Showing 2 results for Seifi
Malahat Kashfi Moghadam, Farnaz Seifi-Skishahr, Lotfali Bolboli,
Volume 24, Issue 3 (7-2024)
Abstract
Background: The present study aimed to investigate the changes in TRx-sh/TRx-s2 levels, GSH values, and total antioxidant capacity following 8 weeks of intense interval training with and without sodium citrate supplementation in diabetic rats.
Methods: In this semi-experimental and fundamental study, 50 male Wistar rats were randomly divided into 5 groups: healthy control, control control, selective - exercise, consumption-sodium citrate supplementation, and drink-sodium citrate supplementation. The training protocol included 8 weeks of HIIT training with an intensity of 90% of the maximum speed. The supplement and exercise-supplement groups received daily (764 mg/kg) sodium citrate supplement in the form of a solution in water, three hours before the exercise. 72 hours after the last training session, blood sampling was done and the ELISA method analyzed research variables. To compare study groups, one-way analysis of variance and LSD post hoc test were used in SPSS software (P≥ 0.05).
Results: The results showed that the levels of TRx-sh/TRx-s2, GSH, and TAC were significantly different among the five research groups (P= 0.001). Also, the results showed the levels of TRx-sh/TRx-s2, TAC, and GSH in the control-diabetic group (P= 0.001), diabetic-exercise (P= 0.001), and diabetic-supplement group (P= 0.001). and diabetic-supplement-exercise (P= 0.001) had a significant decrease compared to the healthy control group. The levels of TRx-sh/TRx-s2, GSH, and TAC in the diabetic-supplement and diabetic-supplement-exercise groups were significantly increased compared to the diabetic control group (P= 0.001). According to the difference in means, the increase of TRx-sh/TRx-s2, TAC, and GSH was higher in the diabetic-supplemented group.
Conclusion: According to the results of the research, it can be assumed that training and sodium citrate supplementation are effective in improving diabetes and this effect is probably exerted by increasing TRx-sh/TRx-s2, TAC, GSH.
Najmeh Seifi, Niloufar Abdollahpour, Gelare Koochakpoor, Nioosha Samadi, Habibollah Esmaily, Majid Ghayour-Mobarhan,
Volume 26, Issue 2 (7-2026)
Abstract
Background: Dietary acid load is thought to contribute to the development of metabolic syndrome through effects on acid–base balance with evidence being inconsistent. This study aimed to examine the associations between dietary acid load indices, Dietary Acid Load (DAL), Potential Renal Acid Load (PRAL), and Net Endogenous Acid Production (NEAP) and risk of metabolic syndrome and its components in an Iranian adult cohort.
Methods: 6,482 adults aged 35-65 years were enrolled from the Mashhad Stroke and Atherosclerosis Study. Dietary intake was assessed using a validated food frequency questionnaire, and dietary acid load indices were calculated. Participants were followed for nearly 10 years. Logistic regression models were used to evaluate associations of DAL, PRAL, and NEAP with the incidence of metabolic syndrome, diabetes, hypertension, and dyslipidemia, adjusting for major confounders.
Results: Following adjustment, no significant associations were found between DAL indices and the incidence of metabolic syndrome or its components. DAL odds ratio (OR) for the highest versus lowest tertile was 0.984 [95% confidence interval (CI): 0.815–1.188; p= 0.868]. For PRAL, the OR was 1.024 (95% CI: 0.865–1.212; p= 0.782), and for NEAP, the OR was 0.902 (95% CI: 0.763–1.066; p= 0.227). None of the indices were significantly related to new cases of diabetes, hypertension, or dyslipidemia (all p> 0.05).
Conclusion: In this Iranian adult cohort, DAL indices were not associated with the risk of metabolic syndrome or its components. Further studies in populations with different dietary habits are needed to clarify potential threshold effects or effect modifiers.
