard method levels)p=0.901(, but obtained results from GLUCOCARD Glucometers had differences with the standard method levels(p≤0.001). Conclusion: Diversity glucometer devices used in various parts of the country highlight the need for similar studies. We recommend use the ONCALL Glucometer with standard principles for glucose monitoring routine.
Mahdieh Molanouri Shamsi, Mehdi Mahdavi,
Volume 15, Issue 5 (7-2016)
Abstract

Background: Myokines released from skeletal muscle have multiple metabolic and hypertrophic effects. On the other hand, one of proposed pathways for effects of exercise training on metabolic diseases is calcineurin signaling pathway. With considering to relation between interleukin-6 (IL-6) and calcineurin, the purpose of this study was to investigate whether the resistance training has an effect on mRNA expression of IL-6 myokine and regulator of calcineurin 1(RCAN-1) in skeletal muscle of diabetic rats.

Methods: Thirty two Rats randomly were divided into the control, training, diabetic control and diabetic training groups. Diabetes induced by streptozotocin (STZ). Training groups performed the 17 sessions of resistance training. The IL-6 and RCAN-1 mRNA expression were measured in Soleus skeletal muscle using the Real-time PCR method. Two-way analysis variance was used for statistical analysis. Also, Statistical significance was set at p<0.05.

Results: The results of this study showed that the mRNA expression of RCAN-1 was increased with resistance training in skeletal muscle of training groups (P<0.05). Also, diabetes was decreased expression of RCAN-1 in skeletal muscle of diabetic groups (P<0.001). Moreover, resistance training was increased mRNA expression of IL-6 in skeletal muscle (P=0.08).

Conclusion: With considering to our results, resistance training with direct effects on skeletal muscle could regulate calcineurin pathway in diabetes and concurrent increase in expression of IL-6 myokine. It seems that activation of this signaling pathway with resistance training could maintain skeletal muscle mass in diabetes.


Mohammad Azimi Alamouti , Niloufar Shayan, Maryam Momeni, Masoumeh Nouri, Azam Koohkan, Ensiyeh Hajizadeh-Saffar, Fatemeh Soltanolizadeh, Maliheh Mahmoudi, Mahin Jamshidi Makiani, Marzieh Ebrahimi,
Volume 18, Issue 3 (3-2019)
Abstract

Background: For nearly 100 years, amniotic membranes have been used to treat various types of skin wounds. Amniotic extract is one of the derivatives of amniotic membrane that contains all the properties of amniotic membrane. The aim of this study was to evaluate the safety of the amniotic membrane extract in the treatment of diabetic ulcers.
Methods: This study was an Open labeled clinical trial without control group. A total of 10 patients with Wagner Grade 2 diabetic foot ulcers were selected in both sexes. The extract was used every 48 hours in the first week and every 72 hours from the second week until the end of the wound treatment. Patients were followed up weekly until wound healing.
Results: In this study 80% of patients were men and 20% were women with mean age (56.7 ± 8.7) years. The ulcer duration was 8.9 ± 2.12 weeks. The mean area of ulcers at the time of entry into the wound group ≥ 500 mm2, 977.5 ± 201.9 and in the wound group ≤500 mm2 was 145.6 ± 36.4. At 4 weeks post treatment, the wound healing rate in the wound group was ≤500mm2 ,98.9 ± 2.40 % and in the wound group ≥mm2 500 was 92.1 ± 7.23%. in sixth week of treatment, ulcers were complete closure  in both groups.
Conclusion: The results of this study suggest that the use of amniotic extract can be effective in the healing of diabetes foot ulcer without any side effects.
Ata Pourabassi, Zahra Kheiry, Sarah Nouriyengejeh, Solmaz-Sadat Naghavi Alhosseini, Farnaz Banakar,
Volume 18, Issue 3 (3-2019)
Abstract

Background: The main problem of modern humans is non-communicable diseases such as diabetes, cardiovascular disease, etc. Diabetes has the highest prevalence. It imposes many costs on society and the patient. Diabetics have special needs for a better life; hence, the researcher's aim is to accomplish them by defining researches and technology missions. Our purpose was to understand the real needs of a diabetic patient. Previous studies were evaluated to find out which one was effective.
Methods: In this research, 120 diabetic children's parents were requested to write a letter entitled "Hi Inventor" and describe any efficient inventions, which could make life easier for their children. Besides, research papers and patents from Iran over the past ten years have been evaluated in terms of their compliance with patients' needs.
Results: Parent's statements gathered in the form of 12 real needs. The main concern was the invasive method of blood glucose testing and they were asking for innovative method to measure blood glucose with less pain. Among published articles by Iranian researchers over the past ten years, 3% of the articles were in some way related to the actual needs of patients with diabetes. A total of 1017 patents from Iran was looked for, there were 3 diabetes-related patents.
Discussion: To sufficiently support the conducting research and identifying research priorities in the country, it is necessary to consider a balanced ratio between fundamental and applied research so that the patients' community can benefit from the early results of research as well.
 
Elaheh Saie, Fariba Mahmoudi, ٍezzat Nourizadeh, Farzaneh Mahmoudi,
Volume 21, Issue 4 (10-2021)
Abstract

Background: Hypoglycaemic effects of Galega officinalis and  silver nanoparticles are established. In the present study, the effects of silver nanoparticles synthetized by Galega officinalis extract were investigated on gene expression of TNF-α, IL-6 and serum levels of liver enzymes in diabetes type 2.
Methods: In the present study 20 male Wistar rats in 4 group(n= 5 in each group) weighing 180- 200 gr were used. Control or nikotinamid and stroptozotosin induced diabetic rats receieved intraperitoneal injection of saline or 2/5mg/Kg silver nanoparticles synthetized by Galega officinalis extract or chemichal method for 14 days respectively. One day after the last injections, serum samples and adipose tissue were collected. Mean serum concentration of glucose, urea, creatinine, alanine amino transferase(ALT), and aspartate amino transferase(AST) were determined by spectrophotometry. Mean relative gene expression of TNF-α and IL-6 were determined by method of real time PCR.
Results: Mean serum levels of ALT and AST enzymes, glucose, urea significantly decreased in diabetic rats receiving chemichal or green silver naoparticles compared to diabetic group. Mean relative gene expression of TNF-α and IL-6 significantly decreased in diabetic rats receiving chemichal or green silver naoparticles compared to diabetic ones.
Conclusion: Both chemical and green synthetized silver nanoparticles may prevent hepatocyes damages and they may improve insulin resistance in diabetes type 2 partly via decresing pro- inflammatory factors.

Page 1 from 1     

© 2024 , Tehran University of Medical Sciences, CC BY-NC 4.0

Designed & Developed by: Yektaweb