Showing 49 results for Ebrahim
Maryam Chinisaz, Azadeh Ebrahim-Habibi, Parichehreh Yaghmaei, Kazem Parivar, Ahmad- Reza Dehpour,
Volume 13, Issue 4 (5-2014)
Abstract
Background: The flexible structure of proteins is one important factor in the formation of ordered aggregates (amyloid fibril). This is a major problem for therapeutic proteins such as insulin. Study on the induction and inhibition of insulin fibrillation process with specific compounds such as aromatic derivatives may provide useful information about means of stabilization of protein structures.
Methods: To induce fibrillation, regular insulin was incubated in phosphate buffer (pH=7.4) during 24 hours. Amyloid formation was investigated by using Congo red absorbance and transmission electron microscopy (TEM). Then nodular amyloidosis was observed in mice upon amyloid fibril injection, after which the excised nodule was studied by Congo red staining and polarized light microscopy. Then, some aromatic compounds effect was investigated on the fibrillation process.
Results: Regular insulin form mature amyloid fibrils at pH=7.4, 37°C after 24 hours. Silibinin had the highest inhibitory effect on that process. Furthermore, Amyloid fibril injection in mice caused nodular amyloidosis.
Conclusion: Regular insulin has a high potential to undergo amyloid aggregation. Nodular amyloidosis confirms fibril formation by insulin under in vitro condition. Silibinin could be considered as a potential compound capable to increase protein structure stability.
Parichehreh Yaghmaei, Faazaneh Abbasi, Azadeh Ebrahim-Habibi, Atieh Hesaraki,
Volume 13, Issue 5 (7-2014)
Abstract
Background : PCOS (Polycystic Ovary Syndrome = PCOS) is a relatively common disease in women of childbearing age. Bisphenol s are chemical groups that are composed of two functional hydroxyl group and most of them are based on methane. In this study, the effects of phenolic compounds, (bisphenol A and AP) in polycystic ovary syndrome were investigated.
Methods : mature Wister rats were classified in six groups . Healthy controls ( healthy rats that received Grape seed Oil as solvent ), PCOS Group ( disease induced by testosterone propionate ) experimental groups 1.2.3.4 , respectively. after induction of PCOS,they received bisphenol- A and AP in doses of25 mg / kg, 50mg/kg, by gavage . Blood samples were taken and the hormones LH, FSH was measured . Ovaries were also to be studied histologically .
Results : The results showed that the amount of LH to FSH ratio increases after induction with bisphenol-A and bisphenols AP,. Furthermore the number of follicles and growing follicles were reduced significantly, and these concequences causing negative effects on polycystic ovary syndrome.
Ghasem Sazegar, Vahid Ebrahimi, Mohammad Javad Saeedi Boroujeni, Shabnam Mohammadi, Ramin Salimnezhad,
Volume 14, Issue 1 (1-2015)
Abstract
Background: Given diabetes mellitus has an adverse effect on spermatogenesis and male fertility, the aim of the present study was to investigate the effect of L-carnitine administration on spermatogenesis and testicular structure in diabetic rats induced with Stereptozotocin.
Methods: In this experimental study, fifteen rats were randomly divided into 3 groups: control group was received citrate buffer. Case group was diabetic rats that received 40 mg/kg carnitine for 16 days. Third group was diabetic rats that did not receive carnitine. After sixteen days, morphometric study was performed. Besides, index of testicular weight was obtained. Then, data were analyzed using SPSS software and ANOVA.
Results: In testicular sections of diabetic rats were observed a disruption and deformity in first layer of somniferous tubules. Statistical analysis showed a significant difference in carnitine group when compared to the control group (P<0.05). There was a significant difference between weight of diabetic rat compared to the control group (P<0.001). Besides, there was the most ratio of testis index in control group.
Conclusion: Our finding showed that short-term L-carnitine administration was affective on the diameter and thickness of seminiferous tubules. Hence, L-carnitine treatment may cause an improvement in spermatogenesis of diabetic men.
Mahsa Soltani-Nobakht , Parichehreh Yaghmaei, Azadeh Ebrahim-Habibi,
Volume 14, Issue 3 (3-2015)
Abstract
Background: Alpha-amylase is the most important enzyme in the digestion of starch. Activators of this enzyme could be potentially used as digestive aids and its inhibitors block the absorption of starch compounds and result in the control of blood sugar levels. This study aimed at the investigation of aromatic compounds on bovine serum alpha-amylase. Methods: Effect of carvacrol, cumyl phenol, tryptamine, tryptophan, N-acetyl-L-tryptophan, Bis phenol A, 2-benzyloxy phenol, 2,6 diisopropyl phenol and 4-chloro-2-isopropyl-5-methyl phenol was investigated on bovine serum alpha-amylase with use of artificial substrate (laboratory kit). Results: Most of tested aromatic compounds showed a similar pattern. All these compounds had 5-30% inhibitory effect on the tested serum with the exception of tryptamine which showed a 20% increase in the enzyme activity. The best inhibitory effect was obtained from cumyl phenol in the range of 30%. Conclusion: This study showed that aromatic compounds with one and two cycles have moderate inhibitory effect on bovine serum alpha-amylase and tryptamine showed a slight activator effect. With regard to these results, indolic and phenolic structures may be effective on alpha-amylase, and in the next step, investigation of these compounds derivatives is suggested.
Farid Bahrpeyma, Mehdi Ebrahimi, Razieh Javadian Kotenaei,
Volume 15, Issue 2 (1-2016)
Abstract
Background: One of the most common complications of Diabetic Polyneuropathy (DPN) is decreased balance and Postural Control disorder. Balance has an important role in static and dynamic activities as a base of activities of daily living. The objective of this study was the evaluation and comparison of dynamic and functional balance in patients with DPN and healthy subjects.
Methods: In this study, dynamic and functional balance of 11diabetic patients with DPN (detected by Michigan questionnaire) and 11 healthy subjects were evaluated by Biodex Balance System (BBS) and Tandem Stance (TS) test in open and closed eyes conditions. The participants were matched by age and BMI. An independent t-test was used to compare balance parameters between patient and normal group. Furthermore, the correlation between dynamic balance parameters of BBS and TS tests were calculated using the Pearson’s Correlation Coefficient.
Results: The results of BBS in patients with diabetic peripheral neuropathy were significantly higher than normal subjects (P<0.05). The mean of time of TS test in diabetic group was significantly lower than healthy subjects (P<0.05). Also there was a significant (P=0.004) negative (r = 0.794) correlation between Medio-Lateral stability index (recorded from BBS) and TS with open eye, in diabetes group.
Conclusion: Older adults with DPN have an impaired functional balance in comparison with matched control subjects and this may expose the patients to danger of falling during daily activities.
Leila Zamanpour, Ebrahim Banitalebi, Seyed Ehsan Amirhosseini,
Volume 15, Issue 5 (7-2016)
Abstract
Background: The purpose of this study is to the comparison of the effect of 12 weeks of sprint training and concurrent aerobic and strength training on high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and insulin resistance in women with diabetes mellitus (T2DM)
Methods: 52 overweight female type 2 diabetic patients (age; 45-60 years old and fasting blood glucose ≥ 126 mg/dl (7.0 mmol/l)) were assessed for eligibility. Participants were assigned to intense interval training group (N=17), concurrent resistance- endurance training group (N=17) and control group (N=18). The combined strength-endurance group did 12 weeks, three sessions per week endurance training with 60 % of maximal heart rate and two session resistance training with 70 % 1-RM. Intense interval training group did three session/week of 4-10 repetition of all out 30s Wingate on ergometer were included 10 weeks of concurrent resistance- endurance training and intense interval training.
Results: The results showed that following sprint training, there were significant changes in hs-CRP (p<0.001), but it wasn’t significant following concurrent training (p=0.062). According to results, TNF-α change were not significant in intense sprint (p=0.11) and concurrent training (p=0.23). Differences were not significant for the fasting blood glucose in the intense interval training groups (p=0.000). Serum insulin levels showed significant increases in the SIT (p<0.000) and concurrent training (p=0.000) significantly. The data showed significant differences in insulin resistance index (HOMA-IR) in intense interval training (p=0.000) and concurrent resistance- endurance training (p=0.008). ANCOVA test showed no significant difference in fasting blood glucose concentrations (P=0.171).
Conclusion: Intense sprint training compare to concurrent strength-endurance training can have better inflammatory status for patients with type 2diabete.
Mohammad Hossein Hajiebrahimi, Atieh Qanehari, Abdurrahman Charkazi, Zahra Hajiebrahimi,
Volume 16, Issue 4 (9-2017)
Abstract
Background: Increasing number of elder people accompanied with an increasing number of subjects with chronic diseases among them. The aim of this study was to compare the results of physical condition of elder people in Grogan city, Golestan, Iran, in 2009 with the results in 2004.
Methods: Through a cross-sectional study using a standard questionnaire data on 884 elder people who were resident in 4th and 5th health station covered by Gorgan health center at 2009 were collected by trained persons as self-report. Participants entered in the study through a census method are asked about their physical condition. Using Qui-Square method, collected data has been analyzed. The results were compared with the outcomes of pervious study (unpublished) at 2004 which has been carried out among 315 elder people in the same study area. SAS 9.2 software has been used for data analyzing.
Results: Mean age of elders at 2009 was 67.20±6.67 years and at 2004 was 67.59±6.72 years. Frequency of Hypertension, hyperlipidemia, asthma, diabetes showed a statistically significant (p<0.05) increase in 2009 compared with 2004. On the other hand, the frequency of epilepsy, losing of teeth, inguinal hernia and heart burn decreased during these years, statistically significant again (p<0.05).
Conclusion: The results of the current study indicated that cardiovascular disease significantly increased in second phase of the study rather than first one. It is necessity to interventions to the control of these problems.
Baharak Najafi, Parisa Taheri Tanjani, Farshad Sharifi, Hosein Fakhrzad, Mahtab Alizadeh, Masoud Arzaghi, Mehdi Varmaghani, Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: The aging of the population is a great challenge of the public health in this century. The health promotion of the elderly people requires a comprehensive and accurate understanding of their health status.
Methods: This cross-sectional study has assessed the health status of 191 old people ≥ 60 in Sistan and Balouchestan province that selected by a multi-level cluster random sampling. General health data was collected using SF-36 questionnaire, nutrition status was assessed using Mini Nutritional Assessment (MNA), depression status was detected by the geriatric depression scale-15 (GDS-15), functional status was assessed using the activity daily living (ADL) and instrumental activity daily living (IADL) questionnaires, as well as, the information about demographic, history of diseases, vaccination, participation in social activities, and the utilization of elderly care services were evaluated by an approved questionnaire. History of hypertension was asked from the participants. Moreover the blood pressures of them were twice measured.
Results: The mean age of the participants was 69.81 (8.32) years. The health status was reported excellent and bad by 4.2% and 9.4% of the participants, respectively. The prevalence of fall in recent year, memory disorder, hearing and visual impairment, and malnutrition were 35.3%, 15.6%, 30.3%, 56.6%, and 8.9%, respectively. The prevalence of dependency in "activity of daily living" and "instrumental activity of daily living" were 25.8% and 58.2%, respectively.
Conclusion: It seems that the prevalence of malnutrition, impaired ADL and IADL, and memory impairment in the older population of Sistan and Baluchestan are above the national and global averages.
Parisa Taheri Tanjani, Mehdi Varmaghani, Neds Nazari, Farshad Sharifi, Hossein Fakhrzadeh, Seyed Masoud Arzaghi, Mahtab Alizadeh Khoee, Mohammad Smaeel Motlagh, Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Elderly people need more receiving health services. Planning to provide services at regional and national levels requires information about the health status of the elderly. This study was performed to assess the health status of East Azarbaijan province.
Methods: In this cross-sectional study, 436 subjects were enrolled (180 men and 258 women) aged ≥ 60 years using multi-level proportioned cluster Random sampling from 19 cities of the province.
Data was collected by a demographic questionnaire , measuring anthropometric characteristics, and blood pressure and using "Mini Nutritional Assessment" ,”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”, and "Lawton’s Instrumental activities of daily living”.
Results: The mean age of the participants was 69.31 years. The self-reported prevalence of diabetes was 34.2%. The prevalence of hypertension in the elderly was 52.5%. The most common complaint of the participants was pain (60.9%). Totally, 46.9% had a difficulty in walking, 44.3% visually impaired, and 26.4% suffered from hearing impairment. Moreover, 44.8% of sleep disorders was found. Also 26% of the participants had depressed mood.
Conclusion: Elderly residents of East Azerbaijan province, has probably a better health status than the average Iranian elderly. However, there is a high prevalence of hypertension and diabetes among older adults of this province that need to more pay attention.
Parisa Taheri-Tanjani, Farshad Sharifi, Neda Nazari, Hossein Fakhrzadeh, Mahtab Alizadeh-Khoee, Mohammad Smaeel Motlagh, Hosna Ataee, Seyed Masoud Arzaghi , Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Alborz Province is one of the provinces that accepted immigrants. Immigration has a profound effect on physical and mental health in elderly. This study was performed to assess the health status of Alborz province older population.
Methods: In this cross-sectional study, 235 subjects were enrolled (113 men and 122 women) aged ≥ 60 years using multi-level proportionated cluster random sampling that selected from 19 cities of this province. Data was collected by a demographic questionnaire, measuring anthropometric characteristics, and blood pressure and using "Mini Nutritional Assessment", ”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”, and "Lawton’s Instrumental activities of daily living”. Data was analyzed with spss21.
Results: The mean age of the participants was 68(6.00) years. The prevalence of anxiety and depression among the participants was as 51.5% and 34%, respectively. At risk or malnutrition was observed in 27% of the participants and 54.5% had suffered dental problems and 49.8% also had problem in walking.
Conclusion: Overall, the health status of elderly people in the Alborz, perhaps slightly better than the national average, but the high prevalence of metabolic disorders also the high prevalence of depression and anxiety require serious intervention by policy makers to promote the health in elderly.
Sepideh Rahimi Moshkeleh, Ebrahim Masoudnia, Vahid Nik Seresht,
Volume 17, Issue 2 (3-2018)
Abstract
Background: One of the risk factors that have been little attention to it in the etiology of type 2 diabetes is lifestyle. The aim of this study was to determine the relationship between components of lifestyle and incidence of type 2 diabetes among people aged 30 to 60 years in Rasht.
Methods: This study was conducted with a case-control design. Data were collected from 150 patients with type 2 diabetes symptoms that had been admitted to Golsar and Heshmat hospitals and Rasht Diabetes Association (Cases) and 150 subjects without type 2 diabetes symptoms (controls) aged 30 to 60 years in Rasht. Measuring tools included checklist of socio-demographic and clinical characteristics and short-form Health-Promoting Lifestyle Profile. Data were analyzed using t-test and chi-square statistics and the software SPSS version 22.
Result: There was a significant difference between people with type 2 diabetes symptoms (cases) and healthy individuals (controls) regarding to age, body mass index (BMI), education level (P< 0.01), marital status (P< 0.05), family history of diabetes, history of smoking, hypertension hypertension, heart disease and job status (P< 0.01). Also, there was a significant difference between the two groups in terms of the components of spiritual growth and self-actualization, stress management, physical activity (P< 0.01), and health responsibility (P< 0.05).
Conclusion: Insufficiency of the lifestyle components, especially spiritual growth and self-actualization, stress management, health responsibility and physical activity are major risk factors for Type 2 Diabetes. Therefore, cognitive and behavioral interventions to modify and improve health-related lifestyles seems necessary.
Elham Ebrahimi, Bahman Sadegi Sedeh, Mohammad Reza Rezvanfar,
Volume 17, Issue 3 (3-2018)
Abstract
Background: Insulin is first choice for gestational diabetes control, but its needed to frequent injections; one thing that is difficult for pregnant women, so interest to metformin consumption is increased. Metformin easily crosses the placenta and its fetal blood levels is equivalent to the level of the mother's blood. Metformin also easily cross the brain barrier and enter the brain. Possible side effects of metformin compared to insulin on fetus brain development was concerned to design of present study.
Methods: In this cross-sectional prospective trial, gestational diabetes women were recruited randomly to insulin (64 patients) and metformin (64 patients) groups and compared for pregnancy and neonatal outcome and also six-month-old infancy developmental indexes. The results considered significant if P value was ≤ 0.05.
Results: Six-month body mass index of insulin group women was significantly more than metformin group(P=0.05), but there was not any significant difference in cesarean section, preterm labor, dystocia, preeclampsia and still birth rate between two groups. Also neonatal characteristics, need to admission and six-month-old infancy developmental indexes according to Ages stages questionnaire were no different between two groups.
Conclusion: Metformin consumption in compare to insulin was not associated with maternal, neonatal and six-month-old infancy developmental indexes side effects.
Mahdi Ghafari, Mohamad Faramarzi, Ebrahim Banitalebi,
Volume 17, Issue 4 (5-2018)
Abstract
Background: Lipid metabolism disorder in muscle plays an important role in creating insulin resistance in skeletal muscle. Perilipin 3 (PLIN3) is one of PLIN proteins in regulation of muscle lipolysis. The purpose of this study was compared two different endurance training intensities on perilipin 3 protein expression in skeletal muscle, serum insulin levels and glucose in streptozotocin-induced diabetic rats.
Method: 24 male Wistar rats were randomly divided into three groups. Low and high and high-intensity and control group. Endurance training was applied three times a week for eight weeks. The low-intensity exercise group was trained to the treadmill by running at a speed of 60 percent of vo2max and high-intensity training 85%Vo2max. The expression of the plin2 protein was analyzed by Western blot technique. To determine the significance of differences between the groups, the results were analyzed using one-way ANOVA and Tukey post-hoc test (α= 0.05).
Results: Direct comparison between the groups by ANOVA showed significant differences in perilipin 3 (p=0.0006). Tukey's post hoc test showed that there was a statistical difference between the mean values of the diabetic control group and high-intensity endurance group (P = 0.01). Perilipin 3 not significantly increased in low-intensity exercise compared to the control group (P=0. 67). Also, the comparison between groups showed, there was significant difference between the three groups. The serum levels of glucose and insulin (respectively p=0.001 and p=.001).
Conclusion: The results of the present study showed that the Effects of with high-intensity endurance training increase the expression perilipin 3 in diabetes rats.
Mohammad Azimi Alamouti , Niloufar Shayan, Maryam Momeni, Masoumeh Nouri, Azam Koohkan, Ensiyeh Hajizadeh-Saffar, Fatemeh Soltanolizadeh, Maliheh Mahmoudi, Mahin Jamshidi Makiani, Marzieh Ebrahimi,
Volume 18, Issue 3 (3-2019)
Abstract
Background: For nearly 100 years, amniotic membranes have been used to treat various types of skin wounds. Amniotic extract is one of the derivatives of amniotic membrane that contains all the properties of amniotic membrane. The aim of this study was to evaluate the safety of the amniotic membrane extract in the treatment of diabetic ulcers.
Methods: This study was an Open labeled clinical trial without control group. A total of 10 patients with Wagner Grade 2 diabetic foot ulcers were selected in both sexes. The extract was used every 48 hours in the first week and every 72 hours from the second week until the end of the wound treatment. Patients were followed up weekly until wound healing.
Results: In this study 80% of patients were men and 20% were women with mean age (56.7 ± 8.7) years. The ulcer duration was 8.9 ± 2.12 weeks. The mean area of ulcers at the time of entry into the wound group ≥ 500 mm2, 977.5 ± 201.9 and in the wound group ≤500 mm2 was 145.6 ± 36.4. At 4 weeks post treatment, the wound healing rate in the wound group was ≤500mm2 ,98.9 ± 2.40 % and in the wound group ≥mm2 500 was 92.1 ± 7.23%. in sixth week of treatment, ulcers were complete closure in both groups.
Conclusion: The results of this study suggest that the use of amniotic extract can be effective in the healing of diabetes foot ulcer without any side effects.
Zhaleh Shademan, Farshad Sharifi, Mahbube Ebrahimpur, Moloud Payab, Seyed Masoud Arzaghi, Hossein Fakhrzadeh,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: Identifying the risk factors for the health of the elderly and designing interventions to improve the health of the elderly is one of the priorities of the health care system in the world today. This first requires the promotion of scientific knowledge in the field of health problems of the elderly.
Methods: In this review conducted in 1399, all studies with the keyword of aging or age-related diseases such as atherosclerosis, osteoporosis, diabetes, dementia, frailty, cognitive impairment, daily life function, nutritional status with organizational affiliation of the Endocrinology and Metabolism Research center or the Elderly Health Research Center of Tehran University of Medical Sciences were reviewed without time limit in databases, PubMed, Web of Science, Scopus and Google Scalar search engines.
Results: A total of 115 studies were found with these keywords. By examining the sampling, method, data analysis and also the removal of similar data, 63 articles were reviewed.
Conclusion: In this regard, the Elderly Health Research center has conducted several studies to localize tools for assessing the health of the elderly, identifying common diseases of the elderly, the prevalence of diseases and syndromes of the elderly and designing several interventional studies in the form of three large studies Kahrizak elderly study, Bushehr elderly health study and Birjand elderly longitudinal study has been discussed in this review.
Parisa Dana, Nasim Hayati Rodbari, Parichehreh Yaghmaei, Zahra Haj Ebrahimi,
Volume 21, Issue 4 (10-2021)
Abstract
Background: Empagliflozin, selective glucose-sodium inhibitor of the latest drugs in the treatment of type 2 diabetes. Diabetes induced hypogonadism disrupts sexual function. There is a direct relationship between reducing blood glucose and reduced libido. In this project, the anti-diabetic drug Empagliflozin in addition to treatment has been studied, in terms of effect on sexual function.
Methods: Type 2 diabetes with injection of 60 mg/kg streptozotocin per body weight was create intraperitoneally. The primary diabetes was treated with two doses of 10 and 25 mg/kg Empagliflozin per body weight. Sexual hormones, biochemical parameters and lipid profile were measured. Evaluation of Sperm parameters and morphological studies were performed on testicular tissue, pancreas and epididymis. Data were analyzed by one-way ANOVA in SPSS software version 22 and P˂0.05 was considered as a significant level.
Results: Empagliflozin significantly increases the quality, survival and natural state of sperm head and tail. Empagliflozin reduces weight in diabetic rats. Empagliflozin Without increasing hyperglycemia by reducing blood glucose affects steroidogenesis, maintains fertility strength in testicles, and increases the level of sex hormones. Empagliflozin significantly increases insulin secretion. Empagliflozin maintains and integrity of pancreatic beta cells. Empagliflozin has no effect on lipid profile.
Conclusion: Empagliflozin in addition positive effects on the treatment of diabetes in the early stage improves sexual function in adult rats.
Marayam Arabloei Sani, Parichehreh Yaghmaei, Zahra Hajebrahimi, Nasim Hayati Roodbari,
Volume 22, Issue 3 (9-2022)
Abstract
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong association between hyperglycemia, oxidative stress and the development of diabetes. Therefore, screening and early diagnosis of this disease in people at high risk can be effective in preventing these complications. The main route of insulin signaling is to control lipid and glucose metabolism, and its imbalance leads to type 2 diabetes. P-Cymene is an aromatic monoterpene with a wide range of therapeutic properties including antioxidant activity. The aim of this study was to evaluate the effect of p-Cymene at a dose of 50 mg / kg in preventing the symptoms of diabetes and serum factors.
Materials and Methods: 30 male Wistar rats weighing approximately 250 g were randomly selected and divided into five groups: control, diabetic control (sham), metformin-treated diabetic (met), and non-diabetic treated. P-Cymene and diabetics treated with P-Cymene were divided. One week after streptozotocin injection, treatment with P-Cymene at a dose of 50 mg / kg was performed by sunflower oil solvent for 28 days by gavage. At the end of the experiment, blood samples were taken from the hearts of rats and the parameters of glucose, insulin, and superoxide dismutase (SOD) were measured.
Results: The results showed that diabetes increased water and food intake as well as glucose levels and decreased insulin (P <0.001) and superoxide dismutase activity in rats and administration of P-Cymene extract improved the symptoms of diabetes and oxidative stress in Became diabetic rat.
Fatemeh Janbozorgi, Farshad Ghazalian, Khosrow Ebrahim, Hosein Abed Natanzi , Mandana Gholami,
Volume 22, Issue 4 (11-2022)
Abstract
Introduction: The purpose of this research was to explain the protective effect of quercetin on cardiac fatigue caused by exercise in skyrunning runners.
Methods: 26 professional sky running athletes voluntarily and purposefully participated in this race. Random people were placed in 2 groups: quercetin (13 people) and placebo (13 people). The race was held in the central Alborz mountains, the total distance traveled was 21 km and 200 meters, the altitude of the starting point was 1650 meters above sea level, the maximum altitude was 3150 meters above sea level. Before and immediately and 1 hour after the end of the race, blood was taken from the subjects. In order to check the changes of the studied variables, the independent T-test was used at the significance level of alpha 0.05.
Results: The amount of cardiac troponin T decreased significantly immediately and 1 hour after the end of the race in the quercetin group compared to the placebo group (P < 0.05). No significant difference was observed between the two groups of quercetin and placebo in the pre-test, immediately after the test and 1 hour after the test (P>0.05).
Conclusion: It seems that the increase of free fatty acids after the competition and long-term sports play an important role in reducing cardiac inotropic during the same period. Skyrunning competitions cause an increase in heart damage indices in professional athletes, despite this, quercetin supplementation reduces the increase in cardiac troponin T and can have a protective effect on the athlete's heart
Mahin Rasuli, Ebrahim Zarrinkalam,
Volume 22, Issue 4 (11-2022)
Abstract
Background: A high-fat diet causes hyperinsulinemia and increases insulin resistance in the body. On the other hand, the oxidative stress caused by hyperglycemia can lead to the exacerbation of hyperglycemia and increase the complications of diabetes, and cardiovascular diseases are one of the most important complications of diabetes mellitus. Therefore, the aim of this study was to investigate the effect of 4 weeks of aerobic training on catalase enzyme activity in the left ventricle and insulin resistance index in male rats treated with streptozotocin and exposed to a high-fat diet.
Methods: In this experimental study, 19 male wistar rats, with an average age of 8-12 weeks and a weight of 200-250 grams, were divided into 3 groups: diabetic control (CD 8), training diabetes (TD 8) and healthy control (C 3). The exercise program included 4 weeks of aerobic exercise with an average of 60 to 75 Vo2max in an increasing manner. Before and 48 hours after the last training session, blood was taken and left ventricular tissue samples were extracted to check the HOMA-IR index and catalase activity by ELISA method. To compare the study groups, one-way analysis of variance and Scheffe's post hoc test were used in SPSS software (p≥0.05).
Results: The results showed that the induction of diabetes with STZ along with a high-fat diet causes a significant decrease in catalase enzyme (P=0.001) and a significant increase in HOMA-IR index, fasting glucose and Li index (P=0.001) in rats. However, doing 4 weeks of aerobic training caused a significant increase in catalase enzyme activity (P=0.001) and a decrease in HOMA-IR index, glucose and Li index (P=0.001).
Conclusion: Aerobic exercise with moderate intensity can be used as an effective non-pharmacological method in the treatment of diabetic cardiomyopathy by increasing catalase activity and reducing resistance to insulitis in diabetes.
Paria Maghouli, Roghayyeh Afroundeh, Mohammad Ebrahim Bahram, Amaneh Pourrahim Ghoroughchi,
Volume 24, Issue 2 (6-2024)
Abstract
Background: The aim of this study was to investigate the effect of eight weeks of circuit resistance training and saffron supplement on visfatin serum levels and insulin resistance in overweight men.
Methods: In this semi-experimental study, 40 obese and overweight students were randomly divided into 4 groups: exercise, exercise+supplement, supplement and control (10 people in each group). The exercise groups performed circular resistance exercises for eight weeks and three sessions each week for 90 minutes in the evening. The supplement and exercise+supplement groups used saffron tablets with a dose of 30 mg per day as a supplement. Blood samples were collected in two phases of the pre-test and 48 hours after the last training session. The data were analyzed using covariance and paired t test at a significant level of P≤0.05.
Results: Correlated t results showed a significant decrease in visfatin and insulin resistance in the post-test of the training, training+supplement and supplement groups compared to the pre-test (P<0.05). The results of the analysis of covariance showed that visfatin increased and the insulin resistance index decreased significantly in the exercise, exercise+supplement and supplement groups compared to the control group (P<0.05).
Conclusion: It seems that eight weeks of circuit resistance training and the addition of saffron help on visfatin serum levels and insulin resistance can lead to the reduction of these two variables in overweight men. The saffron plant can play a protective role due to the presence of flavonoids and by stimulating the secretion of Visfatin.
