Showing 19 results for Tol
Nosratollah Zarghami, Radina Eshtiaghi, Ali Khosrowbeygi, Dian Dayer, Jamai Hallaji,
Volume 3, Issue 1 (16 2004)
Abstract
Diabetes is a common endocrine disease with complications such as retinopathy, nephropathy and neuropathy which has its monitoring through biomarkers desirable. At present, glycosylated hemoglobin (HbAic) is used for monitoring the long term control of glucose levels in diabetic patients. However, absence of a standardized range, has led to investigations that recently have suggested insulin-like growth factor-I (IGF-I) as a good biomarker for monitoring blood glucose levels in diabetics. The aim of this study was to examine the correlation between IGF-I and HbAic in Type 1 diabetes.
Methods: We designed a cross-sectional case-control study. The study composed of 26 newly diagnosed patients with Type 1 diabetes (15 male and 11 female mean age, 23.7±9.1 years) and 26 healthy controls (9 male and 17 female mean age, 24.1±4.4 years). Levels of fasting plasma glucose (FPG), HbA]C) IGF-I and IGF-binding protein-3 (IGFBP-3) were measured in both groups. FPG was measured by enzymatic glucose oxidase method and the colorimetric method was used to measure HbAlc. Determination of total serum levels of IGF-I and IGFBP-3 were done using immunoassay methods. P-value<0.05 was considered as statistically significant.
Results: The mean value of IGF-I concentrations in type 1 diabetics was significantly lower than controls (p< 0.05). A reverse correlation was observed between IGF-I and HbAic. Conclusion: The study indicates that in poorly controlled diabetics, levels of FPG and HbAic rise concurrent with a drop in levels of IGF-I decreases. Our study also showed a significant correlation between IGF-I and HbAie. Therefore, IGF-I could be indirectly used as a biomarker for controlling glucose levels in diabetics.
Hasan Fallah Huseini, Bagher Larijani, Hossein Fakhrzadeh, Bita Radjabipour, Skahin Akhondzadeh, Taiebeh Toliat, Ramin Heshmat,
Volume 3, Issue 2 (16 2004)
Abstract
Background: Previous clinical and experimental studies suggest the valuable effect of antioxidants on lipids status. The present study was designed to investigate the efficacy of silymarin treatment as an antioxidants on lipids profile in type II diabetic hyperlipidemic patients.
Methods: A 4-month randomized double blind clinical trial was conducted in 54 non-insulin dependent diabetic hyperlipidemic patients in a two well – matched groups. First group (n=29) received 200mg silymarin tablet 3 times a day plus standard therapy, while the control group (n=25) received placebo tablet 3 times a day plus standard therapy. The patients were visited monthly and fasting blood glucose, total cholesterol, LDL, HDL cholesterol, triglyceride, SGOT and SGPT were determined at the beginning and at the end of the study after four months.
Results: Results revealed that in silymarin treated patients, fasting blood glucose, LDL and total cholesterol, triglycerid, SGOT, SGPT and glucose level at the end of the study were significantly decreased as compared to beginning of the study. In placebo treated patients fasting blood glucose level at the end of the study were significantly increased as compared to beginning of the study.
Conclusion: In conclusion, the silymarin as an herbal antioxidant have beneficial effects on reducing glucose and lipids profile in type II diabetic patients
Nosratollah Zarghami, Behrang Alani, Habib Onsori, Akram Tamizi, Mehran Mesgari,
Volume 5, Issue 2 (18 2005)
Abstract
Background: Leptin, a peptide hormone, is the product of "ob" Gene. Leptin regulate body weight and composition through reducing appetite and energy expenditure in rodents and humans. The aim of this study was to evaluate differences in expression of Leptin Gene in different tissues of streptozotocin induced diabetic rats.
Methods: 40 Sprague Dawely rat were selected. Intra peritoneal injection was carried out in 20 rats and another 20 rats were used as control. After injection of 60mg/kg Streptozotocin, animals were transformed into diabetic. Glucose was measured by glucose oxidase method. Leptin and insulin were measure by commercially available immunoassay kits. After one week treatment, different tissues including adipose tissues, Spleen, epidydimis, and Liver of both control and experimental animals were dissected. For investigation of any changes of the Leptin gene expression in different tissues, RNA was extracted using Trizo1 method. By using RT-PCR technique, Leptin cDNA and β-actin cDNA as internal control were constructed and PCR was carried out. The RT-PCR products were detected on 2% agarose gel using electrophoresis.
Results: Mean serum levels of Leptin was 5.23± 0.45 ng/ml before injection of streptozotocin and markedly decreased in STZ induced diabetic rats to 0.79±0.25 ng/ml. This decrease was statistically significant P<0.05). There was a direct and significant correlation between leptin and insulin in streptozotocin-induced diabetic rats (r=0.37, P<0.05 ) while, this was reverse in control rats ( r= -0.28, P<0.05). Using RT-PCR method, Leptin gene expression in different tissues including fat epidydimis, liver, and spleen showed that the intensity of leptin band with 452 bp was decreased in diabetic rats in comparison to normal rats. Actin Gene expression was identified in PCR products having 403 bp and the intensity was constant in both groups. The reduction rates of "ob" mRNA in fat epidydimis tissue in STZ diabetic rats was remarkable in comparison to Spleen and Liver.
Conclusion: It is speculated that Leptin gene could be under regulation of insulin dependent mechanism in diabetic rats and by modulating Leptin gene expression in diabetic patients, it may be useful in clinical practices.
Nosratollah Zarghami, Amir Bahrami, Majid Mobasseri, Bagher Larijani, Pooran Karimi, Behrang Alanii,
Volume 5, Issue 3 (17 2006)
Abstract
Background: Diabetes is a common endocrine disease in human kind. In most type II diabetic patients, obesity and overweight status account as the serious health problems worldwide and variety of endocrine factors well known that have regulatory role in weight balance and body composition including Leptin and IGF-I factor. The aim of this study was to examine the correlation between Leptin and IGF-I in type II diabetics and controls.
Methods: As a case- control study, 38 type 2 diabetics (20 males and 18 female with mean age 49.22) and 46 healthy controls (16 males and 30 females with mean age 49.52) are recruited. We measured the concentrations of FPG, IGF-I, HbA1C and IGFBP-3 in both groups. FPG was measured by enzymatic glucose oxidase method and Hb Gold analyzer HPLC was used to measure HbA1C. Determination of Leptin, IGF-I, IGFBP-3 and Insulin concentrations were carried out using ELIZA method. P< 0.05 was considered as statistically significant.
Results: The mean of BMI and age were not significantly different in both groups. The mean serum levels of IGF-I, Leptin, Insulin, FPG and HbA1c concentrations in type II diabetics were significantly higher than controls (P< 0.05). In males, the mean serum levels of Leptin were statistically lower than in females in both groups. There was a strong correlation between IGF-I and IGFBP-3, Leptin and insulin, IGF-I and age, and BMI with FPG in both patients and controls (P< 0.05). A reverse correlation was observed between IGF-I and HbA1c in patients and controls (P< 0.05).
Conclusion: It is speculated that based on this findings, Leptin and IGF-I system could have regulatory roles in body composition and fat content particularly in obese and overweight diabetic patients and have significant correlation with Insulin, glucose, BMI and age.
Amir Bahrami, Nosratollah Zarghami, Liela Khajehali,
Volume 6, Issue 3 (17 2007)
Abstract
Background: Type 2 diabetes mellitus is a common metabolic disorder witht increasing prevalence is increasing worldwide. C-Reactive Protein (CRP) is a marker of systemic inflammation and an independent risk factor for cardiovascular disease (CVD). The aim of this study was to elucidate the correlation between glycemic control and systemic inflammation by measuring serum CRP levels.
Methods: In this cross sectional study 136 patients with type 2 diabetes mellitus (69 females, 67 males) were recruited. In addition to measurement of CRP levels by highly sensitive methods and measurement of hemoglobin A1C effects of influencing factors on the CRP level was considered. Fasting plasma glucose was determined via the glucose oxidase method, HbA1C via HPLC, serum lipid profile enzymatically and hs-CRP with sandwich immunoassay method.
Results: The mean concentrations of CRP levels in these patients (5.2 ± 4.8 mg/L) were higher than normal range and in women greater than men (6.4 ± 5.5 vs. 3.9 ± 3.6 mg/L). Before adjusting for influencing factors the association between hs-CRP levels and hemoglobin A1C was negative but not statistically significant (r= -0.15, P=0.07). After adjusting, the association was negative and significant. (r= -0.22, P= 0.02). In this study the relation between hs-CRP and lipid profile was also determined. There was no significant relationship between the levels of hs-CRP and total cholesterol, LDL-C and HDL-C. A positive correlation between hs-CRP with serum triglyceride and triglyceride / HDL ratio was observed. However, the correlation was not significant.
Conclusion: These results demonstrate that hs-CRP levels is influenced with multiple factors, and increased hs-CRP levels in patients with type 2 diabetes mellitus can not be explained with hyperglycemia alone.
Nosratollah Zarghami, Ghorban Mohammadzadeh, Fereidoon Mamaghani, Reza Hajhosaini, Abbas Mohajeri,
Volume 6, Issue 3 (17 2007)
Abstract
Background: Leptin is a peptide strongly correlated with adiposity and is a potential determinant of obesity and its complications. The aim of this study was to evaluate the correlation between serum leptin levels and different anthropometric indices among obese women.
Methods: This analytical descriptive study consisted of 106 women with different grade of obesity (BMI ³ 25 kg/m2) and 38 women with normal weight (BMI ≤ 25 kg/m2).serum leptin and glucose levels were measured via enzyme immunoassay and glucose oxidase methods respectively.
Results: The mean (± SE) serum leptin concentrations in apparently healthy women with normal weight ,overweight, obese grade I, and obese grade II were 6.88 ± 0.56, 39.30 ± 1.73, 46.60 ±1.04, and 48.22± 3.31 ng/ml respectively. There was a dramatic increase in serum Leptin concentration when the BMI was increased. There was statistically significant differences between all groups in serum leptin concentration (P<0.001). There was a direct and significant correlation between serum leptin concentration and BMI in obese subjects (r= 0.736, P< 0.001). There was no significant correlation between leptin with age, and leptin with WHR neither in normal weight group nor in different grades of obesity groups.
Conclusion: Our findings showed that the serum leptin levels continuously raised with increasing degree of obesity and among different anthropometric indices serum leptin concentration has significant correlation with BMI.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Bagher Larijani,
Volume 7, Issue 1 (18 2007)
Abstract
Background: Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models but its relevance to human diabetes remains uncertain. The aim of this study was to investigate the relationship between serum resistin concentrations with insulin resistance and obesity indices in type 2 diabetes and non-diabetic obese subjects.
Methods: As a case- control study 35 obese subjects with type 2 diabetes (age, 44.60 ± 6.39yr BMI, 34.23±3.92 kg/m2) and 35 obese non-diabetics (age, 43.14±9.13yr BMI, 35.54 ± 4.07 kg/m2) are recruited. Fasting lipid profile was measured by enzymatic methods. NycoCard HbA1c Kit was used to measure HbA1c.The Serum resistin, insulin and glucose levels were measured by an enzyme immunoassay using a commercially available kit and glucose oxidase methods respectively. The insulin resistance index was calculated from fasting glucose and insulin by the homeostasis model assessment (HOMA-IR) formula.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetics were significantly higher than non-diabetics subjects (P<0.05). Serum resistin concentrations were not different between diabetics and non-diabetics obese subjects but were significantly higher in women as compared to men (8.15±4.40 vs. 5.97±2.31 in non-diabetic) and (7.46±3.98 vs. 5.51±3.98 in diabetic) in both groups. Serum resistin was not significantly related to variables measured in both groups. In control group only, we observed a significant and negative correlation between diastolic blood pressure and resistin (r = -0.381 P = 0.024).
Conclusion: Serum resistin concentrations were not significantly different between type 2 diabetes and non-diabetic obese subjects and resistin is unlikely to be a major link between obesity and diabetes in humans.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Amir Bahrami, Baghar Larijani,
Volume 7, Issue 2 (17 2007)
Abstract
Background: Adiponectin is an adipose tissue-derived hormone that low levels of this hormone are associated with obesity, insulin resistance, and type 2 diabetes. The aim of this study was to compare the serum levels of adiponectin in diabetic and non-diabetic obese individuals.
Methods: As a cross-sectional study 35 obese individuals with type 2 diabetes mellitus and 35 non-diabetic obese subjects were enrolled. Two groups were matched for age, gender and body mass index. Fasting lipid profile was measured via the enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c.The Serum Adiponectin, insulin and glucose levels were measured via an enzyme immunoassay, using a commercially available kit and glucose oxidase methods, respectively. The HOMA and QUICKI indices were used to determine insulin resistance and insulin sensitivity, respectively.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetes were significantly higher than non-diabetics (P<0.05). The serum Adiponectin levels was significantly lower in diabetes than non-diabetics (15.74±6.70 vs. 21.52 ± 9.35) and was significantly higher in women than men (19.38 ± 7.33 vs. 12.68 ± 4.28) among diabetic and (24.63 ± 10.52 vs. 17.83 ± 6.21) among non-diabetics groups.
Conclusion: type 2 diabetes mellitus is associated with low serum adiponectin concentrations and probably adiponectin involved in the pathophysiology linking obesity to type 2 diabetes.
Toktam Mahmudzadeh, Marziyeh Saghebjoo, Ali Seghatol Eslami, Mehdi Hedayati,
Volume 13, Issue 3 (3-2014)
Abstract
Background: Diabetes is considered as one of the health problems in all societies. Exercise training
and drug interventions, especially herbal medicines, consider as approaches to improving diabetes.
The objective of this study was to investigate the effect of 6 weeks of aerobic training and Pistacia
atlantica extract consumption on pancreatic β-cells function in streptozotocin-induced diabetic rats.
Methods: Thirty six male Wistar rats divided into five groups: normal control, diabetic control,
diabetes+aerobic training, diabetes+extract, diabetes+aerobic training+extract. Diabetes was induced
by intra-peritoneal injection of streptozotocin (40mg/kg). Exercise program was include 6 weeks of
aerobic training on a treadmill (5 sessions per week, 40 minutes per session, with a speed of 20m/min
and 5% incline). Extract groups were received Pistacia atlantica extract based on body weight, at the
end of each training session. After 6 weeks of aerobic training and Pistacia atlantica extract
consumption, plasma glucose and insulin levels were measured for determination of β-cells function
(HOMA-B). Data were analyzed via ANOVA, with a significant level P<0.05.
Results: HOMA-B index in diabetic control group was significantly higher than normal control group
(P=0.0001). Also mean of HOMA-B index in diabetes+extract and diabetes+exercise training+extract
groups was significantly lower than diabetic control group (P values 0.003, 0.001 respectively) and
between mean of HOMA-B index in diabetic control group with diabetes+aerobic training group were
observed no significant differences (P=0.052).
Conclusion: The results of this study showed that Pistacia atlantica extract consumption, alone and
along with aerobic training leads to significant improvement in pancreatic β-cells function in diabetic
rats. Also extract consumption along with aerobic training in comparison to training alone has had
greater impact on the improvement of pancreatic β-cells function. It seems that aerobic training along
with the use of specific herbal plants can be considered as a complementary therapy in improvement
of diabetics.
Ghazale Valipur, Zatollah Asemi, Mansooreh Samimi, Zohreh Tabassi, Sima-Sadat Sabihi Sabihi, Parvane Saneei, Ahmad Esmaillzadeh,
Volume 13, Issue 4 (5-2014)
Abstract
Background: There are no available reports indicating the effects of Dietary Approaches to Stop Hypertension (DASH) eating plan on insulin resistance, inflammation and oxidative stress among pregnant women with gestational diabetes mellitus (GDM) We aimed to investigate the effects of DASH diet on insulin resistance, serum hs-CRP and biomarkers of oxidative stress among pregnant women with GDM.
Methods: This randomized controlled clinical trial was performed among 32 pregnant women diagnosed with GDM at 24-28 weeks' gestation. Subjects were randomly assigned to consume either the control (n=16) or DASH diet (n=16) for 4 weeks. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fats, total fats, cholesterol, refined grains, and sweets, with a total of 2400 mg/d sodium. The control diet contained 40-55% of its energy as carbohydrates, 10-20% as proteins and 25-30% as total fats. Fasting blood samples were taken at baseline and after 4 weeks of intervention to measure fasting plasma glucose (FPG), serum insulin and hs-CRP, HOMA-IR, plasma total antioxidant capacity (TAC) and total glutathione levels (GSH).
Results: Consumption of DASH diet, compared to the control diet, resulted in decreased FPG (-7.62 vs. 3.68 mg/dL P=0.02), serum insulin levels (-2.62 vs. 4.32 µIU/ml, P=0.03) and HOMA-IR score (-0.8 vs. 1.1 P=0.03). Increased concentrations of plasma TAC (45.2 vs. -159.2 mmol/L P<0.0001) and GSH (108.1 vs. -150.9 µmol/L P<0.0001) were also seen in the DASH group compared with control group. We failed to find a significant difference in mean changes of serum hs-CRP levels between the two diets. Within-group comparisons revealed a significant reduction in plasma TAC and GSH levels in the control diet, while a significant rise in these biomarkers in the DASH diet.
Conclusion: In summary, consumption of DASH diet in pregnant women with GDM had beneficial effects on FPG, serum insulin levels, HOMA-IR score, plasma TAC and total GSH levels. The effects of this dietary pattern on pregnancy outcomes need to be investigated in future studies.
Mehdi Sadeghian, Zatollah Asemi, Maryam Karamali, Parvane Saneei, Esmaillzadeh Ahmad ,
Volume 15, Issue 1 (1-2016)
Abstract
Background: This study was designed to assess the effects of calcium and vitamin D supplementation on the metabolic status of pregnant women with gestational diabetes mellitus (GDM).
Methods: This randomized placebo-controlled trial was performed at maternity clinics affiliated to Kashan University of Medical Sciences, Kashan, Iran. Participants were 56 women with GDM at 24–28 weeks gestation (18 to 40 years of age). Subjects were randomly assigned to receive calcium plus vitamin D supplements or placebo. All study participants were blinded to group assignment. Individuals in the calcium–vita- min D group (n = 28) received 1,000 mg calcium per day and a 50,000 U vitamin D3 pearl twice during the study (at study baseline and on day 21 of the intervention), and those in the placebo group (n = 28) received two placebos at the mentioned times. Fasting blood samples were taken at study baseline and after 6 weeks of intervention.
Results: The study was completed by 51 participants (calcium–vitamin D n = 25, placebo n =26). However, as the analysis was based on an intention-to-treat approach, all 56 women with GDM (28 in each group) were included in the final analysis. After the administration of calcium plus vitamin D supplements, we observed a significant reduction in fasting plasma glucose (p < 0.001), serum insulin levels (p = 0.02) and HOMA-IR (p = 0.001) and a significant increase in QUICKI (p = 0.003) compared with placebo. In addition, a significant reduction in serum LDL-cholesterol (P=0.02) and total cholesterol: HDL-cholesterol ratio (p = 0.003) and a significant elevation in HDL-cholesterol levels (p = 0.01) was seen after intervention in the calcium–vitamin D group compared with placebo. In addition, calcium plus vitamin D supplementation resulted in a significant increase in GSH (p =0.03) and prevented a rise in MDA levels (p = 0.03) compared with placebo.
Conclusion: Calcium plus vitamin D supplementation in women with GDM had beneficial effects on their metabolic profile.
Malihe Akbari Abdolabadi, Bahram Mohebbi, Roya Sadeghi, Azar Tol, Mahmood Mahmoudi Majdabadi,
Volume 16, Issue 1 (1-2017)
Abstract
Background: Overcoming barriers associated with diabetes is considered a logical infrastructure to empower diabetic patients in management of living with diabetes and identify factors which affect these barriers. This study aimed to determine the effect of an educational intervention based on the BASNEF model on barriers to awareness, lifestyle, adaptation, and support in living with diabetes in patients with type 2 diabetes and it's related factors.
Methods: This was a quasi-experimental study which. Performed among 168 patients with type 2 diabetes referred to health centers of Beheshti University of Medical Sciences from August to September 2014. Before the educational intervention, questionnaires of life barriers and the BASNEF structures were completed. After pre-test, the patients were randomly allocated to the case and control groups based on randomizing four block design. Only in the intervention group patients received six education sessions of 45 to 60 minutes that fifth education session with their families, and related staff. The educational program was designed based on the BASNEF constructs (Knowledge, attitude, subjective norm, enabling factors and behavioral intention), and educational content was developed based on the barriers to living with diabetes (awareness, lifestyle, adaptation, and protection). Data analyzed Spss stafware version 20 utelized to data analysis using statistical tests such as independent sample t-test, paired t test, Wilcoxon, McNemar test, and Mann-Whitney U
Results: Our findings showed that there was a significant difference between a score received on components of barriers to of living with diabetes (awareness, lifestyle, adaptation, and protection) and variable of the BASNEF model (knowledge, attitude, subjective norm, enabling factors and behavioral intention) before and after the educational intervention the significant level was set less than 0.05 (P<0.05).
Conclusion: Education in type 2 diabetic patients based on BASNEF, as a model for effective education, can lead to dimensions barriers reduction in (awareness, lifestyle, adaptation, and protection).
Azar Tol, Bahram Mohebbi, Roya Sadeghi, Mehdi Yaseri, Malihe Akbari Abdolabadi, Fateme Dadrast, Parvin Abassi Borojeni,
Volume 16, Issue 1 (1-2017)
Abstract
Background: Improving self-care behaviors happened by self-efficacy which result in better quality of life. Current study aimed at assessing the perceived coping self-efficacy predictors among patients with type 2 diabetes referees to health centers affiliated to Tehran University of Medical Sciences.
Methods: In this cross sectional study which was descriptive and analytical one, perceived coping self-efficacy and its effective factors assessed among 536 type 2 diabetic patients referee to Tehran University of medical Sciences using random sampling based on 11-likert scale questionnaire. This questionnaire included 11 items in demographic variables and 24 items in perceived coping self-efficacy. Collected data analyzed by SPSS version 23 using MANCOVA.
Results: Study findings revealed that age (P=0.013), level of education (P<0.036), and HbA1c (P=0.004) had significant relation with total score of perceived coping self-efficacy. But, variables such as gender, occupation, disease duration, marital status, family history and history of chronic disease had no relation with scales of perceived coping self-efficacy.
Conclusion: Planning theory based intervention programs to improve coping self-efficacy among diabetic patients in low socioeconomic status population and poor diabetes control is recommended.
Nasimeh Sadat Razavi, Fereshteh Majlessi, Bahram Mohebbi, Azar Tol, Kamal Azam,
Volume 16, Issue 3 (3-2017)
Abstract
Background: Patient’s adherence to treatment regimen can predict treatment plan and decrease intensity and symptoms of sickness. This study aimed at determining the effect of educational intervention based on AIM (Ability, Information, Motivation) model on improving adherence of patients with type 2 diabetes.
Methods: This semi experimental interventional study was performed on 180 patients with type 2 diabetes as intervention and control groups. The patients selected using simple random sampling. Study instrument was a questionnaire including demographics (14 items) and AIM model questionnaire (10 items about information, 9items about motivation, 6 items for ability). After baseline, educational intervention was performed in intervention group and post test conducted after six months for both groups. Collected data was analyzed with SPSS software version 23using Mann–Whitney U, Wilcoxon and chi-squared tests. The significant level was considered less than 0.05.
Results: There was no significant difference in demographics and AIM model constructs between two groups (p>0.05). After educational intervention, intervention group revealed a significant difference with control group in terms of information (P<0.001), motivation (P<0.001), ability (P<0.001) and level of HbA1C (P<0.001).
Conclusion: study results revealed AIM model based educational intervention has an important role on treatment adherence among type2 diabetic patients. With increasing patient information and belief regarding disease patient’s motivation will be improved.
Negar Fani, Bahram Mohebbi, Roya Sadeghi, Azar Tol, Ahmadreza Shamshiri,
Volume 17, Issue 1 (3-2018)
Abstract
Background: Adherence to diet is one of the basis of diabetes management in patients with diabetes. Regarding to diabetes control, healthy lifestyle including nutritional behaviors, play an important role in preventing and managing diabetes. However, compliance with a diabetic diet is one of the most important challenges in diabetes control. This study aimed at determining the effect of educational intervention on promoting nutrition adherence among patients with type 2 diabetes referee to south health center of Tehran University of Medical Sciences based on Health Belief Model.
Methods: This interventional study was performed with216 type 2 diabetes patients as population study who referred to health centers in south of Tehran. Participants were randomly allocated to intervention and control groups.
Questionnaires were completed by both groups at baseline, three and six months after intervention. Intervention group received intervention including during the month, six training sessions for 45 to 60 minutes for group training and Q & A With the package held at meetings to assess the diabetes-related complications. SPSS software version 22 utilized to data analysis using t-test and repeated measure analysis. Significance level was set less than 0.05.
Results: Before the intervention, demographics and HBM constructs model were not significantly different in two groups. In intervention group, there were statistically significant differences between all parts of HBM after educational intervention (perceived susceptibility (p <0.001), perceived severity (p <0.001), perceived benefits (p <0.001), perceived barriers (p <0.001), cues to action (p <0.001)), also nutrition adherence (p <0.001) and HbA1c. there was no significant differences in control group after intervention.
Conclusion: According to study results, it can be concluded that education through Health Belief Model can be effective to follow in terms of improved nutrition among patients with type 2 diabetes.
Maryam Zangeneh, Nahid Mohamadi, Tahereh Kolahi, Ghodratolah Roshanei, Masood Khodaveisi, Arezoo Shayan,
Volume 17, Issue 3 (3-2018)
Abstract
Background: Gestational diabetes is one of the most common metabolic disorders during pregnancy. The purpose of this study was to determine Prevalence of Gestational Diabetes Mellitus in Pregnant Women Referred to Therapeutic and Health Centers in Hamadan Town.
Methods: This descriptive-sectional study was done in the year2014 on 620 pregnant women Referred to The health Centers in Hamadan Town. The necessary information was collected by means of a self-made
Questionnaire. The scientific validity of the questionnaire Comments 15 members of the faculty of nursing and midwifery. The necessary amendments were made. To determine the reliability question a pilot study on 10 patients was performed twice with an interval of 10 days and offer 0/91 reliability was confirmed Then the data was analyzed by using SPSS software, independent Fisher test, Chi-square and a=0.05 was taken as the significant level.
Results: 110 of the 620 cases studied (almost 17.1%) suffered from gestational diabetes mellitus and 38 cases of all (almost 6.1%) had overt diabetes. Mean age of the pregnant women was30.6±5 and BMI25.3±4.1 their mean number of pergment was 1.6±0.8. Increasing the hours of mother's work at home, body mass index, household size, number and history of abortion, number of pregnancies and delivery, and the history of diabetes in the family, the chance of having diabetes also significantly increases (P<0.05).
Conclusion: Regarding the great importance of gestational diabetes and its complications on the fetus, diabetes preventive practices demand special attention to pregnant women Regarding the trend of increasing the incidence of pregnant women to gestational diabetes mellitus and the effect of demographic and obstetric factors on its development, screening for women before admission for diabetes and healthy lifestyle education is recommended.
Zohreh Fatollahian, Amirabbas Monazzami, Vahid Tadibi, Ali Mostafaei,
Volume 19, Issue 3 (2-2020)
Abstract
Background: The purpose of this study was to investigate the effect of concurrent training on pre-inflammatory (IL-1β, TNF-α) and anti-inflammatory (IL-10) cytokines gene expression in women with type2 diabetes.
Methods: 18-patients (age30-38, >130 glycemic index) were selected, randomly, and divided into control (n=6) the concurrent training(diabetes, n=6) and the concurrent training (healthy, n=6) groups. The concurrent training protocol consisted of 3 sessions resistance training per week, 8sets with 80% one maximum repetition(
and the endurance training preformed with 30- minutes running (3sets×10 minutes) on a treadmill with 70-80 maximum heart rate(70-80 MHR), immediately. The leukocyte
’s IL-1β, TNF-α and IL-10 genes expression determined by the Real time-PCR technique. The quantitative expression of the cytokines gene was calculated using the 2
-ΔΔ CT method. The between- groups differences in variables were determined by independent t-test (permutation test) through REST software and independent one-way ANOVA.
Results: The results showed that IL-1β, TNF-α mRNA genes expression reduced significantly after the concurrent training in both the training groups in comparison to the control group (P<0.05). In addition, the results also showed that IL-10 mRNA gene expression was not expressed in leukocytes after the concurrent training in both training groups in comparison to the control group (P>0.05).
Conclusion: In conclusion, the results suggest that the concurrent training modulate IL-1β and TNF-α mRNA genes expression significantly in diabetic women but could not change IL-10 genes expression. This type of exercise training seems to be more effective in reducing the expression of pro-inflammatory cytokines than in enhancing anti-inflammatory cytokines.
Seyedeh Sogand Hosseini, Mohammedreza Esmaelzadeh Toloee,
Volume 21, Issue 1 (3-2021)
Abstract
Background: TORC1 protein is an important factor in regulating adipose tissue metabolism. Type 2 diabetes can lead to dysfunction and the development of obesity. Therefore, the aim of the present study was to investigate the effect of eight weeks of high-intensity
interval training (HIIT) and endurance on blood
glucose and TORC1 protein content in subcutaneous adipose tissue of obese with type 2 diabetes rats.
Methods: In this study, 18 head 2 Sprague-Dawley male rats with a mean weight of 270±30 g were selected. After becoming type 1 diabetic through streptozotocin and Nicotine amide solution, they were randomly divided into 3 groups: 1) HIIT training 2) endurance training and 3) control (6 heads per group). Exercise groups exercised 4 days a week for 8 weeks according to HIIT and endurance training programs. SPSS software version 23, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Result: Eight weeks of HIIT and endurance training resulted in a significant decrease in blood glucose level (p<0.0001) and a significant increase in TORC1 protein content (P<0.0001) compared to the control group.
Conclusion: HIIT and endurance training lowered blood glucose levels and increase TORC1 protein content, which this training can be a suitable and non-invasive treatment to control diabetes and also regulate adipose tissue metabolism in type 2 diabetics who are prone to obesity.
Ms. Khadigeh Zameni Jafarkolaei, Dr. Mohammadreza Esmaelzadeh Toloee,
Volume 24, Issue 5 (12-2023)
Abstract
Abstract
Background: This study aimed to compare the effects of high-intensity interval games and high intensity interval training on body composition indicators, aerobic capacity and lipid profiles of obese and overweight girls aged 10 to 12 years.
Methods: In this semi-experimental research, 30 girls (average height 149.26 ± 5.32 m, weight 67.41 ± 7.65 kg, and body mass index 30.14 ± 2.3 kg/m2) with overweight and obesity participated and were randomly divided into the groups of high intensity interval training (10), high intensity interval game (10) and the control (10). Training programs for eight weeks(3d/w), (90-85% of maximum heart rate) and 3-minute recovery (65-75% of maximum heart rate) with 4 times Repetition was done, which was done in the form of running in high intensity interval training and in the form of playing in high intensity interval game. Blood samples were taken to measure the serum levels of lipid profiles (48 hours before and after the intervention period).
Results: The two training groups compared to the control group, increased aerobic capacity and HDL and body fat percentage, TG, TC and LDL (P < 0.010) showed a significant decrease and between the two training groups in TG, LDL and HDL (P<0.01) was a significant difference, with a greater increase in HDL and a greater decrease in TG and LDL was accompanied in the high intensity game group.
Conclusion: High intensity interval games can be suggested as a more suitable solution to improve the lipid profile of obese and overweight girls.
