Showing 37 results for sharifi
Esmat Mosayebi, Maryam Sharifi, Ahmad Abedi,
Volume 15, Issue 4 (5-2016)
Abstract
Background: Diabetes is a chronic and prevalent disease. In recent years, its prevalence has increased because of lifestyle changes, immobility and subsequent obesity. The increase in diabetes prevalence has provoked multiple and scattered interventions by specialists and health care providers in order to control and regulate blood sugar and its related factors. The purpose of this study was to collect and integrate the results of these interventions in two fields of psychological and sport interventions and to investigate the impact of them on control of Glycosylated haemoglonin (HbA1c) in patients with diabetes by meta-analysis method.
Methods: For this purpose 38 acceptable studies (19 sport interventions and 19 psychological interventions), in terms of methodology, were selected and meta-analysis performed on them. This study is based on 38 effect sizes and research instrument is checklist of meta-analysis.
Results: The study findings showed that the effect size of psychological interventions on control of Glycosylated haemoglonbin is 0.67 (p<0.00001) and the effect size of sport interventions is 0.79 (p<0.00001).
Conclusion: according to Cohen’s chart, the effect size of both psychological and sport intervention on control of Glycosylated haemoglonin in patients with diabetes is medium. However, the effectiveness of sport interventions have been obtained more than the psychological intervention
Zahra Jafari, Neda Mehrdad, Farshad Sharifi, Hamid Haghani, Soghra Nikpour,
Volume 15, Issue 4 (5-2016)
Abstract
Background: Prevalence of diabetes increases along with aging. Due to various reasons, rate of falling in the aged suffering from diabetes is higher. Therefore, this study aims at determining factors relating falling of the aged suffering from type 2 diabetes.
Methods: A total of 60 years old or older with type 2 diabetes that referred to selected hospitals of Tehran University of Medical Sciences using continues method. Cases that had experienced falling during last year and controls that had no such experience were assigned to two separate groups. Questionnaire used in this study included demographic data and factors relating falling. Data obtained were analyzed using descriptive statistics, independent t- test, Chi square and logistic regression.
Results: Results showed that postural blood pressure (p=0.02) dizziness (p=0.05), fecal incontinency (p<0.01), auditory disorder (p<0.01), visual disorder (p<0.01), pain in the lower extremity (p= 0.027), taking anti-coagulation medicine (p=0.017) had a significant correlation with falling.
Conclusion: Multivariate logistic regression illustrated that fecal incontinency and auditory disorder happened along with falling in the aged suffering from type 2 diabetes. Therefore, preventing falling must be considered in care plan for such groups of people.
Parisa Taheri Tanjani, Farshad Sharifi, Neda Nazari, Fakher Rahim, Hossein Fakhrzadeh, Seyed Masoud Arzaghi, Mohammadsmaeel Motlagh, Saeid Saeidimehr,
Volume 16, Issue 4 (9-2017)
Abstract
Background: Older people are vulnerable in terms of health status. The elderly`s Khuzestan due to the very warm weather of this region are more at risk for health problems. This study is a report on the health status of the elderly in Khuzestan province in 2012.
Methods: This is a Cross-sectional study, with multi-level proportional cluster Random sampling among people aged ≤ 60 years of Khuzestan province. Nutritional status was assessed by Mini Nutritional Assessment (MNA), depressed mood screening was conducted with Geriatric Depression Scale-15 questionnaire, activities of daily living was evaluated using KATZ ADL and Lawton Instrumental ADL tools.
Results: In this study, 387 people participated. The prevalence of hypertension, diabetes mellitus, depressed mood, and anxiety in the participants, were 38.8%, 28.6%, 34.9 and 38.7, respectively. Hearing loss reported in 33.9% and vision impairment was in 62.2% of the participants. Memory impaired founded in 14.9% of the participants. 4.3% of the elderly suffered from malnutrition and 48.3% were at risk of malnutrition. Dysfunction in ADL were existed in 13.9% and 30.3% of the participants had some degrees of dysfunction in IADL.
Poly pharmacy (consumed more than 3 medications) was observed in 36.5% of older adults in this province. The most common health services need was medical services at home and then transport services.
Conclusion: Although the health status of the elderly in Khuzestan province generally was not worse than the average of Iran, it needs that a special pay attention in some areas, such as hypertension, diabetes, nutritional status and lack of independence in activities of daily living in this age group.
Parisa Taheri Tanjani, Parishad Ghavam, Shima Raeesi, Farshad Sharifi, Hossein Fakhrzadeh, Mohammadsmaeel Motlagh, Neda Nazari,
Volume 16, Issue 4 (9-2017)
Abstract
Background: Improved in health condition, reduced fertility rates, and increased life expectancy has increased number and proportion of elderly population. This study was reported the health status of older population
in North Khorasan province
.
Methods: This is a cross-sectional study that enrolled 99 subjects (40 men and 59 women) ≥ 60 years by a multi-levels proportionate cluster random sampling method.
Required information was gathered by means of a demographic questionnaire. Mini Nutritional Assessment (MNA), Geriatric Depression Scale-15 (GDS-15), Katz's basic activity of daily living, and Lawton's instrumental activity of daily living were administered. Measurements of anthropometric and blood pressure were performed based on standard methods
Results: The prevalence of diabetes and hypertension in elderly, were 17.7% and 57.6%, respectively. Depressed mood was observed in 36.4% of the participants 36.4% of the participants and 18.2 percent of them reported that their health condition was bad. In addition, 73.5% of the elderly had complained about any bodily pain. As well as, 22.6% of the participants used opium at least once during the last year.
Conclusion: It seems that the health status of the elderly in North Khorasan province is not suitable in many indicators, such as hypertension, malnutrition, drug abuse and complaints of pain and their health status was worse than the national average of Iran. A special attention requires to the health status of elderly in this province .
Farshad Sharifi, Neda Nazari, Shervan Shoaee, Hassan Ahmadi, Marjan Asadollahi, Seyed Masoud Arzaghi, Mahtab Alizadeh Khoee, Hossein Fakhrzadeh,
Volume 16, Issue 4 (9-2017)
Abstract
Background: Although several tools for evaluating and screening of cognitive status have been introduced, most of them are not applicable in Iranian elderly population because of cultural differences and high illiteracy rate. This study is report of "Brief Cognitive Assessment Tool"(BCAT) was developed as a cognitive status-evaluating test and reported psychometric characteristics.
Methods: the BCAT tool includes memory assessment using three words recall test with a rating similar to Mini-Cog and the functional status including "ability to dress", "ability to use the phone," " ability to manage own medications", among both two sexes and financial management capabilities in men and ability to prepare food in women. Functional rating is different in educated and non-educated people. Diagnosis of dementia is considered, when memory impairment is accompanied by the dysfunction. Eighty-six residents of a nursing home (41 men and 45 women) among who had inclusion and no had exclusion criteria also consent to participate were randomly enrolled. Concurrent validity was shown as correlation coefficient between the BCAT categorization and score of mini meAntal state examination (MMSE). Criterion validity, sensitivity and specificity of BCAT were evaluated based on global deterioration scale (GDS). Reliability of two raters results within two weeks was indicated by Kappa coefficient.
Results: The sensitivity and specificity and accuracy rate of the BCAT based the GDS was 88.6%, 82.6%, and 84.9%, respectively. The correlation between the MMSE score and results of the BCAT classifying was significant. The Kappa coefficient between the results of two raters was 81.1%.
Conclusion: It seems that the BCAT has good psychometric properties to recognize cognitive impairment among Iranian older adults.
Sakineh Gerayllo , Mohammad Ali Morovati Sharif Abad, Abdorahman Charkazi, Zohreh Karimian Kakolaki, Ensieh Sharifi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Osteoarthritis (OA) is the most common joint disorder and the most prevalent cause of joint pain across the spectrum of middle age to elderly. The purpose of this study was to determine the role of subjective norms and perceived behavioral control on self-care among elderly patients with osteoarthritis who are suffering from OA in Yazd city, Iran.
Methods: A cross-sectional study was conducted and 87 elderly who attained to health centers subjects through simple sampling methods. The data collection instrument was a questionnaire designed for the study which the first includes demographic variables, of subjective norms and perceived behavioral control Part II, and self-care behaviors categories of items Part III. The questionnaires completed by interview and data were analyzed by SPSS18 software using T-Test, ANOVA, correlation coefficient tests.
Results: The mean score of the subjective norms, perceived behavioral control and self-care were 81.85±11.40 (The top 110 scores), 90.19±6.19 (The top 120 scores) and 44.93±5.84 (The top 60 scores), respectively. The results showed that between subjective norms and perceived behavioral control and self-care with demographic variables except education and perceived behavioral control (P =0.001), the history of disease of self-care (P =0.001) and perceived behavioral control and economic status (P =0.002) were not a significant relationship, Also The results Pearson’s correlation test revealed that there was a significant correlation between self-care behaviors and perceived behavioral control (P =0.008, r=0.297).
Conclusion: As for strong association between behavioral control and self-care that we found in our study and high influence and extension of mass media, it recommends to emphasis on using these methods as educational assistance devices in interventional programs in these medias.
Baharak Najafi, Parisa Taheri Tanjani, Farshad Sharifi, Hosein Fakhrzad, Mahtab Alizadeh, Masoud Arzaghi, Mehdi Varmaghani, Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: The aging of the population is a great challenge of the public health in this century. The health promotion of the elderly people requires a comprehensive and accurate understanding of their health status.
Methods: This cross-sectional study has assessed the health status of 191 old people ≥ 60 in Sistan and Balouchestan province that selected by a multi-level cluster random sampling. General health data was collected using SF-36 questionnaire, nutrition status was assessed using Mini Nutritional Assessment (MNA), depression status was detected by the geriatric depression scale-15 (GDS-15), functional status was assessed using the activity daily living (ADL) and instrumental activity daily living (IADL) questionnaires, as well as, the information about demographic, history of diseases, vaccination, participation in social activities, and the utilization of elderly care services were evaluated by an approved questionnaire. History of hypertension was asked from the participants. Moreover the blood pressures of them were twice measured.
Results: The mean age of the participants was 69.81 (8.32) years. The health status was reported excellent and bad by 4.2% and 9.4% of the participants, respectively. The prevalence of fall in recent year, memory disorder, hearing and visual impairment, and malnutrition were 35.3%, 15.6%, 30.3%, 56.6%, and 8.9%, respectively. The prevalence of dependency in "activity of daily living" and "instrumental activity of daily living" were 25.8% and 58.2%, respectively.
Conclusion: It seems that the prevalence of malnutrition, impaired ADL and IADL, and memory impairment in the older population of Sistan and Baluchestan are above the national and global averages.
Parisa Taheri Tanjani, Mehdi Varmaghani, Neds Nazari, Farshad Sharifi, Hossein Fakhrzadeh, Seyed Masoud Arzaghi, Mahtab Alizadeh Khoee, Mohammad Smaeel Motlagh, Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Elderly people need more receiving health services. Planning to provide services at regional and national levels requires information about the health status of the elderly. This study was performed to assess the health status of East Azarbaijan province.
Methods: In this cross-sectional study, 436 subjects were enrolled (180 men and 258 women) aged ≥ 60 years using multi-level proportioned cluster Random sampling from 19 cities of the province.
Data was collected by a demographic questionnaire , measuring anthropometric characteristics, and blood pressure and using "Mini Nutritional Assessment" ,”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”, and "Lawton’s Instrumental activities of daily living”.
Results: The mean age of the participants was 69.31 years. The self-reported prevalence of diabetes was 34.2%. The prevalence of hypertension in the elderly was 52.5%. The most common complaint of the participants was pain (60.9%). Totally, 46.9% had a difficulty in walking, 44.3% visually impaired, and 26.4% suffered from hearing impairment. Moreover, 44.8% of sleep disorders was found. Also 26% of the participants had depressed mood.
Conclusion: Elderly residents of East Azerbaijan province, has probably a better health status than the average Iranian elderly. However, there is a high prevalence of hypertension and diabetes among older adults of this province that need to more pay attention.
Zohreh Vares, Hamid Asayesh, Zahra Aliakbarzade Arani, Fatemeh Sharififard,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Diabetes increases risk of incident or exacerbation geriatric syndromes in elderly and effect of different aspects of their life. This study was conducted to evaluate related factors in the quality of life of elderly diabetics.
Methods: This is a descriptive and analytic study that 88 elderly subjects with diabetes diabetic patients selected from 1400 cases in the age range 60-83 years have file in Kashan Diabetes Center in 2006. Samples were enrolled during about 2 months. Quality of life and a demographic questionaire were administered. The quality of life tool contained 41 questions that have been investigated in three dimensions: general (13-52 points), specificity (27-108 points) and overall (40-160 points). The relationship between QOL and other variables were analyzed by SPSS 16 using univariate and multivariate logistic regression models.
Results: Overall, 65.9% of patients were female and 34.1% male. Results has showed that there are significant relationship beetwin tingling, numbness and vision loss with the general quality of life and treatment type, kidney failure, tingling, numbness, and limb numbness with the special quality of life.
Conclusion: Considering the low quality of life in the majority of elderly diabetics and its role in the development of diabetic complications, results express severe need to care of the elderly and reaffirm the role of care in improvement the health level of older adults.
Parisa Taheri-Tanjani, Farshad Sharifi, Neda Nazari, Hossein Fakhrzadeh, Mahtab Alizadeh-Khoee, Mohammad Smaeel Motlagh, Hosna Ataee, Seyed Masoud Arzaghi , Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Alborz Province is one of the provinces that accepted immigrants. Immigration has a profound effect on physical and mental health in elderly. This study was performed to assess the health status of Alborz province older population.
Methods: In this cross-sectional study, 235 subjects were enrolled (113 men and 122 women) aged ≥ 60 years using multi-level proportionated cluster random sampling that selected from 19 cities of this province. Data was collected by a demographic questionnaire, measuring anthropometric characteristics, and blood pressure and using "Mini Nutritional Assessment", ”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”, and "Lawton’s Instrumental activities of daily living”. Data was analyzed with spss21.
Results: The mean age of the participants was 68(6.00) years. The prevalence of anxiety and depression among the participants was as 51.5% and 34%, respectively. At risk or malnutrition was observed in 27% of the participants and 54.5% had suffered dental problems and 49.8% also had problem in walking.
Conclusion: Overall, the health status of elderly people in the Alborz, perhaps slightly better than the national average, but the high prevalence of metabolic disorders also the high prevalence of depression and anxiety require serious intervention by policy makers to promote the health in elderly.
Assad Assadi, Parisa Tati, Rasul Sharifi, Hassan Nourafcan, Naser Mohebalipour,
Volume 17, Issue 1 (3-2018)
Abstract
Background: Diabetes is one of the most common diseases of the body's endocrine system, Based on present forecasts of its prevalence will increase in human societies. Diabetes mellitus consists of 5 groups, its two major groups: type I diabetes or insulin-dependent and type II diabetes or non-insulin dependent diabetes. The aim of this study was to evaluate the effect of alcoholic extract of green wheat leaves on glucose, cholesterol, triglycerides, LDL, HDL and total antioxidant capacity of blood serum in alloxan-induced diabetic mice.
Methods: In this study, 40 male mice with an average weight of 25-20 grams in eight groups of five rats: The negative control, positive control (sham), Methformin (60mg/kg), green Wheat leaf extract (100, 200, 400, 800 and 1000mg/kg) were tested. Blood glucose was measured at baseline, then in the positive control group and the experimental groups by Alloxan (120mg/kg) Diabetes was induced by intraperitoneally. During the study, the positive control group and experimental groups received aforementioned compounds for 10 days via intraperitoneally and after 48 hours of each group blood samples were taken through the intraventricular anesthesia and glucose, cholesterol, triglycerides, LDL, HDL and total antioxidant capacity in serum were measured. Quantitative results achieved in this research by one-way ANOVA and Tukey post hoc test between the groups studied Considering the significance level of p <% 5 were analyzed.
Results: The results showed that blood glucose changes in green Wheat leaf extract and metformin groups compared with the positive control group and negative control group was significant at the 5% level and In all under study groups blood glucose levels, Compared with the positive control group decreased and is close to the negative control group also in doses of 100, 200, 800 and 1000 mg/kg Reduced blood glucose is better than methformin group. Methformin and green Wheat leaf extract caused a significant increase at all doses studied in the TAC's Blood. Methformin and green Wheat leaf extract on the amounts of LDL, HDL and cholesterol in diabetic groups had no significant effect and did not have significant difference with other groups. There was no significant effect of different doses of green Wheat leaf extract on the blood triglycerides. However, metformin has a significant impact on triglyceride levels.
Conclusion: The results of the effects of green Wheat leaf extract on glucose and serum antioxidant capacity
It can be noted that these extracts in the treatment of diabetes and reduce its complications can be considered as an option.
Sayed Mahmoud Sajjadi-Jazi, Farshad Sharifi, Mehdi Varmaghani, Hamidreza Aghaei Meybodi, Farshad Farzadfar, Vahid Haghpanah, Bagher Larijani,
Volume 19, Issue 3 (2-2020)
Abstract
Background: The aim of this study was to estimate the prevalence of clinical hyperthyroidism at the national and sub-national levels using the claims data.
Methods: National anti-thyroid medications (methimazole and propylthiouracil) sales data in 2014 were extracted from pharmaceutical sales data that were reported by Iran's Food and Drug Administration (FDA). By using prescriptions data of Social Security Insurance Organization (SSIO) and Medical Services Insurance Organization (MSIO) in 2014, age-sex-province proportions of drug consumptions and Defined Daily Dose (DDD) of anti-thyroid medications were calculated. Moreover, by systematic review and meta-analysis of published literatures in hyperthyroidism in Iran, the prescription rate of anti-thyroid medications was calculated. Finally by using the whole data, the prevalence of clinical hyperthyroidism was estimated in each age and sex groups in national and provincial levels.
Results: : The prevalence (95% confidence interval) of clinical hyperthyroidism in Iran in 2014 is 0.32% (0.21-0.51%); 0.44% (0.29-0.68%) in females and 0.2% (0.12-0.33%) in males. Among provinces the least prevalence rate of clinical hyperthyroidism is 0.24% (0.16-0.38%) which belongs to Sistan and Baluchistan, and the highest prevalence rate is 0.38% (0.24-0.6%) which belongs to Gilan.
Conclusion: The prevalence rate that reported by this study is compatible with other surveys which performed in the world and Iran. As a result using claims data is a good source to predict prevalence of chronic diseases that have specific drugs.
Zhaleh Shademan, Farshad Sharifi, Mahbube Ebrahimpur, Moloud Payab, Seyed Masoud Arzaghi, Hossein Fakhrzadeh,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: Identifying the risk factors for the health of the elderly and designing interventions to improve the health of the elderly is one of the priorities of the health care system in the world today. This first requires the promotion of scientific knowledge in the field of health problems of the elderly.
Methods: In this review conducted in 1399, all studies with the keyword of aging or age-related diseases such as atherosclerosis, osteoporosis, diabetes, dementia, frailty, cognitive impairment, daily life function, nutritional status with organizational affiliation of the Endocrinology and Metabolism Research center or the Elderly Health Research Center of Tehran University of Medical Sciences were reviewed without time limit in databases, PubMed, Web of Science, Scopus and Google Scalar search engines.
Results: A total of 115 studies were found with these keywords. By examining the sampling, method, data analysis and also the removal of similar data, 63 articles were reviewed.
Conclusion: In this regard, the Elderly Health Research center has conducted several studies to localize tools for assessing the health of the elderly, identifying common diseases of the elderly, the prevalence of diseases and syndromes of the elderly and designing several interventional studies in the form of three large studies Kahrizak elderly study, Bushehr elderly health study and Birjand elderly longitudinal study has been discussed in this review.
Ali Ghandali, Seyed Mohammad Tavangar, Amir Pejman Hashemi Taheri, Farshad Sharifi, Vahid Haghpanah, Neda Hatami, Mohammad Reza Mohajeri Tehrani, Sayed Mahmoud Sajjadi-Jazi,
Volume 21, Issue 1 (3-2021)
Abstract
Background: In this study, we investigated the diagnostic power of ultrasound in the diagnosis of malignancy in thyroid nodules in Iranian patients. For this purpose, we examined the relationship between ultrasound findings and pathology findings.
Methods: The present study is a retrospective study. The patients with a diagnosis of thyroid nodules who underwent ultrasound and FNA, were included in this study. To assess the relationship between the results of FNA and the ultrasound characteristics of nodules, we classified the results of FNA into malignant and benign groups and then compared ultrasound characteristics between the two groups. In cases which the FNA results were indeterminate (AUS/FLUS or FN/SFN), the postoperative pathology result was considered (if thyroid surgery was done and the result was available).
Results: In total, 201 nodules were included in this study. The results showed that hypoechogenicity, irregular/ill-defined margin, microcalcification, malignant flow pattern in Doppler sonography and concurrent cervical lymphadenopathy with suspicious features were significantly associated with malignant thyroid nodules. However, other ultrasound findings, such as the size and location of the nodule, presence of a cystic components within the nodule, the presence of a Halo sign, and the presence of a taller-than-wide shape, could not distinguish between benign and malignant nodules. Finally, the results of the present study showed that the accuracy of ultrasound in the diagnosis of malignancy in thyroid nodules is high.
Conclusion: This study suggests that the use of ultrasound can be very effective in diagnosing malignancy in thyroid nodules.
Hamed Alizadeh Pahlavani, Mahya Sharifi Rayeni, Arman Rastegari, Reza Moayedi,
Volume 23, Issue 5 (12-2023)
Abstract
Background: Muscle atrophy is one of the serious complications of type 1 diabetes. Important cellular mechanisms including pathways related to mTOR protein are very important in regulating muscle mass; Therefore, this research was conducted to investigate the effect of high-intensity interval training (HIIT) on the intracellular content of the central protein of mechanical target of rapamycin 1/2 complexes in EDL skeletal muscle of rats with type 1 diabetes.
Methods: In this experimental study, 12 three-month-old male Sprague-Dawley rats with an average weight of 300±20 grams were selected. Type 1 diabetes was induced through intraperitoneal injection of streptozotocin solution (50 mg/kg of body weight). These rats were randomly divided into two groups, diabetic exercise, and diabetic control; The training group performed HIIT for six weeks at an intensity of 85-95% of maximum speed. Data analysis was done through an independent t-test in SPSS software version 28. A significance level of 0.05 was considered.
Results: The intracellular content of total and phosphorylated forms of mTOR protein showed a significant increase after six weeks of HIIT (P=0.0001). Also, the ratio of total to phosphorylated intracellular content of mTOR protein showed a significant increase in the training group compared to the control group (P=0.0001).
Conclusion: HIIT increased the intracellular content of total and phosphorylated forms of mTOR protein, which could possibly lead to protein synthesis and increased muscle hypertrophy.
Akbar Ghodratnama, Mahya Sharifi Rayeni, Arman Rastegari, Reza Moayedi,
Volume 24, Issue 1 (3-2024)
Abstract
Background: Cardiac function in diabetic people is affected through different cellular mechanisms; One of these important cellular pathways is the c-Jun N-terminal kinases (JNKs), whose dysfunction can lead to heart failure; Therefore, the aim of this research is to investigate the effect of moderate intensity interval training on total and phosphorylated content of c-Jun N-terminal kinases protein in heart tissue of type 1 diabetic rats.
Methods: In this experimental study, 12 two-month-old male Sprague Dawley rats with an average weight of 300±20 grams were selected. Type 1 diabetes (blood sugar above 300) was induced to rats through intraperitoneal injection of streptozotocin (with a dose of 50 mg per kilogram of body weight) solution. The rats were randomly divided into two groups, diabetic training and diabetic control; The training group performed MIIT for four weeks at an intensity of 55-75% of maximum speed. Data analysis was done through independent t-test in GraphPad Prism software version 9.5. The significance level of the current research is P≤ 0.05.
Results: The intracellular content of JNK protein after four weeks of MIIT showed a significant decrease in both total (P= 0.01) and phosphorylated (P= 0.0001) forms. On the other hand, the ratio of total to phosphorylated intracellular content of JNK protein did not show a significant change after four weeks of MIIT (P= 0.23).
Conclusion: MIIT led to a decrease in the content of total and phosphorylated forms of JNK protein, which could possibly lead to less cell death in cardiac cells of diabetic subjects.
Mahya Sharifi Rayeni, Farhad Daryanoosh, Mohsen Salesi, Maryam Kooshki Jahromi,
Volume 24, Issue 2 (6-2024)
Abstract
Background: Mitophagy is a type of cell death that regulates the quality of mitochondria and can lead to disorders in diseases such as diabetes. Therefore, the purpose of this study was to investigate the effect of high-intensity interval training (HIIT) on the content of proteins related to the mitophagy pathway (LC3 and BNIP3L) in muscle tissue soleus of rats with type 2 diabetes.
Methods: In this experimental study, 18 three-month-old male Sprague Dawley rats with an average weight of 270±30 g were selected. Rats were infected with type 2 diabetes by intraperitoneal injection of a streptozotocin and nicotinamide solution. Rats were randomly divided into two groups: diabetic and diabetic. A healthy control group was also included. The training group performed HIIT for eight weeks at an intensity of 85-95% of the maximum speed. Data analysis was performed using a one-way ANOVA test in GraphPad Prism version 9.5 software. A significance level of P≤ 0.05 was considered statistically significant.
Results: The levels of LC3 and BNIP3L proteins significantly increase after eight weeks of HIIT compared to both the diabetic and healthy control groups (P= 0.0001).
Conclusion: It can be concluded that HIIT by increasing the factors related to mitophagy can cause the cleaning of dysfunctional mitochondria in the muscle of diabetic subjects; However, excessive mitophagy can also cause functional defects in regulating the quality of mitochondria.
