Esfandiar Jahanfar, Abdolhossein Taheri Kalani, Mahmoud Nikseresht,
Volume 24, Issue 2 (6-2024)
Abstract
Background: Type 2 diabetes mellitus, like other inflammatory diseases, causes a change in the levels of pro-inflammatory (such as gremlin-1) and anti-inflammatory (such as pentraxin-3) markers. The aim of the present study was to compare the effects of 10 weeks of aerobic and resistance training on serum levels of pentraxin-3, gremlin-1 and insulin resistance in men with type 2 diabetes.
Methods: In this semi-experimental study, 29 men with type 2 diabetes in the age range of 25-45 years were selected and randomly divided into three groups: aerobic training, resistance training and control. Aerobic training program with an intensity of 55-75% of the maximum heart rate and resistance training with an intensity of 55-75% of one repetition maximum was implemented during 10 weeks and 3 sessions per week. Before and after the intervention period, serum levels of pentraxin-3, gremlin-1 were measured and also insulin resistance index was calculated.
Results: In both aerobic (P= 0.039) and resistance (P= 0.019) training groups, pentraxin-3 serum level increased significantly compared to the control group; but there was no difference between the two groups (P= 0.703). Also, serum levels of gremlin-1 and insulin resistance of the aerobic (P= 0.022 and P= 0.040, respectively) and resistance (P= 0.037 and P= 0.031, respectively) training groups showed a significant decrease compared to the control group; Although there was no difference between the training groups (P= 0.815 and P= 0.659, respectively).
Conclusion: This findings demonstrate that both types of aerobic and resistance training are equally effective in improving inflammatory markers and insulin resistance in type 2 diabetes patients.
Mehrdad Yousefinejad, Mahnaz Omidi, Abdolhossin Taheri Kalani,
Volume 24, Issue 3 (7-2024)
Abstract
Background: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and insulin resistance index in diabetic rats.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P= 0.001 and P= 0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
