Maryam Delfan, Malihe Rabiee, Raheleh Amadeh Juybari,
Volume 20, Issue 3 (2-2021)
Abstract
Background: Imbalance of apoptotic factors plays important role in pathogenesis of diabetes. Considering the role of curcumin supplementation and high-intensity interval training (HIIT) on these factors, the aim of this study was to investigate effects of four weeks of HIIT with curcumin supplementation on Bax and Bcl-2 gene expression in the soleus muscle of diabetic rats.
Methods: Present study was experimental research. 30 male Wistar rats were divided into one normal control (NC), and four diabetic groups: control (DC), supplement (SDC), high-intensity interval training (DHIIT) and high-intensity interval training supplement (SDHIIT). The training protocol was performed five days a week for four weeks, which included five to seven two-minute intervals at 80 to 90% of maximum power until exhaustion and one-minute recovery at 30% of maximum power until exhaustion. At the same time, Curcumin gavage at a dose of 100 mg/kg was performed daily. Bax and BCL-2 gene expression levels were measured by the qReal-TimePCR method and data were analyzed by two-way analysis of variance at a significant level of p≥0.05.
Results: Bcl-2 gene expression was significantly increased in DHIIT and SDHIIT groups compared to DC (P= 0.000). Also, a significant decrease in Bax gene expression was observed in DHIIT and SDHIIT groups compared to DC (P=0.000). There was a significant difference between DHIIT and SDHIIT in Bcl-2 (P=0.000) and Bax (P=0.013) gene expression.
Conclusion: It seems that HIIT in combination with curcumin supplementation, is more effective in improving the balance between apoptosis factors than any of these interventions alone.
Mahtab Rabiee, Mohammad Ali Mazaheri,
Volume 25, Issue 5 (12-2025)
Abstract
Background: In recent years, the prevalence of diabetes has increased significantly. Parents of children with diabetes suffer from many physical and psychological problems; Therefore, various interventions have been designed to improve their quality of life and well-being. These interventions have benefited from a wide range of approaches and methodologies. The present study was conducted with the aim of identifying and reviewing various psychological interventions for parents of children under 6 years old with diabetes and examining their strengths and weaknesses.
Methods: The search for interventional protocols was done through various databases such as Google Scholar, PubMed, Science Direct and Scopus. after checking the data entry criteria, 11 articles were selected and studied.
Results: The interventions used different approaches such as cognitive-behavioral, social learning, family therapy, and positive parenting. The intervention methods were mostly remote and had different consequences for the parent and the child, which has been highlighted. Also, the sample size in these studies was between 30 and 200 parents, and the satisfaction level of the main interventions was reported to be high.
Conclusion: In general, limited interventions have been conducted. Given that interventions focusing on the psychological state of parents can lead to increased social support and improved mental health in parents and children with diabetes, it is hoped that this article will pave the way for examining different approaches.
