Showing 127 results for Type 2 Diabete
Mohammad Ali Sardar, Ali Akbar Shamsian, Morteza Taghavi,
Volume 6, Issue 1 (8-2006)
Abstract
Background: Combination of physical activity and pharmacotherapy in diabetes may augment the effects of the drug and may allow lower doses of medication that can minimize the side effects. The goal of the study was to determine the effectiveness of aerobic training and Glibenclamide combination in type 2 diabetes.
Methods: A total of 28 men with type 2 diabetes were divided to 3 groups randomly: Glibenclamide (5 mg daily) only, Glibenclamide (5 mg daily) plus aerobic training, Glibenclamide (2.5 mg daily) plus aerobic training. Aerobic training protocol was performed for 12 week, 3 days (session) a week, 45 minutes in a session (ergo cycle program at 60-70 % heart rate reserve). Fasting glucose, HbA1c, fasting insulin, c-peptide, and insulin resistance were measured at pre, mid and post treatment periods. Analysis of Variance test (ANOVA) were used to evaluate data.
Results: HbA1c significantly decreased and c-peptide significantly increased in three groups (P<0.05).There were also no between-group differences for c-peptide and HbA1c (P>0.05). Fasting insulin concentration did not alter in three groups, however, insulin resistance decreased ( no significant ) after 12 weeks.
Conclusion: In type 2 diabetic patients, Glibenclamide treatment alone or combination of aerobic training and Glibenclamide treatment, was effective in improving glycemic control in patients with type 2 diabetes .As a result, in patients with type 2 diabetes, the addition of aerobic training to Glibencelamide treatment allow lower doses of Glibenclamide to be used without impairment in glycemic control.
Saeed Sadat Mansouri, Alireza Esteghamati, Yasaman Yousefi,
Volume 6, Issue 1 (8-2006)
Abstract
Background: The relationship between diabetes and periodontal diseases has already been proved, but the effect of non-surgical periodontal therapy on the control of diabetes is controversial. The aim of this study was to determine the effect of this type of treatment on the control of diabetes.
Methods: In this randomized clinical trial 30 type 2 diabetic patients with moderate to severe periodontitis who were referred to the diabetes clinic of Imam Khomeini hospital during 2004-2005 were studied. The treatment procedure was explained for control group and an informed consent was taken. Scaling and root planning was randomly done for 15 patients, while control group were not treated for periodontal disease. The glycated hemoglobin (HbA1C) and clinical attachment loss was measured for all of the patients before and 2 months after treatment.
Results: At the baseline the clinical attachment loss (CAL) was significantly different between two groups. There was no significant difference between baseline HbA1C in the control and the experimental group. After 2 months the HbA1C was reduced in the treated group which was not statistically significant.
Conclusion: In this study non-surgical periodontal therapy had not effect on the control of type 2 diabetes.
Hasan Safaei, Masoud Amini,
Volume 6, Issue 3 (5-2007)
Abstract
Background: Type 2 diabetic patients have higher risk for death from coronary heart diseases than non-diabetic patients. Studies have revealed showed intensive treatment of hyperglycemia only have a small effect on CVD risk. Other risk factors such as Lipid abnormality play a leading role in the increased CVD risk associated with diabetes. The aim of this study was to assess the quality of lipid control and treatment in type 2 diabetic patient with dyslipidemia.
Methods: We studied Data from 602 type 2 diabetic patients who had at least four regular clinic visits every year for medical care in outpatient clinics of Isfahan Endocrinology and Metabolism Research Center, 1999-2003. Patients for Classified in three groups according to lipid levels as low, moderate and high risk. ADA )American Diabetes Association) standard criteria were used for appropriate lipid control.
Results: The mean age, duration of diabetes, HbA1c and BMI were 52.2±9.5 years, 6.8±4.6 years, 9.2±1.7% and 29.4±4.2 Kg/m2 respectively at initial registration. Eighty four percent of patient had LDL cholesterol above 100 mg/dl and 71% had triglyceride level >150 mg/dl, of these patients 47.8% and 41.6% had high risk levels and only 12.4% taking statins and 21.5% taking fibrate for treatment at end of study. Among hyperlipidemic patients levels of LDL-C decreased from 170.8±35.6 mg/dl to119±30.20 (p < .001), triglyceride decreased from 273.8±126 to225.2±97 mg/dl (P<0.004) and HDL-C increased from 43.3±10.6 to 48.4±14.1mg/dl ((P<0.6). Percentage change of lipid level was -35.8%, -17.7% and +7.3% respectively. At the end of fallow-up 50.4% of patients treated with statins and 14.7% with fibrate. Finally, overall control of cholesterol and triglyceride in patients with dyslipidemia was 30% and 37% respectively.
Conclusion: Our findings showed that many of type 2 diabetic patients with dyslipidemia have inadequate control of lipid and lipoprotein. The prevalence of cardiovascular events due to hyperlipidemia in type 2 diabetic patients is high. This fact demonstrates the importance of early interventions for control and treatment these risk factors for prevention of cardiovascular complication in this patients.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Bagher Larijani,
Volume 7, Issue 1 (7-2007)
Abstract
Background: Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models but its relevance to human diabetes remains uncertain. The aim of this study was to investigate the relationship between serum resistin concentrations with insulin resistance and obesity indices in type 2 diabetes and non-diabetic obese subjects.
Methods: As a case- control study 35 obese subjects with type 2 diabetes (age, 44.60 ± 6.39yr BMI, 34.23±3.92 kg/m2) and 35 obese non-diabetics (age, 43.14±9.13yr BMI, 35.54 ± 4.07 kg/m2) are recruited. Fasting lipid profile was measured by enzymatic methods. NycoCard HbA1c Kit was used to measure HbA1c.The Serum resistin, insulin and glucose levels were measured by an enzyme immunoassay using a commercially available kit and glucose oxidase methods respectively. The insulin resistance index was calculated from fasting glucose and insulin by the homeostasis model assessment (HOMA-IR) formula.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetics were significantly higher than non-diabetics subjects (P<0.05). Serum resistin concentrations were not different between diabetics and non-diabetics obese subjects but were significantly higher in women as compared to men (8.15±4.40 vs. 5.97±2.31 in non-diabetic) and (7.46±3.98 vs. 5.51±3.98 in diabetic) in both groups. Serum resistin was not significantly related to variables measured in both groups. In control group only, we observed a significant and negative correlation between diastolic blood pressure and resistin (r = -0.381 P = 0.024).
Conclusion: Serum resistin concentrations were not significantly different between type 2 diabetes and non-diabetic obese subjects and resistin is unlikely to be a major link between obesity and diabetes in humans.
Mohsen Khoshniat Niko, Farah Madarshahian, Mohsen Hassanabadi, Ramin Heshmat, Nasim Khaleghian,
Volume 7, Issue 1 (7-2007)
Abstract
Background: Increasing number of people with diabetes make it the greatest world-wide epidemy which indicates importance of education in physical and mental health of the patients. Since researches report different results about cognition status of diabetic patients, this study was conducted to determine and compare cognitive status in older people with and without type 2 diabetes.
Methods: In this case- control study 80 patients with type 2 diabetes mellitus compare with 80 persons without diabetes. Cases were selected from the patients refer to diabetes outpatient clinic and control group were patients referred to other clinics. Instruments were questionnaire for gathering demographic data, glucometer, DSM-IR-TR questionnaire, FBS for control group and TSH - T4- HbA1c for cases..
Results: The mean scores of MMSE were 23.3 and 26.8 in case and control group respectively. Difference between two groups was significant in MMSE scores (P<0.01), furthermore between men and women of two groups (P<0.01 for both). No significant difference of MMSE scores between men and women in case group was seen (P=0.45). There was negative association between MMSE scores and age also duration of illness according to the results.
Conclusion: Elderly diabetic patients encounter some cognitive impairment which is exacerbated with increasing age.
Mohammad Reza Kalantarhormozi, Seyed Javad Siadatan, Arash Aria, Mohammad Hossein Dabbaghmanesh, Mesbah Shams, Abdosamad Sadeghalvad, Bagher Larijani, Gholamhossein Ranjbar Omrani,
Volume 7, Issue 2 (9-2007)
Abstract
Background: Type 2 diabetes mellitus is the most common type of diabetes which is triggered by various factors such as obesity, hyperlipidemia, hypertension, dietary habits and inheritance. With respect to geographic variation of diabetes prevalence, it is important to know the risk factors regionally.
Methods: As a case-control study, we looked for important risk factors of diabetes in our region. This study consisted of 400 individuals in case group and 400 individuals in control group. All these anthropometric measurements were calculated by standard methods. Blood samples taken from two groups were studied for TG, FBS, Cholesterol and HbA1c. Data are reported as the Mean±SD. P<0.05 was considered as statistically significant.
Results: There was no significant difference between two groups about mean age and sex ratio. Statistically significant difference were found for central obesity, hyperlipidemia, hypertension, polycystic ovarian syndrome (PCOS) and positive family history of diabetes in both groups (P<0.05).
Conclusion: The results showed that central obesity, hyperlipidemia, hypertension, PCOS and positive family history of diabetes are important risk factors of diabetes mellitus in Shiraz. In concordance with the results of this study, screening programme for that risk factor of diabetes in this region is suggested.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Amir Bahrami, Baghar Larijani,
Volume 7, Issue 2 (9-2007)
Abstract
Background: Adiponectin is an adipose tissue-derived hormone that low levels of this hormone are associated with obesity, insulin resistance, and type 2 diabetes. The aim of this study was to compare the serum levels of adiponectin in diabetic and non-diabetic obese individuals.
Methods: As a cross-sectional study 35 obese individuals with type 2 diabetes mellitus and 35 non-diabetic obese subjects were enrolled. Two groups were matched for age, gender and body mass index. Fasting lipid profile was measured via the enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c.The Serum Adiponectin, insulin and glucose levels were measured via an enzyme immunoassay, using a commercially available kit and glucose oxidase methods, respectively. The HOMA and QUICKI indices were used to determine insulin resistance and insulin sensitivity, respectively.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetes were significantly higher than non-diabetics (P<0.05). The serum Adiponectin levels was significantly lower in diabetes than non-diabetics (15.74±6.70 vs. 21.52 ± 9.35) and was significantly higher in women than men (19.38 ± 7.33 vs. 12.68 ± 4.28) among diabetic and (24.63 ± 10.52 vs. 17.83 ± 6.21) among non-diabetics groups.
Conclusion: type 2 diabetes mellitus is associated with low serum adiponectin concentrations and probably adiponectin involved in the pathophysiology linking obesity to type 2 diabetes.
Mohammad Hossein Dabbaghmanesh, Mohammad Reza Kalantarhormozi, Mahmood Soveid, Abdosamad Sadeghalvad, Gholamhossein Ranjbar Omrani,
Volume 7, Issue 2 (9-2007)
Abstract
Background: The relationship between diabetes and serum insulin and Zinc (Zn) levels is complex with no clear cause and effect relationships. Since Zn plays a clear role in the synthesis, storage and secretion of insulin as well as conformational integrity of insulin in the hexametric form, the decreased Zn, which affects the ability of the islet cell to produce and secrete insulin, might then compound the problem, particularly in type 2 diabetes. The aim of this study was to determine the changes of plasma Zn in patients with type 2 diabetes mellitus and healthy control in Shiraz city.
Methods: As a case-control study, we determined the serum Zn levels by atomic absorption spectrophotometer, blood HbA1c levels with columnar chromatographic method and Glucose, by enzymatic colorimetric method in auto analyzer. Data are reported as the Mean±SD and P<0.05 was considered as statistically significant
Results: Results of this study revealed that levels of Zn in serum of diabetic patients is lower than in the healthy control in Shiraz city (P<0.05).
Conclusion: With respect to the result of this study, dietary educations about consuming enriched Zn foods such as sea foods and corn in diabetic patients is necessitated.
Malihe Aveseh, Rohollah Nikooie, Fereshteh Atabi, Zahra Mirzaie Zadeh , Kobra Omidfar, Bagher Larijani,
Volume 13, Issue 2 (1-2014)
Abstract
Background: the aim of this study was to investigate the effect of seven weeks endurance training on
RBP4 gene expression in Soleus and Extensor Digitrum Longouse (EDL) Muscles, liver, visceral and
subcutaneous fat in type 2 diabetic rats.
Methods: 50 male wistar rats (5 weeks years old, weight = 93.7 ± 8.9) were purchased and randomly
divided into four groups: Control (n=10) (C), Trained (n=10) (T), Diabetic Control (n=15) (DC) and
Trained diabetic (n=15) (TD). Diabetes was induced by injection of low dose of streptozotocin (STZ)
and feeding with high fat diet. Insulin resistance accuracy was confirmed by HOMA-IR index and
Real-time PCR was used for mRNA content.
Results: After seven weeks of diabetes induction, the RBP4 mRNA content of the liver (2.37-fold P <
0.01), visceral fat (2.33-fold P < 0.01), and subcutaneous fat (1.83-fold P < 0.05), soleus (1.21-fold
P < 0.05) and EDL (2.03-fold P < 0.05) were increased. After seven weeks of endurance training
significant decrease in RBP4 mRNA content was found in visceral fat (P < 0.05), subcutaneous fat (P
< 0.05) and EDL (P < 0.05) between DC and CD. In addition, significant difference between T and TD
groups was found for RBP4 mRNA content in liver (p < 0.01), subcutaneous fat (P < 0.01) and EDL
(P < 0.01) after seven weeks of endurance training.
Conclusion: Type 2 diabetes considerably increases skeletal muscle RBP4 expression in isoform-
specific manner. This increase is also seen in liver, subcutaneous and visceral fat. In addition,
endurance training decreases the RBP4 expression in EDL, subcutaneous and visceral fat.
Zeinab Shayeghian, Parisa Amiri, Maria E. Aguilar-Vafaie, Mahmoud Parvin, Kobra Roohi Gillani,
Volume 13, Issue 2 (1-2014)
Abstract
Background: Cognitive and emotional deficits in alexithymia lead to various problems in somatic
disorders and other medical conditions for example Diabetics. The aim of this study was to examine
the effect of alexithymia on relationship between self-care and control of blood sugar in type 2
diabetes patients within the Iranian social and cultural context.
Methods: The present study was a cross-sectional investigation. The study sample consisted of 100
(60 females and 40 males, aged 40 to 70 years) type 2 diabetic outpatients visiting Labbafinejad
hospital during the year 2012. Measures for data collection included demographic, anthropometric
and clinical questionnaires, the short scale for diabetes self-care activities and the diabetes-related
quality of life. Blood tests were performed to obtain HbA1c levels and other laboratory measures
related to the study. Data were analyzed using SPSS16 software.
Results: Pearson product correlation results yielded significant negative associations between self-
care activities and alexithymia as well as HbA1c levels in type 2 diabetes patients. Results of
hierarchical regression analyses indicated that diabetes-related self-care activities explained 40% of
HbA1c variance and alexithymia added explanatory variance above and beyond self-care, to jointly
explain 58% of HbA1c variance.
Conclusion: Based on the present findings, diabetes-related self-care and alexithymia predicted
HbA1c levels in patients with type 2 diabetes. Given the evidence on the additive validity of
alexithymia in the prediction of HbA1c levels found in the present study, attention to emotional
competencies and disorders of Iranian diabetic patients may effectively contribute to their control of
diabetes.
Rohollah Nikooie, Malihe Aveseh, Kobra Omidfar,
Volume 13, Issue 2 (1-2014)
Abstract
Background: the aim of the present study was to investigate the effects of diabetes and seven weeks
of endurance training on RBP4 expression in Soleus, extensor digiturom longuse (EDL), liver, visceral
and subcutaneous fat in type 2 diabetic rats.
Methods: Fifty male wistar rats (93.7 ± 8.9 g) were randomly divided into four groups including:
control (C) [n=10], trained (T) [n=10], diabetic control (DC) [n=15] and diabetic trained (TD) [n=15].
The combination of Intraperitoneally injection of streptozotocin (STZ) and high fat diet feeding were
used for diabetes induction. After seven weeks of endurance training, serum RBP4 and its expression
in above tissues were measured by ELISA and western blotting techniques, respectively.
Results: diabetes induction increased the RBP4 expression of the liver (3.57-fold, p < 0.01), visceral
fat (2.02-fold, p < 0.01), and subcutaneous fat (1.84-fold, p < 0.01) and EDL (2.29-fold, p < 0.01) in
DC in comparison to C group. Serum RBP4 concentration was significantly higher in DC (2.9-fold, p
< 0.01) and TD (1.84-fold, p < 0.01) in comparison to C group. Endurance training significantly
decreased serum RBP4 (p < 0.01) and its expression in visceral fat (p < 0.01) in DT in comparison to
DC.
Conclusion: type 2 diabetes extensively decreases the skeletal muscle RBP4 expression in isoform –
specific manner, liver, subcutaneous and visceral fat. In addition, endurance training decreases serum
RBP4 concentration and its expression in visceral fat.
Roya Kolahdouz Mohammadi, Mohammad Javad Hosseinzadeh-Attar, Mina Kolahdouzmohammadi, Mohammad Reza Eshraghian, Elnaz Khorrami, Alireza Esteghamati,
Volume 13, Issue 3 (3-2014)
Abstract
Background: CoQ10 is a lipid-soluble and a powerful antioxidant. Decreased level of this antioxidant
was reported in many conditions like vascular, diabetes, high blood pressure and coronary artery
diseases. With regards to increased oxidative stress in diabetes and its role in the development of high
blood pressure, this study aimed to examine the effect of Q10 supplementation on blood pressure level
and its relation to nitric oxide metabolites (NOx) level in type 2 diabetic patients.
Methods: In this 12-week randomized controlled trial, T2D subjects received either placebo or
coenzyme Q10 (100 mg twice a day). Anthropometric measures, blood pressure, biochemical analysis
including NOx level, fasting blood glucose, glycosylated hemoglobin (HbA1c) and lipid profile were
evaluated at the beginning and after the intervention.
Results: The intervention resulted in a significant improvement in systolic blood pressure
(115.3±27.61 versus 118.2±12.6 mmHg), diastolic blood pressure (77.1±8.22 versus
80.3±12.11mmHg), NOx (Pvalue=0.014) and HbA1c. Moreover Q10 supplementation resulted a
significant decrease in elevated levels of cholesterol.
Conclusions: In conclusion, CoQ10 supplementation (200 mg/day) for 12 weeks, significantly
decreased systolic and diastolic blood pressure, NOx, HbA1c, total cholesterol and LDL-C in type 2
diabetic patients.
Fatemeh Mokhtari, Fahime Esfarjani, Mehdi Kargar Fard,
Volume 13, Issue 4 (5-2014)
Abstract
Background: Physical activity with diet and medication–considered fundamental in the treatment of diabetes. The aim of this study was to determine the effect of combined 12-week aerobic exercise and barley β glucan (BBG) on blood glucose and lipid profile in patients with type 2 diabetes.
Methods: Twenty- four female volunteers (49±5 years) were selected, and after completion of questionnaires, were randomly divided into three groups a) aerobic training with diet group (n=8), b) diet group (n=8) and c) control group (n=8). The diet group used one barley bread per day with 4 gram beta glucan during 12 week. The combined group participated in progressive walking training program with intensity of 60-70% of maximal heart rate 2 to 3 times a week, 20 to 60 minutes in each session in addition to diet program. The variables measured included blood sugar, triglyceride, cholesterol, LDL, HDL. For data analysis ANOVA used to compare mean differences between groups.
Results: Results indicated significant difference in blood sugar between control and experimental groups while non significant changes was observed in lipid profile.
Conclusion: Aerobic exercise and BBG can decrease blood glucose in patients with diabetes Therefore, it should be considered seriously as part of the treatment of these patients.
Esmat Mosayebi, Maryam Sharifi, Mahgol Tavakoli,
Volume 13, Issue 5 (7-2014)
Abstract
Background: One of the important indicators of diabetes treatment and control is enhancement of quality of life in patients with diabetes. Therefore, in recent years, quality of life in these patients regarded by therapists and researchers and increased studies in this field. The aim of this study was collection and integration of these studies results to investigate the effect size of sport and psychological interventions on quality of life in patients with type 2 diabetes by meta-analysis method.
Methods: For this purpose, 25 acceptable studies (15 psychological interventions, 10 sport interventions) in terms of methodology (hypothesis, research method, statistic population, volume of sample, sampling method, instrument measure & statistic analysis method) selected, and meta-analysis performed on them. Research instrument was checklist of meta-analysis.
Results: The study findings showed that the rate of effect size of psychological interventions on quality of life in patients with type 2 diabetes was d=0.95 (p<0.00001) and the effect size of sport interventions on quality of life in this patients was d=2.2(p<0.00001). According to Cohen’s chart both effect sizes of sport and psychological interventions were high.
Conclusion: psychological and sport interventions can be effective on improvement of quality of life in patient with 2 diabetes.
Elaheh Khajouee, Zohreh Elahi-Moghaddam, Morteza Behnam-Rasouli, Naser Mahdavi-Shahri,
Volume 13, Issue 5 (7-2014)
Abstract
Background: Diabetes is a kind of metabolic disorder characterized by hyperglycemia, caused by defect in insulin function, secretion or both. In chronic hyperglycemia different tissues and organs, such as thyroid gland underwent histophysiological alterations. The aim of the present study was to compare the effects of type 1 and type 2diabetes on the serum levels of biochemical factors and histological changes in the thyroid gland in male Wistar rats.
Methods: After induction of type 1 diabetes (Alloxan 135 mg/kg BW) and type 2diabetes (10% fructose administrated through drinking water for 8 weeks) all rats were kept for 2 months. Blood samples were collected at the beginning and in the middle and at the end of experiment for biochemical factors analysis. After that, the thyroid gland of all rats were removed and processed for histological preparation. Then the HE stained sections were examined for thyroid gland volume and follicular surface density measurements, using Cavalieri’s Principle and stereological method, respectively.
Results:The results showed an increase in surface density and a decrease in thyroid volume in type 1 diabetic and type 2 diabetic groups, when compared with control. Furthermore, in type 1 diabetic group, the Triglycerid and Cholesterol levels increased and LDL level decreased, while in type 2 diabetic group, LDL and HDL levels slightly decreased. These results reveal that type 1 and type 2 diabetic conditions probably cause hypo- and hyper activity of thyroid gland, respectively.
Amirabbas Monazzami, Hamid Rajabi, Kobra Omidfar, Ali Mostafaie,
Volume 13, Issue 5 (7-2014)
Abstract
Background: The purpose of this study was to investigate the effects of endurance training on muscle NHE1 and NBC1 gene expressions in type 2 diabetic rats.
Methods: Male wistar rats (n=40), 4weeks old and 93.7±9.8g, were randomly selected and divided into control, diabetic control and diabetic training groups. The Endurance training was performed for 7 weeks on diabetic training groups (running on treadmill forrodent). NHE1 and NBC1 gene expression were determined by Realtime-PCR technique. The differences between groups in variables were determined by an independent t-test using REST Software.
Results: NHE1 mRNA expression reduced significantly in EDL and Soleus by 25% and 19% in the diabetic control group compared with the control group, respectively (P<0/05).NHE1 mRNA expression also reduced significantly in EDL and Soleus by 35% and 29% in the diabetic control group compared with the control group, respectively (P<0/05).Endurance training increased NHE1 and NBC1 geneexpressions in both EDL and Soleus in the diabetic training group.
Conclusion: The present study showed that NHE1 and NBC1 mRNA expressions decreased significantly in the diabetic control group and endurance training increased NHE1 and NBC1 mRNA expressions in the diabetic trained group leading to normalizing the mRNAs in diabetic trained group.
Nooshin Poorsoltan, Yadollah Mehrabi, Zhaleh Shadman, Mahdieh Akhoundan, Arash Rashidi, Mohsen Khoshniat Nikoo,
Volume 14, Issue 1 (1-2015)
Abstract
Background: Physiological stress may affect eating habits and also foods intake may alter the physiological stress. According to the reports of high levels of serum cortisol as a stress biomarker in type 2 diabetic patients the aim of this study was to investigate the relationship between dietary patterns and serum cortisol concentration in type 2 diabetic patents.
Methods: This cross-sectional study was conducted on 241 type 2 diabetic patients in 2013. Major dietary patterns were obtained by factor analysis. Serum cortisol was measured at 8 am. Serum cortisol level was compared among tertiles of dietary patterns using ANCOVA adjusted for confounders (age, sex, BMI, and fasting blood glucose). Linear regression analysis was performed to assess the association between serum cortisol and scores of dietary patterns.
Results: Three major dietary patterns were identified as Western, healthy and healthy like. None of the variables age, waist circumference, body mass index, physical activity level, duration of diabetes and fasting blood glucose was significantly associated with serum cortisol. After adjustment for confounders, no statistically significant difference was found in mean serum cortisol among tertiles of dietary patterns or no statistically significant association between serum cortisol and dietary patterns scores. Mean serum cortisol was 12.95±5.10 nmol/L which was in normal range.
Conclusion: This study showed that in type 2 diabetic patients, normal levels of serum cortisol were not associated with the adherence to Western, Healthy and Healthy like dietary patterns.
Zeynab Nezamdoust , Marziyeh Saghebjoo, Afson Barzgar,
Volume 14, Issue 2 (1-2015)
Abstract
Background: This study was conducted to determine the effect of 12 weeks of aerobic training on serum levels of vaspin and glucose homeostasis variables in patients with type 2 diabetes. Methods: In this quasi-experimental study, 20 women with type П diabetes (mean±SD: age 43.30 ±3.02 yr, body mass index 27.089±3.23 kg/m2 and body fat 29.46 ±2.71%) were randomized into experimental (n = 10) and control (n = 10) groups. Experimental group performed twelve weeks aerobic training (3 times per week at an intensity of 75-85 % of maximum heart rate reserve). Blood samples were collected 24h before and 48h after the training. Data was analyzed by paired and independent samples t-test (P <0.05). Results: Results showed a significant decrease in serum levels of vaspin, fasting blood sugar and insulin resistance index (P value 0.001, 0.01 and 0.007 respectively) ) in experimental group and body weight, body mass index, percent body fat and waist to hip ratio significantly decreased in experimental group (P value 0.002, 0.01, 0.04 and 0.03 respectively). Conclusion: The results of this study showed that aerobic training along with decrease in body weight and percent body fat leads to significant decrease in serum levels of vaspin, fasting glucose and insulin resistance index, so can be considered as a complementary therapy method in patients with type 2 diabetes.
Asiyeh Taji Tabas, Mehdi Mogharnasi,
Volume 14, Issue 3 (3-2015)
Abstract
Background: Nesfatin-1 is an adipokine that released by adipose tissue and participated in the regulation of insulin activity and glucose metabolism. The aim of this research is the investigation the effect of 10 week resistance exercise training on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes. Methods: Eighteen women with type 2 diabetes recruited this study by using of the Purposive Sampling method and were randomly divided into two experimental (n= 10) and control (n= 8) groups. The experimental group participated in resistance exercise training (the exercises training started with 30-50% intensity of one maximum repetition in the first training session and increased to 70-80% intensity of one maximum repetition in the final session) in three times per week for 10 weeks. Also, the control group not participated in exercise program. Blood samples were taken pre-and post-exercise test in the 12 h fasting conditions for evaluation of nesfatin-1, insulin and glucose levels. The resulting data was analyzed by SPSS 21 and used of Kolmogorov-Smirnov, t-independent and dependent t-tests at a significance level of &alpha<0.05. Results: Intra-group changes in the experimental group showed that a significant increase in nesfatin-1 levels and a significant reduction in blood glucose and insulin resistance levels after 10 weeks resistance training (P<0.05). However, there was no significant change in insulin levels (P>0.05). In the comparison between groups, the changes of nesfatin-1 and glucose levels were significantly in pre- and post-exercise test in the experimental group compared with the control group (P<0.05). Conclusion: According to the results of this research, resistance exercise training could be recommended as adjunctive therapy method for women with type 2 diabetes.
Mahnoush Reisi, Firoozeh Mostafavi, Homamodin Javadzade, Behzad Mahaki, Elahe Tavassoli, Gholamreza Sharifirad,
Volume 14, Issue 3 (3-2015)
Abstract
Background: Diabetes is a chronic disease that can cause severe complications such as cardiovascular disease, blindness and kidney failure. Given the importance of self-care in diabetic patients, and considering that inadequate health literacy is a serious barrier for the management of diabetes that can affect patients' participation in self-care, Therefore this study aimed to assess the status of health literacy in patients with type 2 diabetes in three domains of functional, communicative and critical and Determine the factors associated with self-care behaviors in these patients. Methods: A cross-sectional study on 187 diabetic patients referred to Hazrat Ali diabetes clinic in Isfahan. The samples were selected by randomly Convenience sampling method. The level of health literacy and Status of self-care behaviors in patients was assessed by a standardized questionnaire (FCCHL) and (DMSES) respectively. Collected data were analyzed Using the ANOVA, t-independent, Pearson correlation coefficient at SPSS v.21 statistical software. Results: The mean age of the study population was 57.40 ± 11.07. Average health literacy score and self-care behaviors of the participants were 2.28± 0.57 and 3.84 ± 1.56 respectively. There was significant relationship between total health literacy, communicational and critical health literacy with self-care behaviors. There was no significant relationship between functional health literacy and self-care behaviors. Communicational health literacy was associated with diet, physical activity, blood glucose monitoring and foot care. Critical health literacy was associated with physical activity, blood glucose monitoring, foot care, and taking medication. There was no significant relationship between Communicational health literacy and taking medication and also between critical health literacy and diet. Conclusion: Considering that communication and critical health literacy was associated with the self-care of patients with diabetes so Emphasis and consideration should primarily be given on skills related to these domains of health literacy. Since that Patients’ functional HL capabilities that was associated with basic skills in reading and writing was not related to self-care, therefore assessment of education levels alone in the clinical setting is not recommended.
