Showing 3 results for Saadat
Behzad Shamsi, Mahin Hashemipour, Sayed Hossein Saadat, Sayed Mohammad Hasan Emami, Zahra Abdyazdan, Akbar Hasanzadeh, Khosrow Khaibi, Sasan Haghighi, Silva Hovsepian,
Volume 3, Issue 1 (16 2004)
Abstract
Increased prevalence of Helicobacter Pylori (HP) infection is a common feature in diabetics, which is attributable to the presence of diverse predisposing factors. In this study, the prevalence of HP infection has been investigated in type 1 diabetic children.
Methods: In a cross-sectional study, anti-HP antibody (IgG) was measured in 75 type 1 diabetics (aged 2-18 years) and the results were compared with 75 healthy children who were matched for age, sex and socio-economic status. In seropositive diabetic patients with gastrointestinal (GI) symptoms, gastroduodenoscopy was performed to establish the diagnosis.
Results: Sera were positive for anti-HP in 22.7% of diabetics versus 17.3% in controls (P>0.05). No significant difference was observable between seropositive and seronegative diabetic groups as regard to age, sex, age at onset of diabetes, number of outpatient visits during the last 6 months, HbAlc and insulin requirements. Gastrointestinal symptoms were more common in diabetics than the healthy controls the prevalence of these symptoms, however, did not differ significantly between seropositive and seronegative diabetics.
Conclusion: The study indicated that type 1 diabetes is not associated with increased risk of HP infection. Further studies are required to investigate the impact of HP infection treatment on the glycemic control in diabetic children.
Gholam Hossein Ranjbar Omrani, Omid Bazargan Lari, Ali Reza Mehdizadeh, Najaf Zare, Nika Saadat,
Volume 4, Issue 2 (17 2004)
Abstract
Background: Diabetes mellitus is the most common cause of renal failure, blindness, non- traumatic amputation and neuropathy. Homocysteine, a sulfurated amino acid, has a close correlation with Methionine and Cysteine. The conversion of Methionine to Homocysteine and Cysteine is required coenzymes like vitamin B6, B12 and Folate. The effect of Metformin on serum Homocysteine level by decreasing vitamin B12 level in patients with type 2 diabetes mellitus was described previously. Methods: This is a prospective clinical trail study among patients with type 2 diabetes mellitus in Shiraz. 76 patients were divided into two groups (38 patients in each group). First group treated with Metformin 500-2000 mg/day and the second group treated with Glibenclamide 5-20 mg/day with follow up period of at least 6 months. Hb and MCV were used in follow up to detect megaloblastic anemia, indicator of B12 and folate deficiency. Fasting plasma Homocysteine level Hb A1C and blood sugar were measured in baseline and at 3 and 6 months follow up periods.
Results: There was no significant difference between age, sex, weight, height and BMI and baseline serum profile between the two groups. Homocysteine level increased significantly in Metformin group at 3 and 6 months(P=0.003 and 0.001 respectively). Mean plasma homocysteine level after 6 months were 10.98±0.58 μmol/l in Metformin and 10.0± 0.88 μmol/l in Glibenclamide group, with significant difference between the two groups (P=0.001).
Conclusion: Metformin increases the plasma Homocysteine level. Metformin will accumulate highly in gastrointestinal wall and cause malabsorption of vitamin B12, therefore we can conclude that the use of Metformin for 6 months can cause vitamin B12 malabsorption and increase in plasma homocysteine level. Increase in plasma homocysteine level was 7.54% in our study that is higher in comparing to the other studies. It can be explained by longer duration of Metformin therapy in our study. Rising in Homocysteine levels may have detrimental effect on vessels that need further study.
Saadat Karimi- Hasanabad, Maryam Rafraf, Mohammad Asghari-Jafarabadi,
Volume 14, Issue 1 (1-2015)
Abstract
Background: Vitamin D deficiency is an unrecognized epidemic and a common health problem worldwide. The objective of our study was to determine the prevalence of vitamin D deficiency and its relationship with overall and abdominal obesity in adolescent girls.
Methods: This cross-sectional, descriptive study was conducted on girls aged 14-17 years whom were selected by multistage random sampling from four districts of Boukan. Questionnaires about general characteristics, dietary intake and physical activity were completed by interviewing with the subjects. Anthropometric measurements were performed. Fasting blood samples were collected for determining of serum of 25 (OH) D levels. Data was analyzed by using SPSS software and descriptive statistics tests and partial correlation test.
Results: The Mean of serum 25(OH) D was 7.26 (SD 2.81) ng/ml and 100% of subjects had vitamin D insufficiency. According to CDC (Centers for Disease Control and Prevention) criteria the prevalence of overweight, obesity and abdominal obesity were 18.5%, 1.4% and 26.4% respectively. There were significant reverse correlation between serum 25(OH) D and WC (r= -0.112, p=0.047).
Conclusion: The Results of this study indicate that vitamin D deficiency is a major health problem among studied adolescents. Given the reverse association between vitamin D status and abdominal obesity appropriate approaches are needed to improve vitamin D status and lowering the prevalence of obesity among adolescents. Such conditions may prevent prevalence of chronic disease in adolescents' lives over the coming years.
