Mahdi Zamani, Mohammad Amin Tabatabaiefar, Arezoo Savabi Esfahani, Fereidoon Mostafavi, Arya Sotoudeh, Bagher Larijani,
Volume 4, Issue 4 (17 2005)
Abstract
Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which T-cell mediated selective pancreatic β- cell destruction occurs. Half the risk of T1DM development is given by the HLA gene region while the remaining risk is assigned to non-HLA genes , probably those engaged in the formation of antigen interaction complex. The CD4 gene product, which is among the most prominent T-cell surface receptors with a key role in antigen processing, could be regarded as a strong candidate.
Methods: We investigated the possible association of the CD4 gene polymorphism with T1DM using the candidate gene approach. The pyrimidine- rich pentanucleotide repeat polymorphism residing in the promoter region of the CD4 gene was studied. In the present study 92 Iranian T1DM patients and 108 healthy matched control individuals were screened by PCR technique.
Results: The analysis of our results shows the protective association of CD4*A3 (RR= 0.159, 95% CI: 0.036-0.707 Pc=0.025) and the susceptible role of CD4*A5 (RR= 7.379, 95% CI: 1.630-33.414 Pc=0.010) with T1DM.
Conclusion: Our results suggest that the certain CD4 alleles are associated either negatively or positively with T1DM in the Iranian population.
Elham Narmaki, Farideh Shirasb, Mostafa Qorbani, Gity Sotoudeh,
Volume 16, Issue 2 (1-2017)
Abstract
Background: Household food insecurity is defined as limited or uncertain access to nutritionally adequate and safe food or limited ability to obtain foods in socially acceptable ways. The association between food security and obesity had been investigated before but so far, its association with body composition has not been investigated. Therefore, the aim of this study was to investigate the relationship between Food security with anthropometric measurements, body composition and blood pressure in women attending the sport clubs of municipality in west of Tehran.
Methods: This cross-sectional survey was conducted in 397 randomly selected healthy women from 14 sport clubs dependent to mayoralty in North West, South West and West of Tehran. To determine the food security, USDA food insecurity (18-item scale) was used. Weight, height, waist circumference (WC), systolic and diastolic blood pressure (SBP, DBP) were measured according to standard protocols Body composition was measured using body impedance analyzer (BIA). Socio-demographic and socioeconomic status were recorded. Data analysis included chi-square test, ANOVA test and multivariate analyses of variance.
Results: The prevalence of food insecurity in subjects was 54.4% that 45.3% were food insecure without hunger, and 9.1% were food insecure with moderate and severe hunger. Compared to food secure households, people with food insecurity significantly had more general obesity (Body Mass Index > 30kg/m2) and central obesity (Waist > 80 cm) (P-value < 0.0001).Also, most people with high blood pressure were in food insecure group and the association between blood pressure and food security was significant (P-value < 0.0001). Body composition and systolic and diastolic blood pressure of women were significantly greater in the group with food insecurity than food security group (P-value < 0.0001).
Conclusion: The results of this study showed that food insecurity was significantly associated with obesity, fat mass, visceral fat mass and blood pressure.
