Showing 119 results for Larijani
Fatemeh Mohammadzadeh, Kobra Omidfar, Ramin Heshmat, Mazaher Rahmani, Bagher Larijani,
Volume 6, Issue 3 (17 2007)
Abstract
Background: Microalbominuria (MA) is early presentation of renal damage which acts as an independent factor of cardiovascular events in these patients. There are various methods for sampling and also different laboratory tests to measuring albominuria. The aim of this study was to compare of different urine collection methods for measuring albominuria using immunoturbidometry assay which has acceptable accuracy and sensitivity after HPLC (High Performance Lipid Chromathography).
Methods: Forty seven diabetic patients were selected for a cross-sectional study in 2006. For all patients 24-h urine sample were collected, also an overnight urine sample (8 hour long) and spot urine sample (morning time) was provided in the next day. The level of albumin in all samples were measured via immunoturbidometry assay. Then the results of agreement coefficient were accounted and comprised with each others.
Results: In this study 47 patients were selected which 46 of them were type 2 and one of them type 1 diabetic. Our results revealed significant correlation between all methods. In addition agreement coefficient (kappa) was accounted for all methods, time 24-h urine in comparison with 8 hours overnight urine, timed 24-h urine in comparison with spot urine and overnight urine samples in comparison with spot urine which were 0.876, 0.936 and 0.807 respectively.
Conclusion: Regarding significant agreement for screening of microalbominuria between different collecting methods, we suggest 8-h overnight or spot urine sampling carry out instead of 24-h urine collection.
Javad Heidari, Bagher Larijani,
Volume 6, Issue 4 (17 2007)
Abstract
It is estimated that there are 1.1-1.5 billion Muslims worldwide, and prevalence of diabetes is approximately 4.6%. Many patients with diabetes insist on fasting during Ramadan, thereby creates a medical challenge for themselves and their physicians. These patients are susceptible to diabetic complications such as hypoglycemia and hyperglycemia. It is therefore important that medical professionals be aware of potential risks that may be associated with fasting during Ramadan. Patients who insist on Ramadan fasting be assessed before Ramadan and receive appropriate education and instructions related to physical activity, meal planning, glucose monitoring, and dosage and timing of medications. In this article, management of diabetes in Ramadan is discussed.
Mohsen Khoshniat, Zahra Komeylian, Mansoureh Moadi, Maryam Peimani, Ramin Heshmat, Reza Baradar Jalili, Bagher Larijani,
Volume 6, Issue 4 (17 2007)
Abstract
Background: Children with Type 1 diabetes were present one of the greatest challenges in the worldwide. Health-care providers must be sufficiently aware of diabetes so that such children make utmost benefit of their educational opportunities. The aim of the present study was to compare the effect of three educational methods in raising the level of knowledge of school health-care providers. Therefore the best method would be applied for this purpose.
Methods: In this interventional study 132 samples were randomly chosen from the list of school health care providers of Tehran and divided to the three groups (educated by posters, booklets, and group education). A questionnaire was completed for all the three groups before and after the education. Questionnaire consisted of two parts: -demographic information and 16 questions about diabetes information. Scores were analyzed by descriptive and inferential methods (T-test, ANOVA).
Results: The level of knowledge of school health-care providers was weak in 23.5% of the case, average in 59.8% of cases, and good in 16.7% of cases. The level of knowledge in the groups educated by booklets and group education increased meaningfully, while no obvious increase was observed in the group trained via posters.
Conclusion: From the three aforementioned training methods, group education and education by booklets have the most effect on raising the level of knowledge of health-care providers.
Nader Lessan, Maryam Ghodsi, Sadaf Farooqi, Bagher Larijani,
Volume 6, Issue 4 (17 2007)
Abstract
It is estimated that up to 40-70% of obesities is attributable to genetic factors. Monogenic forms of obesity are uncommon. We present the first such reported case in Iran. The patient presented with a history of severe hyperphagia, rapid weight gain and recurrent infections. He was born after a normal pregnancy in a highly consanguineous marriage. His birth weight had been normal. At age of 18 months he weighted 28 kg. Apart from obesity and syndactyly of second/third digits in both feet there were no other abnormalities on physical examination. His fasting serum leptin was 45 ng/ml. Genotyping revealed 66-bp deletion in codon 514 of leptin receptor gene.
Unfortunately he developed another respiratory infection which was unresponsive to intensive treatment and died following a cardiorespiratory arrest. Genetic assessment is recommended in morbid obese patients especially those with a childhood onset. Leptin receptor mutations can be associated with immune system deficiency and recurrent infections.
Ozra Tabatabaei Malazy, Mohammad Reza Mohajeri Tehrani, Mohammad Hossein Forozanfar, Zahra Shaban Nejad, Bagher Larijani,
Volume 6, Issue 4 (17 2007)
Abstract
Background: Pump therapy (CSII) is offered as a safe and effective treatment for patients with type 1 Diabetes. We examined the efficacy and safety of continuous subcutaneous Insulin Infusion Therapy for six months as a before-after clinical trial study among type 1 diabetic patients. This is the first survey of this experience in Iranian patients.
Methods: We recruited, type 1 diabetic patients without chronic complications of diabetes (retinopathy, nephropathy and etc.) and followed them for six months as a before-after clinical study with use of the pump. The efficacy of this way was assessed with HbA1C and fasting blood sugar measurements. Safety was estimated by frequency of clinical hypoglycemia episodes.
Results: Our patients were 7 men and 2 women aged 15 - 39 years with past history of diabetes by ranging from 0.1 to 15 years. Mean level of HbA1C at the beginning of study and after six months follow-up were %8.6 and %7.1, respectively, with significant statistically difference between them (P= 0.02). During pump therapy the mean dose of insulin were decreased to 10 units with statistically significant difference to before investigation (P = 0.03). No case of hypoglycemia and weight loss was seen. One patient had 4 kg weight gain without any significant statistical effect.
Conclusion: It seems CSII Therapy in Iranian patients with type 1 Diabetes mellitus was effective and safe. We can not conclude about possible side effects of pump based on this study.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Bagher Larijani,
Volume 7, Issue 1 (18 2007)
Abstract
Background: Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models but its relevance to human diabetes remains uncertain. The aim of this study was to investigate the relationship between serum resistin concentrations with insulin resistance and obesity indices in type 2 diabetes and non-diabetic obese subjects.
Methods: As a case- control study 35 obese subjects with type 2 diabetes (age, 44.60 ± 6.39yr BMI, 34.23±3.92 kg/m2) and 35 obese non-diabetics (age, 43.14±9.13yr BMI, 35.54 ± 4.07 kg/m2) are recruited. Fasting lipid profile was measured by enzymatic methods. NycoCard HbA1c Kit was used to measure HbA1c.The Serum resistin, insulin and glucose levels were measured by an enzyme immunoassay using a commercially available kit and glucose oxidase methods respectively. The insulin resistance index was calculated from fasting glucose and insulin by the homeostasis model assessment (HOMA-IR) formula.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetics were significantly higher than non-diabetics subjects (P<0.05). Serum resistin concentrations were not different between diabetics and non-diabetics obese subjects but were significantly higher in women as compared to men (8.15±4.40 vs. 5.97±2.31 in non-diabetic) and (7.46±3.98 vs. 5.51±3.98 in diabetic) in both groups. Serum resistin was not significantly related to variables measured in both groups. In control group only, we observed a significant and negative correlation between diastolic blood pressure and resistin (r = -0.381 P = 0.024).
Conclusion: Serum resistin concentrations were not significantly different between type 2 diabetes and non-diabetic obese subjects and resistin is unlikely to be a major link between obesity and diabetes in humans.
Sommayeh Rashid Shomali, Vahideh Montazeri, Seyed Mohammad Akrami, Ramin Heshmat, Bagher Larijani,
Volume 7, Issue 1 (18 2007)
Abstract
Background: High prevalence of consanguineous marriages has been reported in Iran. Since this pattern of marriage may increase the prevalence of diseases with autosomal recessive pattern of expression, the study was assigned to determine this among patients referred to diabetes and osteoporosis clinics of Dr Shariati hospital, Tehran, Iran.
Methods: The consanguineous marriage was studied among 1789 couples of three successive generations via Questionnaire.
Results: The prevalence of consanguineous marriages in three successive generations was 9%, 17% and 19%, respectively with an increasing pattern of prevalence. Overall the prevalence of first cousins marriage was 10% with 69% among consanguineous marriage group. The higher the level of education, the lower the prevalence of consanguineous marriage.
Conclusion: In view of the increasing prevalence of consanguineous marriage that may be followed by some trouble consequences about disease expression, it seems necessary to provide facilities for genetic counseling before marriage for youth.
Adeleh Rezagholizadeh, Ramin Heshmat, Bagher Larijani,
Volume 7, Issue 1 (18 2007)
Abstract
Diabetes accounts as one of the most prevalent diseases worldwide that affects roughly 2 million people with a prevalence of 4.67% in Iran. Despite clinical knowledge of the benefits of optimal glycemic control and preventive care, current studies show that many people with diabetes don't receive such care. Changing physician behavior is a crucial step in implant of scientific evidence into improved patient outcomes. Clinical practice guidelines (CPGs) have emerged as a means for this and for reducing variation in care.
"Iranian guidelines for diabetes mellitus care" is intended for use by health care practitioners involved in the care of people with diabetes in the community, such as general physicians endocrinoligists, podiatrists, nutritionists and optometrists.
Iranian Diabetes Guidelines (IDGs) was designed for the Iranian physicians who manage diabetic patients. IDGs consist management of types of diabetes and their acute and chronic complications in primary, secondary and tertiary care levels, also screening and life style modifications.
IDGs are the first practical guideline for management of diabetic patients in Iran.
Mohammad Reza Kalantarhormozi, Seyed Javad Siadatan, Arash Aria, Mohammad Hossein Dabbaghmanesh, Mesbah Shams, Abdosamad Sadeghalvad, Bagher Larijani, Gholamhossein Ranjbar Omrani,
Volume 7, Issue 2 (17 2007)
Abstract
Background: Type 2 diabetes mellitus is the most common type of diabetes which is triggered by various factors such as obesity, hyperlipidemia, hypertension, dietary habits and inheritance. With respect to geographic variation of diabetes prevalence, it is important to know the risk factors regionally.
Methods: As a case-control study, we looked for important risk factors of diabetes in our region. This study consisted of 400 individuals in case group and 400 individuals in control group. All these anthropometric measurements were calculated by standard methods. Blood samples taken from two groups were studied for TG, FBS, Cholesterol and HbA1c. Data are reported as the Mean±SD. P<0.05 was considered as statistically significant.
Results: There was no significant difference between two groups about mean age and sex ratio. Statistically significant difference were found for central obesity, hyperlipidemia, hypertension, polycystic ovarian syndrome (PCOS) and positive family history of diabetes in both groups (P<0.05).
Conclusion: The results showed that central obesity, hyperlipidemia, hypertension, PCOS and positive family history of diabetes are important risk factors of diabetes mellitus in Shiraz. In concordance with the results of this study, screening programme for that risk factor of diabetes in this region is suggested.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Amir Bahrami, Baghar Larijani,
Volume 7, Issue 2 (17 2007)
Abstract
Background: Adiponectin is an adipose tissue-derived hormone that low levels of this hormone are associated with obesity, insulin resistance, and type 2 diabetes. The aim of this study was to compare the serum levels of adiponectin in diabetic and non-diabetic obese individuals.
Methods: As a cross-sectional study 35 obese individuals with type 2 diabetes mellitus and 35 non-diabetic obese subjects were enrolled. Two groups were matched for age, gender and body mass index. Fasting lipid profile was measured via the enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c.The Serum Adiponectin, insulin and glucose levels were measured via an enzyme immunoassay, using a commercially available kit and glucose oxidase methods, respectively. The HOMA and QUICKI indices were used to determine insulin resistance and insulin sensitivity, respectively.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetes were significantly higher than non-diabetics (P<0.05). The serum Adiponectin levels was significantly lower in diabetes than non-diabetics (15.74±6.70 vs. 21.52 ± 9.35) and was significantly higher in women than men (19.38 ± 7.33 vs. 12.68 ± 4.28) among diabetic and (24.63 ± 10.52 vs. 17.83 ± 6.21) among non-diabetics groups.
Conclusion: type 2 diabetes mellitus is associated with low serum adiponectin concentrations and probably adiponectin involved in the pathophysiology linking obesity to type 2 diabetes.
Aliakbar Nejati Safa, Begher Larijani, Behnam Shariati, Homayon Amini, Adeleh Rezagholizadeh,
Volume 7, Issue 2 (17 2007)
Abstract
Background: The prevalence of depression in diabetic patients is 2-3 times more than general population. The quality of life (QOL) and glycemic control are two important outcome measures of diabetes management. The aim of this research is to study the relationship between depression, glycemic control and QOL in a sample of Iranian diabetic patients.
Methods: One hundred diabetic patients who were referred to diabetes clinic of Dr. Shariati Hospital were included in the study consecutively. The depression subscale of Hospital Anxiety and Depression Scale (HADS-D) were used to determine depression. The World Health Organization Quality of life brief version questionnaire (WHOQOL-BREF) was used to measure QOL. The status of glycemic control was evaluated through measuring HbA1c. Other measured variables included: demographic variables, smoking, diabetes type, body mass index, duration and complications of diabetes and previous history of depression. The linear regression method was implemented to analyze the data.
Results: Depression was observed in 28% of the patients. Glycemic control had a reverse significant correlation with diabetes complications. No significant relationship was found between HbA1c and scores of HADS-D. WHOQOL-BREF subscales scores had no significant relationship with glycemic control. There was a significant relation between scores of HADS-D and WHOQOL-BREF subscales.
Conclusion: Improving quality of life (QOL) is one of the main outcomes in the management of diabetes. According to the result of this study, depression had a prominent relationship with QOL. Thus, careful management of depression may be necessary to improve QOL of diabetic patients.
Hossein Fakhrzadeh, Sara Ghotbi, Bagher Larijani,
Volume 7, Issue 2 (17 2007)
Abstract
High plasma homocysteine is identified as an important risk factor for cardiovascular disease. Epidemiological studies have shown that increased plasma homocysteine is related to a higher risk of coronary heart disease, stroke and peripheral vascular disease. Homocysteine may have an effect on atherosclerosis by damaging the inner lining of arteries and promoting blood clots .Folic acid and other B group vitamins help break down homocysteine in the body and folate fortification of foods reduces the average homocysteine level in the population. Low blood levels of folate are also linked with a higher risk of fatal coronary heart disease and stroke. Homocysteine levels are strongly influenced via diet, as well as via genetic factors. Many common genetic disorders and problems (such as vitamin deficiency) adversely affect the metabolism of homocysteine. Common causes of a high homocysteine level include dietary deficiency of folate and B group vitamins, hypothyroidism, kidney disease, psoriasis, and some medicines. Clinical trials to date have not provided consistent evidence that lowering homocysteine levels reduce strokes, heart attacks and other cardiovascular events notwithstanding it is recommended to lower a high homocysteine level because it is a risk factor for heart disease. Homocysteine abnormalities also contribute to birth defects and dementia and folic acid supplementation in the pre-conceptual period is effective in preventing recurrent and primary neural tube defects.
Malihe Aveseh, Rohollah Nikooie, Fereshteh Atabi, Zahra Mirzaie Zadeh , Kobra Omidfar, Bagher Larijani,
Volume 13, Issue 2 (1-2014)
Abstract
Background: the aim of this study was to investigate the effect of seven weeks endurance training on
RBP4 gene expression in Soleus and Extensor Digitrum Longouse (EDL) Muscles, liver, visceral and
subcutaneous fat in type 2 diabetic rats.
Methods: 50 male wistar rats (5 weeks years old, weight = 93.7 ± 8.9) were purchased and randomly
divided into four groups: Control (n=10) (C), Trained (n=10) (T), Diabetic Control (n=15) (DC) and
Trained diabetic (n=15) (TD). Diabetes was induced by injection of low dose of streptozotocin (STZ)
and feeding with high fat diet. Insulin resistance accuracy was confirmed by HOMA-IR index and
Real-time PCR was used for mRNA content.
Results: After seven weeks of diabetes induction, the RBP4 mRNA content of the liver (2.37-fold P <
0.01), visceral fat (2.33-fold P < 0.01), and subcutaneous fat (1.83-fold P < 0.05), soleus (1.21-fold
P < 0.05) and EDL (2.03-fold P < 0.05) were increased. After seven weeks of endurance training
significant decrease in RBP4 mRNA content was found in visceral fat (P < 0.05), subcutaneous fat (P
< 0.05) and EDL (P < 0.05) between DC and CD. In addition, significant difference between T and TD
groups was found for RBP4 mRNA content in liver (p < 0.01), subcutaneous fat (P < 0.01) and EDL
(P < 0.01) after seven weeks of endurance training.
Conclusion: Type 2 diabetes considerably increases skeletal muscle RBP4 expression in isoform-
specific manner. This increase is also seen in liver, subcutaneous and visceral fat. In addition,
endurance training decreases the RBP4 expression in EDL, subcutaneous and visceral fat.
Leila Eini, Negar Naghash, Bagher Larijani, Jafar Ai, Keivan Majidzadeh, Esmaeil Sadroddiny, Kobra Omidfar,
Volume 13, Issue 2 (1-2014)
Abstract
Background: Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, are
considered as an important source of adult stem cells in tissue engineering and cell therapy. They are
present in various tissues such as, endometrium as the supportive cells. According to anatomical
position of endometrial mesenchymal stem cells that put them in neighborhood of the fetus, they may
have a significant role in fetus tolerance during pregnancy.
This study was conducted to evaluate the molecular mechanism of immunosuppressive affect of
endometrial mesenchymal stem cells.
Methods: Mesenchymal Cells from bone marrow and endometrium were cultured at density of 2 ×105
cells/ml at presence of 100IU/ml and 500IU/ml INF-γ (IFN-gamma) and expression of indoleamine 2
3-dioxygenase (IDO) were studied after 72 hours by real-time PCR and immunocytochemistry.
Results: The study showed that IDO expression in cells exposed to IFN-γ was increased compared to
the cells in the absence of IFN-γ (p<0.05). Additionally, up regulation of IDO expression was higher
in endometrial cells than bone marrow cells.
Conclusion: From these results it is concluded that endometrial mesenchymal stem cells may be used
as a good candidate for cell therapy.
Habib Moazami Goodarzi, Bagher Larijani, Abbasali Keshtkar, Patricia Khashayar,
Volume 13, Issue 2 (1-2014)
Abstract
Background: Discordance (the presence of different categories of T scores in two skeletal sites of a
single patient) can affect the physician’s decision to start medication or not. The present study was
therefore conducted to assess the prevalence of T-score discordance between spine and femoral neck
as well as its risk factors in a group of postmenopausal Iranian women.
Methods: The present analytical cross sectional research was conducted based on the results of
IROSTEOPs study on 8146 postmenopausal women referred to the bone mineral density (BMD)
center of Shariati Hospital affiliated to Tehran University of Medical Sciences between 2000 and
2011. Based on their BMD results, the patients were categorized into three groups: Concordance and
Minor and Major discordance. The factors affecting the risk of developing discordance was then
studied through uni/and multivariate logistic regression.
Results: Discordance between spine and femoral neck was reported in 3741 (45.9%) of the
participants. Multivariate logistic regression revealed that older age, higher number of pregnancies and
higher body mass index (BMI) are the main risk factors for T-score discordance at the studied sites.
The use of hormonal replacement therapy (HRT) on the other hand played a protective role.
Conclusion: It could be concluded that performing BMD at two different sites is necessary for the
Iranian population, particularly postmenopausal women.
Mahdieh Akhoundan, Zhaleh Shadman, Nooshin Poorsoltan, Mozhdeh Soleymanzadeh, Mohsen Khoshniat Nikoo, Bagher Larijani,
Volume 13, Issue 4 (5-2014)
Abstract
Background: Fasting in diabetic patients is accompanied by various changes in metabolism, lifestyle and medication. Evaluation of diabetic patients’ knowledge in the field of fasting conditions, the fasting-induced changes, complications, and ways to deal with them, is the first step towards efficient and effective diabetes self-management training in Ramadan fasting. The purpose of this study was to design a valid and reliable questionnaire on fasting knowledge of diabetic patients and evaluate the knowledge and determinant factors in diabetic patients.
Methods: In this study a questionnaire on diabetic patient’s awareness was designed in 5 sections: 1- fasting conditions in patients with diabetes (fasting status of diabetic patients), 2- drug use, 3- controlling of blood glucose, 4- physical activity and 5- diabetic diet in Ramadan. Validity and reliability (Cronbach's alpha coefficient=0.79) of the questionnaire was confirmed. In a cross-sectional study, the fasting knowledge of 200 diabetic patients of Diabetes and Metabolic disorders clinic were examined, before Ramadan 2012. The association between the knowledge and patients’ age, sex, weight, diabetes duration, educational levels, Ramadan fasting group education, fasting blood sugar, HbA1c and type of diabetes were evaluated.
Results: The mean of total correct answers were 46% with the highest scores in dietary information (62.5%) and lowest in physical activity (18%) and drug use (23%). Significant positive association was found between total and each part scores with patients’ educational level. Also group of participating in the Ramadan fasting education study and group of non- participating, showed significant difference in response to questions.
Conclusion: Findings of this study revealed (indicated) poor fasting knowledge in diabetic patients. Educational programs before Ramadan can increase awareness and could improve self-management of diabetic patients during Ramadan fasting and decrease complications.
Marziyeh Hadavi, Bagher Larijani, Mostafa Qorbani, Babak Eshrati,
Volume 14, Issue 5 (7-2015)
Abstract
Background: Osteoporosis is the most prevalent metabolic bone disease which is characterized by low bone mass and increased risk of fracture. The present study was conducted to assess the prevalence of osteoporosis and T-score discordance between femur and lumbar spine as well as their risk factors in a group of healthy postmenopausal women and men older than 50 years old based on Iranian Multicenter Osteoporosis Study data in phase 3 compared to phase 1.
Methods: This research is a cross-sectional study. 295 men and 397 women in IMOS 3 from Arak and Sanandag, and 868 men and 685 women from Tehran, Mashad, Tabriz, Shiraz and Bushehr were recruited based on randomized cluster sampling
Results: osteoporosis and osteopenia prevalence in men were 32% and 50% respectively, which were more in IMOS 3 compared to IMOS 1 (28% and 49.3%) but no statistical significance was noticed p=0.258. In postmenopausal women there were no difference in osteoporosis and osteopenia prevalence between IMOS 3 and IMOS1. There were no difference in discordance prevalence in IMOS 3 compared to IMOS 1. Logistic regression analysis revealed body mass index and physical activity had protective role against osteoporosis and osteopenia.
Conclusion: It seems osteoporosis in men has greater rate compared to women. Lifestyle changes especially physical activity and nutrition can play a significant role in the prevention of osteoporosis. And based on T-score discordance between femur and lumbar spinebperforming BMD at two different sites is necessary for the Iranian population.
Tahereh Keramati, Farideh Razi, Mohammad Reza Mobinizadeh, Alireza Oliaei Manesh, Bagher Larijani,
Volume 15, Issue 1 (1-2016)
Abstract
Background: Diabetic patients need to be followed for glycemic index regularly and HbA1c test is one of the most important biochemical markers for patient monitoring. HbA1c should be standardized based on international standards, but using internationally accepted assays are expensive. This study aimed to evaluate cost effectiveness of different assays which are currently used in Iran.
Methods: In this economic evaluation study, five HbA1c assays (Pars Azmoon, NycoCard, DS5, Biosystems and CERA STAT 2000) have been evaluated for cost, sensitivity and specificity, true score and also incremental cost-effectiveness ratios. Tosoh G8 has been considered as reference method.
Results: Although none of the assays can be a good alternative for reference method, DS5 and pars azmoon had better cost effectiveness results compared to other assays.
Conclusion: The quality of HbA1c assays need to be improved by using real tariff or the establishment of referral labs.
Habibeh Taghavi Kojidi, Farshad Farzadfar, Niloofar Peykari, Bagher Larijani, Shadi Rahimzadeh, Ehsan Rezaei-Darzi, Sahar Saeedi Moghaddam,
Volume 15, Issue 2 (1-2016)
Abstract
Background: Thyroid cancer is the most common form of endocrine cancer. The age and gender-adjusted incidence of thyroid cancer has increased faster than that of any other malignancy in recent years, with the increased incidence seen in both genders, all ethnic backgrounds and all sizes of thyroid cancer. It appears that the rise in thyroid cancer incidence is not only due to medical surveillance and improved disease detection. In Iran, also scattered studies had been accomplished in different provinces and requirement to more attention and planning for thyroid cancer. Thyroid cancer’s control and prevention requires to the evidence–based strategies in different population groups based on national and provincial comprehensive studies on the prevalence and incidence. Thus we aimed to provide the comprehensive information about thyroid cancer prevalence and trend in national, provincial levels among Iranian population.
Methods: In this study we used some steps respectively to show how thyroid cancer prevalence changes in 1990 to 2010 between different provinces. We aggregate cancer registry data set by province, age categorized, gender and merge with other national covariates that were gathered in Iran. Then, linear regression model and logistic regression model were used to modeling and predicting for other provinces and years.
Results: Mean of thyroid cancer prevalence displayed that prevalence increased with increase in years especially more rapidly from 2002-2010 the prevalence rates were estimated to be (0.0-0.25) and (4.2-13.7) per 100000 in 1990 and 2010 respectively and increased in both females and males. Female to male ratio was 2.5. Highest prevalence thyroid cancer were in four provinces of Iran, Isfahan (mean rate 4.3 per 100000), Yazd (mean rate 4.1 per 100000), Tehran (mean rate 4 per 100000) and Qazvin (mean rate 3.1 per 100000) respectively.
Conclusion: Iran map displayed with increase in years, thyroid cancer prevalence become larger. Additional research on the risk factors for thyroid cancer is needed to explain the difference of thyroid cancer prevalence between provinces.
Maryam Mortezaee, Abbasali Raz, Shole Mansouri, Zohreh Annabestani, Zahra Mirzaeezadeh, Bagher Larijani, Mehrdad Hashemi, Kobra Omidfar,
Volume 15, Issue 5 (7-2016)
Abstract
Background: Insulin resistance and progressive β-cells failure are the key factors in type 2 diabetes mellitus (T2DM) pathogenesis. Many studies support a primary role of RBP4 in insulin resistance and suggest that genetic variations which alter the expression level of RBP4 might influence the risk of T2DM and its complications. Diabetic foot is one of the main complications of diabetes leading to disability and hospitalization. In addition, it reduces quality of life and imposes great cost to patients. The purpose of this study was to evaluate the correlation between two single nucleotide polymorphisms (rs10882273 and rs10882283) of RBP4 genes with diabetic foot ulcer in order to identify a biomarker for prediction of diabetic foot ulcer.
Methods: This is a case-control study. Two single nucleotide polymorphisms of RBP4 genes were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 133 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.
Results: The Chi-square test revealed no significant difference in frequency of TT, CC and TC alleles of rsl0882273 between case and control groups (P=0.414). Also, Comparison of AA, CC and AC alleles of rsl0882283 in both groups did not show significant difference (P=0.85).
Conclusion: According to this study, there is no relationship between two single nucleotide polymorphisms of RBP4 genes (rs10882273 and rs10882283) with diabetic foot ulcer in type2 diabetes patients.
