Showing 3 results for Shamsi
Behzad Shamsi, Mahin Hashemipour, Sayed Hossein Saadat, Sayed Mohammad Hasan Emami, Zahra Abdyazdan, Akbar Hasanzadeh, Khosrow Khaibi, Sasan Haghighi, Silva Hovsepian,
Volume 3, Issue 1 (16 2004)
Abstract
Increased prevalence of Helicobacter Pylori (HP) infection is a common feature in diabetics, which is attributable to the presence of diverse predisposing factors. In this study, the prevalence of HP infection has been investigated in type 1 diabetic children.
Methods: In a cross-sectional study, anti-HP antibody (IgG) was measured in 75 type 1 diabetics (aged 2-18 years) and the results were compared with 75 healthy children who were matched for age, sex and socio-economic status. In seropositive diabetic patients with gastrointestinal (GI) symptoms, gastroduodenoscopy was performed to establish the diagnosis.
Results: Sera were positive for anti-HP in 22.7% of diabetics versus 17.3% in controls (P>0.05). No significant difference was observable between seropositive and seronegative diabetic groups as regard to age, sex, age at onset of diabetes, number of outpatient visits during the last 6 months, HbAlc and insulin requirements. Gastrointestinal symptoms were more common in diabetics than the healthy controls the prevalence of these symptoms, however, did not differ significantly between seropositive and seronegative diabetics.
Conclusion: The study indicated that type 1 diabetes is not associated with increased risk of HP infection. Further studies are required to investigate the impact of HP infection treatment on the glycemic control in diabetic children.
Mohammad Ali Sardar, Ali Akbar Shamsian, Morteza Taghavi,
Volume 6, Issue 1 (19 2006)
Abstract
Background: Combination of physical activity and pharmacotherapy in diabetes may augment the effects of the drug and may allow lower doses of medication that can minimize the side effects. The goal of the study was to determine the effectiveness of aerobic training and Glibenclamide combination in type 2 diabetes.
Methods: A total of 28 men with type 2 diabetes were divided to 3 groups randomly: Glibenclamide (5 mg daily) only, Glibenclamide (5 mg daily) plus aerobic training, Glibenclamide (2.5 mg daily) plus aerobic training. Aerobic training protocol was performed for 12 week, 3 days (session) a week, 45 minutes in a session (ergo cycle program at 60-70 % heart rate reserve). Fasting glucose, HbA1c, fasting insulin, c-peptide, and insulin resistance were measured at pre, mid and post treatment periods. Analysis of Variance test (ANOVA) were used to evaluate data.
Results: HbA1c significantly decreased and c-peptide significantly increased in three groups (P<0.05).There were also no between-group differences for c-peptide and HbA1c (P>0.05). Fasting insulin concentration did not alter in three groups, however, insulin resistance decreased ( no significant ) after 12 weeks.
Conclusion: In type 2 diabetic patients, Glibenclamide treatment alone or combination of aerobic training and Glibenclamide treatment, was effective in improving glycemic control in patients with type 2 diabetes .As a result, in patients with type 2 diabetes, the addition of aerobic training to Glibencelamide treatment allow lower doses of Glibenclamide to be used without impairment in glycemic control.
Mahdieh Molanouri Shamsi, Mehdi Mahdavi,
Volume 15, Issue 5 (7-2016)
Abstract
Background: Myokines released from skeletal muscle have multiple metabolic and hypertrophic effects. On the other hand, one of proposed pathways for effects of exercise training on metabolic diseases is calcineurin signaling pathway. With considering to relation between interleukin-6 (IL-6) and calcineurin, the purpose of this study was to investigate whether the resistance training has an effect on mRNA expression of IL-6 myokine and regulator of calcineurin 1(RCAN-1) in skeletal muscle of diabetic rats.
Methods: Thirty two Rats randomly were divided into the control, training, diabetic control and diabetic training groups. Diabetes induced by streptozotocin (STZ). Training groups performed the 17 sessions of resistance training. The IL-6 and RCAN-1 mRNA expression were measured in Soleus skeletal muscle using the Real-time PCR method. Two-way analysis variance was used for statistical analysis. Also, Statistical significance was set at p<0.05.
Results: The results of this study showed that the mRNA expression of RCAN-1 was increased with resistance training in skeletal muscle of training groups (P<0.05). Also, diabetes was decreased expression of RCAN-1 in skeletal muscle of diabetic groups (P<0.001). Moreover, resistance training was increased mRNA expression of IL-6 in skeletal muscle (P=0.08).
Conclusion: With considering to our results, resistance training with direct effects on skeletal muscle could regulate calcineurin pathway in diabetes and concurrent increase in expression of IL-6 myokine. It seems that activation of this signaling pathway with resistance training could maintain skeletal muscle mass in diabetes.
