Showing 43 results for Disease
Shadi Jalalian, Hossein Abednatanzi, Mandana Gholami, Farshad Ghazalian,
Volume 23, Issue 4 (11-2023)
Abstract
Background: Oxidative stress and insulin resistance in type 2 diabetes are one of the factors in the development of cognitive disorders and Alzheimer's. So measuring the changes in beta amyloid gene expression and insulin resistance as one of the prominent disorders in type 2 diabetes, following HIIT and thyme’s honey consumption is the aim of the research.
Methods: The present study was conducted with 36 young male Wistar rats, which were divided into 4 groups: control (C), interval training (T), thyme’s honey (H) and interval training-thyme’s honey (TH) was performed. The rats in the T and TH groups were trained for two months with intervals and intensity gradually increasing, and in the H and TH groups, they received 3 g/kg of thyme’s honey. Weight, fasting glucose and insulin were measured through the kit and insulin resistance index was done through the formula and gene expression were evaluated by RT-PCR. The findings were subjected to one-way and two-way ANOVA and Bonferroni's test.
Results: Non-significant (NS) increase in weight, significant increase in insulin and significant decrease in gene expression in all intervention groups compared to C, significant decrease in fasting glucose in T and TH groups compared to C, significant decrease in insulin resistance in T group compared to other groups, NS increase was observed in group H and TH compared to C.
Conclusion: HIIT and thyme’s honey had synergistic effect to reduce glucose and beta-amyloid gene expression as a preventive strategy for the occurrence of pathological features related to Alzheimer's and memory impairment in diabetics.
Soosan Soroosh,
Volume 24, Issue 3 (7-2024)
Abstract
Background: We aimed to examine the distribution of all types of musculoskeletal diseases and then to estimate the direct and indirect costs caused by these complaints among soldiers and non-soldiers’ employees in military.
Methods: We recruited all patients referred with musculoskeletal complaints who were admitted to the rheumatology, orthopedics and neurosurgery committees of 501 army hospital from 2013 to 2015. The cost of diagnostic procedures was calculated based on the data of records and the cost of treatment for each complaint was estimated by calculating the average cost of treatment plans proposed by two physical medicine and rheumatology specialists. Indirect costs due to leave and reduced working time and hospitalization and disability were estimated and added to the direct cost.
Results: 2116 patients with an average age of 25.84 ± 8.17 years were examined. 1252 people were soldiers and 864 people were non-soldiers. Fracture (301 cases), lumbar disc bulges and herniation (303 cases), and geno varus/geno valgus (257 cases) were three most common complaints. The most damaged site were lower limbs and spine. In total, 4,120 person-days of absence were estimated for these people annually, and the annual economic effect was calculated to be 1,713,903,120 Tomans.
Conclusion: Musculoskeletal diseases are one of the prevalent health and economic problems in military. Therefore, application of diagnostic and therapeutic strategies and considering the cost & benefit law to reduce the economic burden and disability should be among the priorities of the Army University to prevent and save health costs.
. Zahra Goli, Dr Farzaneh Taghian, Dr Khosro Jalali,
Volume 24, Issue 5 (12-2023)
Abstract
Introduction:The purpose of the research was to compare the effect of two types of raeobic exercise with and without incline on the modulation of oxidative stress and kidney function in CKD mice.Methods:The number of 24 two-month-old C57bl6 female mice weighing 25±26.1 grams were randomly divided into four groups:healthy control,CKD-affected mice,CKD and aerobic exercise without incline and CKD and aerobic exercise with incline were divided. In order to induce CKD,they received adenine powder of 0.2% mg/kg for 4 weeks.The training groups performed eight weeks of treadmill training(5 sessions perweek)one group performed with a 20-degree incline and the other group performed with a zero-degree incline.After the last training session, sampling of blood was done to measure blood urea nitrogen and urea and glutathione concentration by ELISA method.The expression of SIRT1,NRF1 and TNF-α genes was measured by qPCR-Real Time technique. For statistical analysis,one way ANOVA test and Tukey's post hoc test and significance level P≤0.05 were used.Findings:The results showed that induction of CKD caused a significant increase in blood urea nitrogen and a significant decrease in glutathione concentration compared to the healthy control group (P<0.05).On the other hand, in the exercise group, there is a significant increase in glutathione concentration and a significant decrease in blood urea nitrogen (P<0.05).The expression level of SIRT1 and NRF1 in the slope training group increased significantly and the expression level of TNF-α decreased significantly (P<0.05).
