Showing 18 results for Parvin
Ahmad Esmaillzadeh, Parvin Mirmiran, Masoud Mirhosseini, Fereidoun Azizi,
Volume 3, Issue 2 (16 2004)
Abstract
Background: Although dietary guidelines recommend increased intake of grain products to prevent chronic diseases, epidemiologic data regarding whole-grain intake associated with metabolic syndrome is sparse. This study was undertaken to evaluate the relationship between whole-grain intake, metabolic syndrome and metabolic risk factors in Tehran adults population.
Methods: In this cross-sectional study, 827 subjects aged 18-74 were randomly selected from participants of the Tehran Lipid and Glucose Study. Usual dietary intake was assessed using a semi-quantitative food frequency questionnaire and two 24-hour dietary recalls. BMI, FBS, blood pressure, hypertriglyceridemia, hypercholesterolemia, high LDL, low LDL, metabolic syndrome (according to ATP III guidelines) and hypertension (based on JNC VI) were assessed subjects were categorized on quartile cut-points of whole and refined grain intake.
Results: Mean (±SD) consumptions of whole- and refined grains were 93±29 and 201±57 g/d, respectively. Compared with subjects in the lower quartile category, those in the upper category of whole-grain intake had lower prevalence of metabolic risks. Conversely, those in the higher category of refined grain intake had higher prevalence of metabolic risk factors, except for diabetes. After controlling for confounders, a significant decreasing trend was observed for the risk of having hypertriglyceridemia [odds ratios among quartiles: 1.00,0.89, 0.74, 0.61, respectively], hypertension and metabolic syndrome. Higher consumption of refined grains were associated with higher risk of having hypercholestrolemia [1.00, 1.07, 1.19, 1.23), hypertriglyceridemia [1.00, 1.17, 1.49, 2.01), hypertension and metabolic syndrome.
Conclusion: Whole grain intake is inversely and refined grain intake is positively associated with the risk of developing metabolic syndrome. Recommendations to increase whole-grain intake may reduce the risk of developing metabolic syndrome.
Hossein Salari, Bijan Farzami, Parvin Pasalar, Bagher Larijani,
Volume 5, Issue 1 (18 2005)
Abstract
Background: The determination of insulin receptors on RBC membrane is a suitable tool for the study of these receptors in diabetes and its related complications. The common methods for the study is the biopsy of fat or muscular tissues, cell culture or a preparation of certain amount of monocytes which is associated with some difficulties. Present study utilizes RBC's for this purpose.
Methods: Certain amount of RBCs were exposed to a known amount of labeled Insulin and varying concentration of unlabelled Insulin. The competitive effect of Insulin replacement was determined by the measurement of residual receptor radioactivity. This study was carried out in three groups of healthy, poor controlled and good controlled diabetics.
Results: There were significant differences between the normal and poor controlled diabetics (P=0.017). In addition differences in receptor binding was obtained between good controlled diabetics and normal which were not significant (P=0.09). All changes were inversely proportional to the HbA1C of specimen. Using Scat chard plots the number of receptors in each group, normal, poor controlled and good controlled were determined to be 1820 (± 72.8), 1026 (±40.4) and 1230 (± 49.2) respectively.
Conclusion: Considering the above results, it could be seen that the evaluation of the number of receptors in RBC could be a suitable tool for studying the state of insulin receptor in both physiological and pathological conditions.
Javad Heidari, Seyed Mohammad Akrami, Ramin Heshmat, Parvin Amiri, Hossein Fakhrzadeh, Mohammad Pajouhi,
Volume 5, Issue 3 (17 2006)
Abstract
Background: Uncoupling protein-2 (UCP2), one of the mitochondrial transporter memborane protiens, is suggested as a contributor gene for obesity. A common G/A polymorphism in the UCP2 promoter region is associated with obesity and diabetes.
Methods: As a cross-sectional study, 75 healthy 25-64 years volunteers were randomly selected from Tehran University of Medical Sciences population Lab. DNA was exracted from blood samples then polymorphism and A & G Allel frequencies were determined via PCR and RFLP. The correlation between genotype and such clinical and biochemical parameters as BMI, serum cholesterol and TG was investigated. Results were compared with other similar surveys.
Results: The frequencies of the UCP2 -866G/A genotypes in 75 Iranian normal population were AA: 7 (9.4%), GA: 41 (54.6%), and GG: 27 (36%).
Conclusion: Significantly higher HDL cholesterol was detected in people with GG allele (P=0.02) as compared with GA and AA alleles. 866 UCP2 G/A genotype frequencies in our study were significantly different as compared with Japanese population but no with European studies that may emphasize on genetical similarity between Iranian and European Caucasians populations.
Hassan Mirzaei, Taghi Golmohammadi, Seyed Mohammad Akrami, Mahmood Doosti, Manochehr Nakhjavani, Ramin Heshmat, Parvin Amiri,
Volume 6, Issue 1 (19 2006)
Abstract
Background: Peroxisome Proliferators- Activated Receptor-Gamma2 (PPAR- γ2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism and insulin sensitivity. The aim of this study was to evaluate the association of the Pro12Ala polymorphism at the PPAR- γ2 gene in Iranian population with obesity.
Methods: The genomic DNAs of the 156 subjects including obese and healthy isolated from EDTA whole blood. Pro12Ala polymorphism detected by Polymerase Chain Reaction – Restriction Fragment Length polymorphism (PCR-RFLP).
Results: In the obese group , one sample (1.3%) was as homozygote Ala/Ala genotype , 24 samples (30.8%) were Pro/Ala heterozygote and 53 samples (67.9%)as Pro/Pro genotype were identified . in the control group , one sample (1.3%) was as Ala/Ala genotype , 12 samples (15.4%) were Pro/Ala genotype and 65 samples (83.3%) were Pro/Pro genotype. allele frequencies of Ala in obese subjects (qAla=%16.7)were significantly different from those in control subjects (qAla=%8.9).
Conclusion: Our results revealed that Pro12Ala polymorphism in PPAR- γ2 gene associated with obesity in the Iranian population and presence Ala allele cause to significantly higher BMI and lower fasting blood sugar.
Nargol Ahmadi Mahmoodabadi, Hossein Madani, Parvin Mahzooni, Akbar Vahdati,
Volume 6, Issue 1 (19 2006)
Abstract
Background: Artichoke with the scientific name of Cynara scolymuse is a plant from compositae family. In this research, the effect of hydro alcoholic artichoke extract on serum glucose, lipids and lipoproteins and prevention of type 1 diabetes mellitus was investigated.
Methods: Twenty mature male Rats with mean weight of 200-250 gr in four groups were arranged. Rats in the control group, received physiological serum. The Second group (diabetic) received 120 mg/kgbw Alloxan monohydrate. The Third group (diabetic + Glibenclamide) received 0.5 mg/kgbw Glibenclamide in addition of the similar treatment with second group. The Fourth group (Alloxan monohydrate + Cynara scolymus), received 120 mg/kgbw Alloxan monohydrate with 300 mg/kgbw of Cynara scolymus simultaneously. Prescribing materials in all groups was done as interaperitoneal injection(IP). Fourty eight hours after last IP, blood sample was taken from each animal via cardiac puncture to measure blood factors.
Results: The results indicated significant reduction in glucose, cholesterol, triglyceride, VLDL and LDL levels in the treated group with extract and Alloxan monohydrate simultaneously as to compared diabetic group. Also, the result indicated significant increase in HDL level. Hydroalcoholic Artichoke extract could not reduce blood glucose level as compared with Glibenclamide, but had similar effects on other factors in comparison with Glibenclomide.
Conclusion: Artichoke contains antioxidants compounds, that plays a protective role on beta cells against Alloxan. The results of this research indicate that hydro alcoholic extract of Cynara scolymus could effectively prevent type 1 diabetes mellitus.
Mahsa Mohammad Amoli, Rohollah Mousavizadeh, Parvin Amiri, Bagher Larijani,
Volume 6, Issue 2 (18 2006)
Abstract
Background: Pancreatic islet transplantation has been reported as an appropriate method for treatment of type I diabetes patients, however there are strong indications that cytokine and chemokines secreted from transplanted islets play an important role in islet graft rejection in different stage post-transplantation. The NF-kB signaling pathway is activated in response to the stress resulted from isolation and purification process of pancreatic islets. Secretion and release of inflammatory mediators, including MCP-1, result from activation of this pathway which plays important part in activation of inflammatory processes accelerating graft rejection.
Methods: This study was performed to examine the effect of curcumin on secretion of inflammatory mediators and function of pancreatic islets.
Results: We observed that curcumin significantly decreased MCP-1 release from mouse islets compared to the control group and had no effect on function of pancreatic islets.
Conclusion: Investigating the stimulatory signals leading to production and secretion of inflammatory mediators from pancreatic islets and discovering their underlying mechanisms will be useful in finding new therapeutic interventions for blocking inflammatory pathways and improvement in outcome of islet cell transplantation.
Parvin Mirmiran, Ozra Ramezankhani, Homeira Hamayeli Mehrabani, Fereidoun Azizi,
Volume 6, Issue 2 (18 2006)
Abstract
Shirin Hasani Ranjbar, Javad Tavakkoly Bazzaz, Parvin Amiri, Mahsa M.amoli, Bagher Larijani,
Volume 6, Issue 3 (17 2007)
Abstract
Background: Single nucleotide polymorphisms of Adiponectin gene have been associated with BMI, insulin sensitivity and type 2 diabetes, reportedly. In present study we performed a genetic association study for Adiponectin gene at position +45*T/G in type 2 diabetes and normal subjects of Tehran population.
Methods: Diabetic patients were selected from diabetes clinic and normal healthy control subjects aged between 25-64 years selected from zone 17 of Tehran. Adiponectin gene polymorphism was analyzed using PCR-RFLP method in normal healthy controls (N=70), obese diabetic patients (N=80) and non-obese diabetic patients (N=72).
Results: Frequency of TT genotype was 62.5% in non-obese diabetic patients and 78% in control group, that was statistically significant (TT vs TG+GG: P=0.02, OR=2.2, CI:0.98-5.00). There was also a significant difference for allele T and G frequencies when we compared between non-obese diabetic patients and controls group. The frequency of allele G was increased in non-obese diabetic (20.1%) patients compared to controls (12%) (P: 0.04 OR: 1.8 CI: 0.9-3.7).
Conclusion: This study showed TG and GG alleles of Adiponectin gene polymorphism at position +45*T/G are risk factors for development of diabetes mellitus while this effect is independent from BMI and obesity.
Parvin Mirmiran, Nazanin Nouri, Maryam Beheshti Zavareh, Fereidoun Azizi,
Volume 6, Issue 4 (17 2007)
Abstract
Background: Only limited data are available on the benefits of fruits and vegetable consumption on CVD risk factors. The aim of this study was to examine whether and to what extent intake of fruits and vegetables are inversely associated with cardiovascular (CVD) risk factors in adults.
Methods: In this population-based cross-sectional study a representative sample of 840 Tehranian adults (361 men and 479 women) aged 18-74 years were randomly selected in 1998. Usual dietary intake was assessed with the use of food frequency questionnaire. Portion sizes of consumed foods were converted from household measures to grams and analyzed by using Nutritionist III software designed for Iranian foods. Subjects were categorized based on category cut-points. : 0-1.9, 2-2.9, 3.0-3.9, and>=4 servings/d.
Results: In multivariate logistic regression after adjusting for confounders, dietary fruits and vegetable were found to be significantly and inversely associated with CVD risk factors. Adjusted odds ratio for high LDL concentrations were 1.00, 0.88, 0.81, 0.75(P for trend < 0.01) in first model which was adjusted for age, body mass index (BMI), energy intake, smoking status, dietary cholesterol, and prevalence of diabetes mellitus and coronary artery disease, a trend which was not appreciably altered by additional adjustment for education, physical activity, and saturated, polyunsaturated, total fat, Potassium and vitamin C intakes. This association was observed across categories of smoking status, physical activity, and tertiles of the Keys score.
Conclusion: Consumption of fruits and vegetables more than 4 servings a day is associated with lower concentrations of total cholesterol and LDL-C and with decrease in the risk of cardiovascular diseases.
Zeinab Shayeghian, Parisa Amiri, Maria E. Aguilar-Vafaie, Mahmoud Parvin, Kobra Roohi Gillani,
Volume 13, Issue 2 (1-2014)
Abstract
Background: Cognitive and emotional deficits in alexithymia lead to various problems in somatic
disorders and other medical conditions for example Diabetics. The aim of this study was to examine
the effect of alexithymia on relationship between self-care and control of blood sugar in type 2
diabetes patients within the Iranian social and cultural context.
Methods: The present study was a cross-sectional investigation. The study sample consisted of 100
(60 females and 40 males, aged 40 to 70 years) type 2 diabetic outpatients visiting Labbafinejad
hospital during the year 2012. Measures for data collection included demographic, anthropometric
and clinical questionnaires, the short scale for diabetes self-care activities and the diabetes-related
quality of life. Blood tests were performed to obtain HbA1c levels and other laboratory measures
related to the study. Data were analyzed using SPSS16 software.
Results: Pearson product correlation results yielded significant negative associations between self-
care activities and alexithymia as well as HbA1c levels in type 2 diabetes patients. Results of
hierarchical regression analyses indicated that diabetes-related self-care activities explained 40% of
HbA1c variance and alexithymia added explanatory variance above and beyond self-care, to jointly
explain 58% of HbA1c variance.
Conclusion: Based on the present findings, diabetes-related self-care and alexithymia predicted
HbA1c levels in patients with type 2 diabetes. Given the evidence on the additive validity of
alexithymia in the prediction of HbA1c levels found in the present study, attention to emotional
competencies and disorders of Iranian diabetic patients may effectively contribute to their control of
diabetes.
Parvin Mirmiran, Zahra Bahadoran, Firoozeh Hosseini-Esfahani, Fereidoun Azizi,
Volume 13, Issue 2 (1-2014)
Abstract
Background: There are growing concern globally regarding fast food consumption and its
related cardiometabolic outcomes. In this study we investigated whether fast food
consumption could affect the occurrence of metabolic syndrome after 3-years of follow-up in
adults or not.
Methods: This longitudinal study was conducted in the framework of Tehran Lipid and
Glucose Study on 1476 adults, aged 19-70 years old. The usual intakes of participants were
measured using a validated semi-quantitative food frequency questionnaire at baseline.
Biochemical and anthropometric measurements were assessed at baseline (2006-2008) and 3
years later (2009-2011). Multiple logistic regression models were used to estimate the
incidence of the MetS in each quartile of fast food consumption.
Results: The mean age of participants was 37.8±12.3 years old, and the mean BMI was
26.0±4.5 kg/m2
at baseline. Participants in the highest quartile of fast food consumption were
significantly younger (33.7 vs. 43.4 years, P <0.01). Higher consumption of fast food was
accompanied with more increment in serum triglyceride levels after the 3-year follow-up
(10.6±2.3 vs. 4.4±2.3 percent in the fourth and first quartile, respectively, P<0.01). After
adjustment for all of the potential confounding variables, the risk of metabolic syndrome, in
the highest quartile of fast foods compared with the lowest, was 1.85 (95% CI= 1.17-2.95).
Conclusion: We demonstrated that higher consumption of fast foods had undesirable effects
on metabolic syndrome after 3-years of follow-up in Iranian adults.
Zeynab Amirhamidi, Hanieh-Sadat Ejtahed, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: Existing studies show that a poor diet has an effect on the progression of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to systematically summarize the results of studies on the relationship between dietary intakes and NAFLD. Methods: A review of Scopus, PubMed, Cochrane Library, Magiran, Medlib and SID databases and theses in the National Library of the Islamic Republic of Iran was conducted to identify epidemiological studies concerning NAFLD, food groups and dietary patterns. Cross-sectional, case-control and cohort studies with documented in English were selected for this systematic review. Duplication, topic, type of study, study population, variables examined and quality of data reporting of articles were evaluated. Results: Of 2128 articles found in the initial search, 33 were reviewed in full-text of these 6 articles were included in the systematic review. The literature review showed patients with NAFLD consumed more red meat, fats and sweets and less whole grains, fruits and vegetables. The Western dietary pattern was positively associated with the risk of NAFLD and adherence to the Mediterranean diet was negatively correlated to hepatic steatosis. Conclusion: The results of the systematic review indicate that different dietary intakes may be associated with development of NAFLD and its related factors. Due to limited research documented on this topic, further prospective studies are recommended.
Zeinab Shayeghian, Parisa Amiri, Maria E. Aguilar-Vafaie, Mohammad Ali Besharat, Mahmoud Parvin, Kobra Roohi Gilani,
Volume 14, Issue 4 (5-2015)
Abstract
Background: One of the important goals in control diabetes to maintain normal levels of glycated hemoglobin, but different social and psychological factors such as social support and alexithymia play role on process of this control. The purpose of present study was to examine the role of alexithymia on the association of social support and glycated hemoglobin in patients with type 2 diabetes. Methods: This was a cross-sectional study. The study sample consisted of 100 (60% females, 40-60 years) type 2 diabetic out-patients visiting the Labbafinejad hospital in 2013. The sample of the present study was a convenience sample. Measures of data collection included demographic and anthropometric questionnaires, Multidimensional Scale of Perceived Social Support, Toronto Alexithymia Scale and test of glycated hemoglobin. The collected data were analyzed, using multiple regression analysis. Results: Pearson's correlation coefficients showed a significant association between better reported perceived social support and lower alexithymia and glycated hemoglobin. Results of hierarchical linear regression analyses indicated that social support explained 23% and alexithymia 31% of glycated hemoglobin variance. As well as, alexithymia moderated association between perceived social support and glycated hemoglobin in patient with type 2 diabetes. Conclusion: Based on the present data, alexithymia has moderate role on the association between perceived social support and glycated hemoglobin in patient with type 2 diabetes. The results of this study highlight effective psychological factors in glycated hemoglobin which can help in the conceptualization, planning and design of treatment policies for control and treatment of type 2 diabetes.
Parvin Farzanegi, Farzaneh Shokrian,
Volume 15, Issue 1 (1-2016)
Abstract
Background: Type 2 diabetes is a chronic disease that leads to many complications such as atherosclerosis. Matrix Metalloproteinase (MMPs) family plays a key role in atherosclerosis and remodeling of the vessel wall. The aim of this study was determination the Effect of eight weeks aerobic exercise with Portulaca oleracea seeds consumption on MMP-1, MMP-3 and MIP-1α in women with type 2 diabetes.
Methods: In one Quasi-experimental study 28 women with type II diabetes (44 to 65 years old) selected and divided into 4 groups (Exercise, Supplement, Exercise-Supplement and Control groups) randomly. Exercise program included 8 weeks (3 sessions per week) with 50 to 70% of maximum heart rate. Supplemented groups received 7.5 g Portulaca oleracea seeds every day. Blood samples were collected before and after the 8 weeks with 12 hours fasting conditions. P < 0.05 considered statistically significant.
Results: Eight weeks of the aerobic training or portulacalo consumption cause a significant decrease in MMP-1، MMP-3 و MIP-1α levels, in comparison to pretest. However, the effectiveness of combination training and supplement is better in the above indicators. MMP-1 levels showed a significant difference between supplement, training, training- supplement group with control group (P = 0.001) and between supplement exercise group with training- supplement (Respectively P = 0.018, P =0.039). MMP-3 levels showed a significant difference between supplement with training- supplement (P = 0.007) and control group (P = 0.011), exercise group with training- supplement (P = 0.026) and control group (P = 0.04). MIP-1α levels showed a significant difference between training- supplement and control group (P = 0.001).
Conclusion: The results showed both intervention exercise and purslane may be support from due to the effects of antioxidant and anti-inflammatory from oxidative stress induced diabetes and combination therapy was associated with synergistic effects.
Nazanin Moslehi, Firoozeh Hosseini-Esfahani, Farhad Hosseinpanah, Parvin Mirmiran, Parvane Hojjat, Fereidoun Azizi,
Volume 15, Issue 2 (1-2016)
Abstract
Background: The aim of this study was to identify major dietary patterns in Iranian adults and their associations with the risk of type 2 diabetes (T2DM).
Methods: This nested case-control study was conducted among 698 women and men with a mean age of 43.6 ± 12.0 years in the Tehran Lipid and Glucose Study (TLGS). Among participants who were free of T2DM at baseline and developed T2DM during follow-up examinations, individuals with dietary intakes data were considered as cases. Each case was matched to three T2DM free controls on sex, age, and the date of blood drawing. Major dietary patterns were identified using principal component analysis and odds ratios of T2DM were estimated using conditional logistic regression.
Results: In this study, three major dietary patterns were identified. After adjusting for diabetes risk factors, 1-SD increase in score of the dietary pattern characterized by high intake of whole grain, legumes, egg, and red meat (traditional dietary pattern) was associated with reduced risk of T2DM (OR : 0.82; 95% CI: 0.67-0.99).
Conclusion: A whole grain and legumes based dietary pattern may be associated with reduced risk of T2DM in Iranian population.
Azar Tol, Bahram Mohebbi, Roya Sadeghi, Mehdi Yaseri, Malihe Akbari Abdolabadi, Fateme Dadrast, Parvin Abassi Borojeni,
Volume 16, Issue 1 (1-2017)
Abstract
Background: Improving self-care behaviors happened by self-efficacy which result in better quality of life. Current study aimed at assessing the perceived coping self-efficacy predictors among patients with type 2 diabetes referees to health centers affiliated to Tehran University of Medical Sciences.
Methods: In this cross sectional study which was descriptive and analytical one, perceived coping self-efficacy and its effective factors assessed among 536 type 2 diabetic patients referee to Tehran University of medical Sciences using random sampling based on 11-likert scale questionnaire. This questionnaire included 11 items in demographic variables and 24 items in perceived coping self-efficacy. Collected data analyzed by SPSS version 23 using MANCOVA.
Results: Study findings revealed that age (P=0.013), level of education (P<0.036), and HbA1c (P=0.004) had significant relation with total score of perceived coping self-efficacy. But, variables such as gender, occupation, disease duration, marital status, family history and history of chronic disease had no relation with scales of perceived coping self-efficacy.
Conclusion: Planning theory based intervention programs to improve coping self-efficacy among diabetic patients in low socioeconomic status population and poor diabetes control is recommended.
Majid Jahani, Hasan Matinhomaie, Parvin Farzanegi,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Physical activity plays a major role in the prevention of cardiovascular disease and diabetes, but the effect of intense activity on endoplasmic reticulum proteins and apoptosis and necroptosis in diabetic conditions is unclear. The aim of the present study was to investigate the changes of PERK and CHOP proteins in endoplasmic reticulum of cardiac myocytes of diabetic Wistar rats following continuous and interval exercise.
Methods: For this purpose, 32 male white wistar were purchased and were randomly divided into 4 groups of hemogenus 8 rats in each group: Healthy control (C), Diabetic control (D), Diabetic with moderate-intensity continuous training intensity at the 55min on 26 m/min speed (D+MICT) and Diabetic with high-intensity interval training intensity at the 85-90% of maximum speed (D+HIIT); 5 days/week for 8 weeks. For evaluate changes in the expression of the proteins associated with apoptosis and necroptotic death in the diabetic heart muscle myocardium, based on Western blot analysis will be used. Also, the one-way analysis of variance (ANOVA) is used to determine differences between the study groups.
Results: The results showed that induction of type 2 diabetes increased apoptotic and necroptosis cell death (P≥0.05). Therefore, both continuous and intermittent aerobic exercise modulate apoptotic cell death. And both intermittent and continuous exercise had a significant effect on cell necroptosis death.
Conclusion: It seems that different levels of aerobic exercise have different effects on cardiac myocytes cell death in diabetic rats. But more research is needed to confirm the death of diabetic necroptics.
Afshin Khaman Hatami, Kamal Azizbeigi, Zaher Etemad, Parvin Farzanegi,
Volume 25, Issue 5 (12-2025)
Abstract
Background: Aging is associated with Sarcopenia as well as oxidative stress (OS) caused by Ferroptosis. The aim of the present study was to investigate the effect of aerobic exercise training (AT) on OS caused by ferroptosis in sarcopenia model mice.
Methods: Twenty-one C57BL/6 mice (16-24 wks. age) sarcopenia model with an average weight (25-35 g), and 21 healthy mice (6-7 weeks age) were randomly assigned to the following (1) healthy-young control (HYC; n= 7), (2) aerobic training-young (ATY; n= 7), (3) healthy-old control (HOC; n= 7), (4) old control-sarcopenia model (OCS; n= 7), (5) aerobic training-healthy-old (ATHO; n= 7), (6) healthy-old sarcopenia model (HOS= 7). The intervention group underwent AT for eight weeks, five sessions per week at an intensity of 60-80% of aerobic capacity (VO2max). The expression of the glutathione peroxidase (GPX-4) and superoxide dismutase (SOD) genes was measured using Real Time PCR. The Malondialdehyde (MDA) and Fe²⁺concentration in the gastrocnemius muscle was also measured.
Results: It was observed that the enzymes gene expression of SOD and GPX-4 in the (OSC) was significantly decreased compared to the (HOC) (P= 0.001, P= 0.002, respectively), and the MDA and Fe²⁺ was significantly increased (P= 0.001; P= 0.002, respectively). Also, the of SOD and GPX-4 gene expression of enzymes in the ATY, ATHO was significantly increased compared to the HYC, and HOS (P= 0.001; P= 0.002, respectively), and the concentration of MDA and Fe²⁺ was significantly decreased (P= 0.001; P= 0.002, respectively).
Conclusion: Finally, it can be said that aerobic training reduces oxidative stress caused by ferroptosis in Sarcopenia by increasing the enzymes GPX and SOD gene expression and reducing the concentration of MDA and Fe²⁺.
