Showing 30 results for Resistance Training
Farshad Sadeghi, Yaser Kazemzadeh, Abdolali Banaei Far,
Volume 22, Issue 3 (9-2022)
Abstract
Background: Diabetic myopathy is one of the major problems in people with type2 diabetes that knowing its mechanisms can be helpful in controlling and preventing this disease. PAX7 and PGC-1α are two proteins involved in the renewal and metabolism of carbohydrates in skeletal muscle. The aim of this study was to evaluate the effect of 8weeks of resistance training under hypoxia on the content of PAX7 and PGC-1α proteins in the horseshoe muscle of type 2 diabetic rats.
Methods: In this study, 40 male Wistar rats, 10weeks after induction of type2 diabetes, were divided into five groups: healthy control (HC), diabetic control (DC), resistance training (RT), and resistance training in hypoxia (RT-HPX) and hypoxia group (HPX) were divided. Resistance exercises were performed for 8 weeks, 5 sessions per week, in the groups of resistance training and resistance training in hypoxia. The intensity of the exercises started from 30% of the weight of the rats initial and reached 100% of their weight until the end of the training. Resistance training in hypoxia. Hypoxia tent with14.4%oxygen was used to create hypoxia. 48hours after training, tissue samples were taken from horseshoe muscle and evaluated to measure the concentration of PAX7 and PGC-1α proteins.
Results: The results showed that there is a significant difference (P=0.0001) between the research groups in both PAX7 and PGC-1α proteins. Induction of diabetes led to a significant decrease in PAX7, but the hypoxia resistance training group was not significantly different from the healthy control group (P=0.451). PGC1-α protein levels were also significantly decreased in the diabetes induction group compared to the control group (P=0.01), but training in hypoxia increased its levels to more than the healthy control group (P=0.0001).
Conclusion: Hypoxia, resistance training and combination of resistance training in hypoxia increased the amounts of PAX7 and PGC-1α proteins. Therefore, resistance training and temporary and inactive hypoxia exposure can be considered as a suggested solution to improve the indicators related to type2 diabetes in humans.
Masomeh Sarmadiyan, Eidy Aliijani, Fuad Feizolahi, Davood Khorshidi,
Volume 22, Issue 3 (9-2022)
Abstract
Background: Type 1 diabetes is a disorder caused by autoimmune destruction of pancreatic insulin-producing cells. This induction of autoimmunity may be due to genetic and environmental factors. Bax and Bcl2 proteins play an important role in the process of apoptosis.
Methods: In this study, 30 male Wistar rats weighting approximately 200±20gr were randomly selected from available rats in lab (500). Subjects after 2 weeks of familiarity with the environment were randomly divided into 5 groups of 6, including (diabetes + injection, exercise) and (diabetes + exercise) and (diabetes + injection) and (diabetes control to control the passage of time) and (basic diabetes to Defaults) under the same laboratory conditions and developed type 1 diabetes by intraperitoneal injection of streptozotocin (stz) (60 mg / kg). Rats in the diabetic group and the diabetic group + stem cell injection had a total of 17 sessions of resistance training for 5 weeks.
Results: The results of the present study showed that there was no significant difference between the mean of Bax and Bcl2 in the resistance training group with simultaneous injection of stem cells and the training group.
Conclusion: The results of our study showed that performing 17 sessions of resistance training alone with stem cell injection was effective on the expression of Bax protein and Bcl2, but there was no significant difference between the effect of training alone and training with stem cells.
Sajjad Ramezani, Amaneh Porrahim Ghouroghchi, Mohsen Yaghobi, Roghayeh Afroundeh, Mina Rasouli,
Volume 23, Issue 2 (5-2023)
Abstract
Background: During recent decades, physical activity has become a key auxiliary tool in controlling many diseases, including diabetes. The aim of this study was to investigate the effect of 8 weeks of resistance training on the plasma levels of preptin and endothelin 1 in men with type 2 diabetes.
Methods: The current research is semi-experimental. The statistical sample of this study consisted of 38 men with type 2 diabetes, who were randomly divided into two groups of 19 experimental and control. Subjects in the experimental group performed 8 weeks of resistance training three sessions a week with moderate intensity. 24 hours before and after 8 weeks of training, plasma levels of preptin, endothelin 1, and indicators related to type 2 diabetes were measured by the ELISA method. Correlated t-tests and independent t-tests were used to examine intra-group changes. SPSS software was used to analyze the data (P≥ 0.05).
Results: Correlated t results showed that plasma levels of preptin and insulin resistance index (P= 0.001) as well as plasma endothelin 1 (P= 0.001) decreased significantly in the post-test compared to the pre-test of the experimental group. has been found Also, the independent t-test results showed that the plasma levels of preptin, insulin resistance index (P= 0.001) and endothelin 1 (P= 0.002) were significantly lower in the post-test of the experimental group compared to the control.
Conclusion: According to the obtained results, it seems that doing resistance exercises improves glucose sensitivity by reducing preptin and reducing the possibility of blood pressure by reducing endothelin 1 in preople with type 2 diabetes.
Mehdi Zarei, Javad Nakhzari Khodakheir,
Volume 23, Issue 4 (11-2023)
Abstract
Background: Physical activity and exercise training are known as an integral part of weight management and control in overweight or obese people. The aim of this study was to compare the effect of high intensity interval training (HIIT) and intense resistance training on asprosin and C1q/tumor necrosis factor related protein1 (CTRP1) serum levels in overweight and obese men.
Methods: In this semi-experimental study, 31 overweight and obese men were randomly divided into three groups: HIIT training (n=10), intense resistance training (n=11) and control (n=10). The subjects of the experimental groups performed HIIT exercises and intense resistance exercises three times a week for nine weeks. Before and after the intervention, blood samples were taken to measure the serum concentration of asprosin and CTRP1 from the subjects. Analysis of covariance test was used to analyze the data and the significance level was considered as p_value less than 0.05.
Results: The concentration of asprosin in the HIIT group (p=0.013) and intense resistance training (p=0.042) decreased significantly compared to the control group. No significant difference in CTRP1 concentration was observed between groups. However, the concentration of CTRP1 in the HIIT group decreased significantly in the post-test compared to the pre-test.
Conclusion: HIIT training and resistance training in overweight and obese men led to a decrease in asprosin levels. Considering the changes in asprosin, CTRP1 and other anthropometric indicators and lipid profiles, HIIT training seems to have a better efficiency in overweight and obese men.
Vahid Valipour Dehnou,
Volume 24, Issue 5 (12-2024)
Abstract
Background: The beneficial effects of saffron extract and resistance training on the improvement of some diabetes indices have been determined, but their combined effect on BDNF protein levels in rats with type 2 diabetes has not been investigated. Therefore, the aim of the present study was to investigate the effect of saffron extract consumption during resistance training on BDNF protein expression in the hippocampus of rats with type 2 diabetes.
Methods: In this experimental study, 30 adult male rats were randomly divided into five groups: control (C), diabetes (D), diabetes-resistance training (DT), diabetes-saffron extract (DS) and diabetes-saffron extract- resistance training (DTS). Resistance training performed five sessions/w for six weeks. Blood glucose levels and hippocampus BDNF protein levels were measured. To analyze the data, one-way ANOVA was used at the significance level of P< 0.05.
Results: Blood glucose levels of all experimental groups were significantly higher than C group (P= 0.001). Blood glucose levels in DT, DS and DTS groups were significantly lower than D group (P= 0.001). Also, the blood glucose levels of the DTS group were significantly lower than that of the DT group (P= 0.014). In addition, BDNF protein levels of all experimental groups were significantly lower than group C (P< 0.05). Also, BDNF protein levels of D, DT and DS groups were significantly lower than DTS group (P< 0.05). However, BDNF protein levels of D, DT and DS groups were not significantly different (P< 0.05).
Conclusion: Performing resistance training also consuming saffron extract alone and during resistance training reduces blood glucose levels in diabetic rats. However, consumption of saffron extract could increase BDNF protein levels only during resistance training. Therefore, for more efficiency, it is suggested to consume saffron extract during resistance training.
Reza Amini, Abbas Sarmi, Mohammad Reza Afarinesh ,
Volume 24, Issue 5 (12-2024)
Abstract
Background: Alzheimer's disease is the most common type of dementia, which is associated with progressive loss of memory and reaction to the environment. The aim of this study was to investigate the effect of 12 weeks of resistance training with sumac intake on the serum levels of SIR3, SIR4 and AMPK in Alzheimer's male rats.
Methods: In this experimental study, male Wistar rats with an age of 8-10 weeks and an average weight of 230±30 grams were randomly divided into five groups: control, Alzheimer's disease, Alzheimer's disease with sumac supplementation, Alzheimer's disease with resistance training, and Alzheimer's disease with resistance training. Received sumac supplements were divided. To induce Alzheimer's disease, 8 mg/kg of trimethyl tin chloride along with 200 microliters of normal saline were injected intraperitoneally to mice. Resistance training was performed for 12 weeks and 5 days a week on a special rat ladder. 48 hours after the last training session, a blood sample was taken. Serum levels of SIR3, SIR4 and AMPK were evaluated by ELISA method. To check the changes between the control group and other groups using the independent T-test and to check the difference between the other groups using the one-way analysis of variance test and if significant, using the Tukey post hoc test, by SPSS version 29 software at a significance level of P< 0.05 used.
Results: The results of this research showed that 12 weeks of resistance training increases the levels of SIR3 (P< 0.036), SIR4 (P< 0.029) and AMPK (P< 0.447) compared to the Alzheimer group. In addition, adding sumac to the resistance training program had a significant effect on the levels of SIR3 (P< 0.078), SIR4 (P< 0.024) and AMPK (P< 0.002).
Conclusion: Our results suggest that resistance training is associated with the improvement of sirtuin 3, sirtuin 4 and adenosine monophosphate kinase levels in Alzheimer's rats and receiving sumac antioxidant compound leads to doubling of these responses.
Fatemeh Solhdoust, Mohammad Sherafati Moghadam, Bahare Zare,
Volume 24, Issue 6 (2-2025)
Abstract
Background: Endoplasmic reticulum stress leads to unfolded or folded protein response, and ATF4 and CHOP proteins play very important roles in this signalling pathway; Therefore, the aim of this research is the effect of resistance training on the content of ATF4 and CHOP proteins in the left ventricle of the heart of type 2 diabetic rats.
Methods: In this experimental study, 12 two-month-old male Sprague Dawley rats were selected and their weight reached an average of 280±20 gr after four weeks. Type 2 diabetes was induced by injecting nicotinamide solutions (110 mg/kg) and streptozotocin (60 mg/kg). The rats were randomly divided into 2 groups, resistance training and diabetic control; Resistance training consisted of 8 weeks and 3 sessions per week of climbing a vertical ladder with an 85-degree slope, one meter long with 26 steps and 2 cm space between each step. To analyze data, independent t-test was used in SPSS version 29 and Graphpad Prism version 10.2.3. A significance level of P≤0.05 is considered.
Results: The content of ATF4 and CHOP proteins after 8 weeks of resistance training showed a significant change compared to the control group in the left ventricle of the heart (P=0.001).
Conclusion: The increase of ATF4 and CHOP proteins can lead to increased cell death of cardiomyocytes in the left ventricle of the heart of type 2 diabetic subjects through increasing the endoplasmic reticulum stress and initiating the unfolded or folded protein response.
Mehdi Changizi, Rozita Fathi, Rostam Ali Zadeh, Seyed Mohsen Avandi, Ali Khaleghian,
Volume 24, Issue 6 (2-2025)
Abstract
Background: Obesity is known to have metabolic complications including insulin resistance (IR) and metabolic disorder. The aim of this study was to compare the effect of two traditional 12-week circular resistance training methods on the levels of branched and aromatic amino acids and insulin resistance of overweight and obese men.
Methods: The current research method is of the clinical trial type, with Thirty-three overweight and obese men with mean and standard deviation of age, weight and body mass index were 17.7±0.13 years, 92±2.45 kg and 30.70±32 1.32 kg / m2, respectively. They were selected and randomly divided into three groups: circular resistance training (n= 11), traditional resistance training (n= 11) and control (n= 11). The training program consisted of two traditional resistance training protocols and 12-week wave circuits that were exactly the same volume; Which was run three times a week. Blood sampling was performed 48 hours before and after the training protocol and after 8 hours of fasting. HPLC was used to measure serum levels of amino acids.
Results: The results of analysis of variance in the groups showed that circuit training more than 2 times compared to traditional training reduces total BCAAs (35.9 vs. 15.5%) and AAAs in serum (19.5 vs. 9%) and equally the level of insulin resistance. (23 and 26.7 percent, respectively) reduced the door in overweight and obese young men.
Conclusion: The results of this study showed that the level of changes in circular resistance training was higher than traditional. Circular resistance training may be able to prevent obesity-related metabolic disorders.
Mohammad Dastyar, Fatemeh Nikseresht,
Volume 25, Issue 1 (4-2025)
Abstract
Background: The aim of this study was to determine effect of resistance training on the expression of PI3K, AKT1 and mTORc1 in the heart tissue of type 2 diabetes rats and their physiological cardiac hypertrophy.
Methods: 21 male wistar rats (220±20 g) were obese by 6 weeks high fat diet (HFD). After inducing obesity, T2D induced by intraperitoneal injection of streptozotocin (30 mg/kg) in 14 rats. Finally, the rat were randomly assigned to 1) non-diabetes, 2) control T2D, 3) resistance diabetes groups. Rats in the resistance group were completed a resistance
training program, 5 sessions weekly for 6 weeks. PI3K, AKT1 and mTORc1 expression and the weight ratio of left ventricular to heart, left ventricular to body and heart to body were compared by ANOVA between groups.
Results: In response to induction of diabetes, the expression of PI3K, AKT1 and mTORc1 in heart tissue decreased significantly compared to the non-diabetic group (p < 0.05). Resistance training resulted in significant increase in the expression of PI3K, AKT1 and mTORc1 and the weight ratio of left ventricular to heart, heart to body and left ventricular to body compared to control diabetes rats (p < 0.05).
Conclusion: Resistance training is associated with physiological cardiac hypertrophy in diabetic rats, and this improvement can be attributed to the PI3K/AKT1/mTORc1 signaling pathway.
Saleh Afrasyabi,
Volume 25, Issue 3 (7-2025)
Abstract
Background: Today, obesity is closely related to metabolic syndrome and especially type 2 diabetes, which changes the secretion and release of adipocytokines, and different training programs have different results on these indicators. Therefore, the aim of the present study is to investigate the durability of changes caused by exercise programs on adipocytokine indices of obese type 2 diabetic patients.
Methods: In this semi-experimental study, 45 obese men with type 2 diabetes were randomly divided into a control group (no exercise) and 4 exercise groups (aerobic, combined, resistance and high-intensity interval). The exercise program of the groups was considered based on the calories consumed in each session. The participants performed 12 weeks of training programs and 12 weeks of non-training. Physiological, anthropometric indicators and inflammatory and pro-inflammatory indicators (IL-6, TNF-α, resistin and leptin) and anti-inflammatory indicators (adiponectin and SFRP5) were measured before the program and at weeks 6, 12, 18 and 24. became.
Results: After 12 weeks of combined, aerobic, high intensity and resistance training, anti-inflammatory indices (adiponectin and SFRP5) showed a significant increase compared to the baseline (before starting the training program) (P< 0.05). Regarding pro-inflammatory and anti-inflammatory indicators (IL-6, TNF-α, resistin and leptin), a significant decrease was observed in all groups after 12 weeks of training program (P< 0.05). In this study, a significant improvement in weight loss and blood glucose was observed after 12 weeks of exercise program in all 4 exercise groups (P< 0.05). In the second part of the findings (non-training or durability of training effect), it was resistance training that showed a lower percentage decrease (P< 0.05) in anti-inflammatory indices and an increase in pro-inflammatory and inflammatory indices after 12 weeks of non-training, which showed the durability It shows more recovery in obese type 2 diabetic patients (P< 0.05).
Conclusion: The findings of the research showed that high-intensity interval training after 12 weeks can cause a greater effect on inflammatory, pro-inflammatory and anti-inflammatory indicators compared to aerobic, combined and resistance training. But this is the resistance exercise that caused the reduction in inflammatory, pro-inflammatory indicators and increase in anti-inflammatory indicators in obese type 2 diabetic patients to be more permanent. Therefore, the effectiveness of resistance training in non-training conditions from three methods of high-intensity interval training, aerobic and combined (aerobic + resistance) has a greater effect on low-grade inflammation and results in a longer recovery in obese type 2 diabetic patients.
