Showing 3 results for Vassigh
Hossein Fakhrzadeh, Peyman Faridnia, Mehrzad Bahtouei, Mostafa Mohaghegh, Rasool Pourebrahim, Reza Baradar-Jalili, Ali-Reza Vassigh, Masoomeh Nouri,
Volume 1, Issue 2 (18 2002)
Abstract
Introduction: In order to determine the relationship between serum lipid profile and diabetes mellitus as well as other cardiovascular risk factors, we carried out a cross-sectional study of 1255 oil industry workers at the Kharg Island oil terminal.
Methods: Increased levels of total cholesterol (TC≥200mg/dl), triglyceride (TG≥200mg/dl), and low-density lipoprotein (LDL≥130mg/dl) were seen in 32.7%, 39.5% and 18.5% of the workers, respectively. Decreased levels of high-density lipoprotein (HDL<40mg/dl) were seen in 13.1% of workers. 61.3% of the workers had a body mass index (BMI) ≥25kg/m2. Visceral obesity (waist circumference >100cm) was seen 32.4% of workers.
Results: There was a direct and significant relationship between TC levels and BMI (p<0.001), and between TG levels and BMI (p<0.0001). The same correlation existed between waist circumference and both TC (p<0.02) and TG (p<0.06). There was also a direct correlation between LDL levels and waist circumference (p<0.04). 10.6% of workers had some disorder of glucose metabolism. There was a direct correlation between diabetes and both TC and HDL levels (p<0.04 and p<0.05, respectively). 42.4% of workers smoked and 57.4% had a sedentary lifestyle. There was a trend toward lower blood glucose and cholesterol levels as the level of physical activity increased (p=0.1 and p=0.08, respectively). There was a significant difference between blue- and white-collar workers in the prevalence of excess weight, visceral obesity, diastolic hypertension, diabetes and cigarette smoking, but not serum lipid profile and level of physical activity.
Conclusion: The significant prevalence of dyslipidaemia and other cardiovascular risk factors in the oil workers of Kharg Island requires systematic preventive interventions to reduce cardiovascular mortality and morbidity in this population.
Bagher Larijani, Nariman Mossafa, Peyman Shoshtarizadeh, Mehdi Nouraei, Ebrahim Javadi, Ali-Reza Shafaei, Ali-Reza Vassigh,
Volume 2, Issue 1 (17 2003)
Abstract
Background: Diabetes is a hidden epidemic and the most common metabolic disorder in the world. Immune dysfunction (cellular and humoural) is one of the consequences of diabetes, including defects of phagocyte function, notably in chemotaxis, phagocytosis, and killing. Results of studies on phagocyte respiratory burst activity, however, have been contradictory. We studied the respiratory burst of peripheral blood neutrophils and monocytes separately in response to formyl-met-leu-phe (fmlp) and phorbol-12,13-myristate acetate (PMA).
Methods: 36 patients with type 2 diabetes (mean age 53±7 years) and 20 healthy controls (mean age 50±5 years) each provided a 15ml blood sample. Peripheral blood neutrophils and monocytes were separated and purified (>95%) using specific density gradients and short-term culture. We then separately assessed respiratory burst activity in response to fmlp and PMA by the semi-quantitative nitroblue tetrazolium (NBT) test.
Results: Following stimulation with PMA, diabetic neutrophils showed reduced respiratory burst activity compared with normal neutrophils (p=0.097). Following stimulation with fmlp, too, diabetic neutrophils showed reduced respiratory burst activity compared with normal neutrophils, which this time was statistically significant (p=0.027). There was no difference between diabetic and normal subjects with regards to monocyte response to either fmlp or PMA.
Conclusion: It appears that the diminished response and reduced effectiveness of the phagocyte system in people with diabetes can facilitate the onset, exacerbation, and persistence of infection.
Hossein Fakhrzadeh, Iraj Nabepoor, Mohammad Rayani, Ali-Reza Vassigh,
Volume 2, Issue 1 (17 2003)
Abstract
Background: We estimated the prevalence of angina pectoris (AP) and myocardial infarction (MI) in the hyperlipidaemic population of Bushehr using the ROSE questionnaire and ECG changes using the Minnesota code.
Methods: 1036 residents of Bushehr (in southern Iran), aged 30-64 years, were enrolled as part of a 2-year cross-sectional prevalence study of diabetes mellitus and other risk factors for coronary heart disease. All participants completed a ROSE questionnaire and underwent 12-lead electrocardiography. ECG strips were interpreted according to the Minnesota code. The criteria for diagnosing AP was grade 1 or 2 on the angina pectoris diagnostic scale, and for MI, code 1.1 of the Minnesota code or a history of myocardial infarction. Results: The crude prevalence of hypercholesterolaemia was 47.6%, and its age-adjusted prevalence 50.3% in women and 43.9% in men. Mean serum cholesterol was 204.2±49.5mg/dl in women and 195.0±46.1 in men (p=0.003). The prevalence of AP was 4.9%, which, after adjustment for age, came to 5.6% in men and 4.6% in women. The prevalence of AP was 6.3% in subjects with high cholesterol and 3.6% in subjects with normal cholesterol levels (p<0.05). There was a strong association between AP and hypercholesterolaemia in men (p<0.0005). The crude prevalence of MI was 4.1% in subjects with hypercholesterolaemia and 0.9% in subjects with normal cholesterol (p<0.05). In multivariate analysis, MI was correlated with hypercholesterolaemia in both sexes (p<0.05). Similarly, MI in both men and women was associated with diabetes, and in men alone with hypertension (p<0.05). Conclusion: It is imperative to reduce the average cholesterol level of the population of Bushehr in order to decrease the incidence of AP and, ultimately, MI. Interventions to improve people s lifestyle are of one of the effective measures that may be used in this regard.
