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THE EFFECT OF PEER EDUCATION ON SELF-CARE BEHAVIORS AMONG DIABETIC PATIENTS
Zakieh Ahmadi, Tabandeh Sadeghi, Marzeyeh Loripoor,
Volume 15, Issue 6 (7-2016)
Abstract

Background: Education is important aspect of diabetes management and important part of care for these patients. This study aimed to assess the effects of peer education on self-care behaviors among diabetic patients                            

Methods: In this randomized controlled trial, 80 type 2 diabetic patients were selected and randomly allocated into two groups of intervention and control. In the intervention group, In addition to routine training center, patients were receiving health and self- care education in the field of diabetes by peer. In the control group, patients were receiving usual education in accordance with normal procedures by doctors and nurses and through posters and pamphlets of the diabetes center. Study instruments included a questionnaire for demographic variables and self-care behaviors questionnaire (Summary of Diabetes Self-care Activities). Validity and reliability of questionnaire has been confirmed in previous studies. Data were collected at baseline and 12 weeks after the intervention.  Data analysis was done using SPSS V.18. 

Results: After the intervention, mean score of self-care behaviors in the intervention group was increased and showed a significant difference in self-care behaviors between two groups (independent t- test, P=0.001).  In the intervention group, statistically significant difference was found before and after the intervention (paired t-test, P=0.001), whereas in the control group this difference was not statistically significant (paired t-test, p=0/28).                             

Conclusion:  Peer education can improve self-care behaviors. Thus use of this method along with other training methods is recommended.


The Effect of Eight Weeks of Aerobic Exercise on the Expression of Senescence Proteins P53 and P16 in Pancreatic Tissue of Diabetic Mice
Maryam Janbozorgi, Abass Ali Gaini, Siroos Choobineh, Mohamad Reza Tabandeh,
Volume 22, Issue 1 (4-2022)
Abstract
Background: Chronic hyperglycemia is associated with an increase in cellular damage due to oxidative stress and increases insulin resistance and also increases in p53 and p16 beta cells, leading to the induction of senescence in pancreatic insulin-secreting cells. The aim of this study was the effect of eight weeks of aerobic exercise on the expression of senescence proteins P53 and P16 in the pancreatic tissue of diabetic mice.
Methods: In this study, 15 NMRI mice (26.3 ±3.22 g) were divided into three groups randomly: healthy control, diabetic control and diabetic exercise. They were diabetic by HFD for 5 weeks and intraperitoneal injection of STZ. The aerobic training protocol (50-60% Vmax) was 5 days a week for 8 weeks. After anesthesia, blood and pancreatic tissue were removed. Insulin resistance, P53 and P16 protein concentrations in pancreatic beta cells were measured. Data were analyzed by ANOVA with a significance level of p <0.05.
Results: According to the results of eight weeks of aerobic exercise by mice diabetic type 2, a significant decrease in insulin resistance (p = 0.005), protein concentrations of P53 (p = 0.002) and P16 (p = 0.010) in pancreatic tissue was observed.
Conclusion: Aerobic exercise may improve insulin sensitivity and delay cellular senescence due to diabetes by reducing cell senescence factors such as P53 and P16 in beta cells. Therefore, this type of exercise can be considered as a therapeutic approach to improve the condition of these patients.

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