Hamed Rezaei Nasab, Roohollah Ranjbar, Abdol Hamid Habibi, Saeed Shakerian,
Volume 14, Issue 2 (1-2015)
Abstract
Background: The purpose of this study was to compare three intensities of acute aerobic exercise on plasma visfatin concentration in type 2 diabetic males. Methods: Ten men with type 2 diabetes (mean ± SD age 52.6 ± 3.6 years, height 171.3 ± 6.7 cm, Weight 87.58 ± 4.7 kg) participated in the study. In the first session, anthropometric measurements, body composition, and peak oxygen uptake (VO2peak) was measured in all subjects. In the next sessions, subjects completed three acute aerobic exercises on separate days in a crossover design. The three exercise trials performed at intensity of 40%, 60%, and 80% VO2peak after fasting for at least 10 hours. Energy expenditure was 300 kcal for each exercise trial. Blood samples before exercise, immediately after and 24 hours after exercise were collected for measuring visfatin, glucose and insulin. Results: The results showed no significance interaction (p>0.05) between exercise and sampling time. This analysis also revealed significance in the main effects (p>0.05) of the two factors (exercise and sampling time). Pearson correlation showed that there was significant relationship between visfatin and insulin (p<0.05). Conclusion: According to the present results, we can conclude that acute aerobic exercise at different intensities with 300 kcal energy expenditure will not change visfatin levels in type 2 diabetes.
Hamed Rezaei Nasab, Abdolhamid Habibi, Masoud Nikbakht, Mohamad Rashno, Saeid Shakerian,
Volume 18, Issue 4 (4-2019)
Abstract
Background: Oxidative stress plays a key role in the onset and development of diabetes Complications, Including diabetic cardiomyopathy. The purpose of this study was to investigate the role of dichloroacetate (DCA) on SOD and GPX expression following six weeks’ endurance training in cardiac muscle of diabetic male rats.
Methods: In this experimental study, 64 male Wistar rats were selected and randomly divided into eight groups after streptozotocin (STZ) solution diabetic treatment. The endurance training protocol was performed on a treadmill for 6 weeks. In the present study, for Inhibition of PDK4 in the cardiac muscle, intraperitoneal injection of DCA of 50 mg/ kg body weight was used. Gene expressions were measured by Real-Time PCR method. One-way ANOVA and Tukey's test were used to analyze the data.
Results: The results of the study showed that after endurance training, PDK4 gene expression increased and SOD and GPX genes expression in training endurance + diabetic group and endurance training group decreased compared to control group (P <0.05). By Inhibition of PDK4, the of SOD and GPX genes expression increased in DCA + training endurance + diabetic group and DCA + endurance training group compared to control group (P <0.05).
Conclusion: According to the results of this study, DCA injections may reduce the recurrence of free radicals induced by endurance training in diabetic patients by mitochondrial adaptation. Which can reduce the oxidative stress in the heart tissue of diabetic patients and increase cardiac efficiency.
