Zahra Yaghoubi, Bahram Abedi,
Volume 21, Issue 2 (7-2021)
Abstract
Background: Diabetes type 2 is a metabolic disorder that it caused by insulin resistance. The aim of this research was to study the effect of eight weeks of aerobic exercise with ginger supplement on FGF21, Irisin and insulin resistance in women with type 2 diabetes.
Methods: In a quasi-experimental study with pretest posttest design, 24 women with type 2 diabetes were selected available and purposely as sample. The subjects divided randomly into two groups of control (placebo and exercise) and experimental (supplement and exercise). The experimental group take part in an exercise with moderate intensity 65-70 percent of target heart rate and three session per week. Ginger supplementation was performed at the same time for training with daily consumption of 1 g of ginger extract (250 g capsules) and four servings daily. The control group (placebo) also used similar capsules containing roasted flour. To evaluate serum levels of variables, blood sampling was taken from all subjects 24 hr before and after exercise and supplement intervention at 10hr fasting state.
Results: Data were analyzed by using covariance test (p<0.05). The results showed that eight weeks of aerobic training and ginger supplementation lead to increase in Irisin levels (p=0.0001), FGF21 (p=0.0001) and decrease in insulin resistance index (p=0.0001).
Conclusion: Results indicated that using aerobic exercise and ginger supplement versus aerobic exercise could have positive effects on regulatory factors of energy in people with type 2 diabetes.
Farnaz Onsori, Mina Akbari Rad, Maryam Emadzadeh, Ali Moradi, Mohammad-Javad Mojahedi, Alireza Shariati, Mohammad-Ali Yaghoubi,
Volume 23, Issue 3 (9-2023)
Abstract
Background: Diabetic nephropathy is the main cause of end-stage kidney disease in diabetic patients. Several inflammatory markers related with diabetic nephropathy have been investigated so far. It is necessary to identify easily available and cost-effective indices. We aimed to determine the relationship between the neutrophil to lymphocyte ratio and mean platelet volume with diabetic nephropathy.
Methods: This cross-sectional study was performed from 2021 to 2022 in diabetes clinic of Ghaem hospital, Mashhad. Patients with type II diabetes were categorized into two groups: without and with nephropathy (urinary albumin excretion greater than 30 mg/24h or GFR less than 60). Patients’ data, including demographic data, past medical and drug history and lab data were gathered and analyzed.
Results: In total, 100 diabetic patients including 50 with (mean age=64.04±7.40 years) and 50 without nephropathy (mean age=56.06±6.36 years), were studied. Patients with nephropathy were older, had a longer history of diabetes and a higher blood pressure (P < 0.05). However, the distribution of gender, weight, height, and BMI was not significantly different the two groups (P>0.05). The absolute neutrophil count was not significantly different between the two groups (P>0.05), while the mean platelet volume, neutrophil% and neutrophil/lymphocyte ratio were significantly higher in patients with nephropathy (P<0.05).
Conclusion: According to our findings, patients with diabetic nephropathy had higher mean platelet volume, neutrophil%, and neutrophil/lymphocyte ratios compared to diabetic patients without nephropathy.
