Iranian Journal of

Background: Diabetic foot ulcers are important topic in diabetes care. Diabetes is one of the most common metabolic diseases of endocrinology. Raspberry (Rubus fruticosus) has anti-inflammatory, anti-septic and anti-oxidant effects. The aim of present study is healing effects of raspberry extract on the regeneration process of skin wounds in control and diabetic rats.

Methods: In this study, 48 adult male rats were divided into four groups (n=12 each) including: control group (non-treated and non-diabetic rats), sham (eucerin-treated diabetic rats), experimental1 (non-treated diabetic rats) and experimental 2 (raspberry-treated diabetic rats). Diabetes was induced by 55 mg/kg Streptozotocin (STZ) in three groups of rats. A wound with 3 cm length was created on the skin of back side of animals in all groups. The experimental 1 group was treated by eucerin and experimental 2 groups were treated by raspberry extract two times in a day. Microscopic and macroscopic studies were performed on wound healing process on days of 3, 5, 7, 14 and 21.

Results: The findings showed that sham and experimental 1 group had later healing effect comparing with control group. The speed of wound healing in raspberry extract-treated rats (experimental 2 groups) had significantly increased in comparison with control group and the wound surface area has been significantly decreased in comparison with all other groups (P ≤ 0.05).

Conclusion: It seems that topical application of raspberry extract can accelerate the wound healing in diabetic rats and materials in raspberry extract stimulate the collagen synthesis, faster wound contraction and angiogenesis.

Background: Finding effective drugs have been considered for healing diabetic wounds by researchers. The purpose of this study was to evaluate the effects on wound healing ointment Alcoholic extract of grape seed skin is normal and diabetic rats.

Methods:  In this study 48 male Wistar rats into four groups (negative control, positive control, the first experimental, the second experimental) were divided. Groups tested in the injured area of 3 cm²   were created on the left spine. The wound healing was evaluated macroscopically. The results are reported as Mean ± SD. Statistical inference border (P ≥0.05) and (P ≥0.01) and (P ≥0.001).

Results: Compared with normal wound healing in diabetic groups were later and Wound healing in experimental groups treated with Vitis Vinifera more quickly than the control group, respectively.

Conclusions: In this study the skin ointment Vitis Vinifera accelerates the wound healing is normal and diabetic samples.