Showing 30 results for Azizi
Farhad Hosseinpanah, Mehdi Rambod, Fereidoun Azizi,
Volume 6, Issue 3 (17 2007)
Abstract
Background: To determine the prevalence and characteristics of subjects with isolated post challenge hyperglycemia (IPH) defined as fasting plasma glucose (FPG) <126 mg/dl and 2-hour plasma glucose (2h-PG) ≥200 mg/dl.
Methods: We evaluated data and results of Oral Glucose Tolerance Test (OGTT) from 9745 participants in Tehran Lipid and Glucose Study (5589 women and 4156 men) aged>20years, without previously diagnosed diabetes mellitus (DM). A logistic regression model for having IPH was developed among subjects with FPG<126mg/dl to predict.
Results: The prevalence of IPH was 3.1% (n=302). 26.5% (n=80) of subjects with IPH had FPG<100mg/dl. The odds ratios for IPH were statistically significant for FPG≥100mg/dl (OR=9.5 95% CI: 7.1-12.5), age≥40 years (OR=2.6 95% CI: 1.8 - 3.7), triglycerides≥200 mg/dl (OR=2.1 95% CI: 1.6-2.7), hypertension (OR=2.0, 95% CI: 1.5-2.6) and abnormal waist circumference (females≥80, males≥90cm) (OR=1.9, 95%CI: 1.3-2.8).
Conclusion: This analysis showed that in Tehran urban subjects with FPG<126 mg/dl, variables such as FPG≥100 mg/dl, older age, hypertriglyceridemia, hypertension and abnormal waist circumference were significantly associated with higher likelihood of IPH OGTT would hence be recommended in subjects with above mentioned characteristics.
Farzad Hadaegh, Azadeh Zabetian, Fereidoun Azizi,
Volume 6, Issue 4 (17 2007)
Abstract
In April 2005, the International Diabetes Federation (IDF) has formulated a new worldwide definition of the metabolic syndrome in a global consensus statement built on earlier WHO, the ATPIII definitions. The aim of this study was to estimate the prevalence of this syndrome using the IDF definition among Iranian adults and to compare it with the prevalence estimated using the two other definitions.
Methods: The prevalence of the MES was determined according to the three different definitions in 10368 men and women aged≥20 years participated in the cross-sectional phase of the Tehran Lipid and Glucose Study (TLGS). To assess the degree of agreement between different MES definitions, the k test was used.
Results: The prevalence of MES (95% confidence interval) was 32.1% (31.2-33.0) by the IDF definition, 33.2% (32.3-34.1) by the ATPIII and 18.4% (17.6-19.2) according to the WHO definition. The sensitivity, specificity and concordance of the IDF definition for detecting MES were 91%, 89% for the ATPIII definitions and 73%, 77% for the WHO definition, respectively. The k statistics for the agreement of the IDF definition was 66.3±0.01 with the ATPIII and 39.5±0 with the WHO definition.
Conclusion: In the Iranian population, the IDF definition for MES has a good concordance with the ATP III definition and a low concordance with the WHO definition.
Parvin Mirmiran, Nazanin Nouri, Maryam Beheshti Zavareh, Fereidoun Azizi,
Volume 6, Issue 4 (17 2007)
Abstract
Background: Only limited data are available on the benefits of fruits and vegetable consumption on CVD risk factors. The aim of this study was to examine whether and to what extent intake of fruits and vegetables are inversely associated with cardiovascular (CVD) risk factors in adults.
Methods: In this population-based cross-sectional study a representative sample of 840 Tehranian adults (361 men and 479 women) aged 18-74 years were randomly selected in 1998. Usual dietary intake was assessed with the use of food frequency questionnaire. Portion sizes of consumed foods were converted from household measures to grams and analyzed by using Nutritionist III software designed for Iranian foods. Subjects were categorized based on category cut-points. : 0-1.9, 2-2.9, 3.0-3.9, and>=4 servings/d.
Results: In multivariate logistic regression after adjusting for confounders, dietary fruits and vegetable were found to be significantly and inversely associated with CVD risk factors. Adjusted odds ratio for high LDL concentrations were 1.00, 0.88, 0.81, 0.75(P for trend < 0.01) in first model which was adjusted for age, body mass index (BMI), energy intake, smoking status, dietary cholesterol, and prevalence of diabetes mellitus and coronary artery disease, a trend which was not appreciably altered by additional adjustment for education, physical activity, and saturated, polyunsaturated, total fat, Potassium and vitamin C intakes. This association was observed across categories of smoking status, physical activity, and tertiles of the Keys score.
Conclusion: Consumption of fruits and vegetables more than 4 servings a day is associated with lower concentrations of total cholesterol and LDL-C and with decrease in the risk of cardiovascular diseases.
Adel Jahed, Farhad Hosseinpanah, Fereidoun Azizi,
Volume 7, Issue 1 (18 2007)
Abstract
Background: LADA is a subgroup of type 1 diabetes mellitus characterized by its age at diagnosis being more than 30 years, presence of Glutamic Acid Decarboxylase65 (GAD65) autoantibody, and insulin independency in the first 6 months of diagnosis. Our aim was to determine the prevalence and predictors of LADA in a large population-based drug naïve newly diagnosed adult diabetics of Tehran urban population.
Methods: In this cross-sectional study, all newly diagnosed diabetics of Tehran Lipid and Glucose Study aged more than 30 years who were not initialy treated with insulin were tested for GAD antibody titer. Thirty two GAD antibody positive (LADA) and 556 GAD antidody negative patients (type 2 diabetics) were found and compared for anthropometric, clinical and laboratory features.
Results: Mean age of all 588 cases was 54.2±11.6. The prevalence of LADA was %5.44 (CI %95: %3.6-%7.3). Age, sex, BMI, family history of diabetes, diastolic blood pressure, glucose and lipid profile and the prevalence of metabolic syndrome were similar between LADA and type 2 diabetics. Systolic blood pressure were greater in type 2 diabetics than in LADA group. No model could predict the result of GAD antibody measurement.
Conclusion: autoimmune process is present in early stages of diabetes in %5.4 of newly diagnosed adult diabetics assumed to suffer type 2 diabetes mellitus. Using clinical and laboratory features, no model could reliably screen these cases. It seems reasonable to test GAD antibody in all such cases to early find persons more probable to have a more rapid process toward pancreas insufficiency.
Azadeh Zabetian, Farzad Hadaegh, Maryam Tohidi, Farhad Sheikholeslami, Feridoun Azizi,
Volume 7, Issue 1 (18 2007)
Abstract
Background: The aim of this study was to examine the prevalence of the metabolic syndrome (MetS) and its association with coronary heart disease (CHD) in Iranian older individuals.
Methods: In this cross-sectional study, the prevalence of the MetS was determined according to the Third Adult Treatment Panel (ATPIII), the World Health Organization (WHO) and the International Diabetes Federation (IDF) definitions in 720 men and women aged≥65 years. Logistic regression analysis was used to estimate the Odds Ratio (OR) of developing CHD in model 1 an age adjusted model, in model 2 adjusted for age, smoking status, premature history of CHD and LDL cholesterol and in model 3 adjusted for mentioned variables in model 2 plus the components of the MetS according to each definition.
Results: The prevalence of MetS was 50.8%, 41.9% and 41.8% by ATPIII, IDF and the WHO definitions, respectively. IDF had high agreement with the ATPIII definition. In model 2, the ATPIII and the WHO definitions of MetS were associated with CHD by the odds ratio of 1.6 (1.1-2.2) and 1.7 (1.9-2.4), respectively. In model 3, obesity (WHO definition) and high blood pressure (ATPIII and WHO definitions) were associated with CHD.
Conclusion: As defined by the ATPIII and WHO definitions, the MetS was associated with CHD even after adjustment for the conventional CHD risks, but after further adjustment for their components none of these definitions showed association with CHD.
Maryam Tohidi, Hadi Harati, Farzad Hadaegh, Yadollah Mehrabi, Fereidoun Azizi,
Volume 7, Issue 2 (17 2007)
Abstract
Background: Non- alcoholic fatty liver disease (NAFLD) is a pathogenic factor of insulin resistance and type 2 diabetes. On the other hand, the circulating liver enzymes including Aspartate aminotransferase (AST), Alanin aminotranferase (ALT) and Gamma glutamyl transferase (GGT) are commonly elevated in asymptomatic patients with NAFLD.
Methods: As a nested case-control study, AST, ALT, GGT as well as classic diabetes risk factors, homeostatic model assessment of insulin resistance(HOMA- IR) and C-reactive protein (CRP) were measured in 133 non-diabetic subjects at baseline (68 cases and 65 controls). Conditional logistic regression was used to calculate the odds ratio (OR) of diabetes associated with different hepatic markers. We used factor analysis for clustering of classic diabetes risk factors.
Results: In Univariate analysis, both ALT and GGT were associated with diabetes with ORs of 3.07(1.21-7.79) and 2.91(1.29-6.53), respectively. After adjustment for CRP and insulin, ALT and GGT were still predictive of incident diabetes. When the model was further adjusted for anthropometric, blood pressure and metabolic factors resulted from factor analysis (full model), only ALT was independently associated with diabetes [OR=3.06 (1.01-9.26)]. No difference was found between the area under the receiver operating characteristic curves of the models with and without ALT (0.820 and 0.802 respectively, P=0.4)
Conclusion: ALT is associated with incident type 2 diabetes independent of classic risk factors. However, its addition to the classic risk factors does not improve the prediction of diabetes.
Samaneh Azizi, Haleh Sadrzadehyeganeh, Seid Mostafa Hosseini, Milad Daneshimaskooni,
Volume 13, Issue 2 (1-2014)
Abstract
Background: Food insecurity refers to the inability to afford enough food for an active, healthy life.
The metabolic syndrome, otherwise known as syndrome X or the insulin resistance syndrome, is a
collection of cardiovascular risk factors including hypertriglyceridemia, lowered HDL-cholesterol,
glucose intolerance, abdominal obesity and hypertension. Recent studies indicate widespread
prevalence of food insecurity and metabolic syndrome in various regions of Iran. No studies have been
conducted so far to investigate the relationship between food insecurity and the metabolic syndrome in
Iran. This study was conducted to investigate the relationship between food insecurity and metabolic
syndrome in women.
Methods: In this study, 130 women 30 to 60 years old with metabolic syndrome as cases and 130
women without metabolic syndrome as controls referred to clinics affiliated to Shiraz University of
Medical Sciences were selected. The USDA household food security questionnaire was used to assess
food insecurity status. The metabolic syndrome was defined according to the criteria of the Adult
Treatment Pane l II (ATP III).
Results: The prevalence of food insecurity was 69.2% in cases and 45.4% in controls (P< 0.001).
After multiple logistic regression and removal of potential confounders, food insecurity was
significantly associated with metabolic syndrome (OR3.2&CI 95%: 1.9-5.6)(P<0.05).
Conclusion: Given that food insecurity is an important risk factors for metabolic syndrome, Planners
should reduce food insecurity in society, especially women through measures to improve the economic
situation and dietary patterns of households.
Bita Faam, Maryam Zarkesh, Maryam Sadat Daneshpour, Fereidoun Azizi, Mehdi Hedayati,
Volume 13, Issue 2 (1-2014)
Abstract
Background: It is now evident that adipose tissue functions as an endocrine organ by releasing
adipokines, and the levels of a number of inflammatory markers elevated in overweight and obese
individuals. The objective of this study was to examine the association between inflammatory markers
(IMs) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Homocystein (Hcy) and obesity
variables in Tehran Lipid and Glucose Study (TLGS) adults.
Methods: In this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years,
were randomly recruited from among TLGS population. Individuals were categorized based on the
waist circumference. The serum levels of IMs were determined using the Enzyme Linked
Immunosorbent Assay (ELISA) method.
Results: The mean age of participants was 46.1±16.1years and Abdominal obesity were present in
199(56.5%) individuals. The levels of hs-CRP and IL-6 were higher in abdominally obese group
(1507±3.3 vs. 577.8±4.3 ng/mL p<0.001) (3.6±3.3 vs. 1.9±3.8 pg/mL p< 0.001), and in the same
group, the best predictors (based on the adjusted R2) for hs-CRP, IL-6 and Hcy were waist (WC),
waist to height ratio (WHtR) and wrist, respectively. Hip and WHtR were the best predictors for Hcy
and hs-CRP in normal group there was no variable significantly correlated with IL-6, therefore it was
not possible to consider an independent predictor for IL-6.
Conclusion: According to this study, obesity is associated with IM levels, and in abdominally obese
group, the best predictor for Hcy, hs-CRP and IL-6 were Wrist, waist and WHtR respectively.
Parvin Mirmiran, Zahra Bahadoran, Firoozeh Hosseini-Esfahani, Fereidoun Azizi,
Volume 13, Issue 2 (1-2014)
Abstract
Background: There are growing concern globally regarding fast food consumption and its
related cardiometabolic outcomes. In this study we investigated whether fast food
consumption could affect the occurrence of metabolic syndrome after 3-years of follow-up in
adults or not.
Methods: This longitudinal study was conducted in the framework of Tehran Lipid and
Glucose Study on 1476 adults, aged 19-70 years old. The usual intakes of participants were
measured using a validated semi-quantitative food frequency questionnaire at baseline.
Biochemical and anthropometric measurements were assessed at baseline (2006-2008) and 3
years later (2009-2011). Multiple logistic regression models were used to estimate the
incidence of the MetS in each quartile of fast food consumption.
Results: The mean age of participants was 37.8±12.3 years old, and the mean BMI was
26.0±4.5 kg/m2
at baseline. Participants in the highest quartile of fast food consumption were
significantly younger (33.7 vs. 43.4 years, P <0.01). Higher consumption of fast food was
accompanied with more increment in serum triglyceride levels after the 3-year follow-up
(10.6±2.3 vs. 4.4±2.3 percent in the fourth and first quartile, respectively, P<0.01). After
adjustment for all of the potential confounding variables, the risk of metabolic syndrome, in
the highest quartile of fast foods compared with the lowest, was 1.85 (95% CI= 1.17-2.95).
Conclusion: We demonstrated that higher consumption of fast foods had undesirable effects
on metabolic syndrome after 3-years of follow-up in Iranian adults.
Maryam Farahmand , Fahimeh Ramezani Tehrani, Mahnaz Bahri Khomami, Fereidoun Azizi,
Volume 14, Issue 1 (1-2015)
Abstract
Background: The present study was conducted to assess the association between duration of oral contraceptive pills consumption and metabolic syndrome.
Methods: Study subjects were selected among 5532 of women 15-45 years old aged participating in Tehran Lipid and Glucose Study (TLGS). TLGS questionnaires were used for data collection.
Results: Metabolic syndrome and its components did not significantly differ between study sub groups after adjustment for confounders.
Conclusion: OCPs duration of consumption does not affect prevalence of metabolic syndrome among non menopausal women.
Fahimeh Ramezani Tehrani, Sonia Minooee, Masoumeh Simbar, Fereidoun Azizi,
Volume 14, Issue 2 (1-2015)
Abstract
Background: Considering the limited population-based studies and lack of a general consensus on the most sensitive and precise predictor of insulin resistance and metabolic syndrome in the women with polycystic ovary syndrome (PCOS), the present study was performed with the aim of comparing the validity of various available adiposity markers in these patients. Methods: In the national and population-based study of PCOS prevalence, 1772 girls and women, aged 18-45 years, were assessed for the diagnosis of PCOS based on Rotterdam criteria. Waist circumference, body mass index, waist to hip ratio, lipid accumulation product, visceral adiposity index (VAI) and homeostasis assessment model- insulin resistance (HOMA-IR) were calculated. The diagnosis of metabolic syndrome was based on Joint Interim Statement (JIS)criteria and HOMA-IR&ge 2.3 was considered as the resistance cutoff point. Results: In among different markers, VAI served as the best predictor of insulin resistance (sensitivity %60, positive predictive value %83) and metabolic syndrome (sensitivity %97, positive predictive value %95). ROC curve showed the cutoff points of 1.8 and 3.1 as the optimum values for insulin resistance and metabolic syndrome prediction, respectively. Conclusion: It seems that visceral adiposity index is a reliable marker for the screening of cardiometabolic disorders in the women with PCOS.
Ali Delpisheh, Hosein Azizi, Elham Dantalab Esmaeili, Lotfali Haghiri, Gholamali Karimi, Fariba Abbasi,
Volume 14, Issue 3 (3-2015)
Abstract
Background: According to the importance of the family physicians program results in rural areas and government decision to apply this program in urban areas of Iran, This study aimed to determine the quality of care and blood sugar control, blood pressure and blood lipids in diabetic type &Iota&Iota patients in rural areas covered by family physicians. Methods: In this study, 380 patients 30-76 years old with medical records in the health centers of the malekan-Iran in rural areas in 2013, after informed consents were enrolled. Data were collected by interview and HbA1c examinations and using a standard questionnaire. Data analyzed by SPSS19 version. Multivariate logistic regression was used to estimate odds ratios adjusting for diabetes complications and related risk factors. Results: Results showed that 68% Study participants was women’s and average age of patients was 57.86±11.9 and sex ratio of females to males was almost 2.2 with 1. Final analysis showed that HbA1c levels more than 7% (PHbA1c=0.002), cholesterol over 240 mm/dl (Pcholesterol=0.04) and hypertensive over 140/90mm/Hg (PHTN=0.007) 1.52, 2.44 and 1.44 times increased risk of diabetes complications, respectively. Conclusions: The quality of care and blood sugar control in diabetic patients was lower than compared to the American Diabetes Association (ADA) standards, but our results are near to results of Country studies.
Maryam Sadat Daneshpour, Bahareh Sedaghatikhayat, Mehdi Hedayati, Fereidoun Azizi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries. Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density cholesterol (HDL) levels. The present review aims to discover the genetic variant reported in association with MetS. Methods: The database for genotypes and phenotypes (dbGaP) and the database for genetic associations and human genome (HuGE navigator) were utilized in order to search for genes and their corresponding polymorphisms related to MetS. Additionally, an electronic literature search for other Iranian studies and the genetic aspect of TLGS was completed using PubMed. Results: For phenotype selection in PheGenI, 30 traits were chosen and after the analysis, 21 of them were in common results with MetS. After finding the common variation between traits and MetS, omitting the repeated SNPs, 173 variations were remained. Finally, results distinguished six of the most important genetic regions found to have strong association with MetS. Conclusion: Identifying major genes that are responsible for the metabolic syndrome may improve the medical care for treating individuals with metabolic syndrome, and eventually may lead to personalized medicine in which treatment is tailored genetically to the patient’s needs. The present candidate regions is a respectable start to replicate genetic studies in large affected Iranian individual which we hope leads us to improve our medical care in this field.
Zeynab Amirhamidi, Hanieh-Sadat Ejtahed, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: Existing studies show that a poor diet has an effect on the progression of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to systematically summarize the results of studies on the relationship between dietary intakes and NAFLD. Methods: A review of Scopus, PubMed, Cochrane Library, Magiran, Medlib and SID databases and theses in the National Library of the Islamic Republic of Iran was conducted to identify epidemiological studies concerning NAFLD, food groups and dietary patterns. Cross-sectional, case-control and cohort studies with documented in English were selected for this systematic review. Duplication, topic, type of study, study population, variables examined and quality of data reporting of articles were evaluated. Results: Of 2128 articles found in the initial search, 33 were reviewed in full-text of these 6 articles were included in the systematic review. The literature review showed patients with NAFLD consumed more red meat, fats and sweets and less whole grains, fruits and vegetables. The Western dietary pattern was positively associated with the risk of NAFLD and adherence to the Mediterranean diet was negatively correlated to hepatic steatosis. Conclusion: The results of the systematic review indicate that different dietary intakes may be associated with development of NAFLD and its related factors. Due to limited research documented on this topic, further prospective studies are recommended.
Bita Faam, Asieh Zahedi, Mehdi Hedayati, Fereidoun Azizi, Mohammad Ali Mansournia, Maryam Daneshpour,
Volume 15, Issue 1 (1-2016)
Abstract
Background: The scavenger receptor class B type I (SR-BI), as the high density lipoprotein cholesterol (HDL-C) receptor, is a key component in the reverse cholesterol transportation. The objective of this study was to assess the association between exon1 (G→A) polymorphism of SR-BI gene and lipid profiles among the Tehran Lipid and Glucose Study (TLGS) population.
Methods: This cross-sectional study included 774 adults (322 males and 452 females) aged 20–70 years, who were randomly selected from among TLGS population. Anthropometrical and biochemical variables for participants were measured. Selected SR-BI gene polymorphism was determined with restriction fragment length polymorphism (RFLP) using the Alu restriction enzyme.
Results: according to the results of current study, in the Tehran population, the allele frequency of SR-BI (G→A) polymorphism was 0.159 for an allele (minor allele) and 0.841 for G allele. Allele frequencies were in conformity with Hardy–Weinberg equilibrium. The result of this study showed that Subjects with the less common allele (allele A), after adjusting for age, have lower HDL-CandHDL3concentrations (p=0.046, p=0.041 respectively).
Conclusion: lipid disorders are caused by the interaction of environmental and genetic factors; therefore, exon1 (G→A) polymorphism of SR-BI gene could not be the only cause for the abnormality in the HDL-C levels. In future, this polymorphism may be use as a molecular marker for diagnosis.
Nazanin Moslehi, Firoozeh Hosseini-Esfahani, Farhad Hosseinpanah, Parvin Mirmiran, Parvane Hojjat, Fereidoun Azizi,
Volume 15, Issue 2 (1-2016)
Abstract
Background: The aim of this study was to identify major dietary patterns in Iranian adults and their associations with the risk of type 2 diabetes (T2DM).
Methods: This nested case-control study was conducted among 698 women and men with a mean age of 43.6 ± 12.0 years in the Tehran Lipid and Glucose Study (TLGS). Among participants who were free of T2DM at baseline and developed T2DM during follow-up examinations, individuals with dietary intakes data were considered as cases. Each case was matched to three T2DM free controls on sex, age, and the date of blood drawing. Major dietary patterns were identified using principal component analysis and odds ratios of T2DM were estimated using conditional logistic regression.
Results: In this study, three major dietary patterns were identified. After adjusting for diabetes risk factors, 1-SD increase in score of the dietary pattern characterized by high intake of whole grain, legumes, egg, and red meat (traditional dietary pattern) was associated with reduced risk of T2DM (OR : 0.82; 95% CI: 0.67-0.99).
Conclusion: A whole grain and legumes based dietary pattern may be associated with reduced risk of T2DM in Iranian population.
Gholam Reza Azizi Azar Sharabyani, Mozhgan Ahmadi, Saeedeh Shadmehri,
Volume 18, Issue 3 (3-2019)
Abstract
Background: High oxidative stress in pregnant women leads to pathogenesis or progression of disease in newborns. The aim of this study was to investigate the Effect of Endurance Training in Maternal Metabolic Syndrome with Metformin on Oxidant and antioxidant Capacity in their Neonates.
Methods: To implementation of this experimental research, 16 female Wistar rats weighing 100 ± 20 gr randomly were divided into 4 groups including metabolic syndrome + control; metabolic syndrome + metformin; metabolic syndrome + endurance training; metabolic syndrome + metformin + endurance training. The metabolic syndrome model was performed using dietary change and confirmed by the Lee index. Metformin 500 mg was also given at a dose of 100 mg/kg, as well as by daily water intake to the rats. endurance training performed at 5 days a week for 15-40 min with speed of 10-25m/min on treadmill for 8 weeks. Pregnancy was confirmed in rats after vaginal plaque was observed After the pregnancy and delivery period of the rats, newborn babies (4 newborns from each mother as the main sample) were prepared one week after birth for explanation.
Results: The results showed that metformin had no significant effect on superoxide dismutase (SOD) and malondialdehyde (MDA) in comparison with control group, but endurance training and endurance training with metformin resulted in increased SOD and MDA reduction in neonatal heart tissue (p=0.000).
Conclusion: According to the results, it seems that the endurance training of mothers with metabolic syndrome has a protective effect on oxidative and antioxidant systems in their offspring.
Samira Behboudi-Gandevani, Mojgan Modoodi, Razieh Bidhendi Yarandi, Mina Amiri, Amir Abbas Momenan, Fereidoun Azizi, Fahimeh Ramezani Tehrani,
Volume 19, Issue 1 (1-2020)
Abstract
Background: Although a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear. This study aimed to assess the relationship between the history of GDM and the incidence of BC a long term population based study.
Methods: To conduct this research, 4076 women aged 20-50 years who participated in the first phase of Tehran-Lipid-and-Glucose-Study, who had at-least one pregnancy were included. Each participants were asked about the history of GDM every 3 years. They was evaluated about the occurrence of breast cancer (BC). Cox-survival analysis was used to measure the Hazard-ratio (HR) for both groups with and without history of GDM
Results: The study population included 886 women with prior GDM and 3,909 women without history of GDM. The median duration of follow-up among women with and without the history of GDM were 12.12 and 11.62 years, respectively. The incidence of BC was 0.64 per 1,000 year-olds with confidence=interval of 95% (0.44-0.91). Among them, 4 cases were reported in women with GDM and 26 cases in women without GDM. (Incidence of 0.36 per 1000 person-years with confidence=interval 95% (0.11-0.99) in women with prior GDM and 0.73 per 1,000 person-years with confidence=interval 95% (0.49-1.1) in women without a history of GDM.
Conclusion: Our study showed that the history of GDM is not an independent risk factor for breast cancer.
Reza Salboukhi, Masoumeh Azizi, Ali Zavari, Nagmadin Espandar,
Volume 23, Issue 2 (5-2023)
Abstract
Background: Expression of FoxO transcription factors whould increase during certain forms of atrophy. In a dephosphorylated state, FoxOs participate in ubiquitin-mediated proteasomal degradation through the transcriptional activation of E3-ubiquitin ligases such as MAFbx/atrogin-1. Therefore, the study aimed to determine the effect of combination of continuous exercise and resveratrol supplementation on foxo-1 and Atrogin-1 gene expression in the left ventricular tissue of male Wistar rats.
Methods: In this study, 25 male Wistar rats with 180-250 g weight were randomly classified into 5 groups, including healthy control (n=5), diabetic control (n=5), diabetic resveratrol (n=5), diabetic-continuous exercise (n=5), and resveratrol+ continuous exercise+ diabetes (n=5). After inducing diabetes by intraperitoneal injection of streptozotocin, animals in expremental groups were carried out an 8-week exercise program on a treadmill with 60-75% Vo2max. One-way ANOVA and Tukey test with statistical level (P<0.05) was used to compare the differences between groups.
Results: The results showed that gene expression of Atrodin-1 were significantly markedly in the ARDM group compared to the DM group (P= 0.02) but the gene expression of foxo-1 only was significantly changed (P= 0.001) in ARDM group to compared with the other groups (P>0.05).
Conclusion: It seems that the Foxo1 gene expression fluctuations along with the significant decrease in the expression of the atherogen-1 gene can be improving the diabetic heart as a non-pharmacological method.
Masoumeh Azizi, Fatemeh Mokhari Domakani, Reza Baledi,
Volume 24, Issue 1 (3-2024)
Abstract
Background: Diabetic cardiomyopathy is one of the main risk factors related to diabetes, which can be caused by atrophy of the cardiomocytes. It is supposed that the MuRF1 gene intermediate as an agent for heart atrophy. Hence, the purpose of current study was to investigate the effect of eight weeks' aerobic exercise protocol on murf1 gene expression in cardio-myocyte of diabetic Wistar rats.
Methods: In this study, 30 male Wistar rats with an age of eight weeks and an average weight of 288 grams were randomly divided into three groups of 10 including healthy control, diabetic control and aerobic exercise group after two weeks of adaptation to the environment. The exercise groups went under aerobic training programs using treadmill (5 days/wks., for 8 wks.) 60%-75% Vo2max. MuRF1 mRNA level was measured in cardio myocyte using Real-Time PCR. The results were compared by statistical methods.
Results: The changes in the expression of Murf1 genes expression in cardio-myocyte of diabetes group were significantly higher than the other groups (P< .05). The expression of Murf1 gene in continuous training group reduced significantly after eight weeks' aerobic exercise training (P󠇟< .05).
Conclusion: This study demonstrated that eight weeks' aerobic exercise training can lead to reduction of Murf1 genes expression level and might be a good prescription for diabetic persons. However, further studies are needed to confirm this theory.
