Showing 7 results for Rahmati
Azam Karami Paskohani, Masoud Rahmati , Abdolreza Kazemi ,
Volume 14, Issue 3 (3-2015)
Abstract
Background: Diabetic neuropathy leads to skeletal muscle atrophy however atrophy signaling mechanisms are not well documented. The aim of the present study was to investigate Sunday Driver (Syd) gene expression in soleus muscle of Wistar male rats with diabetic neuropathy. Methods: Twelve male Wistar rats were randomly assigned in 3 groups: diabetic trained, diabetic untrained and healthy control. Two weeks after STZ injection (45 mg/Kg), diabetic neuropathy was demonstrated with mechanical allodynia and thermal hyperalgesia tests and after which moderate endurance training protocol was performed for 6 weeks. 48 hours after final training session, the rats were dissected and soleus muscle tissues were removed. Also Sydgene expression was measured with Real time- PCR methods. Results: Soleus muscle weight was decreased in diabetic groups (P=0.001), but compared with diabetic untrained group, was higher in diabetic trained group (P=0.001). Sydgene expression in diabetic untrained group was higher than healthy control group (P=0.001). Also, compared with diabetic untrained group, training significantly decreased Sydgene expression and blood glucose levels in diabetic trained group. (P=0.001 and P=0.0001, respectively). Conclusion: In soleus muscle of diabetic rats, Sydm RNAup-regulation is involved in development of muscle atrophy and training as a non-pharmacotherapy strategy can modulate and get it close to normal levels. So, it is suggested that Syd should be noted as a novel treatment in diabetes disease.
Masoud Rahmati, Abdolreza Kazemi, Naimeh Nekoie , Hadi Kerendi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: The possibility that childhood obesity is a chronic disease in adulthood becomes enormous. The incidence and spread of obesity has increased substantially over the past two decades. The importance of personal health and quality of life has prompted researchers to study in this field. The aim of this study was to investigate the changes of serum levels of leptin, insulin, lipid profile, and body mass index after a period of sprint interval training in obese children. Methods: In this study, 30 obese children aged 9 to 11 years were randomly targeted placed in two groups (Training and control group). Sprint interval training was conducted for 8 weeks. Before and after training, measurements of leptin, insulin, lipid profile, and body mass index were measured. Data were analyzed using independent t-test (p<0.05). Results: Data analysis showed that after training, leptin, insulin and cholesterol levels were significantly reduced (p=0.001). Also, a significant decrease in BMI was seen (p=0.01). Conclusion: Sprint interval training on leptin, insulin and cholesterol in obese children has a significant impact and this exercise improve body mass index in these individuals.
Masoud Rahmati, Abdolreza Kazemi, Mohammad Hosein Archangi, S.jalal Taherabadi,
Volume 14, Issue 6 (9-2015)
Abstract
Background: Neuropathic pain is associated with a profound impact on quality of life and daily activity in patients and caused high medical costs. Because of the nerves destructive nature in this disease, the neurotrophins are high regarded for their possible effects on survival, growth and development and neuronal functions as a possible therapeutic strategy. So the aim of this study is investigation of the chronic effects of decreased activity in neuropathic pain form on the NFG gene expression in the sciatic nerve of Spinal nerve ligated rats.
Methods: Ten adult male Wistar rats in the weight range of 250±30 gr randomly were divided into two groups including healthy control (C), ligation sciatic nerve ligation. Over the six weeks neuropathic pain behavior tests were conducted continually in groups. In the end change of NGF gene expression in sciatic nerve was measured with Real time PCR technique and calculated using the 2-&Delta&DeltaCT method.
Results: After 6 weeks, neuropathic pain behavior tests showed that pain threshold of thermal hyperalgesia and mechanical allodynia in the SNL group was significantly lower than the control group (P&le0.05). In addition, NGF gene expression in sciatic nerve ligation group compared to controls increased significantly (P&le0.05).
Conclusion: The findings of this study suggest that the development of neuropathic pain and decreased physical activity is associated with increased endogenous NGF. Although it is not clear that increase in NGF expression is due to the nature of neuropathic pain or nerve damage, it is clear that excessive expression of NGF is associated with neuropathic pain.
Faranak Sadeghipour, Reza Gharakhanlou, Mansoureh Movahedin, Masoud Rahmati,
Volume 15, Issue 1 (1-2016)
Abstract
Background: Glycogen synthase kinase 3 beta is a key regulator of many signaling pathways. It is reported that Inhibition of this kinase results neuronal survival. Accordingly in this study we investigated the effect of endurance training on the gene expression of GSK-3β in the sensory areas of the spinal cord of male Wistar rats with diabetic neuropathy.
Methods: we randomly assigned 16 male Wistar rats into four groups: healthy control, healthy trained, neuropathy control, neuropathy trained. Intraperitoneal injection of a STZ (streptozotocin) solution (45 mg/kg) was used to induce diabetes. At two weeks after STZ injections, the mechanical allodynia and thermal hyperalgesia tests demonstrated the presence of diabetic neuropathy. A moderate endurance training protocol was performed for a six- week period. At 24 hours after the final training session, the rats were sacrificed and the L4-L6 sensory neurons of the spinal cord tissue were removed. GSK-3β mRNA expression was performed using real time-PCR.
Results: Statistical analysis shows that neuropathy trained experiences a decrease in gene expression in comparison to neuropathy control (P=0.02). On the other there was significant difference between healthy control and neuropathy control (P=0.02). However, there was no significant difference between healthy control and neuropathy trained.
Conclusion: we claim that endurance training will effectively decrease the expression of GSK-3β in the sensory areas of spinal cord of male Wistar rats with diabetic neuropathy. Endurance training as a non- pharmacotherapy strategy can modulate and return GSK-3β to approximate normal levels.
Masoud Rahmati , Zohreh Ahmadi , Rahim Mirnasoori , Mohammad Fathi ,
Volume 15, Issue 3 (2-2016)
Abstract
Background: In the last few years several polymorphisms variants with significant association to power and sprint performance of elite athletes have been verified. Meantime, the IL-6 gene was introduced as a proper candidate to imply a person alteration into an elite athlete. Therefore, the goal of the present study is to examine the association between IL6 gene polymorphism and power sport using meta-analysis to gather further evidence compared to individual reports.
Methods: Science direct, Google Scholar and Pub Med databases have been searched until March 2015. Articles were studied based on key word IL6 accompanied with polymorphism, mutation, variant and power sport were studied. Statistical software STATA was used to analyze the data.
Results: Ten articles included into the final meta-analysis and Systematic review. The survey of the obtained data from the articles revealed that 292 persons were as an entire group of athletes and 559 people were as a control group. For the allele G vs. C 1.43odds ratio (95% confidence interval: 1.03 -1.99), for the allele GG vs. GC 1.74odds ratio (95% confidence interval: 1.28- 2.36), for the allele GG vs. GC + CC 1.71 odds ratio (95% confidence interval: 1.24 -2.36) and GG + GC vs. CC allele model 0.96 odds (95% confidence interval: 0.77-1.20) was revealed. The relationship between the polymorphism 1800795GG genotype and exercise can be statistically significant (P<0.05).
Conclusion: Generally, the result of the present study indicates that the IL6-174 G/C polymorphism is associated with better performance of elite athletes in power sports. The findings suggest that the genetic profiles might influence human physical performance. Therefore, it is recommended that researcher use IL6-174G/C polymorphism as one of the selected factor for Sports talent.
Nasim Azari, Masoud Rahmati, Mohammad Fathi,
Volume 17, Issue 2 (3-2018)
Abstract
Background: There are many research have been done so far about the effect of exercise training on diabetic type 2 related risk factors. But in this regard there is no study performed in Iran. So, the aim of the present study was to investigate the effect of endurance exercise training on some diabetic type 2 dependent variables in the form of systematic review and meta-analysis of studies that were performed in Iran.
Methods: In this research PubMed, Embase, Cochran, Scopus, ISI, Google Scholar, Science direct, Sid and Magiran databases were searched for Persian sources. Data analysis were done using STATA software version 12.0.
Results: Generally, 242 articles were founded in primary search, which 24 articles were included in this research. Finally research were evaluated 592 Iranian's peoples which 294 peoples as a control group (96 male and 198 women) and 298 peoples as a training group (97 male and 201 women).The results indicate that there were significant association between endurance exercise and blood glucose levels (P=0.0001,-1.016,-0.656;95%CI), insulin (P=0.0001,-1.042,-0.682;95%CI), insulin resistance (P=0.0001;-0.563,-0.217;95%CI).
Conclusion: Generally, this systematic review and meta-analysis study was demonstrated endurance exercise could be related with decrease diabetes type 2 related risk factors. So, it is recommended that sport and medicine experts use endurance exercise as a non- pharmacological intervention for treatment of diabetes type 2 patients.
Fatemeh Nikseresht, Mostafa Bahrami, Masoud Rahmati,
Volume 21, Issue 5 (1-2022)
Abstract
Background: The objective of this experimental study was to determine the effect of 6 weeks of high intensity interval training (HIIT) on G6Pase expression in liver tissue, serum insulin and glucose and insulin resistance in obese rats with type 2 diabetic and compared with non-diabetic obese group.
Methods: 28 male Wistar rats aged 10 weeks (220 ± 10 g) were obesed by 6 weeks of high-fat diet (HFD). Then type 2 diabetes induced in 14 rats by intraperitoneal injection of STZ (30 mg/kg). Finally, the studied rats were divided into 4 same groups: 1) control obese, 2) interval obese, 3) control diabetic, 4) interval diabetic. Interval groups participated in an interval exercise program of 5 sessions per week for 6 weeks consists of 10 repetitions of a 40-second run on the treadmill with 2-minute rest (active rest) between repetitions. 48 hours after the lasting session, fasting levels of glucose, serum insulin and G6Pase expression in liver tissue in all 4 groups were measured and compared with 2 way ANOVA.
Results: Compared with diabetic control groups, HIIT in diabetic group resulted in significant decrease fasting glucose (p= 0.001). HIIT also led to an increase in serum insulin (p= 0.006) without change in G6Pase expression (p= 0.102) compared to the diabetic control group.
Conclusion: Improved glucose response to interval training in type 2 diabetic rats may be rooted in increase insulin without changes in hepatic G6Pase expression. Measurement of activity or expression of other liver enzymes is suggested for general conclusion.
