Showing 30 results for Azizi
Fahimeh Ramezani Tehrani, Sonia Minooee, Masoumeh Simbar, Fereidoun Azizi,
Volume 14, Issue 2 (1-2015)
Abstract
Background: Considering the limited population-based studies and lack of a general consensus on the most sensitive and precise predictor of insulin resistance and metabolic syndrome in the women with polycystic ovary syndrome (PCOS), the present study was performed with the aim of comparing the validity of various available adiposity markers in these patients. Methods: In the national and population-based study of PCOS prevalence, 1772 girls and women, aged 18-45 years, were assessed for the diagnosis of PCOS based on Rotterdam criteria. Waist circumference, body mass index, waist to hip ratio, lipid accumulation product, visceral adiposity index (VAI) and homeostasis assessment model- insulin resistance (HOMA-IR) were calculated. The diagnosis of metabolic syndrome was based on Joint Interim Statement (JIS)criteria and HOMA-IR&ge 2.3 was considered as the resistance cutoff point. Results: In among different markers, VAI served as the best predictor of insulin resistance (sensitivity %60, positive predictive value %83) and metabolic syndrome (sensitivity %97, positive predictive value %95). ROC curve showed the cutoff points of 1.8 and 3.1 as the optimum values for insulin resistance and metabolic syndrome prediction, respectively. Conclusion: It seems that visceral adiposity index is a reliable marker for the screening of cardiometabolic disorders in the women with PCOS.
Ali Delpisheh, Hosein Azizi, Elham Dantalab Esmaeili, Lotfali Haghiri, Gholamali Karimi, Fariba Abbasi,
Volume 14, Issue 3 (3-2015)
Abstract
Background: According to the importance of the family physicians program results in rural areas and government decision to apply this program in urban areas of Iran, This study aimed to determine the quality of care and blood sugar control, blood pressure and blood lipids in diabetic type &Iota&Iota patients in rural areas covered by family physicians. Methods: In this study, 380 patients 30-76 years old with medical records in the health centers of the malekan-Iran in rural areas in 2013, after informed consents were enrolled. Data were collected by interview and HbA1c examinations and using a standard questionnaire. Data analyzed by SPSS19 version. Multivariate logistic regression was used to estimate odds ratios adjusting for diabetes complications and related risk factors. Results: Results showed that 68% Study participants was women’s and average age of patients was 57.86±11.9 and sex ratio of females to males was almost 2.2 with 1. Final analysis showed that HbA1c levels more than 7% (PHbA1c=0.002), cholesterol over 240 mm/dl (Pcholesterol=0.04) and hypertensive over 140/90mm/Hg (PHTN=0.007) 1.52, 2.44 and 1.44 times increased risk of diabetes complications, respectively. Conclusions: The quality of care and blood sugar control in diabetic patients was lower than compared to the American Diabetes Association (ADA) standards, but our results are near to results of Country studies.
Maryam Sadat Daneshpour, Bahareh Sedaghatikhayat, Mehdi Hedayati, Fereidoun Azizi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries. Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density cholesterol (HDL) levels. The present review aims to discover the genetic variant reported in association with MetS. Methods: The database for genotypes and phenotypes (dbGaP) and the database for genetic associations and human genome (HuGE navigator) were utilized in order to search for genes and their corresponding polymorphisms related to MetS. Additionally, an electronic literature search for other Iranian studies and the genetic aspect of TLGS was completed using PubMed. Results: For phenotype selection in PheGenI, 30 traits were chosen and after the analysis, 21 of them were in common results with MetS. After finding the common variation between traits and MetS, omitting the repeated SNPs, 173 variations were remained. Finally, results distinguished six of the most important genetic regions found to have strong association with MetS. Conclusion: Identifying major genes that are responsible for the metabolic syndrome may improve the medical care for treating individuals with metabolic syndrome, and eventually may lead to personalized medicine in which treatment is tailored genetically to the patient’s needs. The present candidate regions is a respectable start to replicate genetic studies in large affected Iranian individual which we hope leads us to improve our medical care in this field.
Zeynab Amirhamidi, Hanieh-Sadat Ejtahed, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: Existing studies show that a poor diet has an effect on the progression of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to systematically summarize the results of studies on the relationship between dietary intakes and NAFLD. Methods: A review of Scopus, PubMed, Cochrane Library, Magiran, Medlib and SID databases and theses in the National Library of the Islamic Republic of Iran was conducted to identify epidemiological studies concerning NAFLD, food groups and dietary patterns. Cross-sectional, case-control and cohort studies with documented in English were selected for this systematic review. Duplication, topic, type of study, study population, variables examined and quality of data reporting of articles were evaluated. Results: Of 2128 articles found in the initial search, 33 were reviewed in full-text of these 6 articles were included in the systematic review. The literature review showed patients with NAFLD consumed more red meat, fats and sweets and less whole grains, fruits and vegetables. The Western dietary pattern was positively associated with the risk of NAFLD and adherence to the Mediterranean diet was negatively correlated to hepatic steatosis. Conclusion: The results of the systematic review indicate that different dietary intakes may be associated with development of NAFLD and its related factors. Due to limited research documented on this topic, further prospective studies are recommended.
Bita Faam, Asieh Zahedi, Mehdi Hedayati, Fereidoun Azizi, Mohammad Ali Mansournia, Maryam Daneshpour,
Volume 15, Issue 1 (1-2016)
Abstract
Background: The scavenger receptor class B type I (SR-BI), as the high density lipoprotein cholesterol (HDL-C) receptor, is a key component in the reverse cholesterol transportation. The objective of this study was to assess the association between exon1 (G→A) polymorphism of SR-BI gene and lipid profiles among the Tehran Lipid and Glucose Study (TLGS) population.
Methods: This cross-sectional study included 774 adults (322 males and 452 females) aged 20–70 years, who were randomly selected from among TLGS population. Anthropometrical and biochemical variables for participants were measured. Selected SR-BI gene polymorphism was determined with restriction fragment length polymorphism (RFLP) using the Alu restriction enzyme.
Results: according to the results of current study, in the Tehran population, the allele frequency of SR-BI (G→A) polymorphism was 0.159 for an allele (minor allele) and 0.841 for G allele. Allele frequencies were in conformity with Hardy–Weinberg equilibrium. The result of this study showed that Subjects with the less common allele (allele A), after adjusting for age, have lower HDL-CandHDL3concentrations (p=0.046, p=0.041 respectively).
Conclusion: lipid disorders are caused by the interaction of environmental and genetic factors; therefore, exon1 (G→A) polymorphism of SR-BI gene could not be the only cause for the abnormality in the HDL-C levels. In future, this polymorphism may be use as a molecular marker for diagnosis.
Nazanin Moslehi, Firoozeh Hosseini-Esfahani, Farhad Hosseinpanah, Parvin Mirmiran, Parvane Hojjat, Fereidoun Azizi,
Volume 15, Issue 2 (1-2016)
Abstract
Background: The aim of this study was to identify major dietary patterns in Iranian adults and their associations with the risk of type 2 diabetes (T2DM).
Methods: This nested case-control study was conducted among 698 women and men with a mean age of 43.6 ± 12.0 years in the Tehran Lipid and Glucose Study (TLGS). Among participants who were free of T2DM at baseline and developed T2DM during follow-up examinations, individuals with dietary intakes data were considered as cases. Each case was matched to three T2DM free controls on sex, age, and the date of blood drawing. Major dietary patterns were identified using principal component analysis and odds ratios of T2DM were estimated using conditional logistic regression.
Results: In this study, three major dietary patterns were identified. After adjusting for diabetes risk factors, 1-SD increase in score of the dietary pattern characterized by high intake of whole grain, legumes, egg, and red meat (traditional dietary pattern) was associated with reduced risk of T2DM (OR : 0.82; 95% CI: 0.67-0.99).
Conclusion: A whole grain and legumes based dietary pattern may be associated with reduced risk of T2DM in Iranian population.
Gholam Reza Azizi Azar Sharabyani, Mozhgan Ahmadi, Saeedeh Shadmehri,
Volume 18, Issue 3 (3-2019)
Abstract
Background: High oxidative stress in pregnant women leads to pathogenesis or progression of disease in newborns. The aim of this study was to investigate the Effect of Endurance Training in Maternal Metabolic Syndrome with Metformin on Oxidant and antioxidant Capacity in their Neonates.
Methods: To implementation of this experimental research, 16 female Wistar rats weighing 100 ± 20 gr randomly were divided into 4 groups including metabolic syndrome + control; metabolic syndrome + metformin; metabolic syndrome + endurance training; metabolic syndrome + metformin + endurance training. The metabolic syndrome model was performed using dietary change and confirmed by the Lee index. Metformin 500 mg was also given at a dose of 100 mg/kg, as well as by daily water intake to the rats. endurance training performed at 5 days a week for 15-40 min with speed of 10-25m/min on treadmill for 8 weeks. Pregnancy was confirmed in rats after vaginal plaque was observed After the pregnancy and delivery period of the rats, newborn babies (4 newborns from each mother as the main sample) were prepared one week after birth for explanation.
Results: The results showed that metformin had no significant effect on superoxide dismutase (SOD) and malondialdehyde (MDA) in comparison with control group, but endurance training and endurance training with metformin resulted in increased SOD and MDA reduction in neonatal heart tissue (p=0.000).
Conclusion: According to the results, it seems that the endurance training of mothers with metabolic syndrome has a protective effect on oxidative and antioxidant systems in their offspring.
Samira Behboudi-Gandevani, Mojgan Modoodi, Razieh Bidhendi Yarandi, Mina Amiri, Amir Abbas Momenan, Fereidoun Azizi, Fahimeh Ramezani Tehrani,
Volume 19, Issue 1 (1-2020)
Abstract
Background: Although a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear. This study aimed to assess the relationship between the history of GDM and the incidence of BC a long term population based study.
Methods: To conduct this research, 4076 women aged 20-50 years who participated in the first phase of Tehran-Lipid-and-Glucose-Study, who had at-least one pregnancy were included. Each participants were asked about the history of GDM every 3 years. They was evaluated about the occurrence of breast cancer (BC). Cox-survival analysis was used to measure the Hazard-ratio (HR) for both groups with and without history of GDM
Results: The study population included 886 women with prior GDM and 3,909 women without history of GDM. The median duration of follow-up among women with and without the history of GDM were 12.12 and 11.62 years, respectively. The incidence of BC was 0.64 per 1,000 year-olds with confidence=interval of 95% (0.44-0.91). Among them, 4 cases were reported in women with GDM and 26 cases in women without GDM. (Incidence of 0.36 per 1000 person-years with confidence=interval 95% (0.11-0.99) in women with prior GDM and 0.73 per 1,000 person-years with confidence=interval 95% (0.49-1.1) in women without a history of GDM.
Conclusion: Our study showed that the history of GDM is not an independent risk factor for breast cancer.
Reza Salboukhi, Masoumeh Azizi, Ali Zavari, Nagmadin Espandar,
Volume 23, Issue 2 (5-2023)
Abstract
Background: Expression of FoxO transcription factors whould increase during certain forms of atrophy. In a dephosphorylated state, FoxOs participate in ubiquitin-mediated proteasomal degradation through the transcriptional activation of E3-ubiquitin ligases such as MAFbx/atrogin-1. Therefore, the study aimed to determine the effect of combination of continuous exercise and resveratrol supplementation on foxo-1 and Atrogin-1 gene expression in the left ventricular tissue of male Wistar rats.
Methods: In this study, 25 male Wistar rats with 180-250 g weight were randomly classified into 5 groups, including healthy control (n=5), diabetic control (n=5), diabetic resveratrol (n=5), diabetic-continuous exercise (n=5), and resveratrol+ continuous exercise+ diabetes (n=5). After inducing diabetes by intraperitoneal injection of streptozotocin, animals in expremental groups were carried out an 8-week exercise program on a treadmill with 60-75% Vo2max. One-way ANOVA and Tukey test with statistical level (P<0.05) was used to compare the differences between groups.
Results: The results showed that gene expression of Atrodin-1 were significantly markedly in the ARDM group compared to the DM group (P= 0.02) but the gene expression of foxo-1 only was significantly changed (P= 0.001) in ARDM group to compared with the other groups (P>0.05).
Conclusion: It seems that the Foxo1 gene expression fluctuations along with the significant decrease in the expression of the atherogen-1 gene can be improving the diabetic heart as a non-pharmacological method.
Masoumeh Azizi, Fatemeh Mokhari Domakani, Reza Baledi,
Volume 24, Issue 1 (3-2024)
Abstract
Background: Diabetic cardiomyopathy is one of the main risk factors related to diabetes, which can be caused by atrophy of the cardiomocytes. It is supposed that the MuRF1 gene intermediate as an agent for heart atrophy. Hence, the purpose of current study was to investigate the effect of eight weeks' aerobic exercise protocol on murf1 gene expression in cardio-myocyte of diabetic Wistar rats.
Methods: In this study, 30 male Wistar rats with an age of eight weeks and an average weight of 288 grams were randomly divided into three groups of 10 including healthy control, diabetic control and aerobic exercise group after two weeks of adaptation to the environment. The exercise groups went under aerobic training programs using treadmill (5 days/wks., for 8 wks.) 60%-75% Vo2max. MuRF1 mRNA level was measured in cardio myocyte using Real-Time PCR. The results were compared by statistical methods.
Results: The changes in the expression of Murf1 genes expression in cardio-myocyte of diabetes group were significantly higher than the other groups (P< .05). The expression of Murf1 gene in continuous training group reduced significantly after eight weeks' aerobic exercise training (P󠇟< .05).
Conclusion: This study demonstrated that eight weeks' aerobic exercise training can lead to reduction of Murf1 genes expression level and might be a good prescription for diabetic persons. However, further studies are needed to confirm this theory.
