Iranian Journal of

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Background: Adiponectin and omentin-1 are adipokines with insulin-sensitizing properties. The aim of this study was to investigate the effect of resistance training on serum levels of adiponectin and omentin-1 in Streptozotocin-induced diabetic rats. Methods: Twenty four male Wister rats (12-14 weeks’ old) were randomly divided into three groups: non-diabetic control, diabetic control, and diabetic training. The rats in diabetic training group were subjected to a resistance training program (3 days/wk, for 4 wk) consisted of climbing a ladder carrying a load suspended from the tail. Following four weeks resistance training serum glucose, insulin, lipid profile, adiponectin, and omentin-1 concentrations were measured. Results: Serum levels of omentin-1 and adiponectin were significantly lower in diabetic control group compare with non-diabetic control group (P<0.001). After 4 weeks of resistance training serum adiponectin levels was significantly higher in diabetic trained group compared with diabetic control group (P= 0.028), but we did not find any significant difference in omentin-1 levels between two diabetic groups. Morever, we did not find any significant difference in serum lipid profile among all groups. Four weeks resistance training did not change serum glucose and insulin concentrations in diabetic rats. Conclusion: This study indicated that resistance training could increase serum adiponectin levels in diabetic rats without significant changes in lipid profile, glucose, insulin, and omentin-1 concentrations. It seems low intensity and short term duration of resistance training had important roles in failure of significant changes of omentin-1, glucose, and insulin concentrations.

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Background: kallikrein 7 (KLK7), a serine protease with a chymotrypsin-like specificity, is able to cleave human insulin in the A- and B-chain. The aim of this study was to investigate the effects of aerobic exercise training on plasma KLK7 concentration and insulin resistance index (HOMA-IR) in normal and overweight sedentary women.

Methods: Twenty-eight sedentary women, aged 24-60 years, voluntary participated in this study and according to body mass index status divided into normal (n=15) and overweight (n=13) groups. All subjects completed an 8-week progressive aerobic exercise training program (running with 40- 80% Heart rate reserve). Metabolic and Anthropometric (body weight, BMI, body fat percentage) parameters in addition to plasma KLK7 concentrations were measured at baseline and end of training program.

Results: Body fat percentage significantly decreased (P<0.05) and maximum oxygen consumption increased (P<0.05) by this training program in both training groups. At baseline, plasma KLK7 concentration in overweight women was significantly higher compared with normal weight group (P<0.05). Plasma KLK7 concentrations significantly increased after 8-week aerobic exercise training only in normal weight group (P<0.05). Changes in plasma KLK7 concentrations were not correlated with changes in insulin concentration and insulin resistance index (P<0.05).

Conclusion: Aerobic exercise training could be an effective factor to increase plasma KLK7 concentration in sedentary women. These data do not support a role of plasma KLK7 in insulin resistance alterations.