Showing 5 results for Valipour dehnou
Zahra Nourollahi, Vahid Valipour Dehnou, Rasoul Eslami,
Volume 18, Issue 4 (4-2019)
Abstract
Background: Physical activity is an effective stimulant for improving the health of elderly people with metabolic syndrome by increasing energy consumption and thus reducing body fat. The purpose of this study was to investigate the effect of 8 weeks of high intensity circuit training (HICT) on serum BDNF and Irisin levels and body weight in elderly women with metabolic syndrome in Khorramabad city.
Methods: In this semi-experimental study, 18 females (age 71.00 ± 6.17 years; weight 62.22 ± 9.18 kg; height 153.67 ± 3.27 cm) with metabolic syndrome voluntarily participated. During their daily routine, the subjects participated in an 8-week HICT protocol that performed 3 sessions per week. 24 hours before the training protocol and 48 hours after the training protocol, the fasting blood sample was taken by the laboratory expert between 7:30 minutes to 8 hours. ELISA kits were used to measure serum levels of BDNF and Irisin. The paired-Samples T test was used to identify any significant differences and statistical significance was set at p < .05.
Results: The results showed a significant increase in serum BDNF (p = .001) and Irisin (p = .033) levels and significant decrease in body weight (p = .001) in comparison with pre-test values in elderly women with metabolic syndrome.
Conclusion: High intensity circuit training in elderly women with metabolic syndrome increases serum BDNF and Irisin concentrations and possibly, the increase in these two factors can have beneficial effects on the lipid profile and finally body weight of these individuals.
Mohammad Sharif Bagheri, Vahid Valipour Dehnou, Ahmad Hematfar,
Volume 18, Issue 6 (9-2019)
Abstract
Background: Increased expression of HDAC5 reduces the expression of GLUT4 in slow-twitch fibers, and this mechanism has not been studied in diabetes. Therefore, the purpose of study was to investigate the effect of six weeks endurance training on protein levels of GLUT4 and HDAC5 in soleus muscle in diabetic rats.
Methods: For this purpose, 32 male Wistar rats (weight: 245±9.4 g) were randomly divided into 4 groups: diabetic, diabetic and training, training, and control. At 8 weeks of age, diabetes was induced by streptozotocin. The endurance training was carried out five times per week for 6 weeks. 24 hours after the completion of the protocol, the mice were sacrificed and their soleus muscle was extracted. Then, the protein levels of GLUT4 and HDAC5 were measured using ELISA method. One-way ANOVA was used to analyze the data at a significant level of P<0.05.
Results: Results showed significant differences between control and training (P=0.008), training and diabetic training (P=0.004), and training and diabetic (P=0.0005) groups in GLUT4 levels. But, in HDAC5, results showed that there is not significant differences only between control and training groups (P=0.99), and there are significant differences among other groups (P<0.05). Also, there is a significant inverse relationship between the protein levels of GLUT4 and HDAC5 (P=0.012, r =-0.439).
Conclusion: It seems that six weeks moderate intensity endurance training increases protein levels of GLUT4. But endurance training only can decreases protein levels of HDAC5 in diabetes.
Saeed Naimi, Vahid Valipour Dehnou, Masoud Moeini,
Volume 22, Issue 6 (3-2023)
Abstract
Background: One of the complications of type 2 diabetes is the development of neurocognitive disorders, and DCX and AMPA may be involved in this disorder. Therefore, this study aimed to investigate the effect of aerobic exercise on the DCX and AMPA in the hippocampus of rats with type 2 diabetes.
Methods: 32 eight-week-old male rats were divided into control (C), diabetes (D), diabetes-exercise (DT), and exercise (T) groups. Diabetes was induced by streptozotocin injection. The exercise was carried out for six weeks. Finally, the rats were dissected, and their hippocampus tissue was extracted. Proteins were measured by the ELISA method.
Results: There was nonsignificant difference between the DCX of the C group and the T and DT groups (p>0.05). But there was a significant difference between the DCX of the C and diabetic groups (p =0.05). Also, a significant difference was observed between the diabetic groups and the T group (p<0.05). AMPA in diabetic groups were significantly lower than in C and T groups (p<0.05) While the difference between C and T groups and D and DT groups was not significant (p>0.05). Also, a significant negative correlation was observed between AMPA and DCX with blood glucose.
Conclusion: Diabetes reduces the AMPA and DCX but exercise nonsignificantly reduces the effect of diabetes on those. According to the appropriate duration of exercise, there is a possibility that due to the significant negative correlation between these proteins and glucose, the intensity of exercise can significantly reduce the negative effect of diabetes on those.
Somaye Emamrezaee, Vahid Valipour Dehnou, Aliyavar Azizpour Fard,
Volume 23, Issue 6 (1-2024)
Abstract
Background: BDNF decrease, and HbA1c and Asprosin increase in diabetic people and exercise can reverse these effects, but the effect of vigorous exercise on Asprosin and BDNF in elderly diabetic people have not been investigated. Therefore, the aim of the present study was to investigate the effect of high-intensity functional exercise on Asprosin and BDNF and their relationship with glucose and HbA1c in elderly diabetic men and women.
Methods: In this semi-experimental study, 24 elderly diabetic men and women (age: 67.25 ± 5.84, BM: 70.29 ± 13.01, height: 160.92 ± 10.29) participated. The initial blood sample was taken while fasting. After 90 minutes, the subjects performed the exercise for 50 minutes. The second blood sample was taken 10 minutes after the high-intensity functional exercise. BDNF, Asprosin, HbA1c, and glucose levels were measured by ELISA method. To analyze the data, T-tests, covariance and Pearson's correlation coefficient were used.
Results: Asprosin and BDNF decreased (P< 0.0005) and increased (P< 0.0005), respectively in both groups. There was no significant difference between Asprosin and BDNF in elderly diabetic men and women in pre-test and post-test (P> 0.05). There was a significant negative correlation between BDNF with Asprosin, HbA1c and glucose and a significant positive correlation between Asprosin with HbA1c and glucose (P< 0.05).
Conclusion: Vigorous exercise decrease and increase Asprosin and BDNF in elderly diabetic men and women, respectively. Also, considering the significant negative relationship between BDNF with glucose and HbA1c and the significant positive relationship between Asprosin with glucose and HbA1c, it seems that vigorous exercise by reversing the changes of asprosin and BDNF causes possible improvement in levels of glucose and HbA1c.
Dr Vahid Valipour Dehnou,
Volume 24, Issue 5 (12-2023)
Abstract
Background: The effects of saffron extract and resistance training on some diabetes indices have been determined, but their combined effect on BDNF levels in rats with type 2 diabetes has not been investigated. Therefore, this study aimed to investigate the effect of saffron extract during resistance training on BDNF levels in the hippocampus of rats with type 2 diabetes.
Methods: In this experimental study, 30 adult male rats were divided into five groups: control (C), diabetes (D), diabetes-resistance training (DT), diabetes-saffron extract (DS) and diabetes-saffron extract- resistance training (DTS). Resistance training performed five sessions/w for six weeks. Blood glucose levels and hippocampus BDNF levels were measured. Data was analyzed using one-way ANOVA at the significance level of p<0.05.
Results: Blood glucose levels of all groups were significantly higher than C group (p=0.001). Blood glucose levels in DT, DS and DTS groups were significantly lower than D group (p=0.001). Also, the blood glucose levels of the DTS group was significantly lower than that of the DT group (p=0.014). However, BDNF levels of all groups were significantly lower than C group (p<0.05). Also, BDNF levels of D, DT and DS groups were significantly lower than DTS group (p<0.05). However, BDNF levels of D, DT and DS groups were not significantly different (p<0.05).
Conclusion: Resistance training also saffron extract alone and during resistance training reduce blood glucose levels in diabetic rats. However, saffron extract increases BDNF levels only during resistance training. Therefore, for more efficiency, saffron extract should be consumed during resistance training.
