Mohammad-Reza Rouini, Sima Sadray, Yalda H. Ardakani, Maryam Mokhberi, Sedaghat Solmaz,
Volume 6, Issue 2 (18 2006)
Abstract
Background: Metformin is used in treatment of non-insulin-dependent diabetes mellitus (NIDDM). The present study was aimed to study the pharmacokinetic and pharmaco-dynamic of metformin 500 mg tablet in healthy volunteers.
Methods: The test and reference metformin hydrochloride 500 mg tablets were administered to 12 healthy volunteers in a cross-over study. Metformin serum concentration and decrease in blood sugar levels (dBSL) were used for study of pharmacokinetic and pharmacodynamic.
Results: There was no correlation between phramacodynamic and pharmacokinetic para-meters. Also there was no increase in dBSL-(AUC0-12) with increase metformin serum concentration-time. The results of our study show that both products could be bioequivalent according to serum concentration and not blood sugar data.
Conclusion: There was no concentration – effect (dBSL) correlation for both products. Metformin didn’t decrease the blood glucose in healthy volunteers. In some volunteers there was no increase in blood sugar after meal and dextrose 20% oral solution administration which could be related to decreased absorption of glucose from gastrointestinal tract caused by metformin.
Ata Pourabassi, Zahra Kheiry, Sarah Nouriyengejeh, Solmaz-Sadat Naghavi Alhosseini, Farnaz Banakar,
Volume 18, Issue 3 (3-2019)
Abstract
Background: The main problem of modern humans is non-communicable diseases such as diabetes, cardiovascular disease, etc. Diabetes has the highest prevalence. It imposes many costs on society and the patient. Diabetics have special needs for a better life; hence, the researcher's aim is to accomplish them by defining researches and technology missions. Our purpose was to understand the real needs of a diabetic patient. Previous studies were evaluated to find out which one was effective.
Methods: In this research, 120 diabetic children's parents were requested to write a letter entitled "Hi Inventor" and describe any efficient inventions, which could make life easier for their children. Besides, research papers and patents from Iran over the past ten years have been evaluated in terms of their compliance with patients' needs.
Results: Parent's statements gathered in the form of 12 real needs. The main concern was the invasive method of blood glucose testing and they were asking for innovative method to measure blood glucose with less pain. Among published articles by Iranian researchers over the past ten years, 3% of the articles were in some way related to the actual needs of patients with diabetes. A total of 1017 patents from Iran was looked for, there were 3 diabetes-related patents.
Discussion: To sufficiently support the conducting research and identifying research priorities in the country, it is necessary to consider a balanced ratio between fundamental and applied research so that the patients' community can benefit from the early results of research as well.
