Showing 2 results for Shamlou kazemi
Saeid Shamlou Kazemi, Ali Heidarianpour,
Volume 23, Issue 3 (9-2023)
Abstract
Background: During menopause, women are more exposed to the risk factors of many diseases, including metabolic syndrome, and sirtuin-1 may be involved in this disorder. The aim of this study was to investigate the effect of circular resistance training and moderate intensity continuous training on metabolic indices and Sirtuin1 serum level in women with metabolic syndrome.
Methods: This study was conducted as a clinical trial in women with metabolic syndrome in two intervention groups (15 people in resistance training group and 15 people in continuous training group) and a control group (15 people). The intervention group underwent an exercise program for eight weeks and three sessions per week, and the control group had their own routine program. After the last training session, serum levels of Sirtein1 and lipid factors were measured. To analyze the data, t-test and covariance were used at a significant level (P≤0.05).
Results: The results of the t-test showed that there was a significant difference in the intra-group changes of the studied variables (SIRT1, HDL, LDL, TG, FBS, Total Cholesterol) in both exercise groups (P≥0.05), but in No significant difference was observed in the control group (P<0.05). The results of the covariance test showed that there is a significant difference between the three groups in the indices (SIRT1, HDL, LDL, TG, FBS, Total Cholesterol) after the test (P<0.05).
Conclusion: Eight weeks of circular resistance training program and continuous training with moderate intensity has a positive effect on metabolic indices and serum level of Sirtuin1 in people with metabolic syndrome.
Zoliekha Rahimi, Saeid Shamlou Kazemi, Ali Hemati Afif,
Volume 25, Issue 4 (9-2025)
Abstract
Background: Moderate and intense aerobic exercise increases the production of free radicals, and on the other hand, the use of antioxidant supplements such as grape seed extract (GSE) has been suggested as one of the ways to deal with oxidative stress. Based on this, the aim of this study was to determine the interventions effect of combined exercise and consumption of GSE on some factors of oxidative and antioxidant stress in postmenopausal women with type 2 diabetes.
Methods: The current study was conducted as a clinical trial on the 80 women with type 2 diabetes, who were randomly divided into four groups (20 people): control, exercise, GSE supplement, exercise + GSE supplement. The combined exercise protocol consisted of aerobic (20 minutes of treadmill running at an intensity of 60–70% of reserve heart rate) and strength training (at an intensity of 70% of one repetition maximum), which was performed for eight weeks (five days/week). GSE supplement was taken in the form of 200 mg capsules daily (morning and noon). Samples (five cc) were taken before and after eight weeks of interventions. In order to determine the acceptance or rejection of the null hypothesis of intragroup and intergroup changes, was used the two-way AVOVA, and then Tukey's post hoc test to determine different groups by SPSS version 25 (P≤ 0.05).
Results: The values of total antioxidant capacity (TAC) and serum glutathione reduction (GSH) in the GSE and exercise + GSE groups increased significantly compared to the control and exercise groups (P= 0.001). Serum malondialdehyde (MDA) levels in the GSE group showed a significant decrease compared to the control and exercise groups (P= 0.001).
Conclusion: It seems that the intervention of grape seed extract is more effective in reducing oxidative stress than combined exercise. The consumption of this extract alone, as well as with combined exercise, has a significant effect on increasing the total antioxidant capacity and reducing GSH (glutathione).
