Showing 2 results for Saremi
Behzad Azadbakht, Abbas Saremi, Mojtaba Khansooz,
Volume 23, Issue 2 (5-2023)
Abstract
Background: The effects of exercise on kidney tissue in withdrawal syndrome are unclear. In this study, the effect of 8 weeks of endurance training on the protein levels of cytochrome C, caspase 8 and caspase 3 in the kidney tissue of diabetic and diabetic rats with withdrawal syndrome was investigated.
Methods: 32 male Wistar rats were used in this experimental study. After the induction of diabetes, the rats were randomly divided into 4 groups of 8. Including: diabetes control (D), morphine diabetes (D.M), diabetes + endurance training (D.ET), morphine diabetes+endurance training (D.M.ET). Then, in addicted groups, the oral method was used for morphine dependence. The training groups performed 8 weeks of endurance training protocol. At the end of the study, all rats were anesthetized, dissected and their kidneys were separated and kept at -70 degrees for further investigations. Protein levels of the indicators of this study were measured by ELISA kits. Data were analyzed using one-way ANOVA and Tukey's post hoc test at a significance level of P≤0.05.
Results: The results of this study showed a significant decrease in caspase 3 protein levels in D.ET (P=0.000), D.M.ET (P=0.000) and cytochrome C levels in D.ET (P=0.000), D.M.ET (P=0.000) groups in Comparison with group D. Also, caspase 8 protein levels in D.M.ET group (P=0.015) compared to D group and D.M.ET group (P=0.038) compared to D.M group showed a significant decrease (P≥0.05).
Conclusion: Endurance training can probably have a positive and protective effect on the reduction of kidney tissue apoptosis in diabetic and diabetic withdrawal syndrome rats.
Abbas Saremi, Omid Zafarmand,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Irisine is a new myokine that is released from the membrane protein fndc5 and has positive effects on metabolism. The aim of the present study was to investigate the effect of high-intensity interval training on plasma irisin levels and glycemic indices in obese and type 2 diabetic people.
Methods: A systematic search of published English and Persian articles was conducted from PubMed, Web of Science, Scopus, SID, and Magiran databases up to 20 November 2024. The mean difference and 95% confidence interval (CI) were calculated using a random-effects model. Heterogeneity was assessed using the (I2) test and publication bias was assessed using visual analysis of funnel plots and Egger's test.
Results: A total of 11 studies and 264 obese and type 2 diabetic subjects were included in the present meta-analysis. The results showed that high-intensity interval training significantly increased irisin [WMD = 1.448 ng/ml (2.280 to 0.616), P= 0.001], significantly decreased glucose [WMD = -12.127 mg/dl (-24.180 to -0.074), P= 0.049] and insulin resistance [WMD= -1.275 (-0.567 to -1.983), P= 0.001] compared to the control group in obese and type 2 diabetic subjects. While insulin [WMD= -0.249Iu/ml (3.402 to -3.901), P= 0.894] was not significantly reduced.
Conclusion: Overall, the findings of the present meta-analysis indicate that high-intensity interval training plays an effective role in irisin, glucose, insulin, and insulin resistance to high-intensity interval training. High-intensity interval training increases irisin, decreases glucose, insulin, and insulin resistance in obese and diabetic individuals. Lifestyle modification and exercise training are preferred treatment strategy in obese and type 2 diabetic people.
