Showing 3 results for Rouhollah
Somaye Karimi Moghadam, Elaheh Lael- Monfared, Rouhollah Barghbani, Mohammad Reza Ghezekgharshi, Rezvan Rajabzadeh, Davood Robat Sarpooshi,
Volume 16, Issue 6 (10-2017)
Abstract
Background: Considering the importance of chronic diabetes and significant impact on patients' quality of life, A study to evaluate health-related quality of life in type II diabetic patients referred to diabetes clinic in Sabzevar And factors associated with planning and designing health promotion interventions in the areas studied
Methods: This cross-sectional study in which 197 patients with type II diabetes referred to diabetes clinic participated. Of data through a two-part questionnaire that included demographic characteristics, social and Quality of Life Questionnaire, which has a five physical, psychological, social, economic and disease and treatment, collected and then using SPSS version 16 and using Chi-square tests, ANOVA, t-test and Spearman correlation coefficient were analyzed.
Results: The findings of the study suggests that most participants in the study were in the age group aged 50 to 60, 77.2% female, 85.8% were married, 74.6 percent were housewives. Average quality of life in terms of physical functioning, role limitations due to emotional problems and emotional health and physical pain was good. There was a significant difference between the score of physical function, feeling well and pain according to education (P≤ 0/05).
Conclusion: The findings of this study have informed us about the impact of diabetes on the quality of life of patients with this disease, which can be used to plan the care of chronic patients and improve their quality of life.
Mahdi Maghami, Saeed Keshavarz, Rouhollah Haghshenas, Elham Eftekhari,
Volume 21, Issue 4 (10-2021)
Abstract
Background: Diabetes is one of the most common chronic diseases in today's society. The aim of this study was to investigate the effect of endurance training and nettle consumption on the protein and gene expression of AKT, GLUT4 and insulin in male of muscle soleus of diabetic rats.
Methods: After adaptation to the environment, 40 male Wistar rats were divided into 5 groups: control (C), diabetes (D), nettle+diabetes (UD), exercise+diabetes (ED) and exercise+nettle+diabetes (EUD). After developing and confirming the diabetes model by injection of STZ, rats in the exercise groups performed an endurance training protocol for eight weeks and rats in the nettle groups consumed nettle extract 5 days a week. After completion of the protocol and extraction of soleus muscle, RT-PCR method was used to measure gene expression, Western blot and immunohistochemically method was used to measure protein expression of glut-4 and AKT respectively and ELIZA method was used to measure glucose and insulin.
Results: The results showed that the protein and genes expression of GLUT4 and AKT in the diabetic group compared to the control group was significantly reduced (P<0.001) while the expression of these two variables was significantly increased in the ED and EUD groups (P<0.001) that this increase was greater in the EUD group. The effect of nettle alone on the expression of these two variables was not significant. Glucose, insulin and insulin resistance increased significantly in the diabetes group, while these decreased significantly in the ED and EUD groups (P<0.001).
Conclusion: The synergist of the combination of nettle and exercise significantly improves the improve of diabetes, while each alone has little effect on diabetes-related variables.
Negar Sarhangi, Mandana Hasanzad, Fatemeh Rouhollah, Shekoufeh Nikfar, Farshad Sharifi, Negar Niknam,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Pharmacogenomics (PGx), as a growing field of personalized medicine, aims to optimize the efficacy and safety of medications by studying the association between germline genetic variations and drug responses. The present cross-sectional study aims to evaluate the allele frequency of the NUDT15 genetic variant in the Iranian population to provide insights into personalized treatment decisions in the Iranian population.
Methods: A representative sample set of 1142 unrelated healthy Iranian individuals aged 18 and older genotyped using the Infinium Global Screening Array-24 BeadChip.
Results: We identified a pharmacogenetic variant with minor allele frequency (MAF) ≥1% among the present studied population which may explain the substantial variability in drug response phenotypes among different populations
Conclusion: The results of our study revealed significant genetic variation among Iranian populations that could significantly influence clinical decision-making. This study shows the frequency pattern of the effective variant of NUDT15 in determining the phenotype in Iranian population.
