Showing 3 results for Shahidi
Mohsen Eimen-Shahidi, Hossein Hosseinzadeh,
Volume 2, Issue 1 (17 2003)
Abstract
In this article, we review animal models of types 1 and 2 diabetes mellitus. Models of type 1 diabetes are discussed in two parts, genetic and chemical. Models of type 2 diabetes are discussed in four parts – rat and mouse models, dietary induction, and selective breeding. Models are assessed regarding metabolic disturbances, the condition of the pancreas, long-term complications, and research benefits.
Fereshteh Shahidi, Faramarz Yazdani, Abbasali Gaieni, Poran Karimi,
Volume 18, Issue 5 (7-2019)
Abstract
Background: Diabetic cardiomyopathy is the first cause of death in diabetic patients and angiogenesis is the most important mechanism for the recovery of heart blood flow in physiologic and pathologic conditions. The purpose of this study was to compare the effect of eight weeks of moderate continuous and sever interval training on heart angiogenesis in Wistar male diabetic rats.
Methods: 32 Wistar rats were randomly assigned into 4 groups: healthy non-exercised, diabetic no exercise, diabetic + moderate continuation and diabetic + severe interval exercises. Two types of exercises were calibrated and the exercise intensity was determined based on the maximum oxygen consumption and 5 days a week. The pro-angiogenic (VEGF, MMP2, TGFβ1) and anti-angiogenic (TIMP2) agents of the left ventricle of the heart were taken from the rat after 48 hours of the last training session. Western blot method was used to evaluate the synthesis of proteins involved in angiogenic route. Data were measured by one-way variance analysis with repeated measurements (P =0/000).
Results: The results showed that the levels of proangiogenic VEGF, MMP2, TGFβ1 significantly increased, but the anti-angiogenic factor of TIMP2 decreased (P <0.05). In addition, the maximum level of oxygen consumed in both continuous and periodic training groups showed a significant increase.
Conclusion: Moderate and continuous exercise increases angiogenic factors in the heart of diabetic Wistar rats, which is a good way to reduce the mortality rate of diabetes.
Majid Kashef, Mojtaba Salehpour, Fereshteh Shahidi, Nematallh Nejatmand Malari,
Volume 23, Issue 2 (5-2023)
Abstract
Background: The main cause of death of diabetic patients is heart disease. Exercise improves insulin resistance and reduces the mortality of diabetic patients. The aim of this research was the effect of six weeks endurance training on some miRs related to diabetic cardiomyopathy, FBS and insulin resistance index in male Wistar rats.
Methods: After induction of diabetes, male Wistar rats with an average weight of 200gr and age of 8 weeks were randomly classified into four groups: sham, control, endurance training and healthy. Endurance training was performed for 6 weeks. Gene expression was investigated using Real Time PCR. The statistical tests of this research were One Way Anova and T Correlated. The data were normalized by GapDh method and 2-(∆∆CT).
Results: Endurance training leads to a significant decrease in FBS (P: 0.00) and insulin resistance index (P: 0.00) and there was a significant increase in VO2peak (P: 0.001). The expression levels of miR-373 and miR-195 in the exercise group did not change significantly compared to the diabetic control group (P > 0.05). But the effect of training led to an increase in the expression of miR-373 (P: 0.4) and a decrease in the expression of miR-195 (P: 0.9).
Conclusion: Aerobic exercise improved the aerobic capacity of the exercise group. In addition, exercise led to the relative improvement of diabetes complications (increasing the expression level of miR-373 and decreasing the expression level of miR-195). Therefore, it is recommended that patients with cardiomyopathy should focus on aerobic exercises.
