Iranian Journal of

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Background: Polycystic ovary syndrome(PCOS) is the most endocrinopathy in women and the most common causes of anovulatory infertility. Women with this disorder moreover the common manifestations such as,irregular menses, hirsutism and infertility, are susceptible to serious consequences like increase risk of endometrial carcinoma, dyslipidemia, hypertention, glocose intolerance, diabetes, cardiovascular problems and probably breast cancer. This study was conducted to demostrate the demographic, clinical,metabolic and hormonal conditions of the PCOS patients. Methods: A case-control study was performed on females with PCOS age group 15-40 years referring to endocrine and gynecology clinics. A control healthy woman was selected for each patient. The diagnosis of PCOS was made based upon the prescence of chronic anovolation and hyperandrogenemia .Other causes of hyperandrogenism were excluded by appropriate clinical and laboratory evalution .In all patients with PCOS and control women, appropriate medical history was taken and physical examination was done.Blood pressure ,body weight, height ,BMI,waist/hip ratio,score of hirsotism,acne, and other signs of androgen excess were determined.A venous blood sample were obtained at morning after 12_14hours fasting for measuring FBS, TG, Chol., LDL, HDL and hormonal profile,souch as:PROL,17_OH Progestrone,Te,DHEA-S and TSH.Case of late onset adrenal hyperplasia ,hypotyroidism and pituitary prolactinoma were excluded.The diagnosis of dyslipidemia was made upon the base of NCEP guidelines.Data was analyzed with Mann_Whitney U,T tests and Fisher’s and Chi_Square Tests with SPSS-11. Results: Mean age were similar in both patients and controls.Mean of BMI and diastolic pressure were significantly higher in PCOS women in comparison with controls . Hirsutism and oligomenorrhea were the most frequent clinical features(72.7% and 69.1% respectively). SerumTG level was significantly higher in PCOS women in comparison with controls.There were no significant difference in FBS,Chol,LDL and HDL between patients and controls. The prevalence of high triglyceride ,high cholesterol and high LDL levels were significantly higher in PCOS women in comparison with controls,but there were no significant difference in the prevalence of IFG and low HDL levels. The prevalence of high TG and high Chol level were significantly higher in obese PCOS women in comparison with non obese patients.There was no significant difference in the prevalence of high LDL and low HDL levels between obese and nonobese patients. Serum level of total Testostrone was significantly higher in PCOS women in comparison with controls.There were no significant difference in serum levels of DHEA-S,17-OH Progestrone, Prolactine and TSH between patients and controls. Conclusion: The prevalence of obesity and dyslipidemia were higher in PCOS women in comparison with healthy women. For obese women with PCOS ,behevioral weight management is the main component of overall treatment strategy and these patients counseling about the importance of life style management ,diet and exercise shoud be emphasized. The patients should screened for dyslipidemia, diabetes and hypertension. In this study there was no significant difference in FBS between two groups and IGT and DM may be better detected by OGTT. In all PCOS women for detecting dyslipidemia a fasting lipid profile is indicated

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Objective: Health of old people is one of the critical issues in many societies that needs to accurate health policy making and adjust planning in health issues of elderly. The present study designed to compare the efficacy of the two traditional and electronic training methods in nutritional issues in order to life style modification in old people to develop of healthy elderly. Methods: This survey was a quasi-experimental method via applying the Pre-test and Post-test among 65+ years old people in a retirement association of Sari province, Mazandaran state. By simple random sampling method, 60 old people were selected, and then trained in two separated classes to 15 persons as women and men (30 persons) via film technique. The other method was a traditional which applied in the two separated classes of 15 persons as women and men (30 persons) by book technique. The questionnaire applied to measure of nutritional knowledge made up by the health center. Data were described by using SPSS software in accordance to descriptive statistics indexes (mean and standard deviation), and inferential statistics indexes (independent T and dependent T) were used in order to generalize results. Findings: The mean score of increasing knowledge in training group by film was 18/57 and the mean score in training group by book was 16/90 (T =5/299, df= 58). To satisfaction evaluating, the mean score in training group by film was 59 and the mean score in training group by book was 35/73 (T =1/96, df=58). Conclusion: Based on results training of old people by electronic method as a film is more effective than traditional method to increasing of nutritional knowledge in elderly. On the other hand, they had more satisfaction to life style modification by using film method in comparison with traditional method as book reading technique. Also, the training cost of the elderly via educational film is lower than training by book. So, should be suggested to consider in training by film rather than book as an efficient and effective method to improve of elderly health.

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Introduction: The height measurements in the elderly are associated with several problems. In this study we used a model to predict of the Iranian people aged height from age, shin length and forearm length. Methods: A total 165 aged people ≥60 years were randomly selected based on medical record number of about 800 eligible older people who lived in Kahrizak Charity Foundation. Standing height, shin length and forearm length were measured. Data from 99 participants were used to creat a predicting multivariate linear regression model for estimation of standing height of older men and women. The data of the rest 66 participants were used for models testing. Result: The following equations were created: Men height = 78.928+ (1.430× shin length) + (0.817×forearm length)-(0.176×age) The height of women = 71.694+ (1.414×shin length) + (1.084× forearm length)-(0.277× age) R2 were calculated as 0.63 for men and 0.52 for women. Error of estimation was +0.44 cm and it was - 0.16cm and +1.09cm for men and women respectively. Estimated heights were not significantly different from standing statures. Conclusion: height was predictable from shin length and for forearm lengths and also age with a relatively small error in the estimation among Iranian older people. The error of model is more in women than men.

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Introduction: Aspects of social and economic development in ICT has led to new applications of these technologies. Using the portal geriatrics’ is an access point to a wide range of resources and information in the content for geriatric medicine specialists, physicians and other health care workers, elderly and their families. It provides integrated information on the sources and applications of heterogeneous. The National Portal of Geriatric Medicine is the best solution to resolve this problem.This study compares the experience of few developed countries and offer the geriatrics’ portal. Methods: This paper is based on valid studies, library and internet searches in databases like as science directly, Springer, Proquest, and advanced search in Google to review the literature on the geriatrics portal in selected the countries. Findings: Developing a portal is a strategy to support the development and maintenance of all the desirable features of the portal and user needs’ analysis. It could also, characterize the structure and integrated system of geriatric care. It makes the integrity to fulfill of the main condition portal services and the content that offer to the elderly.

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Objective: The present study describes assessing physical health status of old people in different age groups in Tehran metropolitan area. The outcomes of this study could help to health policy makers to develop of better health policy in gerontology field by determine of priorities of care in different age groups of old people and effect of socio-economic components on elder’s’ physical health. Method: This was a cross sectional study in 2010. The participants were (N=402) aged 60 years old and over which have underrepresented from Shahid Beheshti university. The survey methods were via face- to-face interviews, and just in a few cases as telephone interviews. The instrument to data collection included demographic questionnaire, SF-36 short form and ADL tools. Data analyzed by Stata and SPSS Ver.15 through t-test, one-way ANOVA. Regression models applied as well. Findings: Based on the results 45% of elderly were in (60-69) years old, 36.5% were in (70-79) years old, and 18.5% were 80+ years old. The median age was 71.5±8.9 years. Regarding ADL, 18.2% of elderly were dependent 22.3% were semi dependent, and 59.5% of participants were independent to do activity of daily living. Regarding physical functioning, 29.6% of elderly had severe limitation 32.6% had moderate limitation, and 37.8% had no limitation in their physical function. Components of age, sex, marital status, education, job, income, insurance, housing, and living with whom had significant association with physical health status in old people. Although based on regression model and considering in effect of conflict variables, age and sex had more effect to predict of activity of daily living in old people. Age, sex, to be alone, and financial problems were the most predictors on physical function in aged people. Conclusion: The important components that effect on physical health of elderly related to fragile elderly from aspect of socio economic factors. Based on the results of this study aged elderly and old women were more disable to do Activity of Daily Living (ADL). Regarding physical function age, sex, living with whom, and financial dependency were significant components in relation with physical function. In other words, older people, women, elderly who did not live with their spouse, and elderly who were dependent in financial aspect to others had more difficulty in physical function.

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Objective(s): The purpose of the present study is to better understand relationships between mental health components (Psychological distress, Psychological wellbeing) and utilization of health services and community aged care services among the Iranian elderly living in Sydney metropolitan area. These findings will, in part, fill the gap in gerontological knowledge and also help to health policy makers, social fairness, increasing fairness to the Iranian elderly migrants, and also increasing their more access to the aged care services. Material & methods: In this cross sectional study 302 old people were selected via a random sample among 1209 Iranian aged people 65 years old and over migrated in Australia. In this study 302 old people 65 years old and over participated who lived in Sydney state’s of Australia for at least 6 months prior to the survey. This study has done in 2005-7. Multiple methods were utilized to collect data including telephone interviews, face to face interviews, or a written survey instrument by mail. The tools used were based on the “annual elderly health survey in 2000” through Australian ministry of health. The mental health instruments applied were psychological well being (Yeild), and psychological distress (K6). The service utilization tools included utilization of aged care services (basic and supportive), and use of health services. T test, ANOVA and liner regression applied to predict of mental health components by SPSS ver.15 soft wear. Results: demonstrated that the majority of respondents reported feeling so sad and nervous most of the time in the last four weeks. The bulk of respondents had moderate level of psychological distress. About one quarter of respondents had lower level of feeling of wellbeing in the last four weeks preceding this study. Use of health services and community basic aged care services are predicted by mental health status of Iranian elderly respondents. However, mental health status could not predict utilization of community supportive aged care services. Conclusion: Generally, use of interpreters and organized community services were predicted with mental health components among the Iranian elderly migrants.

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Introduction: Studying of physical and mental health of older adults is important for health care services to elderly. With increasing ageing population and chronic diseases among older people, the expenditure of ageing services will increase. Thus, it is necessary to clear a cut point chronological age for starting ageing career. The aim of this paper is to understand health differences between two cohorts (60-64 and 65-69) of older adults. Methods: This study is cross-sectional and descriptive-analytical study. Data collected by structured questionnaire. The study population was 60 -64 and 65-69 cohort groups of older adults who living in rural and urban areas of Tehran in 2011. The sample size was estimated 400 people those were chosen using cluster sampling. Findings: The findings of study showed significantly differences between two groups of older adults, 60-64 and 65-69, in terms of physical health that measured using activity of daily living(ADL) and limitation of physical function. In contrast, there were no significant differences between two age groups in psychological wellbeing and mental illness. Based on results, complementary health services can start from 65 years old and providing counseling services according to women and men differences.

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Introduction: Mental disorders are common in the elderly.The purpose of this study was to assess the general health status and its related factors among people ≥ 65 years in different districts of Tehran. Methods: This study has used data of the participants ≥ 65 years old in urban health equity and response tool (Urban-HEART) study. Finally the data of 1313 elderly were considered for this study. Variables included demographic characteristics (gender, age, education level, family size, marital status and employment status) and mental health using the Persian GHQ -28 questionnaire (domains: somatic, depression, insomnia and anxiety) and quality of life using the SF12. Results: The mean age of participants was 73.68 (5.91) (women=627 and men=686). GHQ-28 median of scores the participants were 24.00 (22.00)[20.00 (27.00) in women and 19.00 (19.00) in men (P<0.01)].Based on GHQ-28 cut-point 23, 50.2%of the participants had mental health problems, [61.2% women and 40.1% men (P<0.01)].The residents of third municipality districts had the best mental health (26.3% of men and 38.5% of women had mental health problems) and the aged of 20th municipality district had the worst health status (65.7% of males and 84.2% of women had mental health problems).In multivariable logistic regression model, for each year of increment age, 2.9% chance of mental health problems increased (P<0.01). With increasing level of education, mental health status was improved (P trend < 0.01). The relationship between family size and mental health was not significant (P =0.06). Conclusion: Mental health status of the elderly in Tehran was worse than the many other countries. The elderly lived in 20th municipal district, had the worst and the dwellers in the 3th district had the best mental health status.

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Increasing of the aging population in most of the developed countries should be more attention to the health issues of this aged group. In Iran, the ageing program has been launched and some institutes or organizations have been in charge of this program. The coordination of health policies and activities in elderly care programs and ageing networks could be helped to improve of elderly life span. This paper discusses the performance of different organizations and or other relevant entities regarding an ageing program in Iran and also comparing those activities to the other developed countries.

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Background: Reducing in mortality rate due to improved health status in recent years has led to an increased number of elderly people in the world. Therefore, this study aimed to determine the structure of the home care plane in developed countries to provide practical implementations for Iran. This paper is based on valid studies, library and internet searches in databases like science directly, Springer, Proquest, and advanced search in Google to review the literature on the home care programs in developed countries. Results: Documents showed that developed countries have established the aimed, needs, priorities programming of the elderly home care plan. Those groups of countries have designed the home care services to care of older people in their homes respect to maintained of their function and ability as independent individuals. Conclusion: The investigations have been shown that community-based services and home care programs that is not considered as a medical service component, could be eliminated the support needs, and helped the elderly people to live independently and continue their life with quality. Considering the significant role of home services in the prevention of hospital readmission in elderly and to maintain of independency rate and also increasing the quality of life in elderly people, is a necessary issue in Iran that makes to improve on the quality of life in Iranian seniors

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Background: Falling is one of the health problems among aged population. Elderly living in institutions are at greater risk of falling than those dwellings in the community, due to their health status and environmental conditions. This study was designed and conducted aimed to address the factors affecting falls in Kahrizak Charity Foundation (KCF). Methods: This is a prospective longitudinal study, which 194 of residents of KCF were participating in it with inclusion criteria were selected by Random Cluster sampling. They were enrolled after signing an informed consent. At baseline the data of demographic, lifestyle, past medical history and visual ability were collected by interviewing. The anthropometric measurements were performed as well. Cognitive status data were collected using abbreviated mental test (AMT) questionnaire and mini mental state examination (MMSE), balance status was assessed using the Tinetti mobility test (TMT) and its balance and gait sub- scores, depression was detected using the geriatric depression scale-15 (GDS-15). The participants were monitored for the falls occurrence its complications by daily call with caregivers and filling out the special forms for the recording of the falls occurrence by the head nurse. Data were analyzed using univariate and multivariable Cox-regression models. Results: The mean age of the participants was76.02 (8.82) years and the mean follow-up days was 754.40±189.26 days. 44 cases of falls were recorded during follow-up (over two years). The fall rate was 22.7 subjects per 100 participants per year. History of stroke, Parkinson's disease, visual loss, taking antidepressants, TMT score and TMT balance sub-score after adjustment (for age, sex, body mass index and survival time) were associated with falls. Conclusion: The falls among nursing home elderly residents were associated with a history of chronic diseases such as stroke and Parkinson's diseases, visual acuity, use of antidepressants and the TMT and its balance sub score.

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Background: Because of various health problems, the risk of the death in the elderly is higher than adults. The purpose of this study was to investigate the causes of the death, and comparing the cause of death that recorded on the death certificates and those were extracted from the medical records review. Methods: Variables included the demographic characteristics (age and sex), time of death and the cause of death were recorded in the death certifies and those were extracted from the medical records. Results: The mean of death age was 83.8 (8.50) years and in women and men were 84.2 and 81.5 years, respectively, (P < 0.01).The most prevalent cause of death was sudden cardiac death based on both death certificates recorded and review of medical records were 42.5% and 25.9% respectively. Sudden cardiac death in both methods was higher in women than men. Using the kappa, the highest degree of correspondence about the cause of death between two method was about gastrointestinal bleeding (K = 0.76) and then the cancers (K = 0.71) and respiratory infections (K =0.67). Total Kappa of two methods for causes of mortality was 0.50. The most cases of death were reported during 12:00 – 13:59 and 8:00 – 9:59am, time period (16.2 % and 14.1% respectively). Conclusion: the causes of deaths, which are recorded in the elderly nursing homes, do not have enough accuracy. Due to the high incidence of sudden cardiac death in elderly in nursing homes, resuscitation facilities and teams may be helping to reduce these types of death.

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Background: One of the common problems of the elderly, which increase of its prevalence with aging is the dementia and the cognitive impairment. We can help the involved patients to have a better quality of life with early diagnosis of the cognitive impairment. The aim of this study was an assessment of the validity and reliability of the Persian version of the abbreviated mental test (AMT) among the older people in a nursing home setting. Methods: 176 eligible elderly people aged ≥ 60 years living in KahrizakCharity Foundation (KCF), were selected randomly based on medical record number. Demographic information and past medical history of the participants were collected. Geriatric depression scale 15 (GDS-15), global deterioration scale (GDS) forms and also the Persian version of the abbreviated mental test (AMT) were administered. The participants were assigned to two groups the normal and impaired cognitive groups, based on DSM-IV diagnostic criteria. The GDS cut-points were used for assessment of validity, sensitivity and specificity of the Persian version of AMT. Results: The mean age of the participants was 77.30 (7.94) years. The Persian version of AMT had good discriminated validity in diagnosis of normal and impaired cognitive participants (7.35 ± 2.33 and 5.99 ± 2.29, P < 0.01 respectively) and at cut-point AMT< 8,(based on GDS cut-point) it had a sensitivity and specificity 92.15 % and 81.50% respectively. The sensitivity and specificity based on theism IVcriteriawere 64.9% and 64.0% at cut-off point equal to 7, respectively. The internal consistency of the Persian version of AMT was acceptable (Cronbach’salpha coefficient =0. 76). As well as the external reliability (intra-rater) of this instrument was good inter-class correlation coefficient (ICC) = 0.89) Conclusion: The Persian version of the AMT has appropriate validity and reliability in Iranian older people.

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Background: Although several tools for evaluating and screening of cognitive status have been introduced, most of them are not applicable in Iranian elderly population because of cultural differences and high illiteracy rate. This study is report of "Brief Cognitive Assessment Tool"(BCAT) was developed as a cognitive status-evaluating test and reported psychometric characteristics.
Methods: the BCAT tool includes memory assessment using three words recall test with a rating similar to Mini-Cog and the functional status including "ability to dress", "ability to use the phone," " ability to manage own medications", among both two sexes and financial management capabilities in men and ability to prepare food in women. Functional rating is different in educated and non-educated people. Diagnosis of dementia is considered, when memory impairment is accompanied by the dysfunction. Eighty-six residents of a nursing home (41 men and 45 women) among who had inclusion and no had exclusion criteria also consent to participate were randomly enrolled. Concurrent validity was shown as correlation coefficient between the BCAT categorization and score of mini meAntal state examination (MMSE). Criterion validity, sensitivity and specificity of BCAT were evaluated based on global deterioration scale (GDS). Reliability of two raters results within two weeks was indicated by Kappa coefficient.
Results: The sensitivity and specificity and accuracy rate of the BCAT based the GDS was 88.6%, 82.6%, and 84.9%, respectively. The correlation between the MMSE score and results of the BCAT classifying was significant. The Kappa coefficient between the results of two raters was 81.1%.
Conclusion: It seems that the BCAT has good psychometric properties to recognize cognitive impairment among Iranian older adults.

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Background: The aging of the population is a great challenge of the public health in this century. The health promotion of the elderly people requires a comprehensive and accurate understanding of their health status.
Methods: This cross-sectional study has assessed the health status of 191 old people ≥ 60 in Sistan and Balouchestan province that selected by a multi-level cluster random sampling. General health data was collected using SF-36 questionnaire, nutrition status was assessed using Mini Nutritional Assessment (MNA), depression status was detected by the geriatric depression scale-15 (GDS-15), functional status was assessed using the activity daily living (ADL) and instrumental activity daily living (IADL) questionnaires, as well as, the information about demographic, history of diseases, vaccination, participation in social activities, and the utilization of elderly care services were evaluated by an approved questionnaire. History of hypertension was asked from the participants. Moreover the blood pressures of them were twice measured.
Results: The mean age of the participants was 69.81 (8.32) years. The health status was reported excellent and bad by 4.2% and 9.4% of the participants, respectively. The prevalence of fall in recent year, memory disorder, hearing and visual impairment, and malnutrition were 35.3%, 15.6%, 30.3%, 56.6%, and 8.9%, respectively. The prevalence of dependency in "activity of daily living" and "instrumental activity of daily living" were 25.8% and 58.2%, respectively.
Conclusion: It seems that the prevalence of malnutrition, impaired ADL and IADL, and memory impairment in the older population of Sistan and Baluchestan are above the national and global averages.
 

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Background: Elderly people need more receiving health services. Planning to provide services at regional and national levels requires information about the health status of the elderly. This study was performed to assess the health status of East Azarbaijan province.
Methods: In this cross-sectional study, 436 subjects were enrolled (180 men and 258 women) aged ≥ 60 years using multi-level proportioned cluster Random sampling from 19 cities of the province.
Data was collected by a demographic questionnaire , measuring  anthropometric characteristics, and blood pressure and  using "Mini  Nutritional Assessment" ,”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”,  and "Lawton’s Instrumental activities of daily living”.
Results: The mean age of the participants was 69.31 years.  The self-reported prevalence of diabetes was 34.2%. The prevalence of hypertension in the elderly was 52.5%. The most common complaint of the participants was pain (60.9%). Totally, 46.9% had a difficulty in walking, 44.3% visually impaired, and 26.4% suffered from hearing impairment. Moreover, 44.8% of sleep disorders was found. Also 26% of the participants had depressed mood.
Conclusion: Elderly residents of East Azerbaijan province, has probably a better health status than the average Iranian elderly. However, there is a high prevalence of hypertension and diabetes among older adults of this province that need to more pay attention.

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Background: Alborz Province is one of the provinces that accepted immigrants. Immigration has a profound effect on physical and mental health in elderly. This study was performed to assess the health status of Alborz province older population.
Methods: In this cross-sectional study, 235 subjects were enrolled (113 men and 122 women) aged ≥ 60 years using multi-level proportionated cluster random sampling that selected from 19 cities of this province. Data was collected by a demographic questionnaire, measuring anthropometric characteristics, and blood pressure and using "Mini Nutritional Assessment", ”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”, and "Lawton’s Instrumental activities of daily living”. Data was analyzed with spss21.
Results: The mean age of the participants was 68(6.00) years.  The prevalence of anxiety and depression among the participants was as 51.5% and 34%, respectively. At risk or malnutrition was observed in 27% of the participants and 54.5% had suffered dental problems and 49.8% also had problem in walking.
Conclusion: Overall, the health status of elderly people in the Alborz, perhaps slightly better than the national average, but the high prevalence of metabolic disorders also the high prevalence of depression and anxiety require serious intervention by policy makers to promote the health in elderly.

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Background: The adipokines omentin-1, vaspin, and retinol binding protein-4 (RBP-4) are mediators of body composition and adipose tissue that contribute to metabolic changes caused by obesity. The aim of this study was to determine the association between serum levels of these adipokines with body composition indices and metabolic status in different phenotypes of body size.
Methods: In the present cross-sectional study, a total of 350 women, including 127 metabolically healthy (MH) subjects and 223 metabolically unhealthy (MUH) subjects participated. The subjects were considered as MH in the presence of at least 4 of the five following metabolic indices: TG ≤ 1.70  mmol/L, LDL-C≤ 2.60 mmol /L, TC≤ 5.20 mmol /L, HDL-C≥1.30, and HOMA-IR≤ 1.95; otherwise subjects were considered as MUH.
Results: The results showed that serum levels of omentin-1 have a significant positive association with MHS (OR = 1.04, p <0.0001). Even after controlling the confounding factors of age, sex and weight, this relationship was still significant. Plasma levels of vaspin and RBP-4 were not significantly related to MHS. Furthermore, there was a significant correlation between omentin-1 and body mass index (r = 0.31, p = 0.02) and body fat percentage (r = 0.32, P = 0.02) in MH subjects. In the healthy group, serum levels of RBP-4 were positively correlated with fat percentage (r = 0.68, p <0.0001) and body fat mass (r = 0.74, P <0.0001) and were negatively correlated with fat-free mass (r = -0.74, P <0.0001) and total body water (r = -0.76, P <0.0001). There was no statistically significant correlation between serum vaspin levels and body composition indices in both groups.
Conclusion: Serum levels of adipokines may be an appropriate predictor for metabolically healthy status. Further studies in this field can reveal possible mechanisms.

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Background Due to the high prevalence of diabetes in the general population and companionship with psychiatric disorders, this study was aimed to examine the effectiveness of dialectical behavior therapy in reducing anxiety and improving social function in patients with diabetes.
Methods: This was a semi-experimental design with pretest-posttest and control group. The Community of study included all diabetic patients have been admitted to the Shahid Mohammadi hospital of Bandarabbas in the first half of 1395. The participants (24 people) were selected using available sampling and subsequently assigned into a control and an experimental group. The Members of the experimental group received dialectical behavior therapy for 8 sessions but the control group received no intervention. Beck Anxiety and California social adjustment were applied as pre-test and post-test. The obtained data were analyzed by MANCOVA method.
Results: The results of MANCOVA showed that dialectical behavior therapy was significantly effective in reducing anxiety and improving social adjustment in diabetic patients.
Conclusion: Based on these results it is necessary to improve the psychological rehabilitation of diabetic patients by applying the more effective interventions.
 

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Background: Diabetes mellitus is a worldwide prevalence of metabolic diseases and its important complications are gastrointestinal disturbances. A wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like diabetes and cancer. However, the poor oral bioavailability and instability of curcumin had greatly limited its further applications. The purpose of this study was to evaluate the effects of Nanocurcumin on the oxidative stress and tissue changes of small intestine in diabetic mice.
Methods: In this experimental study, animals were divided to five groups: Control, sham, diabetic (Intraperitoneal injection of 120 mg/kg of Streptozotocin) and diabetic groups treated with Nanocurcumin (7.5 and 15 mg/kg body weight) for 21days. At the end of experiment, catalase (CAT) activity and Malondialdehyde (MDA) level were measured in intestinal tissue. For histological assessment, villi length and crypt depth in small intestine were investigated.
Results: The oral administration of Nanocurcumin significantly increased intestinal CAT activity (P<0.05) and decreased MDA level (P<0.001). Also, the Villi length in diabetic groups treated with Nanocurcumin showed a significant increase compared to diabetic group (P<0.05).
Conclusion: The findings of this study showed that Nanocurcumin has a protective effect on diabetes-induced digestive disorders due to its antioxidant properties.